JPH0789852A - Water-soluble powder containing calcium in high concentration and its production - Google Patents

Abstract

PURPOSE:To obtain water-soluble powder of calcium and to provide its production for evaporating only water from an organic acid or an organic acid- containing liquid having dissolved calcium in high concentration, powdering. CONSTITUTION:This water-soluble powder of calcium is obtained by dissolving a calcium-containing substance in an organic acid or an organic acid-containing liquid, evaporating only water, powdering. The powder is obtained by evaporating only water in a solution of calcium in the organic acid or the organic acid- containing liquid from the solution by using spray dryer, etc. The powder can dissolve calcium in water in a high ratio of 30 times as much as in milk and has neither unpleasant taste nor smell which calcium has essentially. The powder makes an irritating smell of an organic acid even into a mild acidity, can be orally administered as it is or added to various kinds of foods and orally administered and supply all users from old people to children with calcium while enjoying its taste.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a water-soluble powder of calcium and a method for producing the same, and more specifically, to remove only water from a solution of an organic acid or a liquid containing an organic acid in which a high concentration of calcium is dissolved. TECHNICAL FIELD The present invention relates to a water-soluble powder of calcium which is vaporized and powdered, and a method for producing the same.

[0002]

It has been widely recognized that calcium is an essential component for bone and tooth formation, but recently it has been clarified that it is the most important nutrient that supports all life phenomena. Calcium is now attracting attention at the forefront of medicine. Calcium deficiency for humans
It has been pointed out that it causes not only osteoporosis but also diseases such as cancer, hypertension, arteriosclerosis, myocardial infarction, cerebral infarction, diabetes, and immune disorders, and it is also recognized that large amounts of calcium-containing foods must be taken. Has been done.

The Ministry of Health and Welfare of Japan recognizes the current situation that diseases such as osteoporosis, which is thought to be due to calcium deficiency, are frequently occurring, and has taken the conventional calcium intake of 600 mg / day as required for the human body. , Just recently, corrected to 800mg / day. However,
This target intake value is a value calculated as the amount of calcium of 100 mg per 100 ml of milk, and in fact, even if 800 ml of milk is drunk, only half of 400 ml of calcium is absorbed in the body.

Ingested calcium is absorbed only in the body by being ionized in the stomach, but it also contains substances such as phosphorus, fat and protein which inhibit the absorption of calcium. In some cases, it has been found that the utilization rate of calcium is reduced by that amount.

Therefore, the content of calcium in milk is 100 mg / 100 ml, which is said to have the highest calcium content in foods and good absorbability, but recently, many researchers have found it. For the above reasons, it has been announced that the absorption utilization rate of calcium contained in milk is not necessarily good. In fact, Japanese people have a much lower fracture rate than Westerners, who consume many times more milk and dairy products than Japanese people. It is also true that some scholars are present, and it is also persuasive.

Therefore, 800 recommended by the Ministry of Health and Welfare
If calcium is taken only from milk per day, it means that a huge amount of milk of 1600 mg per day must be consumed. In any case, it has been widely recognized that a large amount of calcium must be taken, but we suggest a proper method for how to get the required amount of calcium. Not what you are doing.

[0007] In addition, recently, as a human dietary habit, except for people in the European region and the desert region, which have been forced to survive by relying on dairy animals for a long time, the function of the body is milk after the weaning period. Shocking research results have also been reported (categories of education and medical science, July 25, 1993) that cataracts are likely to occur when such people drink a large amount of milk, which is not suitable for ingestion of foods. This suggests that milk contains a large amount of not only calcium but also fat, protein, phosphorus and the like, which suggests an adverse effect of simultaneously ingesting fat and protein together with calcium.

Therefore, it is not only natural that milk cannot supplement the required amount of calcium,
At present, it is also pointed out that there is a risk, and it is in a situation where it is necessary to consider ingesting a shortage of calcium from other foods and drinks. However, even in dried sardines, sardines, hijiki seaweed, grilled seaweed, etc., which are known as calcium-containing foods other than milk, the calcium content is far below the daily requirement, and in the end, it is a normal diet. It is not possible to get the required amount of calcium from. As a result, a chronic calcium deficiency occurs, which causes the above-mentioned various diseases.

[0009] Furthermore, regarding the case of vitamin D known to promote absorption of calcium, vitamin D is not only produced from provitamin D in the body by sunlight irradiation, but also ingested from foods. , Vitamin D ingested becomes active vitamin D by the action of parathyroid hormone, and helps absorption of calcium from the intestinal tract. This action, together with parathyroid hormone, causes calcium from bone to be absorbed. It is known that, as a result, excessive intake of vitamin D causes disorders such as hypercalcemia, uremia, and osteomalacia.
The current situation is that Vitamin D is not recognized as a medicine by A.

