CN108348477A - Transdermic absorbent delivery device and its manufacturing method - Google Patents
Transdermic absorbent delivery device and its manufacturing method Download PDFInfo
- Publication number
- CN108348477A CN108348477A CN201680065384.2A CN201680065384A CN108348477A CN 108348477 A CN108348477 A CN 108348477A CN 201680065384 A CN201680065384 A CN 201680065384A CN 108348477 A CN108348477 A CN 108348477A
- Authority
- CN
- China
- Prior art keywords
- cover film
- film
- transdermic absorbent
- delivery device
- layer portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 description 1
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- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
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- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 125000005590 trimellitic acid group Chemical class 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00072—Packaging of dressings
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F15/00—Auxiliary appliances for wound dressings; Dispensing containers for dressings or bandages
- A61F15/001—Packages or dispensers for bandages, cotton balls, drapes, dressings, gauze, gowns, sheets, sponges, swabsticks or towels
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- A—HUMAN NECESSITIES
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/12—Layered products comprising a layer of synthetic resin next to a fibrous or filamentary layer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/06—Interconnection of layers permitting easy separation
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- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Preparation (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The present invention provides transdermic absorbent delivery device (2).Transdermic absorbent delivery device (2) includes：The cover film (10) of anti-solvent penetration, with being connected in a manner of integrated by means of the first broken line (13) and first layer portion (11) stacked on top of each other and second layer portion (12), non-sealed regions (15) and sealing area (14) are formed between the first layer portion and the second layer portion, the non-sealed regions (15) configure along first broken line (13), the sealing area (14) is configured in a manner of the peripheral part other than the part along first broken line for surrounding the non-sealed regions, it is formed with the cutting part (17) of closed form in the part for forming the non-sealed regions (15)；Transdermic absorbent formed article (20), it is configured at the first layer portion (11) in the non-sealed regions (15) and between the second layer portion (12), the cover film (10) is fixed on the inside of the cutting part (17)；And bonding sheet (30), it is pasted onto the exterior face of the cover film in a releasable manner.
Description
Technical field
The present invention relates to transdermic absorbent delivery device and its manufacturing methods.
Background technology
Conventionally, there is known keeping having as the effective component of transdermic absorbent for supporting on the skin using bonding sheet
Material transdermic absorbent formed article transdermic absorbent delivery device.
For example, Patent Document 1 discloses wound dressing.The wound includes with dressing：Inner lining material；Pressure-sensitive adhesion
Oxidant layer is coated in a part for inner lining material；And absorbent web, it is pasted on inner lining material by means of adhesive unit, and
Gap is provided for the diffusate of wound, wherein includes for inhibiting microorganism to be oozed from external environment in pressure sensitive adhesive layer
The antiseptic of networking.
The electro-ionic osmosis delivery device of medicament is disclosed in patent document 2.The equipment has：Backing (cover portion), has
Recess portion；Medicament absorbent material is accommodated in the recess portion；Wet end is pasted on the backing in a releasable manner, to cover
The recess portion；And liquid reservoir, it is installed on the inside face of the wet end, the medicament etc. for making the medicament absorbent material be absorbed
Sample is divided to be absorbed by patient contact surface.
In patent document 3, the wound covering material of the surface of a wound for covering and protecting body is disclosed.The wound cover
Material has：Binder backing material, by formation such as film or non-woven fabrics；Adhesive layer is set to the binder backing material
On one side；And aqueous gel layer, aqueous gel layer are pasted on adhesive layer.
In addition, in patent document 4~6, it was also proposed that the transdermic absorbent delivery device with similar structure.
(existing technical literature)
(patent document)
Patent document 1：No. 4335317 bulletins of Japanese Patent Publication No.
Patent document 2：No. 4879442 bulletins of Japanese Patent Publication No.
Patent document 3：No. 3973420 bulletins of Japanese Patent Publication No.
Patent document 4：No. 4262934 bulletins of Japanese Patent Publication No.
Patent document 5：No. 5059584 bulletins of Japanese Patent Publication No.
Patent document 6：No. 4975534 bulletins of Japanese Patent Publication No.
Invention content
(problem to be solved by the invention)
The purpose of the present invention is to provide with the structure different from various transdermic absorbent delivery devices as described above
New Percutaneous absorbent delivery device and its manufacturing method.
(means used to solve the problem)
The transdermic absorbent delivery device of an embodiment of the invention is characterised by comprising：(a) anti-solvent penetration
Property cover film 10, have be connected in a manner of integrated by means of the first broken line 13 and first layer portion 11 stacked on top of each other and
Second layer portion 12 is formed with non-sealed regions 15 and sealing area 14, institute between the first layer portion and the second layer portion
It states non-sealed regions 15 to configure along first broken line 13, the sealing area 14 is to surround the edge of the non-sealed regions 15
The mode for the peripheral part other than the part of first broken line configures, and is formed with and closes in the part for forming the non-sealed regions
Close the cutting part 17 of shape；(b) transdermic absorbent formed article 20,120,220 are configured at described in the non-sealed regions 15
Between first layer portion 11 and the second layer portion 12, it is fixed on the cover film 10 in the inside of the cutting part 17；And (c)
Bonding sheet 30 is pasted on the exterior face of the cover film 10 in a manner of it can remove.
The manufacturing method of the transdermic absorbent delivery device of an embodiment of the invention is characterised by comprising：Work
Sequence 1 supplies the cover film of anti-solvent penetration；Process 2 forms the cutting part of closed form in the cover film；Process 3, in institute
State the one side configuration transdermic absorbent formed article of cover film；The transdermic absorbent formed article is fixed on institute by process 4
State cover film；Process 5 makes medicament support in the transdermic absorbent formed article；Process 6, by the cover film along regulation
Folding line, the first film portion of the side for clamping the broken line in being formed in the cover film and be formed in the other side
Between second film portion, the transdermic absorbent formed article is sandwiched；Process 7 is surrounding the transdermic absorbent formed article
The region of peripheral part other than the part opposed with first broken line, between first film portion and second film portion into
Row sealing；And bonding sheet is pasted on institute by process 8 in the part at least covering the cutting part in a manner of it can remove
State the exterior face of cover film.
(The effect of invention)
Transdermic absorbent delivery device according to the present invention and the percutaneous absorbtion manufactured using the manufacturing method of the present invention
Agent delivery device is accommodated with transdermic absorbent formed article between the first layer portion and second layer portion of the cover film of folding,
Around the transdermic absorbent formed article, sealed between first layer portion and second layer portion.As a result, because transdermic absorbent supports portion
The liquor that part is supported is sealed, therefore can prevent liquor leakage or volatilization diffusion in the process of circulation.
In addition, between the first layer portion and second layer portion of cover film, can be not necessarily to form seal area along the part of broken line
Therefore if domain compared with the case where entire periphery of transdermic absorbent formed article is surrounded by sealing area, can reduce sealing
Region.Therefore, can percutaneous absorbent delivery device formed compact, thus can seek the raising of portability.
When using the transdermic absorbent delivery device of the present invention, a part for cover film is removed from bonding sheet.At this point, covering
Epiphragma is broken in cut portion, and the inside region of cover film surrounded by cutting part remains together with transdermic absorbent formed article
On bonding sheet.Which therefore, when unpacking, no matter making transdermic absorbent delivery device towards direction, will not occur percutaneously to inhale
Receive the case where agent formed article is peeled off from bonding sheet.Therefore, in the same manner as common alite paste, only by removing sheet of membrane, you can
It simply pastes on the skin.
Moreover, it is assumed that be accommodated between two panels film (film and stripping film that have supported transdermic absorbent formed article) through
In the case of skin absorbent formed article, when in use, a side form (stripping film) is whole (to have supported percutaneous suction with another side form
Receive agent formed article film) a part removed and abandoned from bonding sheet.At this point, being attached with in film in the stripping being stripped
The liquor being impregnated in transdermic absorbent formed article, therefore when abandoning stripping film, the liquor being attached on stripping film
It is wasted.In this regard, due to not having stripping film in the delivery device of the present invention, because the liquor of waste may be not present.Using this
When the delivery device of invention, a part for the sheet of membrane is only abandoned.At this point, the hermetic unit of cover film is all dropped, but
As described above, the size of hermetic unit reduces due to unsealed along the membrane part of broken line.Therefore, it is lost when capable of reducing using
Thus the membrane part abandoned can reduce material cost.
Like this, the transdermic absorbent delivery device as the present invention of the novel device of liquor can expand the application of liquor
Field, and the new application of liquor can be opened up.
