JPH0741427A - Antibiotic absorption improver and feed - Google Patents
Antibiotic absorption improver and feedInfo
- Publication number
- JPH0741427A JPH0741427A JP5206808A JP20680893A JPH0741427A JP H0741427 A JPH0741427 A JP H0741427A JP 5206808 A JP5206808 A JP 5206808A JP 20680893 A JP20680893 A JP 20680893A JP H0741427 A JPH0741427 A JP H0741427A
- Authority
- JP
- Japan
- Prior art keywords
- antibiotic
- cabbage
- mugwort
- absorption
- pears
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、ヒト及び動物の抗生
剤吸収を改善する医薬、及び、動物の抗生剤吸収を改
善する動物用飼料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicine for improving absorption of antibiotics in humans and animals, and animal feed for improving absorption of antibiotics in animals.
【0002】[0002]
【従来の技術】従来、ヒトの疾患や感染症に対しては各
種抗生物質が投与されている。一方、畜水産業界におい
ては、家畜、家禽または養殖魚を効率よく飼育するため
に、大規模経営、過密飼育が行われているが、このよう
な飼育に対しても、抗生物質の大量投与が採用されてい
る。2. Description of the Related Art Conventionally, various antibiotics have been administered for human diseases and infectious diseases. On the other hand, in the livestock and fisheries industry, large-scale management and overcrowding are carried out in order to efficiently breed livestock, poultry or farmed fish. Has been adopted.
【0003】しかし、抗生物質の使用は、動物の体内へ
の残留や蓄積などに起因する生体の安全性に対する影響
や、耐性菌の発現に起因して、更に強力な抗生物質の投
与が必要となるなどの点で問題が指摘されている。また
抗生物質が投与された動物の排出物に残留する抗生物質
による環境汚染の問題もある。そこで、この抗生物質の
投与量を減らすことが望まれている。抗生物質の投与量
を減少させるには、消化管からの抗生物質の吸収を高
め、より少量で高投与量と同等以上の効果を現しめるこ
とが考えられる。しかし、いまだに抗生物質の吸収を改
善させるような物質はいまだに見つかっていない。However, the use of antibiotics requires a stronger administration of antibiotics due to the influence on the safety of the living body due to the residual or accumulation in the body of animals and the development of resistant bacteria. It has been pointed out that there is a problem. There is also a problem of environmental pollution due to antibiotics remaining in the effluents of animals administered with antibiotics. Therefore, it is desired to reduce the dose of this antibiotic. In order to reduce the dose of antibiotics, it is considered that the absorption of the antibiotics from the digestive tract is increased, and a smaller dose is more effective than a high dose. However, no substance has yet been found that improves the absorption of antibiotics.
【0004】[0004]
【発明が解決しようとする課題】本発明は、前述のよう
な従来の抗生物質の投与量を併用により減少させる吸収
促進剤を提供することにある。DISCLOSURE OF THE INVENTION The present invention is to provide an absorption enhancer which can reduce the dose of conventional antibiotics as described above in combination.
【0005】[0005]
【課題を解決するための手段】本発明者らは、このよう
な状況に鑑みて種々検討した結果、刺梨単独、または、
刺梨、ヨモギ及びキャベツから選ばれる2種以上を組み
合わせて抗生物質と同時に、または、抗生剤の投与前後
に投与すると意外にも、抗生剤の吸収が改善されること
を見いだした。Means for Solving the Problems As a result of various investigations in view of such a situation, the present inventors have found that pears alone or
It was surprisingly found that when two or more kinds selected from prickly pears, mugwort and cabbage are combined and administered simultaneously with the antibiotic or before and after the administration of the antibiotic, absorption of the antibiotic is improved.
【0006】つまり本発明は、刺梨単独、または、刺
梨、ヨモギ及びキャベツよりなる群より選択された2種
以上の組み合わせよりなる抗生剤吸収改善剤、および、
抗生剤の吸収を改善する動物用飼料である。That is, the present invention relates to an antibiotic absorption improver consisting of prickly pears alone or a combination of two or more selected from the group consisting of prickly pears, mugwort and cabbage, and
Animal feed that improves the absorption of antibiotics.