As described above, even milk, which is said to have the highest absorbability, has a very small amount absorbed into the human body, and an excessive intake of milk is rather harmful to the human body. At present, it is extremely difficult to supplement the required amount of calcium from food,
It seems that it has been recognized as common sense that the intake of calcium from other than food should be considered.

As a manifestation of this recognition, it can be seen that calcium preparations as so-called health supplements are on the market. However, many commercially available calcium preparations are usually sold as tablets,
Aside from healthy people, swallowing this can often be a pain for people with illnesses that require high calcium intake, especially the elderly.

[0012] Of course, in order to improve the problem of difficulty in drinking, attempts have been made to granulate or liquefy calcium preparations, but even in this case, the problem inherent in calcium preparations, namely, water Difficult to dissolve in,
The three major drawbacks are that it has an unpleasant taste peculiar to calcium, such as bitterness and astringency, and is difficult to drink, and that it is hard to absorb into the human body.
It remains unsolved.

Also in the field of medicine, when bleeding due to a traffic accident or the like, the pH in the body suddenly becomes acidic, and if you do not quickly adjust it to neutral or weak alkaline, your life will be precious. It is known to be dropped. For that purpose, an aqueous solution of calcium chloride for injection containing calcium solubilized is used, but this is incapable of oral administration, and even when used for injection, it causes a paradox phenomenon and causes shock death. Danger has been pointed out. Therefore, Professor Toyoyuki Tamura of Nihon University School of Medicine and others report that the appearance of water-soluble calcium that can be orally administered and that can rapidly supplement high-concentration calcium is awaited.

The inventors of the present invention have been conducting research for many years as a subject of a calcium preparation having excellent absorbability into the human body and a calcium preparation in consideration of ease of drinking. -56795, Japanese Patent Publication No. 1-
Japanese Patent Application No. 13991, Japanese Patent Publication No. 1-13692, Japanese Patent Application No. 3-200851, and Japanese Patent Application Laid-Open No. 5-161480.

The invention disclosed in Japanese Patent Publication No. 60-56795 described above relates to the production of an electrolytically refined product of oyster shells containing a large amount of mineral components and exhibiting a high concentration of ionized calcium. It has been demonstrated that the absorption of substances in the intestine is excellent and that the rate of deposition on bones is extremely high, and even today, medical institutions such as affiliated hospitals of each university prevent adult diseases, It is actively used as a dietary supplement for treatment.

The inventions disclosed in Japanese Examined Patent Publication No. 1-13691 and Japanese Examined Patent Publication No. 1-13692 are a mixture of electrolytic boley ionized calcium with a mixture of reduced maltose and an organic acid. It has an improved irritation and taste that it originally has, and is characterized in that it makes it possible to ingest calcium in a delicious manner.

Based on such technical basis, the present inventors have improved the unpleasant taste and unpleasant odor peculiar to a calcium preparation, and have completed a preparation containing calcium at a high concentration and solubility in water. As a result of repeated studies aimed at achieving the improvement of the above, a water-soluble calcium preparation capable of solving all of these problems was completed.

[0018]

Therefore, an object of the present invention is to remove the unpleasant taste and unpleasant odor inherent in a calcium preparation, to ingest a high concentration of calcium in a delicious manner, and to improve its solubility in water. And to provide a method for producing the preparation.

[0019]

DISCLOSURE OF THE INVENTION The present invention has been proposed to achieve the above-mentioned object, wherein a calcium-containing substance is dissolved in an organic acid or an organic acid-containing liquid, and a solution state is obtained. It has an important feature in that it is pulverized by evaporating only one. That is, according to the present invention, there is provided a water-soluble powder of calcium, which comprises dissolving a calcium-containing substance in an organic acid or an organic acid-containing liquid, and then evaporating only water to obtain a powder. Further, according to the present invention, there is provided a method for producing a water-soluble powder of calcium, which comprises evaporating only water from an organic acid solution of a calcium-containing substance or a solution of an organic acid-containing liquid to form a powder.

[0020]

DETAILED DESCRIPTION OF THE INVENTION The most technical feature of the present invention is that a calcium-containing substance is made into a solution state of an organic acid, then only water is evaporated, and powdered in a state where calcium and the organic acid are bound. It is in. In other words, as it is, since the solubility in water is low, conventional calcium, which had a very low absorption in the human body even after drinking, was easily ionized to improve its absorption in the human body. In addition, although it has been already proposed by the applicant, even in the case of this preparation, even when dissolved in organic acids such as fermented lactic acid and citric acid, the dissolution rate of calcium is 100 ml.
However, it is at most 100 mg, and a calcium preparation having high solubility in water has been demanded.

