JPH0748249A - Ointment plaster - Google Patents

Abstract

PURPOSE:To provide an ointment plaster capable of hygienically and simply administering an accurate amount of an ointment on the surface of a skin without staining a hand finger, excellent in the storage stability of the ointment, and not causing the irritation of the skin on the surface of the plaster-applied skin. CONSTITUTION:An ointment 2 is wrapped and sealed with a support film 1 limited in a water-vapor permeability of 0.5-100g/m<2>.24h. A sealing method such as a hot-pressing method is preferably adopted for sealing the support film. When used, the sealed product is opened from the sealed part 3 and developed into the ointment plaster in which the plaster 2 has been coated on one side of the support film 1. The ointment plaster in made to adhere to the surface of the skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ointment patch which allows an ointment to be easily applied to the skin surface, and more specifically, a precise amount of the ointment can be sanitized without contaminating fingers or the like. The present invention relates to an ointment patch that can be administered.

[0002]

2. Description of the Related Art Conventionally, an ointment has been widely used as one means for administering a drug. Ointments are usually semisolid external preparations with appropriate viscosity, and have been prepared for many drugs due to their ease of use.In addition to topical drugs such as steroids and non-steroids in recent years, Many ointments have also been developed for systemic drugs.

[0003] Ointments are generally applied by rubbing them directly on the skin surface with fingers, or by spreading them on a suitable supporting base material such as gauze or cotton cloth at the time of use and then sticking them on the skin surface. Used in. In such a method, the ointment touches the fingers during application, which is not hygienic, and the application operation is troublesome. Furthermore, it is difficult to accurately control the dose of the ointment, and in general it is uneconomical to apply more than the required amount of ointment,
There is also a risk of contamination by adhering to clothes. In particular, when administering a systemic drug, it is necessary to strictly control the dose from the viewpoint of maintaining an effective blood concentration.

Therefore, there is also adopted a method in which an ointment is spread and applied on an appropriate supporting film in advance, and then a separator is laminated on the surface of the ointment or stored in a folded state until it is used.

However, even with such a method, if the ointment is not sufficiently sealed, the vaporized and evaporated components such as water and alcohols in the ointment are reduced during storage and cannot be used. It is difficult to say that the ointment is sufficiently sufficient in terms of storage stability, such as the ointment flowing during storage and protruding from the edge of the support film.

[0006] Further, it is conceivable to further wrap the above-mentioned support film on which an ointment is spread with a packaging material for hermetically-preserving, but this is by no means an effective method from the viewpoint of complexity of production and economical efficiency. I can't say.

[0007]

In view of the above-mentioned problems of the prior art, the present inventors can make a general-purpose ointment into a patch form that is easy to apply and can store the spread ointment in a sealed manner. It is an object to provide an ointment patch having excellent operability and economy.

[0008]

The inventors of the present invention have conducted extensive studies to achieve the above object, and as a result, the ointment was hermetically sealed with a supporting film regulated to a specific water vapor transmission rate. It has been found that a patch that can achieve the intended purpose can be obtained without the need for a special packaging material by opening and deploying from the seal portion, and the present invention has been completed.

That is, the ointment patch of the present invention has a moisture permeability of 0.
The ointment should be sandwiched and contained from the front and back sides with a support film of 5 to 100 g / m ² · 24 h, and the edge openings of the support film on the front and back sides should be sealed so that only the ointment inclusion part is sealed. It is characterized by.

The support film used for the ointment patch of the present invention is a so-called when the moisture or alcohol contained in the ointment to be encapsulated does not evaporate or volatilize and the seal portion is spread and applied to the skin surface. Water vapor transmission rate is 0.5 to 100 g / m ² · 24 h, preferably 1 to ² so that occlusive bandage therapy can be performed.
The one adjusted to the range of 0 g / m ² · 24 h is used. If the moisture vapor transmission rate is less than 0.5 g / m ² · 24 h, it tends to increase skin irritation after being applied to the skin surface, inhibiting excretion and breathing from inside the skin. Also, the moisture vapor transmission rate is 100
If it exceeds g / m ² · 24 h, skin irritation will be reduced, but since the sealing effect will be reduced, the moisture and alcohol in the ointment contained during storage will evaporate and volatilize, and the ointment will be effectively used. The rate may decrease.