Description of the drawings
Fig. 1 is the vertical view for the part for having cut off the transdermic absorbent delivery device of the present invention.
Fig. 2 is the II-II line sectional views for schematically showing Fig. 1 of transdermic absorbent delivery device shown in Fig. 1.
Fig. 3 is the sealing area and non-sealed regions for the cover film for showing transdermic absorbent delivery device shown in FIG. 1
Figure.
Fig. 4 is the figure for showing the manufacturing process of transdermic absorbent delivery device shown in Fig. 1.
Fig. 5 A are the figure used for transdermic absorbent delivery device shown in definition graph 1.
Fig. 5 B are the figure used for transdermic absorbent delivery device shown in definition graph 1.
Fig. 5 C are the figure used for transdermic absorbent delivery device shown in definition graph 1.
Fig. 5 D are the figure used for transdermic absorbent delivery device shown in definition graph 1.
Fig. 6 is the sectional view same as Fig. 2 for the first variation for showing transdermic absorbent delivery device.
Fig. 7 is the sectional view same as Fig. 2 for the second variation for showing transdermic absorbent delivery device.
Fig. 8 is the vertical view same as Fig. 1 for the third variation for showing transdermic absorbent delivery device.
Fig. 9 is the vertical view same as Fig. 1 for the 4th variation for showing transdermic absorbent delivery device.
Figure 10 is the vertical view same as Fig. 1 for the 5th variation for showing transdermic absorbent delivery device.
Figure 11 is the vertical view same as Fig. 1 for the 6th variation for showing transdermic absorbent delivery device.
Figure 12 is the vertical view same as Fig. 1 for the 7th variation for showing transdermic absorbent delivery device.
Figure 13 is the vertical view same as Fig. 1 for the 8th variation for showing transdermic absorbent delivery device.
Figure 14 is the sealing area and non-tight for showing the cover film in the transdermic absorbent delivery device of the 8th variation
Similarly scheme with Fig. 3 in region.
Figure 15 A are the figure of the transdermic absorbent delivery device for illustrating the 8th variation used.
Figure 15 B are the figure of the transdermic absorbent delivery device for illustrating the 8th variation used.
Figure 15 C are the figure of the transdermic absorbent delivery device for illustrating the 8th variation used.
Figure 15 D are the figure of the transdermic absorbent delivery device for illustrating the 8th variation used.
Specific implementation mode
Hereinafter, with reference to attached drawing, illustrate the implementation of the transdermic absorbent delivery device (hereinafter simply referred to as " equipment ") of the present invention
The manufacturing method of mode and its.
1-1. overall structure
Referring to FIG. 1 and FIG. 2, the entirety that equipment is indicated with reference numeral 2 is pressed by multiple thin slices or film layer.In reality
It applies in mode, the major part of equipment 2 is made of cover film 10 and bonding sheet 30.As shown in Figure 1, the flat shape of equipment 2 is
The opposite side extended with the opposite side extended to first direction D1 and to the second direction D2 at a right angle about first direction D1
Quadrangle.But the flat shape of equipment 2 is without being limited thereto, can also be round, ellipse and other polygons.
1-2. cover film
Preferably, the plastic tab or film, laminated film that cover film 10 is constituted using the material by anti-solvent penetration are come shape
At as long as can be not particularly limited using common heat-sealing come use.As specific material, polyolefins can be enumerated
(such as polyethylene, polypropylene etc.), polyesters (such as polyethylene terephthalate, polybutylene terephthalate (PBT), poly- naphthalene
Naphthalate etc.), polyvinyl chloride, polyvinylidene chloride, polyamide (such as nylon 6, nylon66 fiber etc.), polyimides,
Ethylene-vinyl alcohol etc. and these high molecular copolymers.Preferably, it is constituted using by the material of plastic tab or plastic foil
Thin slice or film, front and back side plastic layer between be configured with aluminium foil composite material or front and back side plastic layer between
Being configured with vapor deposition has the aluminum layer (Aluminum laminate film) of composite material of plastic layer of aluminium etc..
Preferably, it is coated with remover in at least exterior face of cover film 10.As remover, the stripping of silicon class can be used
Agent, or the non-silicon class remover using fluorine class remover etc..
Cover film 10 is sealed to form by carrying out three directions in the state of rectangular film doubling.Cover film 10 exists
The central portion of first direction D1 under its unfolded state, it is curved along broken line (the first broken line) 13 extended to second direction D2
Folding.The upper layer part (first layer portion) for the upside for being configured at Fig. 2 is formed in the side for the broken line 13 for clipping cover film 10 as a result,
11, it is formed with the lower layer part (second layer portion) 12 for the downside for being configured at Fig. 2 in the other side.Upper layer part 11 passes through folding with lower layer part 12
Line 13 is connected and stacked on top of each other in a manner of integrated.Preferably, upper layer part 11 has same planar shaped with lower layer part 12
Shape and identical size, and it is stacked on top of each other in entire surface.
As shown in figure 3, being formed with sealing area 14 and non-tight between the upper layer part 11 and lower layer part 12 of cover film 10
Region 15.In addition, in figure 3, sealing area 14 is the region of chequer, the remaining region in cover film 10 is non-tight
Region 15.
Non-sealed regions 15 are the region of such as quadrangle, but the shape of non-sealed regions 15 is not particularly limited, and also may be used
Think semicircle etc..Non-sealed regions 15 have on D1 and second direction D2 in a first direction is less than upper layer part 11 and lower layer part 12
Size.Non-sealed regions 15 configure in a manner of close to 13 side of broken line of cover film 10 in the first direction dl, and
The central portion of cover film 10 is configured on second direction D2.More specifically, in the first direction dl, the side of non-sealed regions 15
Edge part along broken line 13 configure, be configured to more lean on than the edge part of upper layer part 11 and lower layer part 12 in the edge part of the other side
Nearly central portion side.In a second direction d 2, the edge part of the both sides of non-sealed regions 15 is configured to than upper layer part 11 and lower layer
The edge part in portion 12 is closer to central portion side.
Sealing area 14 is the region of such as "U" font formed by three direction sealings.In sealing area 14,
Upper layer part 11 is bonded and is sealed by means of heat-sealing 18 with lower layer part 12.Relative to non-sealed regions 15, sealing area 14 configures
In side opposite with broken line 13 in the first direction dl and adjacent with the both sides of second direction D2.Sealing area 14 connects as a result,
Surround to continuous property the peripheral part other than the part along the broken line 13 of non-sealed regions 15.By means of the sealing area being thusly-formed
14 are surrounded with broken line 13, non-sealed regions 15 in entire periphery, thus form confined space in non-sealed regions 15.
As shown in FIG. 1 to 3, the cutting part 17 of closed form is formed in cover film 10.Cover film 10 is divided as a result,
For the inside region 19A surrounded by cutting part 17 and it is configured to the lateral area 19B more more outward than cutting part 17.In cover film
Under 10 unfolded state, cutting part 17 is in a manner of across the part for corresponding to upper layer part 11 and corresponding to the part of lower layer part 12
It is formed.Under the unfolded state of cover film 10, cutting part 17 has the flat shape of such as quadrangle.However, cover film 10
Can be such as ellipse, length as long as the flat shape closed form of the cutting part 17 under unfolded state, is not particularly limited
The cyclic form of circle etc..
Cutting part 17 is formed in the part for being used to form non-sealed regions 15 of cover film 10.In the rugosity of cover film 10
Under state, cutting part 17 is configured with along the boundary of non-sealed regions 15 and sealing area 14.
Cutting part 17 can be continuous joint-cutting, or intermittent perforation.In addition, cutting part 17 can be from covering
The one side of film 10 to the so-called of another side cuts shape entirely, or near the one side for not cutting cover film 10
A part of and remaining so-called hemisection shape.Preferably, the case where cutting entirely is has remained the part that a part is not cut
So-called perforation.Moreover it is preferred that for ease of avoiding the evaporation of the solvent of percutaneous absorbtion medicament, dispersing, cutting part 17 is half
It cuts.In the illustrated embodiment, cutting part 17 is the hemisection extended to from the exterior face of cover film 10 near inside face.
1-3. transdermic absorbent formed articles
As shown in Figures 1 and 2, in the non-sealed regions 15 of cover film 10, match between upper layer part 11 and lower layer part 12
It is equipped with transdermic absorbent formed article (hereinafter referred to as " formed article ") 20.By means of hot sticky knot 21, formed article 20 is consolidated
Due to the inside region 19A of cover film 10.Hot sticky knot 21 is formed by spot welding, and multiple heat are distributed in formed article 20
Binding part 21.
