JPH0759540A - Arachidonic acid-containing healthy food - Google Patents

Abstract

PURPOSE:To provide a healthy food essentially containing a fatty oil with arachidonic acid content at a specific level or higher, this useful for maintaining good physical condition or improving physical condition. CONSTITUTION:This healthy food consists of a fatty oil >=2(pref. 20-99)wt.% in arachidonic acid content so as to be >=2(pref. >=10)wt.% arachidonic acid content of the final food as the essential ingredient. The fatty oil containing arachidonic acid at relatively high concentrations can be obtained by culturing arachidonic acid-productive bacteria belonging to Mortierella in the presence of glucose (as carbon source) yeast extract (as nitrogen source) and pref. soybean oil followed by extracting and concentrating the arachidonic acid-contg. fraction.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an arachidonic acid-containing health food containing a fat / oil containing a relatively large amount of arachidonic acid as an essential component, which is effective for maintaining a good physical condition and improving physical condition.

[0002]

2. Description of the Related Art Arachidonic acid is a biological precursor of prostaglandin, and its pharmacological effect has recently attracted attention. Arachidonic acid is synthesized in vivo from linoleic acid via γ-linolenic acid and dihomo-γ-linolenic acid, and this synthetic arachidonic acid is converted to prostaglandins, which is considered to exert its effect. Has been. Therefore, it has been proposed to use arachidonic acid or linoleic acid, which is a biosynthetic raw material thereof, as an active ingredient of medicines and health foods. For example, JP-A-59-62522 proposes that linoleic acid and arachidonic acid are orally administered together with a surfactant as a water-soluble composition and used for the prevention and treatment of digestive system disorders.

However, linoleic acid is contained in a large amount in ordinary fat and oil foods, and although it is easily available and a desired effect can be expected by ingestion as food, arachidonic acid is food such as fish, meat and eggs. It is contained only in a small amount, and it is difficult to inexpensively obtain a sufficient amount to expect its pharmacological effect. In addition, JP-A-59-62522
No. 6,068,047 uses purified free fatty acid form of arachidonic acid, which is not practical because it is expensive.

[0004]

In view of such circumstances, the present inventors have conducted earnest research to obtain a practical health food using arachidonic acid, and as a result, for example, Japanese Patent Laid-Open No.
Oils and fats containing a high concentration of arachidonic acid obtained by the microbiological method as disclosed in JP-A-3-44891 and JP-A-2-86789 are suitable for that purpose, and health containing such oils and fats is suitable. The present invention has been completed by finding that foods are practical and that their intake is useful for maintaining a good physical condition, improving physical condition, and the like.

[0005]

[Means for Solving the Problems] That is, the present invention provides a health food containing arachidonic acid, which comprises an oil and fat having an arachidonic acid content of 2% by weight or more as an essential component.

[0006] Since no arachidonic acid content of 2% by weight is found among naturally occurring fats and oils, the present invention relates to a fat or oil obtained from a microorganism having an arachidonic acid-producing ability. The amount is 2% by weight or more, preferably 10 to 99% by weight, more preferably 2
0 to 99% by weight of fats and oils is added as an essential component. If the amount of arachidonic acid is too small, the compounding effect cannot be expected, so that the content of arachidonic acid in the composition of the present invention is 2% by weight or more, preferably 10% by weight or more based on the entire composition. Blend so that

Such fats and oils containing a relatively high concentration of arachidonic acid can be prepared by, for example, the method disclosed in JP-A-63-44891.
an arachidonic acid-producing bacterium belonging to the genus lla), which is obtained by culturing in the presence of soybean oil, preferably using glucose extract as a carbon source and yeast extract as a nitrogen source, and extracting and concentrating an arachidonic acid-containing fraction. You can Also,
According to the method disclosed in Japanese Patent Application Laid-Open No. 2-86789, filamentous fungus of the genus Entomophthora is cultivated in a medium to which an organic polybasic acid is added to accumulate arachidonic acid at a high concentration in the microbial cells. By collecting, it can be mass-produced quickly and inexpensively.

The health food of the present invention may be constituted by oils and fats containing such a relatively high concentration of arachidonic acid alone or a mixture thereof, or in addition to such oils and fats containing arachidonic acid, docosahexaenoic acid. (Less than,
DHA) and eicosapentaenoic acid (hereinafter EP
A)), γ-linolenic acid, α-linolenic acid, linoleic acid, fats and oils containing these acids, for example, soybean oil, sesame oil, refined fish oil, vitamins such as d-α-tocopherol, and oyster meat extract. Other amino acids, vinegar, salt, sweeteners, seasonings such as spices, and the like may be appropriately contained.