The material of the support film is not limited as long as it satisfies the above-mentioned moisture permeability, and specifically, polyolefins such as polyethylene and polypropylene, polyesters such as polyethylene terephthalate, polyvinyl chloride and polyvinyl. Vinylidene chloride, ethylene /
Various plastic films such as vinyl acetate copolymer, ethylene / vinyl alcohol copolymer, polyurethane, polyamide and polytetrafluoroethylene can be preferably used. Further, the support film is not limited to a single layer film, and a laminate of plastic films made of the above materials or a laminate film of paper, woven cloth, non-woven cloth, knitted cloth, metal foil, etc. on these plastic films also has the above-mentioned moisture permeability. It can be used if it is satisfactory. further,
To adjust the water vapor transmission rate within the scope of the present invention, a method of adjusting by selecting the film material, perforating treatment, foaming treatment,
Examples thereof include a method of adjusting the moisture permeability of the whole by performing a lamination treatment, a method of adjusting the film by changing the film thickness, and the like.

The thickness of the support film is inversely proportional to the water vapor transmission rate, and can be appropriately set in consideration of the material of the support film used and the water vapor transmission rate. Usually, in the case of only a plastic film, it is 2 to 30 μm, preferably 3 to
The thickness is about 25 μm. In addition, when the thickness of the support film is extremely thin, or when there is no so-called stiffness, from the viewpoint of handleability, coating of a known adhesive or adhesive on the back side of the support film, a binder made of natural rubber, etc. By means of coating, heat fusion, pressure bonding, etc., a relatively rigid, self-supporting backing material such as paper, plastic film, non-woven fabric, woven fabric, knitted fabric, etc. is temporarily adhered and laminated in a state of being easily peeled off. It is preferable to keep. In this case, after sticking the ointment patch of the present invention on the skin surface, it is preferable to have followability (flexibility) for movement of the stuck skin surface.
It is desirable that these temporarily adhered self-supporting backing materials be peeled off after being applied to the skin surface.

Furthermore, when the ointment patch of the present invention is opened, spread and applied to the skin surface, the support film should have appropriate softness so as to sufficiently follow the movement of the skin surface. Preferably, the cantilever method has a bending resistance of 0.5 to 60 m (according to JIS L-1096).
It is preferable to use m, especially 2 to 20 mm. If the bending resistance is less than 0.5 mm, the self-supporting property as a supporting film will be insufficient, which makes it difficult to handle the ointment patch of the present invention when opening it from the seal portion or during the sticking operation. There is a possibility that it is necessary to temporarily attach the self-supporting backing material. Further, if the bending resistance exceeds 60 mm, the flexibility of the support film becomes poor, which makes it difficult to attach the support film to a curved surface such as a bent portion and may cause a problem in the skin followability after attachment.

The ointment patch of the present invention has a structure in which the front and back surfaces are composed of the above-mentioned supporting films, and the ointment is enclosed in a sealed state therebetween. The support films constituting the front and back surfaces may be composed of two films as shown in FIGS. 1 (a) and 1 (b), and as shown in FIGS. 2 (a) and 2 (b). You may bend one support film in the center part, and it may be folded in two in what is called a palm-joint state. It is preferable to fold one support film in two in a palm-like state from the viewpoints of ease of production and less discomfort on the skin surface after development and application.

As a method of interposing the ointment between the support films constituting the front and back surfaces, a predetermined amount of the ointment is spread-coated on one side of the support film by means of a bar coating method, a roll coating method, a die coating method or the like. After that, a method of pasting another supporting film on it, a method of injecting an ointment into a supporting film that is previously formed into a bag shape leaving an opening only at one place, and then adhesively sealing the opening can be mentioned. To be In order to securely hold the ointment on the surface of the support film, improve the self-supporting property when applying it to the skin surface, and improve the feeling of application (softness), foaming of polyethylene or polyurethane on the surface of the support film. A body, a non-woven fabric or the like may be laminated as an intermediate layer, and an ointment may be provided on the surface of this intermediate layer.

In the present invention, it is important to surely administer the ointment to the skin surface. Therefore, the ointment needs to have the ointment layer clearly present on the support film or on the surface of the intermediate layer. However, it is not preferable that the ointment is completely impregnated into the support film or the intermediate layer, because it causes poor adhesion to the skin surface and variation in dose.