As long as liquid or pasta percutaneous absorbtion medicament (hereinafter referred to as " medicament ") 22 can steadily be impregnated or be kept
Component is not particularly limited formed article 20.It is, for example, possible to use cotton fabric (such as absorbent cotton, gauze etc.), synthesis fibre
Dimensional fabric (such as non-woven fabrics, polyester, polyethylene, polyvinyl etc.), sponge, paper etc..As sponge, such as foam can be used
The synthetic sponge or natural sponge of polyurethane etc..Anyway, formed article 20 can be according to supporting in the medicine on formed article 20
The type of agent 22 selects best material.
Formed article 20 is accommodated in the state of doubling and folding between the upper layer part 11 of cover film 10 and lower layer part 12.
The shape of the formed article 20 of unfolded state is for example to prolong with the opposite side extended to first direction D1 and to second direction D2
The quadrangle for the opposite side stretched.However, the shape of the formed article 20 of unfolded state is without being limited thereto, can also be it is for example round,
Polygon other than ellipse or quadrangle.
The central portion of first direction D1 under the unfolded state of formed article 20, formed article 20 is along to second direction
The broken line (the second broken line) 25 that D2 extends is bent.As a result, configuration is formed in the side for the broken line 25 for clipping formed article 20
Upper layer part (third layer portion) 23 in the upside of Fig. 2 is formed with (the 4th layer of the lower layer part for the downside for being configured at Fig. 2 in the other side
Portion) 24.Preferably, upper layer part 23 is connected by means of broken line 25 in a manner of integrated and stacked on top of each other with lower layer part 24.On
Layer portion 23 has same flat shape and identical size with lower layer part 24, and stacked on top of each other in entire surface.
The broken line 25 of formed article 20 is configured along the broken line 13 of cover film 10.The upper layer part 23 of formed article 20 and covering
The inside face of upper layer part 11 in the inside region 19A of film 10 is mutually stacked, and is fixed on the upper layer part 11 by hot sticky knot 21.Load
The lower layer part 24 and the inside face of the lower layer part 12 in the inside region 19A of cover film 10 for carrying component 20 are mutually stacked, and are passed through
Hot sticky knot 21 is fixed on the lower layer part 12.
In addition, the structure of the binding part between formed article 20 and cover film 10 is not limited to be distributed in as described above
The mode of multiple positions is formed, such as can also be that the binding part of linear extension or the binding part of planar expansion are formed in 1 position
It sets or multiple positions.
Medicament 22 is liquid, gel or pasta material with the effective component as percutaneous absorbtion medicament.Such as
Aqueous solution or organic solvent dissolved with effective component can be enumerated.As organic solvent, as long as can be used for percutaneous absorbtion with sticking
Agent is not particularly limited.In addition, also including the organic ion liquid as the solvent of strong solubility energy.In turn, further include it
Mixture.As organic solvent, aliphatic ester (such as isopropyl cetylate, isopropyl myristate, lactic acid can be enumerated
Hexadecane ester, diethyl sebacate, lauric acid hexyl ester, isooctyl acid cetyl ester, Lauryl lactate, ethyl oleate etc.), glycol
Class (such as ethylene glycol, propylene glycol, 1,3 butylene glycol, polyethylene glycol, polypropylene glycol, glycerine etc.), alcohols (such as ethyl alcohol, third
Alcohol, isopropanol, butanol etc.) etc..
As organic ion liquid, the bronsted of the room temperature liquid formed by aliphatic acid and organic amine compound can be enumerated
The salt of type.As aliphatic acid or organic amine compound, as long as can be used for sticking agent, it is not particularly limited.Aliphatic acid can be enumerated
(such as levulic acid, octanoic acid, capric acid, oleic acid, stearic acid, isostearic acid etc.), low-grade alkylamine (such as it is diethanol amine, two different
Propanolamine, triethanolamine, triisopropanolamine etc.).
Transdermal absorption accelerator can be added in medicament 22.As transdermal absorption accelerator, higher alcohols (example can be enumerated
Such as cetanol, stearyl alcohol, laruyl alcohol, cetostearyl alcohol, myristyl alcohol, oleyl alcohol) or menthol or limonene.In turn, can make
With from esters solvent (such as isopropyl myristate, isopropyl cetylate, diethyl sebacate, propene carbonate etc.) or N-
1 kind or more of the ingredient selected in N-methyl-2-2-pyrrolidone N.In addition, surfactant can be used, as the surface-active
Agent can enumerate nonionic class surfactant, anionic based surfactants, cationic based surfactants, amphoteric surface's work
Property agent.As nonionic class surfactant, can enumerate such as Arlacel-20, anhydro sorbitol list palmitic acid
Ester, Arlacel-83, glycerin monostearate, ten polyglycereol monolaurates, the poly- ricinoleate ester of six glycerine,
Polyoxyethylene (9) dodecyl ester, polyoxyethylene (2) dodecyl ester, polyoxyethylene (4,2) dodecyl ester, polyoxyethylene
(5) nonyl phenylester, polyoxyethylene (7,5) nonyl phenylester, polyoxyethylene (10) nonyl phenylester, polyoxyethylene (3) octyl
Phenylester, polyoxyethylene (10) oleyl amine, polyoxy (5) oleyl amine, polyoxy (5) oleamide, gathers polyoxyethylene (10) octyl phenyl ester
Ethylene oxide (2) monolaurate, glyceryl monostearate, Emulsifier EL-60 (rilanit special) etc..
As anionic based surfactants, can enumerate such as NaLS, dodecyl sulphate potassium, dodecyl sulphur
Triethylenetetraminehexaacetic acid hydramine, cetyl sulfate, sodium lauroyl sarcosine, two -2- ethylhexylsulfosuccinates sodium, polyoxyethylene (10)
Lauryl ether sodium phosphate, polyoxyethylene (4) lauryl ether sodium phosphate, polyoxyethylene (5) cetyl ether sodium phosphate, polyoxyethylene
(6) oleyl ether sodium phosphate etc..
As cationic based surfactants, can enumerate such as stearyl trimethyl ammonium chloride, distearyl dimethylammonium chloride
Ammonium, benzalkonium chloride, stearalkonium chloride etc..
As amphoteric surfactant, can enumerate such as phosphatidyl choline, lauryl dimethyl oxyneurine, 2- alkane
Base-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaines etc..As the surfactant in addition to described, bay also can be used
Acyl diglycollic amide.
So-called " effective component " is not particularly limited as long as can be used as the effective component of percutaneous absorbtion medicament, can
Enumerate non_steroidal anti_inflammatory drug (NSAID) (such as Indomethacin, Flurbiprofen, Ketoprofen, Diclofenac etc.), local anaesthesia
Agent (such as lidocaine, totokaine etc.), C16H25NO2, Eperisone, ramelteon, donepezil, Escitalopram, Garland he
Quick, ramelteon, morphine, Oxycodone, Paxil, Ropinirole, pergolide, Ondansetron, Raloxifene, sieve replace dagger-axe
Spit of fland, Aripiprazole, fentanyl, apomorphine, Memantine, amantadine, Tulobuterol, orinase, glibenclamide, former times difficult to understand
Cloth peaceful, neostigmine, nicardipine, dopamine etc..It is possible to further use the combination of these effective components.In addition, drug effect
The ingredient of the combination by acid and base by ionic liquid also can be used in ingredient.For example, as preferable example, conduct can be enumerated
The combination of the non_steroidal anti_inflammatory drug of acid and the local anesthetic as base.
So-called " solvent " refers to the aqueous solution or above-mentioned organic solvent for dissolving effective component.In addition, organic solvent is
Refer to the solvent for including the transdermal absorption accelerator.That is, as organic solvent, as long as can be used for percutaneous absorbtion with sticking agent i.e.
Can, it is not particularly limited.In addition, the organic ion liquid of the solvent as strong solubility is also contained in wherein.In addition, further including it
Mixture.
1-4. bonding sheet
As shown in Figures 1 and 2, bonding sheet 30 has：Substrate layer 33；And adhesive layer 34, it is set to and substrate layer 33
The opposed face of cover film 10 (inside face).Adhesive layer 34 is set to the entire inside face of substrate layer 33.