【0007】本発明においては、刺梨単独、または、刺
梨、ヨモギ及びキャベツから選ばれる2種以上を組み合
わせたものを有効成分として抗生物質と同時に、また
は、抗生剤の投与前後に投与するが、動物に投与する際
には、刺梨、ヨモギ及びキャベツ自体を生または乾燥、
粉砕などを経てそのまま投与してもよいし、常法により
食品、飼料に添加してもよい。[0007] In the present invention, prickly pears alone or a combination of two or more selected from prickly pears, mugwort and cabbage is administered as an active ingredient simultaneously with an antibiotic or before or after administration of an antibiotic. , Prickly pears, mugwort and cabbage itself when administered to animals,
It may be administered as it is after pulverization or the like, or may be added to foods and feeds by a conventional method.
【0008】本発明で使用される刺梨は、もともと中国
貴州産のバラ科の多年生灌木植物である。また、その果
実がジュース、ジャム及び酒等の素材として注目されて
いる。刺梨の果実は薬理作用を有することが知られてお
り、防癌効果、コレステロール低下作用及び抗ストレス
作用に基づく抗潰瘍等に有用であるといわれている。The pear used in the present invention is a perennial shrub plant of the family Rosaceae originally from Guizhou, China. In addition, the fruit has been attracting attention as a material for juice, jam, liquor and the like. The pears fruits are known to have a pharmacological action, and are said to be useful for antiulcer and the like due to their cancer-preventing effect, cholesterol-lowering effect and anti-stress effect.
【0009】本発明にかかる抗生剤吸収改善剤、およ
び、抗生剤の吸収を改善する動物用飼料において、刺梨
はその果実を用いるが、その形態は特に限定されず、果
実を生のまま用いることができるし、あるいは通常用い
られる方法により、乾燥粉末状にして用いることもでき
る。また、水、有機溶剤または水と有機溶剤の混合物に
より抽出した有効成分を含むエキスなどとしても用いる
ことができる。[0009] In the antibiotic absorption improver according to the present invention and the animal feed for improving the absorption of antibiotics, the pears use the fruit thereof, but the form thereof is not particularly limited, and the fruit is used as it is raw. Alternatively, it can be used as a dry powder by a commonly used method. It can also be used as an extract containing the active ingredient extracted with water, an organic solvent or a mixture of water and an organic solvent.
【0011】有機溶剤としては、例えばメタノール、エ
タノール、n−プロパノール、n−ブタノール、アセト
ン、酢酸エチル、エーテル、塩化メチレン、クロロホル
ム、ベンゼン、四塩化炭素、石油エーテル等が使用さ
れ、これらの有機溶剤は1種または2種以上の混合物と
して用いることができる。As the organic solvent, for example, methanol, ethanol, n-propanol, n-butanol, acetone, ethyl acetate, ether, methylene chloride, chloroform, benzene, carbon tetrachloride, petroleum ether, etc. are used. Can be used alone or as a mixture of two or more.
【0013】市販されている商品名、刺梨エキスパウダ
ーMF(刺梨エキス30%、デキストリン70%含有、
丸善製薬株式会社製)などを刺梨エキスとして用いるこ
ともできる。Commercially available product name, Sashiri extract powder MF (containing 30% Sashimi extract and 70% dextrin,
Maruzen Pharmaceutical Co., Ltd.) and the like can also be used as the pear extract.
【0014】また、本発明で使用されるヨモギはキク科
の植物であり、止瀉薬、抗腹痛薬及び止血薬などの用途
が知られ、更に、グラム陽性菌にのみ弱い抗菌作用があ
ることが知られ、キャベツはアブラナ科の植物であり、
食用に用いられている。The wormwood used in the present invention is a plant of the Asteraceae family, and is known to be used as an antidiarrheal drug, an anti-abdominal pain drug, and a hemostatic drug, and further, it has a weak antibacterial action only against Gram-positive bacteria. Known, cabbage is a plant of the Brassicaceae family,
It is used for food.