Further, the amount of the ointment to be included in the ointment patch of the present invention can be variously changed depending on the kind of disease to be treated and the kind of drug in the ointment.
The average thickness of the ointment layer when the seal portion is opened and expanded is set to 0.1 to 5 mm, preferably 0.2 to 2 mm. Further, the shape and size of the ointment patch of the present invention is preferably a square with one side of about 3 to 15 cm before opening and unfolding.

The types of ointments to be encapsulated include oil-based ointments, emulsion-based ointments prepared by a conventionally known method.
A water-soluble ointment or the like is not particularly limited and a commercially available product may be used. Further, as the drug species contained in the ointment, any of local and systemic drugs can be used, and specifically, corticosteroids, analgesic and anti-inflammatory agents, hypnotic sedatives, tranquilizers, and anti-inflammatory agents. Hypertension, antihypertensive diuretics, antibiotics,
One or two drugs such as anesthetics, antibacterial agents, antifungal agents, vitamins, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improvers, antiemetics, antitumor agents and biomedical agents. It can be contained in combination with one or more kinds.

In the ointment patch of the present invention, the inner part of the ointment is hermetically sealed. In sealing, an uncoated portion to which the ointment is not applied is formed in the peripheral portion of the support film, and the uncoated portion is sealed by an adhesive means. Since it is necessary to open the seal portion at the time of use, the adhesive is adhered in a peelable state instead of permanent adhesive.
As the adhesive strength of the seal portion, the T peel adhesive strength is 30 to 80.
0 g / 20 mm width, preferably 100-400 g / 20
Adjust to about mm width. T-peel adhesion is 30g / 20m
If the width is less than m, the adhesive strength is not enough to maintain the hermeticity, and if external stress is applied during storage, the seal part may be damaged and the volatile components of the ointment to be encapsulated may decrease. In some cases, the ointment may flow out. On the other hand, if the T-peel adhesive strength exceeds 800 g / 20 mm width, the sealing property is sufficient, but the seal portion is difficult to peel off when opening during use, and in some cases the support film may be broken, which is not preferable.

Therefore, as the above-mentioned sealing method, for example, polyethylene, polypropylene, chlorinated polypropylene, polyethylene terephthalate, ethylene / vinyl acetate copolymer as an easily peelable sealant material, or modified products of these are used. It is preferable that the material is coated on the adhesion portion of the support film and then adhesively sealed by means such as pressurization or thermocompression. Needless to say, a publicly known pressure-sensitive adhesive or adhesive may be used as long as the sealing property can be sufficiently maintained.

Further, in the case of sealing the supporting film as described above, when the supporting film is sealed leaving the peripheral portion as shown in FIG.
If a known medical adhesive layer made of a polymeric substance such as a silicone type or vinyl ether type is formed on the inner surface side, the ointment patch of the present invention is opened, spreads, and adheres to the skin surface when it is applied to the skin. Is preferable because it can be reinforced. In the present invention, if the support film has sufficient skin followability, the phenomenon of falling off during application can be sufficiently prevented by the skin adhesion of only the ointment.

As a method of using the ointment patch of the present invention,
Specifically, the seal portion of the support film containing the ointment is peeled and opened to develop so that the ointment layer is exposed. At this time, as shown in FIG. 2, if the support film is sealed with the peripheral edge portion remaining, the peripheral edge portion serves as a gripping portion at the time of opening, so that the opening operation becomes easy.

When the ointment patch of the present invention is prepared by folding a single support film (FIG. 2).
After development, a patch having an ointment applied on one side of a single support film having a double area after development is obtained, and this patch is applied to the skin surface to be applied. On the other hand, when the ointment patch of the present invention is prepared by laminating two support films (see FIG. 1), when all the seal parts are opened, the ointment is applied to one surface of each of the two support films. The patch in the state of being applied is obtained. In this case, it is usually difficult to apply an equal amount of the ointment onto the two support films, and thus the two patches are applied to the applied skin surface, respectively. Particularly in the case of an ointment containing a systemic drug, the application site is not particularly limited, so
This is a preferable method because the pasting area per sheet is smaller than that in the case of the above two-fold. In the case of opening an ointment patch consisting of two support films, if the three side seal parts are opened leaving one side seal part, it is apparently the same one patch as the above two-folded patch. can do.

