JPH0753351A - Compound for bathing agent and cosmetic - Google Patents

Abstract

PURPOSE:To promote the effect of fermented rice extract to be used as a component of a bathing agent and a cosmetic. CONSTITUTION:A ferro-soferric salt is added to a fermented rice extract to improve the moisture-retaining effect of a bathing agent and cosmetic on the skin and promote the effect of the fermented rice extract.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to formulations for bath salts and cosmetics.

[0002]

Conventionally, fermented rice extract is said to be good for beauty and health. In particular, recently, it has been revealed that studies on rice fermented extract are effective for atopic dermatitis, such as at university hospitals and national children's hospitals. Utilizing such characteristics of the fermented rice extract, it has recently been investigated for use in bath salts and cosmetics.

[0003]

However, when fermented rice extract is used in bath salts and cosmetics, the effect of keeping the skin warm is recognized, but it cannot be said to be sufficient in terms of the moisturizing effect.

[0004]

[Means for Solving the Problems] As a means for solving the above-mentioned conventional problems, the present invention provides a bath agent and a cosmetic composition mainly comprising a mixture of fermented rice extract and divalent and trivalent iron salts. It is provided.

[Fermented rice extract] A fermented rice extract is usually obtained by steaming or cooking rice bran, adding enzymes, yeast, etc. to the rice bran, and fermenting the fermented product obtained by fermentation and heating. It is what is done. The above-mentioned fermented rice extract contains alcohol, various amino acids and the like.

[Divalent and trivalent iron salt] The divalent and trivalent iron salt of the present invention is an inorganic substance such as an iron hydrochloride, a sulfate, a phosphate, a nitrate, etc. showing an intermediate property between divalent iron and trivalent iron. Organic salts such as salts, formates, acetates, propionates, etc., in which a large amount of iron (III) salts are added to an aqueous solution of a strong alkali such as sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide. Transition when valence conversion to ferric iron is caused, or when ferric iron salts are added to a large amount of an aqueous solution of a strong acid such as hydrochloric acid or sulfuric acid to cause valence conversion to ferric iron It is obtained as a form. Specific examples of the method for producing a divalent and trivalent iron salt are shown below.

[0007] 1. Trivalent iron salt than 1.0mg of ferric chloride _{(Fe Cl 3 · 6H 2 O} ) 100
Pour into 0.5 ml of 0.5N aqueous sodium hydroxide solution, stir to dissolve, and leave to stand overnight. The resulting insoluble material is filtered off, the filtrate is neutralized with hydrochloric acid and then concentrated under reduced pressure to dry and crystallize in a desiccator. Thus, a chloride of divalent and trivalent iron supported on sodium chloride (hereinafter referred to as iron chloride (II, III)) is obtained, and 50 ml of iron chloride (II, III) is separated from the supported product. 80% aqueous solution of isopropyl alcohol is added to collect the eluted components, which are concentrated under reduced pressure to remove the solvent and dried. By repeating the above-mentioned extraction-concentration-drying operation several times, 0.25 mg of iron (II, III) chloride is obtained.

[0008] 2. Bivalent iron salt than the 1.0mg ferrous sulfate _{(Fe SO 4 · 7H 2 O} ) 10
It is poured into 0 ml of a 0.5 N hydrochloric acid aqueous solution, dissolved by stirring, and left to stand overnight. The resulting insoluble material is filtered off, the filtrate is concentrated under reduced pressure and dried in a desiccator. 10 to the obtained dry powder
80 ml of 80% isopropyl alcohol aqueous solution is added to collect the eluted components, which are concentrated under reduced pressure to remove the solvent and dried. By repeating the above extraction-concentration-drying operation several times,
6 mg of iron chloride (II, III) are obtained.

The divalent and trivalent iron salts of the present invention are sodium chloride,
Supported on inorganic compounds such as sodium sulfate, ammonium chloride, ammonium sulfate, zinc chloride, zinc sulfate, zinc oxide, zinc hydroxide, zinc acetate, diatomaceous earth, bentonite, silica, alumina, and organic compounds such as vitamins, hormones, proteins, and lipids. However, even in that case, the action of the divalent and trivalent iron salt does not change.

[Blending] Divalent and trivalent iron salts are added and blended in the above-mentioned fermented rice extract, and divalent and trivalent iron is usually contained in the above-mentioned fermented rice extract in an amount of 10 ^-2 to 10 ^-18 g / ml. It is added at a concentration. If desired, a third component such as vitamins, minerals, fragrances, pigments, and cooling agents may be appropriately added to the above composition.

[0011]

When the divalent and trivalent iron salt is dissolved in water, it has a function of activating water by breaking hydrogen bonds between water molecules and reducing clusters. The water thus activated by the divalent and trivalent iron salt is smoothly absorbed by the skin in the bath preparation and cosmetics of the present invention to give proper moisture to the skin, and the skin of the active ingredient in the fermented rice extract is also skin. Promotes absorption into. Further, since divalent and trivalent iron itself has a physiologically active action, it has a remarkable effect on the skin or health.

[0012]

【Example】

[Production of fermented rice extract] To 100 kg of rice bran, 160 liters of water is added and saccharified with a saccharifying enzyme at 60 ° C for 12 hours, and then yeast is propagated and alcohol fermentation by the yeast is carried out for 23 days. After completion of fermentation, sodium chloride is added, and the mixture is squeezed, filtered, and sterilized by heating to obtain 200 liters of fermented rice extract.