Substrate layer 33 is formed by non-woven fabrics, fabric, synthetic resin thin slice or their complex.Material as substrate layer 33
Material, can enumerate such as polyethylene, polypropylene, makrolon, polyesters, polyamide, polyvinyl chloride, cotton, polyurethane, in addition, also
Their complex can be enumerated.
Adhesive layer 34 is using the binder that can play required cohesive force between the exterior face of cover film 10.This
Outside, in the case where the cutting part 17 of cover film 10 is complete cuts, it is preferable that using can prevent from supporting in the medicament of formed article 20
22 binders leaked to the outside by the interface of cover film 10 and adhesive layer 34.Specifically, it can properly select using propylene
The binder of acids, synthetic rubber class, natural rubber class etc., but preferably, can enumerate and be with the copolymer of acrylic monomer
Acrylic adhesive (2-EHA, butyl acrylate, ethyl acrylate, the methyl methacrylate of main component
Ester etc.), the synthetic rubber class of the bonding imparting agent of styrene-isoprene-styrene copolymer (SIS) and terpene resin etc. etc. it is viscous
Tie agent.In order to improve resistance to fluidity, as plasticizer, can and with trimellitic acid esters plasticizer or polyesters plasticizer.
The adhesive layer 34 of bonding sheet 30 is pasted onto the exterior face of cover film 10 in a manner of it can remove.It is covering as a result,
The outboard bonds layer 34 and substrate layer 33 of film 10 are sequentially laminated.It is curved that there is bonding sheet 30 broken line 13 along cover film 10 to bend
Folding part 35.The side for clipping bending part 35 in bonding sheet 30 is formed with the conduct in the face of the side for constitution equipment 2
The upper surface of one face portion 31 is formed in the other side below second face of conduct in the face of the other side for constitution equipment 2
Portion 32.Upper surface portion 31 is pasted onto the exterior face of the upper layer part 11 of cover film 10, and lower face 32 is pasted onto the lower layer part of cover film 10
12 exterior face.
Bonding sheet 30 is arranged in a manner of the entire exterior face for covering cover film 10.If however, the covering covering of bonding sheet 30
At least inside region 19A of film 10, then may be arranged as the exterior face for partly covering cover film 10.
1-5. stripping film
As shown in Figures 1 and 2, it is preferable that in the neighboring of bonding sheet 30, set between cover film 10 and bonding sheet 30
Set stripping film 38,39.Stripping film 38,39 is bonded in the adhesive layer 34 of bonding sheet 30 in a manner of it can remove.
In the example of diagram, stripping film 38,39 is respectively arranged at the upper layer in the upper surface of bonding sheet 30 portion 31 and cover film 10
Between portion 11 and below bonding sheet 30 between 32 and the lower layer part 12 of cover film 10.Stripping film 38,39 is formed as to second
Direction D2 extends band-like, along the edge with 35 opposite side of bending part in the upper surface of bonding sheet 30 portion 31 and lower face 32
Portion is arranged.
In addition, stripping film 38,39 may also be disposed on only one in upper surface portion 31 and lower face 32.In addition, stripping film 38,
39 can also be set to the state along the broken line bending extended to length direction between cover film 10 and bonding sheet 30.
The material of stripping film 38,39 is not particularly limited, but such as polyethylene, polypropylene, polyesters can be used.In addition, right
The surface of stripping film 38,39 can carry out silicon processing, to be convenient to remove with lotion.
2. manufacturing method
With reference to Fig. 4, the manufacturing method of the equipment 2 with the above structure is illustrated.
Manufacturing process includes following 1~process of process 10.Hereinafter, being illustrated to each process.
Process 1：Supply cover film
In manufacturing process 50 shown in Fig. 4, supplied along the conveying direction D3 continuitys from the left side of figure towards right side
To cover film 10.The posture that cover film 10 is parallel to conveying direction D3 with the second direction D2 (Fig. 1 and with reference to Fig. 3) conveys.
Process 2：Form cutting part
Cutting part 17 is formed by making cutter 51 be connected to the bottom surfaces of cover film 10.Although not shown, it but is clipping
Cover film 10 and the opposite side with cutting machine 51 is provided with supporting table, in the cover film 10 folded by cutting machine 51 and supporting table
Upper formation cutting part 17.As described above, selecting to cut according to the type (continuous joint-cutting, is cut, hemisection at perforation entirely) of cutting part 17
The type of machine 51.
Process 3：Supply formed article
Formed article 20 is positioned over the upper side of cover film 10 by means of formed article feedway 52.At this point, supporting
Component 20 is placed in the inside region 19A of cover film 10.
Process 4：Fixed formed article
It is welded in formed article 20 and multiple positions of cover film 10 by such as ultrasonic spot welder 53, to form heat
Binding part 21.
Process 5：Supplying medicament
From medicine feeding apparatus 54 to 20 supplying medicament 22 of formed article.
Process 6：It is folded over film and formed article
The first folding machine that the cover film 10 conveyed to conveying direction D3 is arranged with formed article 20 on transport path
Structure 55 is folded along the broken line 13,25 (referring to FIG. 1 and FIG. 2) extended to conveying direction D3 (second direction D2).
Process 7：Heat-sealing
A pair of of membrane part (upper layer part 11 and the lower layer of cover film 10 will be formed in by folding by using heat sealing machine 56
Portion 12) in outer side region 19B carry out heat-sealing 18.The heat-sealing 18 is for sealing three other than the broken line 13 in cover film 10
The sealing in three directions of edge part, to the inside region 19A of cover film 10 without sealing.As a result, in the formation of cover film 10
While the sealing area 14 of "U" font and non-sealed regions 15 surrounded by sealing area 14 and broken line 13, portion will be supported
Part 20 is accommodated in the confined space for being formed in non-sealed regions 15.
Process 8：Supply bonding sheet
In the case where having stored the cover film 10 of the folded state of formed article 20, supplied with the posture of adhesive layer 34 upward
And it is superimposed bonding sheet 30, and it is defeated along conveying direction D3 together with cover film 10 to be superimposed upon the bonding sheet under cover film 10 30
It send.Bonding sheet 30 is arranged at the second fold mechanism 57 in transport path and extends along to conveying direction D3 (second direction D2)
Cover film 10 broken line 13 bend, the partial stack of bonding sheet 30 being bent is in the top of cover film 10.
In process 8, the bonding sheet 30 for being pasted with stripping film 38,39 to the edge part of adhesive layer 34 in advance can be supplied,
The bonding sheet that the stripping film 38,39 being supplied respectively to bonding sheet 30 can also be pasted onto before being bent by the second fold mechanism 57
30。
Process 9：Lamination
It is pressurizeed from upper and lower directions to the cover film 10 covered by bonding sheet 30 using laminater 58 so that bonding sheet 30
Adhesive layer 34 is bonded in the exterior face of cover film 10.
Process 10：Punching
Using the die cutter 59 of the blade with the profile along equipment 2 come to as described above by laminated more
The layered product that a thin slice or film are constituted is punched out.The punching is carried out to the peripheral part other than the part along the broken line of layered product
It cuts.
In the above description, the process 2 for forming cutting part 17 in cover film 10 is set in immediately to be used to supply and is supported
Before the process 3 of component 20, but the process 2 for being used to form cutting part 17 can be for being folded over film 10 and formed article 20
Any time before process 6 carries out, such as can be after the process 4 of fixed formed article 20 or the process 5 of supplying medicament 22
It carries out later.
In addition, in the above description, the process 8 for supplying bonding sheet 30 to be set in the work for the sealing for carrying out three directions
After sequence 7, but in the case where discontinuously supplying bonding sheet 30 being cut into small pieces in advance, bonding sheet 30 will be discontinuously being supplied
It is superimposed upon after the exterior face of cover film 10 with dividing, the part of the bonding sheet 30 for not being superimposed cover film 10, it can be along viscous
The outer peripheral region of sheeting 30 carries out the sealing in three directions.
3. using
The use of equipment 2 to being manufactured in method as described above illustrates.
As shown in Figure 5A, when in use, first, catch bonding sheet 30 as in upper surface portion 31 be pasted with stripping film 38
Edge part, and remove upper surface portion 31 from the upper layer part of cover film 10 11.Wherein, cover film 10 is divided into medial area by cutting part 17
Domain 19A and lateral area 19B, therefore bonding sheet 3 is removed from the lateral area 19B in the upper layer part 11 of cover film 10, but upper layer
The inside region 19A in portion 11 is cut open from lateral area 19B along cutting part 17 and is retained on bonding sheet 30.In addition, fixed
It is also retained on bonding sheet 30 via inside region 19A in the formed article 20 of the inside region 19A of cover film 10.