The patch of the present invention is characterized in that it has the above-mentioned constitution and that the pressure-sensitive adhesive layer is formed on the support in a nonuniform thickness. By doing so, when the drug for transdermal absorption contained in the adhesive layer migrates to the skin surface side by diffusion transfer, the drug in the thin part is completely released at an early stage, The thick part of the drug takes longer to complete the release. Therefore, the patch having various release patterns can be obtained by variously changing the formation pattern of the pressure-sensitive adhesive layer.

[0025]

EXAMPLES Examples of the present invention will be shown below and will be described more specifically. In the following, parts and% mean parts by weight and% by weight.

Further, the moisture permeability in the following examples is JIS
According to Z-0208, the value at 23 ° C and relative humidity of 0 to 90% is measured, and the bending resistance is 45 ° cantilever at 23 ° C and relative humidity of 65% according to the cantilever method specified in JIS L-1096. Extrusion distance from die tester (m
m) was measured. The T-peel adhesive strength was measured by cutting the outer peripheral seal portion of each patch with a width of 20 mm and using a Tensilon type tensile tester at a tensile speed of 100 mm / min at room temperature.

Example 1 Polyethylene terephthalate film (thickness 12 μm,
Water vapor permeability 14g / m ² · 24h, bending resistance 10mm, area 7
cm.times.15 cm) on one side with a fountain die coater, leaving an ointment-uncoated portion with a width of 10 mm on the outer periphery.
A water-soluble ointment was applied to a thickness of 5 mm.

An adhesive of ethylene / vinyl acetate copolymer system as a sealant material is applied to the ointment-unapplied portion on the outer periphery of the film, and the films are folded in two so that the ointment-applied surfaces overlap with each other, and then the outer periphery is adhered. The adhesive-applied part of (1) was heat-sealed to hermetically seal it to obtain the ointment patch of the present invention.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 180 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal portion could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without wrinkling. In addition, no floating or dropping phenomenon was observed after application, and the adhesion to the skin surface was good, and no ointment squeezed out from the edge of the support film or skin irritation was observed, and the application feeling was good. there were.

Example 2 Biaxially oriented polypropylene film (thickness 30 μm, moisture permeability 2.5 g / m ² · 24 h, bending resistance 25 mm, area 10
cm × 10 cm) 1.2m with a comma roll coater on the outer surface leaving an ointment-uncoated portion with a width of 20mm
Oily ointment was applied to a thickness of m. Thus, two films coated with the ointment were prepared.

A polyethylene adhesive as a sealant material having a width of 12 mm was applied to the ointment-uncoated portion of the outer periphery of each film, and a double-sided adhesive tape was attached to the outer periphery thereof. Then, make sure that the ointment-coated surfaces overlap each other.
The sheets were adhered to each other, and the adhesive-applied portion of the outer peripheral portion was thermocompression-bonded to perform hermetic sealing to obtain an ointment patch of the present invention.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 330 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal part could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without wrinkling. In addition, in addition to the skin adhesiveness of the ointment layer for sticking and fixing the skin surface, double-sided adhesive tape was used to reinforce the skin adhesive strength, so no floating or falling phenomenon was observed after sticking, and adhesion to the skin surface Is extremely good, neither ointment squeeze-out from the edge of the support film nor skin irritation is observed,
The sticking feeling was good.

Example 3 Polyethylene terephthalate film (thickness: 25 μm,
Water vapor transmission rate 7g / m ² · 24h, bending resistance 17mm, area 10
(cm × 15 cm), a polyester-based adhesive was applied to the entire one surface, and then a polyester-based nonwoven fabric (basis weight: 8 g / m ² ) was laminated and adhered to the central part while leaving a width of 15 mm each on the outer peripheral part.

Then, using a fountain die coater, the whole surface of this non-woven fabric was coated with an emulsion ointment to a thickness of 1.5 mm (thickness on the surface not impregnated into the non-woven fabric) so that the ointment-coated faces overlap each other. The film was folded in two and adhered to each other, and the adhesive-applied portion of the outer peripheral portion was thermocompression-bonded to perform hermetic sealing, to obtain an ointment patch of the present invention.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 270 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal portion could be easily peeled and opened by hand, and the spread ointment patch could be easily applied to the skin surface without wrinkles. In addition, no floating or dropping phenomenon was observed after application, and the adhesion to the skin surface was good, and no ointment squeezed out from the edge of the support film or skin irritation was observed, and the application feeling was good. there were.

