JPH0741427A - Antibiotic absorption improver and feed - Google Patents

Abstract

PURPOSE:To provide an antibiotic absorption improver safe to both humans and animals, etc., and to provide an animal feed improving antibiotic absorption. CONSTITUTION:The antibiotic absorption improver containing (A) Rosa roxburghii singly or (B) at least two kinds selected from among Rosa roxburghii, mugwort and cabbage. The other objective animal feed improving antibiotic absorption. This improver, which is inexpensive, highly safe and essentially harmless, can reduce antibiotic does through its antibiotic absorption improving effect.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicine for improving absorption of antibiotics in humans and animals, and animal feed for improving absorption of antibiotics in animals.

[0002]

2. Description of the Related Art Conventionally, various antibiotics have been administered for human diseases and infectious diseases. On the other hand, in the livestock and fisheries industry, large-scale management and overcrowding are carried out in order to efficiently breed livestock, poultry or farmed fish. Has been adopted.

However, the use of antibiotics requires a stronger administration of antibiotics due to the influence on the safety of the living body due to the residual or accumulation in the body of animals and the development of resistant bacteria. It has been pointed out that there is a problem. There is also a problem of environmental pollution due to antibiotics remaining in the effluents of animals administered with antibiotics. Therefore, it is desired to reduce the dose of this antibiotic. In order to reduce the dose of antibiotics, it is considered that the absorption of the antibiotics from the digestive tract is increased, and a smaller dose is more effective than a high dose. However, no substance has yet been found that improves the absorption of antibiotics.

[0004]

DISCLOSURE OF THE INVENTION The present invention is to provide an absorption enhancer which can reduce the dose of conventional antibiotics as described above in combination.

[0005]

Means for Solving the Problems As a result of various investigations in view of such a situation, the present inventors have found that pears alone or
It was surprisingly found that when two or more kinds selected from prickly pears, mugwort and cabbage are combined and administered simultaneously with the antibiotic or before and after the administration of the antibiotic, absorption of the antibiotic is improved.

That is, the present invention relates to an antibiotic absorption improver consisting of prickly pears alone or a combination of two or more selected from the group consisting of prickly pears, mugwort and cabbage, and
Animal feed that improves the absorption of antibiotics.

[0007] In the present invention, prickly pears alone or a combination of two or more selected from prickly pears, mugwort and cabbage is administered as an active ingredient simultaneously with an antibiotic or before or after administration of an antibiotic. , Prickly pears, mugwort and cabbage itself when administered to animals,
It may be administered as it is after pulverization or the like, or may be added to foods and feeds by a conventional method.

The pear used in the present invention is a perennial shrub plant of the family Rosaceae originally from Guizhou, China. In addition, the fruit has been attracting attention as a material for juice, jam, liquor and the like. The pears fruits are known to have a pharmacological action, and are said to be useful for antiulcer and the like due to their cancer-preventing effect, cholesterol-lowering effect and anti-stress effect.

[0009] In the antibiotic absorption improver according to the present invention and the animal feed for improving the absorption of antibiotics, the pears use the fruit thereof, but the form thereof is not particularly limited, and the fruit is used as it is raw. Alternatively, it can be used as a dry powder by a commonly used method. It can also be used as an extract containing the active ingredient extracted with water, an organic solvent or a mixture of water and an organic solvent.

As the organic solvent, for example, methanol, ethanol, n-propanol, n-butanol, acetone, ethyl acetate, ether, methylene chloride, chloroform, benzene, carbon tetrachloride, petroleum ether, etc. are used. Can be used alone or as a mixture of two or more.

Commercially available product name, Sashiri extract powder MF (containing 30% Sashimi extract and 70% dextrin,
Maruzen Pharmaceutical Co., Ltd.) and the like can also be used as the pear extract.

The wormwood used in the present invention is a plant of the Asteraceae family, and is known to be used as an antidiarrheal drug, an anti-abdominal pain drug, and a hemostatic drug, and further, it has a weak antibacterial action only against Gram-positive bacteria. Known, cabbage is a plant of the Brassicaceae family,
It is used for food.

In the practice of the present invention, the leaves of mugwort and cabbage are used, but the form is not particularly limited, and the leaves can be used as they are, or can be made into a dry powder by a commonly used method. Can be used.
It can also be used as an extract containing the active ingredient extracted with water, an organic solvent, or a mixture of water and an organic solvent.

These extracts are concentrated, diluted,
It is used by drying or by removing the solvent.

For example, by immersing in 5 parts by weight of water per 1 part by weight of raw material, boiling and extracting for 30 minutes, filtering, and concentrating the resulting filtrate by heating to 3.6 parts by weight, An extract is obtained. Then, the extract can be pulverized by spray drying, freeze drying, reduced pressure drying (vacuum concentration) or the like.

The antibiotic absorption-improving agent of the present invention and the administration period for obtaining the antibiotic absorption-improving effect of feed may be administered together with the antibiotic, that is, at the same time, before administration of the antibiotic, or antibiotics. It may be after administration of.

The amount of the pears to be used in the present invention and a combination of two or more selected from the group consisting of pears, mugwort and cabbage varies depending on the form of administration and the animals to be administered. None, and also depends on the amount of antibiotic administered.

For example, when an absorption improver consisting of a combination of two or more kinds selected from the group consisting of prickly pears, mugwort and cabbage is administered to livestock such as pigs as a powdered extract, usually 1 weight of the antibiotic is used. The blending ratio is 0.1 part by weight or more, preferably 1 part by weight or more, and more preferably 3 parts by weight or more with respect to parts. The same applies when the pears are given alone.