The present invention can appropriately meet such a demand, and by pulverizing by the above-mentioned means,
Promptly for water, and 30 for 100 cc of water
As much as 00 mg of calcium was dissolved, and surprisingly, even the pungent taste originally possessed by some organic acids such as lactic acid, acetic acid, and malic acid turned into a mellow sourness, resulting in bitterness and astringency. It succeeded in removing unpleasant tastes such as tastes and unpleasant odors, and improved taste and odor. And, by making it powdery or granular, even if it is drunk as it is, it is even more difficult to swallow it even if it is dissolved in water and drunk, it is difficult for the elderly and children to swallow like the conventional tablets provided. As described above, it is understood that the three major drawbacks of the calcium preparation, which are difficult to drink, difficult to dissolve, and difficult to absorb, can be solved at once by the present invention. Ah

< Calcium-Containing Substance > The calcium-containing substance that can be used in the present invention means seaweeds such as shells, crustaceans, corals, bones, hijiki, wakame, and kelp, which were developed by the present inventors. Furthermore, calcium carbonate, calcium phosphate, calcium hydroxide (slaked lime), calcium lactate, including calcium oxide obtained by baking at least one calcium-containing substance of animal or plant origin such as spinach and parsley at high temperature. Any of the mineral-containing calcium-containing substances such as calcium gluconate can be used. Among them, calcium oxide obtained by burning oyster shell and / or seaweed as a raw material at a high temperature is most preferably used.

The high-temperature calcined calcium oxide is obtained, for example, by using the animal and / or plant-derived raw material at a high temperature of 900 to 1100 ° C., preferably 930 to 970 ° C., for 40 to 80 minutes, preferably 50 minutes to 50 minutes. 7
It is obtained by firing for about 0 minutes. The product is usually a white powder.

<Organic Acid or Organic Acid-Containing Liquid> Examples of the organic acid or organic acid-containing liquid capable of dissolving calcium include organic acids such as lactic acid, citric acid, malic acid and acetic acid, and liquids containing the organic acid. Can be mentioned. As the organic acid-containing liquid, juice of fruits such as pineapple and papaya, that is, fruit juice is used, and in particular, in terms of the solubility of calcium and the taste of the produced granules, the skin of pineapple containing lactic acid as a main component is peeled. Juice containing parts is most preferably used. Hereinafter, in the present invention, the organic acid or organic acid-containing liquid that dissolves the calcium, simply,
Sometimes called "calcium solution".

<Powderization of Calcium Dissolution Solution> Calcium has different solubilities depending on the type of organic acid, but if a uniform solution state is formed regardless of the solubility, by evaporating only water from this, A water-soluble powder in which calcium and an organic acid component are bound can be used. In the present invention, it is considered that the water-soluble calcium powder produced has no unpleasant taste and odor because the components having unpleasant taste and unpleasant odor are simultaneously removed in the step of evaporating only water.

As means for pulverizing, granulation accompanied by spraying with a spray dryer, a method of pulverizing after vacuum drying using a belt conveyor, a method of freeze-drying by a freeze-drying method, etc. are used. The powderizing means using a spray dryer is most preferable in that a granular powder having a substantially spherical foam structure can be obtained.

The spray dryer sprays the calcium solution in a mist state from above the cyclone-like device, evaporates only water by hot air blown from the upper and lower side surfaces, and instantaneously removes only calcium and organic acid components. This is a method of forming a granule, and in the meantime, a binder such as dextrin or carboxymethyl cellulose, or ascorbic acid or fructose may be added as needed.

The addition of the binder is effective in increasing the particle size of the product, and the amount to be added can be appropriately changed depending on the particle size of the desired product. By the way, the particle size of the product when the binder is not added is about 0.005 mm to 0.02 mm, and in order to obtain a particle size larger than this, by adding the binder, , 0.01 mm to 2 m
A product with a particle size of the order of m is obtained.

In the calcium solution using the pineapple juice described above, the sugar contained in the juice functions as an appropriate binder, has a slightly large particle size, and has a porous surface and almost spherical granules. Powders can be formed. The organic acid-containing calcium preparation granulated by a spray dryer is characterized in that the shape of the granules is almost spherical and has a porous structure, and this structure rapidly and excellently dissolves in water. It becomes a factor to show.

[0030]

The present invention will be described below with reference to examples.
The present invention is not limited to this example without departing from the technical idea of the present invention.