Example 4 Polyethylene film (thickness 3 μm, moisture permeability 18 g / m
² · 24h, bending resistance 5 mm, on one side of an area 5 cm × 10 cm), and temporarily attached by heat bonding a 80μm thick release paper as a self-supporting backing material, the outer circumference using a fountain die coater on the other surface of the film The oil-and-fat ointment was applied to a thickness of 1.5 mm, leaving an ointment-free part having a width of 15 mm.

Thereafter, in the same manner as in Example 1, an ethylene / vinyl acetate copolymer adhesive as a sealant material was applied to the ointment-unapplied portion on the outer periphery of the film so that the ointment-coated surfaces overlap each other to form a film. It was folded in two and stuck together, and the adhesive-coated portion of the outer peripheral portion was thermocompression-bonded to perform hermetic sealing to obtain an ointment patch of the present invention.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 330 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handling property during use, the seal portion can be easily peeled and opened by hand, and the ointment patch after spreading can be easily skinned by peeling the backing material after application without causing wrinkles. It could be attached to the surface. In addition, no floating or dropping phenomenon was observed after application, and the adhesion to the skin surface was good, and no ointment squeezed out from the edge of the support film or skin irritation was observed, and the application feeling was good. there were.

Example 5 Polyethylene terephthalate film (thickness 12 μm,
A chlorinated polypropylene adhesive as a sealant material with a width of 5 mm is applied to the outer surface of one side with a water vapor permeability of 14 g / m ² · 24 h and a bending resistance of 10 mm), and the three applied parts are heated and pressure bonded to 7 cm x 7 cm. Was molded into a bag shape.

Next, the emulsion ointment was poured from the opening of the obtained bag, and after the injection, the injected ointment was flattened to a thickness of 3 mm by a laminating roll, and the opening was heated and pressure-bonded to form a hermetic seal. Then, the ointment patch of the present invention was obtained.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 390 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal part could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without causing wrinkles. In addition, no floating or dropping phenomenon was observed after application, and the adhesion to the skin surface was good, and no ointment squeezed out from the edge of the support film or skin irritation was observed, and the application feeling was good. there were.

Example 6 A vinylidene chloride / vinyl chloride copolymer (thickness: 2 μm, moisture vapor transmission rate: 16 g / m ² · 24 h, bending resistance: 0.3 mm, area: 4 cm × 10 cm) was used as a supporting film. A two-fold ointment patch was obtained in the same manner as in Example 1 except that the thickness was 1.0 mm and the chlorinated polypropylene adhesive was used as the sealant material.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 290 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability at the time of use, the seal part can be easily peeled and opened by hand, and the ointment patch after development has some wrinkles, but can be easily applied to the skin surface. It was Further, although a slight floating occurred after application, no drop-off phenomenon was observed, and the skin adhesion showed no practical problem.
Furthermore, no ointment squeezed out from the edge of the supporting film and no skin irritation was observed, and the feeling of application was good.

Example 7 A polyethylene terephthalate film (thickness: 50 μm, moisture vapor transmission rate: 4 g / m ² · 24 h, bending resistance: 85 mm, area: 3 cm × 6 cm) was used as a supporting film, and a special ointment had a thickness of 1.0 mm. Is 2 as in the first embodiment.
A folded ointment patch was obtained.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 150 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal part could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without wrinkles. However, when applied for a long time, the floating phenomenon gradually occurs,
A phenomenon of slightly protruding ointment from the edge of the support film was also observed. No skin irritation was observed, but a slight feeling of discomfort such as a tightness was produced.

Example 8 Biaxially oriented polypropylene film (thickness 10 μm, moisture permeability 8 g / m ² · 24 h, bending resistance 9) as a supporting film
mm, area 7 cm × 4 cm), the thickness of the ointment to be applied was 1.0 mm, and a polyester adhesive was used as the sealant material, in the same manner as in Example 1 to obtain a double-fold ointment patch. It was

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 15 g / 20 mm width. Further, at 23 ° C. and 65% R.S. H. When the ointment was stored for 1 month under the condition (1), the weight loss rate of the ointment was 3%, slight floating was observed in the seal portion, and slight ointment oozing was observed from this portion.

Regarding the handleability during use, the seal part could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without wrinkles.
Further, no floating or dropping phenomenon was observed after application, and neither ointment squeeze-out from the edge of the supporting film nor skin irritation was observed, and the application feeling was good.