Next, as shown in Figure 5 B, the edge part for being pasted with stripping film 39 in catching 32 below bonding sheet 30, from
The lower layer part 12 of cover film 10 removes lower face 32.As a result, as shown in Figure 5 C, the inside region 19A of cover film 10 is entire outer
Zhou Shangcong lateral areas 19B is cut, and entire lateral area 19B is removed from bonding sheet 30.At this point, on bonding sheet 30, remain with
The entire inside region 19A and entire formed article 20 of cover film 10.On the bonding sheet 30 of expansion, the medial area of cover film 10
Domain 19A and formed article 20 are retained with the state of expansion.
As shown in Figure 5 D, the equipment 2 of the lateral area 19B of cover film 10 is eliminated by the way that adhesive layer 34 is placed on skin
It is pasted on 100.Finally, stripping film 38,39 is removed from the adhesive layer 34 of bonding sheet 30, entire adhesive layer 34 is pasted onto skin
On 100.
In addition, when removing bonding sheet 30 from the lateral area 19B of cover film 10, maintaining in cover film 10 securely
Side region 19A while the state of adhesive layer 34 for being bonded in bonding sheet 30, inside region 19A need along cutting part 17 from
Lateral area 19B is cut.Therefore, the cohesive force of the depth of the hemisection in cutting part 17 and adhesive layer 34 is come true according to following situation
It is fixed：In the state that the inside region 19A of cover film 10 and formed article 20 are retained in together on bonding sheet 30, it can will cover
The lateral area 19B of film 10 is removed from bonding sheet 30.
As described above, according to the equipment 2 of embodiment, in the shape for removing the lateral area 19B of cover film 10 from equipment 2
Under state, formed article 20 is retained on bonding sheet 30, therefore can formed article 20 and bonding sheet 30 be pasted onto skin together
On 100.In addition, without adjusting formed article 20 relative to this operation of the position of bonding sheet 30, therefore medicament will not adhere to
On the finger of user of service.
In addition, according to the equipment 2 of embodiment, since the liquor of medicament 22 will be used as to be immersed in formed article 20, because
This not only can easily seek the agent that sticks of liquor, but also compared with the case where using ointment formulation or tape preparation, can obtain
The advantages of releasable property and the good liquor of Percutaneously absorbable capable of must being administered.
In addition, according to the equipment 2 of embodiment, in the state of before unpacking, formed article 20 is folded, in formed article
20 upper layer part 23 and the face for being only fixed on cover film 10 in lower layer part 24 are opposed with cover film 10, in the one side of opposite side
Upper layer part 23 is opposed with lower layer part 24.It is therefore possible to prevent the medicament 22 supported in formed article 20 is attached in cover film 10
The part for not keeping formed article 20 the case where.Therefore, it is possible to inhibit to lead to the throwing of medicament 22 because being attached to cover film 10
Thus the case where entering the reduction of amount can effectively play the purpose of following equipment 2, that is, by the liquor of specified amount relative to rule
Fixed skin area carries out percutaneous dosing.
More than, above-mentioned embodiment is illustrated to illustrate the present invention, but the present invention is not limited to above-mentioned embodiment party
Formula.
For example, in the embodiment shown, illustrating that there are one percutaneous absorbtions for storage between two layers of cover film
The example of agent formed article, but in the present invention, also can store multiple transdermic absorbents between two layers of cover film and support portion
Part.
In addition, in the above-described embodiment, illustrating what two stackings of the transdermic absorbent formed article folded were set
Example, but in the present invention, also one transdermic absorbent can be supported into portion by being stacked two transdermic absorbent formed articles
Part is fixed on a layer of cover film, and another transdermic absorbent formed article is fixed on another of cover film
Layer on.
4. variation
Hereinafter, with reference to Fig. 6~Figure 15 D, to illustrate that (transdermic absorbent delivers the equipment of the variation of first variation~the 8th
Equipment).In addition, in the variation of first variation~the 8th, for structural element same as above-mentioned embodiment, scheming
Same reference numeral is assigned in 6~Figure 15 D, and the description thereof will be omitted.
[first variation and the second variation]
Fig. 6 shows that the equipment 102 of first variation, Fig. 7 show the equipment 202 of the second variation.Equipment shown in Fig. 6
In 102, two components 123,124 for being separated from each other are stacked as formed article 120, in equipment 202 shown in Fig. 7, as load
Component 220 is carried, there are four component 223a, 223b, 224a, 224b, these components 223a, 223b, 224a, 224b is each stacked for setting
Two.
As shown in FIG. 6 and 7, in first variation and the second variation, load is formed by the component being separated from each other
Two layers (third layer portion and the 4th layer of portion) of component 120,220 are carried, thus lack flexible formed article with by bending
It compares, two layers can be compactly superimposed in a thickness direction the case where two layers to be formed.Therefore, formed article 120,
220 shortage flexibility and be difficult in the case of folding, can be formed by using this mutually independent component third layer portion and
4th layer of portion, to manufacture the equipment 102,202 that formed article 120,220 is compactly accommodated in cover film 10.
As shown in FIG. 6 and 7, manufacture have the third layer portion 123 being made of the formed article being separated from each other, 223a,
223b and the 4th layer of portion 124,224a, 224b equipment 102,202 when, in the cover film 10 of unfolded state relative to
The central portion (straight line portion for forming the first broken line 13 that oriented second direction D2 extends) of one direction D1, in a manner of symmetrical
Formed article 123,124,223a, 223b, 224a, 224b are configured, and is fastened to cover film 10.Work as edge as a result,
When the first broken line 13 and being folded over film 10, by the formed article 123 for being used to form third layer portion, 223a, 223b and it can be used for
Form the formed article 124 in the 4th layer of portion, 224a, 224b are stacked in entire surface mutually.Thereby, it is possible to be reliably prevented dipping
Liquor in each formed article 123,124,223a, 223b, 224a, 224b be attached in cover film 10 do not keep support portion
The part of part.
In addition, in the present invention, the feelings in third layer portion and the 4th layer of portion are formed in multiple formed articles by being separated from each other
Under condition, formed article quantity can arbitrarily be set, the two or four being not limited to the described above.In addition, that will support as described above
In the case that component is configured relative to the cover film of unfolded state in a manner of symmetrical, it is preferable to use even number supports
Component keeps the formed article in third layer portion consistent with the 4th layer of formed article quantity in portion.However, in the present invention, third layer
The formed article in portion and the formed article quantity in the 4th layer of portion can also be different.
In addition, the present invention allows a transdermic absorbent formed article to be stored without folding, in this situation
Under, the technical issues of there are about preventing medicament to be attached to cover film, but can realize the sealing area of cover film diminution and
The reduction of membrane part to be discarded when the densification for the integral device brought and use.In the case, transdermic absorbent is carried on a shoulder pole
The layer that component is only fixed on the side of cover film is carried, thus can cutting part only be set in the layer.
[third variation]
As shown in figure 8, the equipment 302 of third variation is in a folded configuration in addition to including the composition folding on first direction D1
The first edge portion 311 of the end of 13 side of line, the composition side opposite with broken line 13 on first direction D1 end second
The third edge part 313 of the end of composition side on edge part 312, second direction D2 and the composition on second direction D2 are another
4th edge part 314 of side end, further include by cut off the corner between second edge portion 312 and third edge part 313 come
The first sloping edge portion 315 for both connecting, by cut off the corner between second edge portion 312 and the 4th edge part 314 come
Connect second sloping edge portion 316 of the two.
Like this, in the equipment 302 of third variation, two corners of the side opposite with broken line 13 are cut off.Therefore,
When in use, when catching the edge part for being pasted with stripping film 38 in bonding sheet 30, in the first sloping edge portion 315 and second
Sloping edge portion 316, it is difficult to catch the edge part for being pasted with stripping film 38 in bonding sheet 30.Therefore, promote in second edge
Portion 312 catches bonding sheet 30, thus promote along a first direction D1 from cover film 10 remove bonding sheet 30.
The end of 312 side of second edge portion of the first direction D1 in the cutting part 17 of cover film 10 is formed in to vertical
It is configured in the mode that the direction of first direction D1 extends, therefore, as described above, when by bonding sheet 30, D1 is removed along a first direction
When, it can be along the cutting part 17 relative to first direction D1 arranged perpendiculars, by the inside region 19A of cover film 10 swimmingly from outer
Side region 19B is cut (with reference to Fig. 5 A).