<Example 1> Preparation of calcium powder Thoroughly wash the oyster shells, remove the black areas, and then crush
About 8k crushed by a machine to a size of 5cm x 5cm
g prepared. In addition, thoroughly wash the hijiki to about 5
I prepared kg. Next, the size of 80 cm x 80 cm x 5 cm
The crushed oyster shell and hijiki in a titanium tray of Kisa
Then, it was baked at 950 ° C. for 1 hour in an electric furnace. After firing
Oyster shells and hijiki are crushed with a colloid mill and the average particle size is about
200 mesh white powder of calcium oxide (Sample 1)
Got

Preparation of Water-Soluble Calcium Powder 100 parts by weight of sample 1 and 900 parts by weight of pineapple juice (squeezed skin portion at the same time) were mixed at room temperature and gradually heated to 70. It completely dissolved in the vicinity of ° C. This calcium solution was kept warm at 75 ± 5 ° C. and filtered, and the filtrate was supplied to a spray dryer to be granulated to obtain spherical granular powder having an average particle size of about 7 μ. This powder has a refreshing acidity on the palate and
Up to 3000 mg in cc dissolved quickly forming a clear solution. In other words, the aqueous solution of the water-soluble calcium powder of the present invention can contain calcium at a concentration as high as 30 times as much as 100 mg of calcium contained in 100 ml of milk. It will be understood that it is completely free of sex-inhibiting phosphorus, fat, and protein, and that it is a breakthrough that can be added to any food and beverage to ingest delicious calcium. .

<Example 2> 110 parts by weight of precipitated calcium carbonate was added little by little to 900 parts by weight of the pineapple juice used in Example 1, and after the predetermined amount was added, taking care not to overflow the liquid by foaming. After the gas bubbling stopped, the mixture was filtered, and the filtrate was granulated in the same manner as in Example 1. This powder also had a refreshing sour taste and quickly dissolved in water.

<Example 3> Calcium hydroxide (slaked lime)
Granule powder was obtained in the same manner as in Example 1 except that 90 parts by weight of the solution was mixed with 900 parts by weight of a 50% aqueous citric acid solution and dissolved at 75 ± 5 ° C. Although this powder had a slightly stronger sourness than that of Example 1, it was extremely mellow and easier to drink than the original sourness of citric acid.

<Effect of application of calcium powder> Using the calcium powder obtained in Example 1, the effect on human bone mass was measured under the following conditions. 81 to 37 years old without metabolic disorders that may affect bone metabolism
Thirty-two adult males and females aged 32 years were used as a control group that did not take calcium, and as a group receiving calcium, 900 mg / day of the calcium powder obtained in Example 1 was divided into 3 times immediately after eating. And take it orally,
For both groups, bone densities of the 2nd, 3rd and 4th lumbar vertebrae were measured with Norland's xR-2 at 3 months, 6 months and 12 months.
It was measured by a 6-type dual energy X-ray absorption measuring device. Table 1 shows the average values of all the two groups.

[0036] From the above results, in the control group not supplemented with calcium, there was a phenomenon of bone mass of 2 to 3% with the lapse of time of 3, 6 and 12 months, whereas it was 900
On the contrary, in the group receiving mg of the water-soluble calcium powder of the present invention, an increase in bone mass was observed.

[0037]

According to the present invention, there is provided a water-soluble calcium powder containing a high concentration of calcium in a state in which an organic acid component and calcium are bound to each other.
Double the rate of dissolution of calcium in water, and without the unpleasant taste and odor inherent to calcium,
Moreover, even the pungent odors of organic acids have a mellow sourness, and they can be taken orally as they are or added to all foods and drinks. It is a preparation that can supplement calcium while enjoying.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 33/10 9454-4C 35/56 7431-4C 35/78 C 8217-4C 35/80 Z 8217 -4C 47/12 G

Claims (7)

[Claims] 1. A water-soluble powder of calcium, characterized in that a calcium-containing substance is dissolved in an organic acid or an organic acid-containing liquid and then only water is evaporated to form a powder. 2. The calcium-containing substance is oyster shell and / or
Alternatively, the water-soluble powder according to claim 1, which is activated calcium obtained by baking seaweed. 3. The water-soluble powder according to claim 1, wherein the organic acid-containing liquid is pineapple juice. 4. The water-soluble powder according to claim 3, wherein the pineapple juice is a pineapple juice containing a skin portion of the pineapple. 5. The water-soluble powder according to claim 1, wherein the powder is a substantially spherical granular powder having a porous structure. 6. A method for producing a water-soluble powder of calcium, which comprises evaporating only water from an organic acid solution of a calcium-containing substance or a solution of an organic acid-containing liquid to form a powder. 7. The production method according to claim 6, wherein the pulverization is performed by granulating means using a spray dryer.