Further, the mixing ratio of the prickly pear, mugwort and cabbage in the present invention is not particularly limited, but usually, it is 0.
25 to 400 parts by weight and 0.5 to 800 parts by weight in terms of cabbage leaf weight, and preferably 0.5 mugwort.
~ 200 parts by weight and cabbage 1 to 400 parts by weight,
Preferably 1 to 100 parts by weight of mugwort and 5 to 2 of cabbage.
It is 00 parts by weight.

In the present invention, any basal feed for animals may be used as the basal feed for veterinary animals to which sashimi alone or two or more kinds selected from sashimi, mugwort and cabbage are added. Examples of raw materials for these basic feeds are:
Grains such as corn, mylo and wheat flour, such as defatted rice bran and bran as malaria, fish meal and skim milk as animal-based feed, vegetable oil meal such as soybean oil meal, and others such as calcium carbonate, calcium phosphate, salt and vitamins B _2, DL methionine, choline chloride,
Manganese sulfate, dried iron sulfate, calcium iodate, copper sulfate, dried zinc sulfate, sodium saccharin and the like are produced by mixing these. The blending ratio of these raw materials is variously changed and modified according to the animal to be treated.

In the case of producing a feed by adding sashimi alone or two or more kinds selected from sashimi, mugwort and cabbage to these basic feeds to produce a feed, at least, for example, pears alone, Alternatively, it is desirable to add 0.001% by weight or more as a dry weight of pears, mugwort and cabbage extract, and more preferably
It is recommended to add it in a proportion of 0.01% by weight or more.

Animals to which the improved feed of the present invention, that is, pears alone or a feed containing two or more kinds selected from pears, mugwort and cabbage, are to be fed, livestock, poultry, pets, seafood and the like. Is included. As domestic animals, pigs, cows,
Horses, goats, sheep, rabbits, poultry such as chickens, quail, turkeys, ducks, pets such as dogs and cats, seafood such as yellowtail, Thailand, flounder, blowfish, horse mackerel, amberjack, salmon. , Carp, eel, sweetfish, trout, char, shrimp and the like.

Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.

[0026]

[Examples] 3 kg of fresh mugwort leaves were immersed in 15 liters of water, subjected to boiling heat extraction for 30 minutes, filtered, and the obtained filtrate was heated and concentrated to 1.8 kg to obtain an extract. Then, this extract was powdered by spray drying to obtain a dry extract of mugwort. Further, cabbage was similarly pulverized to obtain a cabbage extract dry powder. And the brand name sold by Maruzen Pharmaceutical Co., Ltd., Pear extract powder MF (30% of pear extract, 70% of dextrin)
1500 g, and the above-mentioned wormwood extract dry powder 67
5 g and 225 g of the cabbage extract dry powder were mixed to obtain 2400 g of a mixed pear, mugwort and cabbage extract mixed powder. The obtained mixed powder was administered to pigs together with antibiotics.

[0027]

[Test Examples] Further, the effects of the present invention will be specifically described with reference to test examples. In the following test examples, dried pears, mugwort and cabbage extract dry powders produced in the above examples, that is, mixed in a weight ratio of 2: 3: 1 were used. In addition, in Tables 1 and 2, χ ² test was performed, and “*” and “**” in the table represent the risk factors p <0.05 and p <0.01, respectively.

Test Example 1 SLC: 4 male ICR mice each (5-6 weeks old, 25-33 g body weight) were treated with 10 mg / kg of the antibiotic amoxicillin (AMPC) and dried powder of pear, mugwort and cabbage extract. Oral administration was performed at the compounding ratio shown in Table 1, and blood was collected 2 hours later. Then, the AMPC concentration in the serum was measured and compared with the AMPC single administration group,
It was certified. The AMPC concentration in serum was measured by the disc method using Sarcina luteas (Gram-positive AMPC-sensitive bacterium) strain (Test Example 2 was also measured).

[0029]

[Table 1]

From Table 1, in the combination group of AMPC and pears, and in the combination group of AMPC and pears, mugwort and cabbage extract, the absorption improving effect was clearly seen in a dose-dependent manner as compared with the administration group of AMPC alone. .

(Test Example 2) AMPC 10 mg / kg alone and 6 mg of dried pear, mugwort and cabbage extract powder were added to each of 6 SPF male pigs (1 month old, body weight: about 15 kg) and added to the feed. Blood was collected 0.5, 1, 2, 3, and 6 hours after feeding. Measure the AMPC concentration in the serum and
The MPC alone and the compounded one were compared. The composition of the feed is shown in Table 3.

[0032]

[Table 2]

[0033]

[Table 3]

From Table 2, even after 0.5 to 6 hours after the administration, the absorption improving effect was clearly seen as compared with the AMPC single administration group.

From the above-mentioned test, it was suggested that the antibiotic absorption improver and the feed according to the present invention have an excellent antibiotic absorption-improving action, so that the dose of the antibiotic can be reduced. . Therefore, the value of the present invention is very high.

Claims (6)

[Claims] 1. An antibiotic absorption improver containing pears. 2. An antibiotic absorption improver containing two or more kinds selected from piercing pears, mugwort and cabbage. 3. An antibiotic absorption improver containing pears, mugwort and cabbage. 4. A veterinary feed which improves absorption of antibiotics containing pears. 5. An animal feed for improving absorption of antibiotics, which comprises two or more selected from prickly pears, mugwort and cabbage. 6. A feed for animals which improves absorption of antibiotics by adding pears, mugwort and cabbage.