[the 4th variation]
As shown in figure 9, in the equipment 402 of the 4th variation, 13 side of broken line on the first direction D1 of stripping film 38,39
End 410 be formed as extending along second direction D2 linearity on the whole, but in the length direction central portion of the end 410
It is formed with the bulge 420 of 13 side of the broken line expansion towards first direction D1.In addition, only showing the stripping film 38 of side in Fig. 9
Bulge 420, but bulge 420 is similarly formed in the stripping film 39 of the other side.
As a result, (with reference to Fig. 5 C) in the state of eliminating the lateral area 19B of cover film 10 from equipment 402, when in order to
When removing stripping film 38,39 from the adhesive layer 34 of bonding sheet 30 and catching the end 410 of stripping film 38,39, can easily it exist
The bulge 420 catches stripping film 38,39.
[5th variation]
As shown in Figure 10, in the equipment of 5th variation 502, the broken line 13 on the first direction D1 of stripping film 38,39
The end 510 of side, which is wriggled along second direction D2 with corrugated shape, to be extended.The stripping film 38 formed with such corrugated shape,
39 end 510 is formed with the bulge 520 of 13 side of the broken line expansion towards first direction D1.In each stripping film 38,39,
Multiple bulges 520 are set in a manner of interval in a second direction d 2.
As a result, (with reference to Fig. 5 C) in the state of eliminating the lateral area 19B of cover film 10 from equipment 502, when in order to
When removing stripping film 38,39 from the adhesive layer 34 of bonding sheet 30 and catching the end 510 of stripping film 38,39, can easily it exist
The bulge 520 catches stripping film 38,39.
[the 6th variation]
As shown in figure 11, in the same manner as the equipment 302 of third variation shown in Fig. 8, the equipment 602 of the 6th variation is removed
Include except first edge portion 611, second edge portion 612, third edge part 613 and the 4th edge part 614, further includes passing through
The corner between second edge portion 612 and third edge part 613 is cut off to connect first sloping edge portion 615 of the two, pass through
The corner between second edge portion 612 and the 4th edge part 614 is cut off to connect second sloping edge portion 616 of the two.
As a result, in the same manner as the third variation, promote to catch bonding sheet 30 in second edge portion 612 and along
One direction D1 is removed from cover film 10.It therefore, can be by cover film along the cutting part 17 relative to first direction D1 arranged perpendiculars
10 inside region 19A is swimmingly cut from lateral area 19B (with reference to Fig. 5 A).
In addition, in the 6th variation, for the adhesive layer 34 of bonding sheet 30, stripping film 638,639 is stuck as from viscous
30 state outstanding of sheeting.More specifically, each stripping film 638,639 is in the first direction dl than the second edge portion of bonding sheet 30
612 more protrude outward, and are tilted respectively than the first sloping edge portion 615 and second of bonding sheet 30 in a second direction d 2
Edge part 616 more protrudes outward.Be easy to as a result, the part more protruded outward than bonding sheet 30 catch stripping film 638,
639。
Therefore, it can swimmingly carry out catching in bonding sheet 30 in order to remove bonding sheet 30 from cover film 10 and being pasted with stripping
The action (with reference to Fig. 5 A) of edge part from film 638 and in order to remove stripping film 638,639 from the adhesive layer 34 of bonding sheet 30
And catch the action of stripping film 638,639.
[the 7th variation]
As shown in figure 12, in the equipment 702 of the 7th variation, stripping film 738,739 intervened in the state of bending in
Between cover film 10 and the adhesive layer 34 of bonding sheet 30.Each stripping film 738,739 has：Outer layer portion 740, is pasted onto adhesive layer
34；And internal layer portion 742, via the broken line 741 extended to second direction D2 (referring to Fig.1) with the first party in outer layer portion 740
It is connected to the one end of D1, and intervenes between outer layer portion 740 and cover film 10.
The broken line 741 of stripping film 738,739 is configured at one opposite with the edge part of bonding sheet 30 in the first direction dl
Side.The internal layer portion 742 of stripping film 738,739 is shorter than outer layer portion 740 in the first direction dl.Internal layer portion 742 and cover film 10
Exterior face is contacted without stickup.
Due to the intervention in the internal layer portion 742 of stripping film 738,739, outer layer portion 740 and the cover film 10 of stripping film 738,739
Between easy to produce gap.Therefore, it is easy to catch in bonding sheet 30 (with reference to Fig. 5 A) when removing bonding sheet 30 from cover film 10
The edge part for being pasted with stripping film 738.
In addition, the internal layer portion 742 of stripping film 738,739 is not pasted onto bonding sheet 30, therefore shelled when being removed from bonding sheet 30
When from film 738,739, the internal layer portion 742 of stripping film 738,739 can be easily caught, and can swimmingly remove stripping film
738、739。
[the 8th variation]
As shown in figure 13, in the equipment 802 of the 8th variation, for bonding cover film 10 upper layer part 11 and lower layer
The heat-sealing 18 in portion 12 be not set to the end of the side opposite with broken line 13 in the first direction dl on this point, and it is above-mentioned
Embodiment equipment 2 (with reference to Fig. 2) it is different.
As a result, as shown in figure 14, it in the 8th variation, is formed between the upper layer part 11 and lower layer part 12 of cover film 10
There are the first non-sealed regions 815 configured along broken line 13, to surround the part along broken line 13 of the first non-sealed regions 815
The sealing area 814 and the side opposite with broken line 13 being configured on first direction D1 that the mode of peripheral part in addition configures
End and sealing area 814 between the second non-sealed regions 816.
First non-sealed regions 815 are the area corresponding to the non-sealed regions 15 (with reference to Fig. 3) in above-mentioned embodiment
Domain, sealing area 814 are that the second non-tight is eliminated (with reference to Fig. 3) corresponding to the slave sealing area 14 in above-mentioned embodiment
The region in region 816.First non-sealed regions 815 are surrounded with broken line 13 on entire periphery by sealing area 814, are existed as a result,
First non-sealed regions 815 form confined space.
It is formed in the part of the first non-sealed regions of formation 815 in the upper layer part 11 and lower layer part 12 of cover film 10
Same first cutting part 817 with the cutting part 17 (reference Fig. 3) of above-mentioned embodiment.Formed article 20 is fixed on cover film
The part surrounded by the first cutting part 817 in 10 the first non-sealed regions 815.
Second non-sealed regions 816 are opened in the peripheral part other than the boundary between sealing area 814.It is covering
The part of the second non-sealed regions of formation 816 in the upper layer part 11 of film 10, is formed with along the side between sealing area 814
The second cutting part 822 that boundary extends to second direction D2, the second non-sealed regions of formation in the lower layer part 12 of cover film 10
816 part is formed with the third cutting part 823 extended to second direction D2 along the boundary between sealing area 814.
First cutting part 817, the second cutting part 822, third cutting part 823 can be successional joint-cutting, or
Intermittent perforation.In addition, the first cutting part 817, the second cutting part 822, third cutting part 823 can be from the one of cover film 10
The so-called of the face of the face of side to the other side is cut entirely, or do not cut the part near the one side of cover film 10 and
Remaining so-called hemisection shape.Preferably, the case where cutting entirely is worn to have remained the so-called of part that a part is not cut
Hole.Moreover it is preferred that for ease of avoiding the evaporation of the solvent of percutaneous absorbtion medicament, dispersing, cutting part 817 is hemisection.Figure 13
Shown in the first cutting part 817 be the hemisection extended to from the exterior face of cover film 10 near inside face.
Cover film 10 is divided into the inside region 830 surrounded by the first cutting part 817, is configured at the first cutting part 817
Outside and the first lateral area 831 of the inside of the second cutting part 822 and third cutting part 823, be configured at the second cutting part
Second lateral area 832 in 822 outside and be configured at third cutting part 823 outside third lateral area 833.
As shown in figure 13, curved along the broken line 13 of cover film 10 by bonding sheet 30 in the same manner as the embodiment
Folding, is pasted onto the exterior face of the upper layer part 11 of cover film 10 and the exterior face of lower layer part 12.It is formed in the institute of cover film 10 as a result,
The first cutting part 817, the second cutting part 822 and the third cutting part 823 stated are by bonding sheet 30 from outer side covering.
As shown in fig. 15, when using the equipment 802 of the 8th variation, first, such as upper surface portion of bonding sheet 30 is caught
31 edge part and formation are bonded in the part of the second lateral area 832 of the cover film 10 of the part, are cut on one side along second
It cuts portion 822 (3 and Figure 14 referring to Fig.1) and cuts the second lateral area 832 from cover film 10, on one side by the upper surface of bonding sheet 30 portion 31
It is removed from the upper layer part 11 of cover film 10.