[Production of divalent and trivalent iron salt] 1 g of ferrous sulfate (Fe SO ₄ .6H ₂ O) was put in 5 ml of 12N hydrochloric acid aqueous solution, and after stirring, insoluble components were filtered off with a filter paper (No. 5C). Filter. A part of the solution portion is sampled, concentrated under reduced pressure, and dried in a desiccator. 10 to the obtained dry powder
80 ml of 80% isopropyl alcohol aqueous solution is added to collect the eluted components, which are concentrated under reduced pressure to remove the solvent and dried. Crystals are obtained by repeating the above-mentioned extraction-concentration-drying operation several times. A 5% aqueous solution of the crystal was prepared, and its 0.0
1 ml of filter paper for paper chromatograph No. 51A (2
cm × 40 cm) Spot 3 cm inside from the bottom edge, n
-Butanol: acetic acid: water = 5: 1: 4 volume ratio The mixture is mixed with a developing solvent at 20 ° C. for 15 hours for upward development. After the development, the filter paper was dried and then spray-developed with a 1% potassium ferricyanide aqueous solution as a coloring reagent on the filter paper, and it was confirmed that the developed position of the crystal was Rf = 0.07 at one spot. Then, a similar paper chromatographic test was performed on a 1: 1 equivalent mixture of Fe Cl ₂ and Fe Cl ₃ , and the result of folding and development was 2 spots Rf
= 0.095 (Fe Cl ₂ ) and Rf = 0.36 (Fe C
l ₃ ) was confirmed. The above paper chromatographic test confirmed that the crystal was not a mixture but a single compound. Then, 0.1 g of the crystal is dissolved in distilled water to make 100 ml to prepare a test solution. Part 2.
5 ml is placed in a 50 ml volumetric flask, 2.5 ml of 0.1% orthophenanthroline aqueous solution and 2.5 ml of sodium acetate-acetate buffer (pH 4.5) are added, and the whole is filled with distilled water up to the marked line. After standing at room temperature for 30 minutes, the absorbance is measured at 510 nm. The divalent iron in the test solution was 0.01 from the standard curve obtained by the same method for the FeCl ₂ aqueous solution.
It was 9 g / 100 ml. Next, when the test solution was added to the volumetric flask in the above operation, 1.0 ml of 10% hydroxylamine hydrochloride aqueous solution was added in advance to reduce ferric iron to ferrous iron. The amount of divalent iron obtained in this case is 0.03
It was 8 g / 100 ml. Therefore, the amount of trivalent iron is 0.0
38 g / 100 ml-0.019 g / 100 ml = 0.01
It was 9 g / 100 ml, and it was found that the crystals contained equivalent amounts of divalent iron and trivalent iron. From the above test, it is estimated that the crystal is Fe ₂ Cl ₅ .x H ₂ O.

Example 1 [Bathing Agent] A liquid bathing agent was prepared according to a conventional method according to the formulation (unit: g) shown in Table 1.

[Table 1] Fifty healthy people with a normal bathtub at home were filled with 100 liters of hot water (sarayu) and 60 g of each sample was added to the bath bath once a day for 7 consecutive days. , And evaluated the skin beautifying effect. As a result, Table 2 shows the smoothness of the skin after bathing, and Table 3 shows the moisturization of the skin after bathing.

[Table 2]

[Table 3] From the results shown in Tables 2 and 3, in Example 1, both the skin beautifying effect and the moisturizing effect can be considerably improved.

The bathing agent of Example 1 was used by 10 patients with atopic dermatitis in ordinary households once a day continuously for 1 month, and the evaluation results are shown in Table 4.

[Table 4] From the results of Table 4, 90% of the patients with atopic dermatitis showed an improving effect.

[Example 2] [Body shampoo] A body shampoo was prepared according to a conventional method according to the formulation (unit: g) shown in Table 5.

[Table 5] Fifty healthy people were allowed to use the above-mentioned body shampoo once a day for 7 consecutive days to evaluate the skin beautifying effect. As a result, Table 6 shows the smooth feeling of the skin after use, and Table 7 shows the moist feeling of the skin after use.

[Table 6]

[Table 7] From the results shown in Tables 6 and 7, in Example 2, both the skin beautifying effect and the moisturizing effect can be considerably improved.

The body shampoo of Example 2 was used by 10 patients with atopic dermatitis and the effect after washing was investigated. The results are shown in Table 8.

[Table 8] From the results in Table 8, the effect on atopic dermatitis patients is small.

[0018]

Therefore, the use of the composition of the present invention makes it possible to obtain bath salts and cosmetics having excellent effects on beauty and health.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Kenji Shirata 2-53-1, Tenjin-cho, Takatsuki-shi, Osaka (72) Inventor Koichiro Muramatsu 15-33 Fujimi-cho, Naka-ku, Aichi Prefecture (72) Inventor Makino Shinji Aichi Prefecture, Hazu-gun, Hazu-machi, Oaza, Nishi-Hazame, No.18, Gochu, I / E Co., Ltd.

Claims (1)

[Claims] 1. A bathing agent and a cosmetic composition mainly comprising a mixture of fermented rice extract and divalent and trivalent iron salts.