Example 9 A polyethylene film (having a thickness of 15 μm) was used as a supporting film.
m, moisture permeability 4 g / m ² · 24 h, bending resistance 12 mm, area 8 cm × 15 cm), the thickness of the applied ointment was 1.0 mm, and no adhesive was applied to the uncoated part of the ointment. A two-fold ointment patch was obtained in the same manner as in Example 1 except that the polyethylene film was thermocompression-bonded and sealed.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 1180 g / 20 mm width. Further, at 23 ° C. and 65% R.S. H. When the ointment was stored for 1 month under the condition (1), the weight loss rate of the ointment was 1% or less, and the ointment was not squeezed out.

Regarding the handleability at the time of use, the sealed portion could not be opened by hand, and it was cut with scissors and opened and developed. The ointment patch after spreading could be easily applied to the skin surface without wrinkles. Further, no floating or dropping phenomenon was observed after application, and neither ointment squeeze-out from the edge of the supporting film nor skin irritation was observed, and the application feeling was good.

Comparative Example 1 Aluminum foil (thickness 10 μm) as a supporting film
And polyethylene terephthalate film (thickness 38μ
m) laminated film (water vapor transmission rate 0.2 g / m ² · 24)
h, bending resistance of 24 mm, area of 7 cm x 15 cm),
A half-folded ointment patch was obtained in the same manner as in Example 1, except that the ointment was applied to the polyethylene terephthalate film side.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 210 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When stored under the conditions of 1 month for 1 month, the weight loss rate of the ointment is 1% or less,
No ointment squeeze out was observed.

Regarding the handleability during use, the seal part could be easily peeled and opened by hand, and the ointment patch after spreading could be easily applied to the skin surface without wrinkles.
In addition, no floating or dropping phenomenon was observed after application, and no ointment was squeezed out from the edge of the supporting film. However, itching occurred in the applied part and a rash was seen on the skin surface after peeling and removal, which was a problem in practical use.

Comparative Example 2 A polyvinyl chloride film (thickness 10
μm, moisture permeability 180g / m ² · 24h, bending resistance 1mm,
An ointment patch having two patches was obtained by the same method as in Example 2 except that the area of 10 cm × 10 cm was used.

The adhesive strength (T peel adhesive strength) of the seal portion of the obtained ointment patch was 160 g / 20 mm width.
Further, at 23 ° C. and 65% R.S. H. When the ointment was stored for 1 month under the condition (1), the weight loss rate of the ointment was 7%, and discoloration was observed in the ointment to be encapsulated.

The handling properties and feeling during use were the same as in Example 2, but the desired therapeutic effect was difficult to be sufficiently exerted because the amount of transpiration and volatilization components in the ointment was reduced. .

[0065]

As described above, the ointment patch of the present invention does not require individual packaging because the ointment is hermetically enclosed by the support film having a specific moisture permeability, and the ointment has good storage stability. At the same time, it can be easily opened at the time of use, and a patch having a fixed amount of ointment adhered thereon can be obtained. Moreover, the feeling of sticking, opening, and operability at the time of sticking are excellent, and it can be expected that the skin irritation during sticking is reduced and a desired pharmacological effect is exhibited. Moreover, since it can be made into a patch type using a commercially available ointment, it is excellent in versatility.

[Brief description of drawings]

1 shows one embodiment of an example of the ointment patch of the present invention, (a) is a perspective view and (b) is a sectional view taken along line XX of (a).

FIG. 2 shows a mode of another embodiment of the ointment patch of the present invention, (a) is a perspective view and (b) is a sectional view taken along line XX of (a).

[Explanation of symbols]

 1 Support film 2 Ointment 3 Seal part

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[Procedure amendment]

[Submission date] September 21, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0024

[Correction method] Delete

Claims (4)

[Claims] 1. A water vapor transmission rate of 0.5 to 100 g / m ² · 24 h
Sandwich the ointment from the front and back with the support film of
An ointment patch, characterized in that the edge opening portions of the support film on the front and back surfaces are sealed so as to seal only the ointment encapsulation portion. 2. The ointment patch according to claim 1, wherein the supporting film has a bending resistance of 0.5 to 60 mm in the cantilever method. 3. The T-peel adhesion of the seal portion is 30 to 800.
The ointment patch according to claim 1, which has a width of g / 20 mm. 4. The ointment patch according to claim 1, wherein the sealing means is heat fusion.