The upper surface of bonding sheet 30 portion 31 is removed from the first lateral area 831 in the upper layer part 11 of cover film 10 as a result, on
The inside region 830 in layer portion 11 is cut open along the first cutting part 817 from the first lateral area 831, and is stayed on bonding sheet 30.
In addition, the formed article 20 for being fixed on the inside region 830 of cover film 10 is stayed in via inside region 830 on bonding sheet 30.
Then, as shown in fig. 15b, 32 edge part and formation below bonding sheet 30 is caught to bond in the portion
Third outside area is cut in the part of the third lateral area 833 of cover film 10 along third cutting part 823 from cover film 10 on one side
Domain 833, on one side from 32 below the lower layer part 12 of cover film 10 stripping bonding sheet 30.
As a result, as shown in figure 15 c, the inside region 830 of cover film 10 is cut on entire periphery from the first lateral area 831
It opens, entire first lateral area 831 is removed from bonding sheet 30.At this point, remaining with the medial area of cover film 10 on bonding sheet 30
Domain 830, the second lateral area 832, third lateral area 833 and formed article 20.On the bonding sheet 30 of expansion, cover film 10
Inside region 830 and formed article 20 be kept with the state of expansion.
As shown in figure 15d, the equipment 802 for eliminating the first lateral area 831 of cover film 10 is positioned over adhesive linkage 34
The mode of skin 100 is pasted.By the second lateral area 832 and third of removing cover film 10 from the adhesive layer 34 of bonding sheet 30
Entire adhesive layer 34 can be pasted onto on skin 100 by lateral area 833 (5C referring to Fig.1).
According to the equipment 802 of the 8th variation, by the way that the second non-sealed regions 816 are arranged in cover film 10 (with reference to figure
13 and Figure 14), the second lateral area 832 and third lateral area 833 of cover film 10 play in above-mentioned embodiment
The same effect (with reference to Fig. 5) of stripping film 38,39.Therefore, seek the reduction of number of components by omitting stripping film 38,39,
Equipment 802 can be used in the method similar to above-mentioned embodiment.
(explanation of reference numeral)
2：Transdermic absorbent delivery device；10：Cover film；11：The upper layer part (first layer portion, the first film portion) of cover film；
12：The lower layer part (second layer portion, the second film portion) of cover film；13：The broken line (the first broken line) of cover film；14：Sealing area；
15：Non-sealed regions；17：Cutting part；18：Heat-sealing；19A：Inside region；19B：Lateral area；20：Transdermic absorbent supports portion
Part；21：Hot sticky knot；22：Percutaneous absorbtion medicament (medicament)；23：Transdermic absorbent formed article upper layer part (third layer portion)；
24：Transdermic absorbent formed article lower layer part (the 4th layer of portion)；25：Transdermic absorbent formed article broken line (the second broken line)；30：
Bonding sheet；31：The upper surface of bonding sheet portion (first facial)；32：Below bonding sheet (the second face)；33：Substrate layer；34：
Adhesive layer；35：Bending part；38：Stripping film；39：Stripping film；50：Manufacturing process；51：Cutting machine；52：Formed article supply dress
It sets；53：Ultrasonic spot welder；54：Medicine feeding apparatus；55：First fold mechanism；56：Heat sealing machine；57：Second fold mechanism；
58：Laminater；59：Die cutter；100：Skin；102：Transdermic absorbent delivery device；120：Transdermic absorbent supports
Component；123：Form the formed article in third layer portion；124：Form the formed article in the 4th layer of portion；202：Transdermic absorbent delivers
Equipment；220：Transdermic absorbent formed article；223a、223b：Form the formed article in third layer portion；224a、224b：Form the
The formed article in four layers of portion；302：Transdermic absorbent delivery device；315：First sloping edge portion；316：Second sloping edge
Portion；402：Transdermic absorbent delivery device；420：The bulge of stripping film；502：Transdermic absorbent delivery device；520：Stripping
The bulge of film；602：Transdermic absorbent delivery device；638、639：Stripping film；702：Transdermic absorbent delivery device；738、
739：Stripping film；740：Outer layer portion；741：Broken line；742：Internal layer portion；802：Transdermic absorbent delivery device；814：Seal area
Domain；815：First non-sealed regions；816：Second non-sealed regions；817：First cutting part；822：Second cutting part；823：The
Three cutting parts；830：Inside region；831：First lateral area；832：Second lateral area；833：Third lateral area.
Claims (19)
1. a kind of transdermic absorbent delivery device, which is characterized in that including：
(a) cover film of anti-solvent penetration is had and is connected in a manner of integrated by means of the first broken line and stacked on top of each other
First layer portion and second layer portion, be formed with non-sealed regions and seal area between the first layer portion and the second layer portion
Domain, the non-sealed regions are configured along first broken line, the sealing area with surround the non-sealed regions along
The mode of peripheral part other than the part of first broken line configures, and closure is formed in the part for forming the non-sealed regions
The cutting part of shape；
(b) transdermic absorbent formed article, the first layer portion and the second layer portion being configured in the non-sealed regions
Between, the cover film is fixed on the inside of the cutting part；And
(c) bonding sheet is pasted on the exterior face of the cover film in a manner of it can remove.
2. transdermic absorbent delivery device according to claim 1, which is characterized in that the transdermic absorbent formed article
(20) have and be connected in a manner of integrated by means of the second broken line (25) and third layer portion (23) and the 4th stacked on top of each other
Layer portion (24).
3. transdermic absorbent delivery device according to claim 2, which is characterized in that the transdermic absorbent formed article
The second broken line (25) along the cover film the first broken line (13) configure.
4. transdermic absorbent delivery device according to claim 1, which is characterized in that the transdermic absorbent formed article
(120,220) have and formed with the discrete parts that is separated from each other and third layer portion stacked on top of each other (123,223a, 223b) and the
Four layers of portion (124,224a, 224b).
5. transdermic absorbent delivery device according to any one of claim 2 to 4, which is characterized in that the percutaneous suction
Receive agent formed article third layer portion (23,123,223a, 223b) and the 4th layer of portion (24,124,224a, 224b) in entire surface
It is upper stacked on top of each other.
6. the transdermic absorbent delivery device according to any one of claim 2 to 5, which is characterized in that
The first layer portion in the third layer portion (23,123,223a, 223b) and the cover film of the transdermic absorbent formed article
(11) inboard portion of the cutting part (17) in is mutually stacked,
The second layer portion in the 4th layer of portion (24,124,224a, 224b) and the cover film of the transdermic absorbent formed article
(12) inboard portion of the cutting part (17) in is mutually stacked.
7. the transdermic absorbent delivery device according to any one of claim 2 to 6, which is characterized in that
The third layer portion (23,123,223a, 223b) of the transdermic absorbent formed article is fixed on the first of the cover film
Layer portion (11),
The 4th layer of portion (24,124,224a, 224b) of the transdermic absorbent formed article is fixed on the second of the cover film
Layer portion (12).
8. transdermic absorbent delivery device according to any one of claim 1 to 7, which is characterized in that
The bonding sheet (30) has substrate layer (33) and is set to the face opposed with the cover film (10) of the substrate layer
Adhesive layer (34),
The adhesive layer is pasted on the cover film in a manner of it can remove.
9. transdermic absorbent delivery device according to claim 8, which is characterized in that there is stripping film (38,39), it is described
Stripping film (38,39) is configured at the cover film and the bonding sheet along at least part of the neighboring of the bonding sheet
Between, the adhesive surface of the bonding sheet is pasted in a manner of it can remove.
10. transdermic absorbent delivery device according to any one of claim 1 to 9, which is characterized in that the bonding sheet
(30) along the first broken line (13) of the cover film bend, be pasted on the first layer portion (11) of the cover film exterior face and
The exterior face in second layer portion (12).
11. transdermic absorbent delivery device according to any one of claim 1 to 8, which is characterized in that the cover film
(10) it is aluminum layer.