In particular, it has been found that the inclusion of DHA together with arachidonic acid promotes the action of arachidonic acid in the body and further improves its effect as a health food. Generally, when DHA is added in a weight ratio of 0.5 to 7 times with respect to arachidonic acid, a desired promoting effect is obtained.

Further, by incorporating oyster meat extract together with arachidonic acid, both fatty acid and amino acid can be ingested, and health food and further effects can be expected. Generally, the oyster meat extract has a weight ratio to arachidonic acid of 2 to 150 times, preferably 15 to 50 times.
The desired effect is obtained when added in a doubled ratio.

The health food of the present invention comprises an oil solution,
Emulsion, soft capsule, hard capsule,
It can be in the form of tablets, granules, solids, chewables, dressings, confectionery and the like. The health food of the present invention is not limited to humans, but may be feed for mammals such as dogs, cats, rats, rats, guinea pigs, monkeys, and baboons. For example, according to a conventional method, a solid or liquid feed is used. It can also be an additive. Such feeds are also included in the health food of the present invention.

The health food of the present invention is usually 50 to 2000 mg / day when the daily intake of arachidonic acid is an adult.
The daily dose is preferably 200 to 500 mg / day. For mammals other than humans, the daily intake of arachidonic acid is 1 to 50 mg / kg, preferably 5 to 10 mg / kg. This allows
It can improve fatigue, beauty, constipation, neuralgia, back pain, and stiff shoulder.

[0013]

The present invention will be described in more detail with reference to Examples and Experimental Examples, but the present invention is not limited thereto. In addition, "%" in an Example means "weight%."

Example 1 A soft capsule was manufactured according to a conventional method according to the following formulation. Ingredients Amount of arachidonic acid-containing oil 50.0% (containing 22% or more arachidonic acid) Purified fish oil containing eicosapentaenoic acid (EPA) 18.5% (containing 28% or more EPA and 12% or more DHA) docosahexaenoic acid (DHA) containing purified fish oil 30.0% (EPA containing 8% or more, DHA containing 30% or more) Vitamin E extract 1.5%

Example 2 A dressing was produced according to a conventional method according to the following formulation.

Example 3 First, arachidonic acid powder was prepared according to a conventional method according to the following formulation.

Arachidonic acid-containing fats and oils were dissolved in ethanol as a solvent, and the remaining raw materials were mixed, and this solution was added, mixed and dispersed for adsorption, and then heated and dried to remove the solvent and arachidone. Acid powder was used. Using the arachidonic acid powder thus obtained, a hard capsule was manufactured according to a conventional method according to the following formulation.

Example 4 Using the arachidonic acid powder prepared in Example 3, tablets were manufactured according to a conventional method according to the following formulation.

Experimental Example The soft capsules obtained in Example 1 were given to 10 boys and 20 girls over 40 years old, 6 capsules per day, divided into several doses, taken after meals, and continued for 2 months to improve their physical condition. They reported subjective effects on improving constipation, skin tone changes, neuralgia, low back pain, and stiff shoulders. As a result, 12 out of 30 people reported that it was effective for improving physical condition about 2 weeks to 1 month after the start of taking the drug. In addition, 10 out of 30 were effective after 3 days to 1 month for improving constipation, and 10 out of 30 were “well” after 1 week to 1 month for skin tone.
I reported. In addition, 8 out of 30 people reported that neuralgia, low back pain, and stiff shoulders became easier after 1 month to 1.5 months.

[0020]

According to the present invention, since arachidonic acid-containing fats and oils that can be mass-produced at low cost are used instead of arachidonic acid in the form of free fatty acid, a practical health food containing arachidonic acid is provided. Furthermore, by adding DHA-containing oils and fats and oyster meat extract in addition to arachidonic acid-containing oils and fats, the action of arachidonic acid in the body is promoted, and health foods with improved efficacy can be obtained.

Claims (8)

[Claims] 1. A health food containing arachidonic acid, which comprises an oil and fat having an arachidonic acid content of 2% by weight or more as an essential component. 2. The arachidonic acid content of fats and oils is 10% by weight.
The above is the arachidonic acid-containing health food according to claim 1. 3. The arachidonic acid content of fats and oils is 20% by weight.
The above is the arachidonic acid-containing health food according to claim 2. 4. A soft capsule form.
The arachidonic acid-containing health food described. 5. The arachidonic acid-containing health food according to claim 1, further comprising docosahexaenoic acid-containing fats and oils. 6. The arachidonic acid-containing composition according to claim 5, wherein the docosahexaenoic acid content is 0.5 to 7 times the arachidonic acid content. 7. The arachidonic acid-containing health food according to claim 1, which is in the form of a hard capsule mixed with an oyster meat extract. 8. The arachidonic acid-containing health food according to claim 1, which is in the form of tablets mixed with oyster meat extract.