12. a kind of manufacturing method of transdermic absorbent delivery device, which is characterized in that including：
Process 1 supplies the cover film of anti-solvent penetration；
Process 2 forms the cutting part of closed form in the cover film；
Process 3 configures transdermic absorbent formed article in the one side of the cover film；
The transdermic absorbent formed article is fixed on the cover film by process 4；
Process 5 makes medicament support in the transdermic absorbent formed article；
Process 6 clips the broken line by the cover film along defined folding line in being formed in the cover film
Between the first film portion and the second film portion for being formed in the other side of side, the transdermic absorbent formed article is sandwiched；
Process 7, the area of the peripheral part other than the part opposed with the broken line for surrounding the transdermic absorbent formed article
Domain is sealed between first film portion and second film portion；And
Bonding sheet is pasted on the cover film by process 8 in the part at least covering the cutting part in a manner of it can remove
Exterior face.
13. the manufacturing method of transdermic absorbent delivery device according to claim 12, which is characterized in that in the process
The process 2 is executed after 1 and before the process 6.
14. the manufacturing method of transdermic absorbent delivery device according to claim 12 or 13, which is characterized in that described
In process 6, the broken line is formed by the part being stacked with the transdermic absorbent formed article in the cover film
Mode fold the cover film so that be sandwiched in the transdermic absorbent formed article being folded together with the cover film
Between first film portion and second film portion.
15. the manufacturing method of transdermic absorbent delivery device according to claim 14, which is characterized in that in the process
In 4, institute is fixed in the part for being equivalent to first film portion in the cover film with the part for being equivalent to second film portion
State transdermic absorbent formed article.
16. the manufacturing method of transdermic absorbent delivery device according to claim 15, which is characterized in that in the process
In 2, to cross over the part corresponding to first film portion in the cover film and the part corresponding to second film portion
Mode forms the cutting part.
17. the manufacturing method of transdermic absorbent delivery device according to claim 16, which is characterized in that in the process
In 8, crossing over first film portion and second film portion in a manner of covering the broken line, the bonding sheet is pasted on
The exterior face of the cover film.
18. the manufacturing method of the transdermic absorbent delivery device according to any one of claim 12 to 17, feature exist
In before the process 8, along at least part of the neighboring of the bonding sheet, stripping film being pasted on described viscous
The adhesive surface of sheeting.
19. a kind of transdermic absorbent delivery device, which is characterized in that including：
The cover film (10) of anti-solvent penetration is had and is connected in a manner of integrated by means of the first broken line (13) and mutually
Stacked first layer portion (11) and second layer portion (12), between the first layer portion and the second layer portion, be formed with along
The first non-sealed regions (815) of first broken line (13) configuration, with surround first non-sealed regions (815) along
The sealing area (814) and be configured at and first folding that the mode of peripheral part other than the part of first broken line configures
The second non-sealed regions (816) between the end and the sealing area (814) of line (13) opposite side；
The first cutting part (817) of closed form is set in the first layer portion (11) and the second layer portion (12) and is used for
Form the part of first non-sealed regions (815)；
Second cutting part (822), the portion for being used to form second non-sealed regions (816) in the first layer portion (11)
Point, it is arranged in a manner of extending along the boundary between the sealing area (814)；
Third cutting part (823), the portion for being used to form second non-sealed regions (816) in the second layer portion (12)
Point, it is arranged in a manner of extending along the boundary between the sealing area (814)；
Transdermic absorbent formed article (20) is configured between the first layer portion (11) and the second layer portion (12), in institute
It states and is fixed on the cover film (10) on the inside of the first cutting part (817)；And
Bonding sheet (30) bends along the first broken line (13) of the cover film (10), institute is pasted in a manner of it can remove
The exterior face for stating cover film is cut to cover first cutting part (817), second cutting part (822) and the third
Cut portion (823).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-221975 | 2015-11-12 | ||
| JP2015221975 | 2015-11-12 | ||
| PCT/JP2016/083247 WO2017082301A1 (en) | 2015-11-12 | 2016-11-09 | Percutaneous absorption agent delivery device and manufacturing method therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108348477A true CN108348477A (en) | 2018-07-31 |
Family
ID=58695415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680065384.2A Pending CN108348477A (en) | 2015-11-12 | 2016-11-09 | Transdermic absorbent delivery device and its manufacturing method |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10932955B2 (en) |
| EP (1) | EP3360545A4 (en) |
| JP (1) | JP6752215B2 (en) |
| CN (1) | CN108348477A (en) |
| WO (1) | WO2017082301A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113164423A (en) | 2018-10-04 | 2021-07-23 | 美德阿利克斯株式会社 | Formulations stabilized with non-aqueous solvents |
| WO2021065697A1 (en) * | 2019-09-30 | 2021-04-08 | 株式会社メドレックス | Layered patch |
| CN117137726B (en) * | 2023-10-27 | 2023-12-22 | 江苏益仁堂生物科技有限公司 | Collagen repair patch and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4781293A (en) * | 1987-12-23 | 1988-11-01 | Pfizer Hospital Products Group, Inc. | One step dressing delivery system |
| JPH0748249A (en) * | 1993-08-04 | 1995-02-21 | Nitto Denko Corp | Ointment plaster |
| JP2010155810A (en) * | 2008-12-29 | 2010-07-15 | Nitto Denko Corp | Ointment cataplasm |
| CN104024358A (en) * | 2011-12-21 | 2014-09-03 | 3M创新有限公司 | Adhesive patch assembly with overlay liner and system and method for making same |
| CN204033820U (en) * | 2014-07-18 | 2014-12-24 | 天津市博爱生物药业有限公司 | Folding patch |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4894190U (en) * | 1972-02-10 | 1973-11-10 | ||
| JPS5717614U (en) * | 1980-07-02 | 1982-01-29 | ||
| US4627429A (en) * | 1986-02-28 | 1986-12-09 | American Home Products Corporation | Storage-stable transdermal adhesive patch |
| JP3523334B2 (en) * | 1994-07-02 | 2004-04-26 | 久光製薬株式会社 | Plaster structure for iontophoresis |
| US5976117A (en) | 1996-09-25 | 1999-11-02 | 3M Innovative Properties Company | Wound dressing |
| US6496727B1 (en) | 2000-05-31 | 2002-12-17 | Becton, Dickinson And Company | Medicament-loaded transdermal reservoir and method for its formation |
| JP3973420B2 (en) | 2001-12-28 | 2007-09-12 | ライフケア技研株式会社 | Method for producing wound dressing |
| JP4262934B2 (en) | 2002-06-03 | 2009-05-13 | 株式会社ニチエイ | Sheet patch |
| US7084150B2 (en) * | 2002-10-25 | 2006-08-01 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| JP2006044793A (en) | 2004-07-01 | 2006-02-16 | Nitto Denko Corp | Package for plaster patch |
| DE102006011338A1 (en) * | 2006-03-09 | 2007-09-13 | Grünenthal GmbH | paving packaging |
| JP5059584B2 (en) | 2007-01-11 | 2012-10-24 | 日東電工株式会社 | Patch packaging structure |
| JP4975534B2 (en) | 2007-07-04 | 2012-07-11 | 日東電工株式会社 | Patch packaging structure |
-
2016
- 2016-11-09 WO PCT/JP2016/083247 patent/WO2017082301A1/en active Application Filing
- 2016-11-09 CN CN201680065384.2A patent/CN108348477A/en active Pending
- 2016-11-09 JP JP2017550360A patent/JP6752215B2/en not_active Expired - Fee Related
- 2016-11-09 EP EP16864262.7A patent/EP3360545A4/en not_active Withdrawn
- 2016-11-09 US US15/774,441 patent/US10932955B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4781293A (en) * | 1987-12-23 | 1988-11-01 | Pfizer Hospital Products Group, Inc. | One step dressing delivery system |
| JPH0748249A (en) * | 1993-08-04 | 1995-02-21 | Nitto Denko Corp | Ointment plaster |
| JP2010155810A (en) * | 2008-12-29 | 2010-07-15 | Nitto Denko Corp | Ointment cataplasm |
| CN104024358A (en) * | 2011-12-21 | 2014-09-03 | 3M创新有限公司 | Adhesive patch assembly with overlay liner and system and method for making same |
| CN204033820U (en) * | 2014-07-18 | 2014-12-24 | 天津市博爱生物药业有限公司 | Folding patch |
Also Published As
| Publication number | Publication date |
|---|---|
| US10932955B2 (en) | 2021-03-02 |
| EP3360545A1 (en) | 2018-08-15 |
| EP3360545A4 (en) | 2019-05-22 |
| JP6752215B2 (en) | 2020-09-09 |
| JPWO2017082301A1 (en) | 2018-08-30 |
| US20180318567A1 (en) | 2018-11-08 |
| WO2017082301A1 (en) | 2017-05-18 |
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Application publication date: 20180731 |