【0015】本発明を実施する際、ヨモギ及びキャベツ
は、その葉を用いるが、その形態は特に限定されず、葉
を生のまま用いることができるし、あるいは通常用いら
れる方法により乾燥粉末状として用いることができる。
また、水、有機溶剤または水と有機溶剤の混合物により
抽出した有効成分を含むエキスとしても用いることがで
きる。In the practice of the present invention, the leaves of mugwort and cabbage are used, but the form is not particularly limited, and the leaves can be used as they are, or can be made into a dry powder by a commonly used method. Can be used.
It can also be used as an extract containing the active ingredient extracted with water, an organic solvent, or a mixture of water and an organic solvent.
【0016】これらのエキスはそのまま、濃縮、希釈、
乾燥、または、溶剤を除去して用いられる。These extracts are concentrated, diluted,
It is used by drying or by removing the solvent.
【0017】例えば、生の原料1重量部に対し水5重量
部に浸漬し、30分間煮沸熱抽出後、ろ過し、得られた
ろ液を3.6重量部になるまで加熱濃縮することによ
り、エキスが得られる。そして、このエキスを噴霧乾
燥、凍結乾燥、減圧乾燥(真空濃縮)等により、粉末化
することができる。For example, by immersing in 5 parts by weight of water per 1 part by weight of raw material, boiling and extracting for 30 minutes, filtering, and concentrating the resulting filtrate by heating to 3.6 parts by weight, An extract is obtained. Then, the extract can be pulverized by spray drying, freeze drying, reduced pressure drying (vacuum concentration) or the like.
【0018】本件発明の抗生剤吸収改善剤及び飼料の抗
生剤吸収改善効果を得るための投与時期は、抗生物質と
共に、すなわち同時に投与してもよいし、抗生物質の投
与前、または、抗生物質の投与後であってもかまわな
い。The antibiotic absorption-improving agent of the present invention and the administration period for obtaining the antibiotic absorption-improving effect of feed may be administered together with the antibiotic, that is, at the same time, before administration of the antibiotic, or antibiotics. It may be after administration of.
【0019】本発明における刺梨、及び、刺梨、ヨモギ
及びキャベツよりなる群より選択された2種以上の組み
合わせよりなるものの使用量は、投与する形態及び投与
される動物等によって異なるため特に限定されず、ま
た、投与される抗生物質の量によっても異なる。The amount of the pears to be used in the present invention and a combination of two or more selected from the group consisting of pears, mugwort and cabbage varies depending on the form of administration and the animals to be administered. None, and also depends on the amount of antibiotic administered.
【0020】例えば、刺梨、ヨモギ及びキャベツよりな
る群より選択された2種以上の組み合わせよりなる吸収
改善剤を粉末化エキスとして豚等の家畜に投与する場合
には、通常、抗生物質1重量部に対し、粉末化エキス
0.1重量部以上であり、好ましくは1重量部以上、更
に好ましくは3重量部以上の配合比である。刺梨を単独
で与える場合も同様である。For example, when an absorption improver consisting of a combination of two or more kinds selected from the group consisting of prickly pears, mugwort and cabbage is administered to livestock such as pigs as a powdered extract, usually 1 weight of the antibiotic is used. The blending ratio is 0.1 part by weight or more, preferably 1 part by weight or more, and more preferably 3 parts by weight or more with respect to parts. The same applies when the pears are given alone.
【0021】さらに、本発明における刺梨とヨモギ及び
キャベツの配合比は特に限定されないが、通常、刺梨エ
キス1重量部に対し生のヨモギの葉重量に換算して0.
25〜400重量部及びキャベツの葉重量に換算して
0.5〜800重量部であり、好ましくはヨモギ0.5
〜200重量部及びキャベツ1〜400重量部、更に、
好ましくはヨモギ1〜100重量部及びキャベツ5〜2
00重量部である。Further, the mixing ratio of the prickly pear, mugwort and cabbage in the present invention is not particularly limited, but usually, it is 0.
25 to 400 parts by weight and 0.5 to 800 parts by weight in terms of cabbage leaf weight, and preferably 0.5 mugwort.
~ 200 parts by weight and cabbage 1 to 400 parts by weight,
Preferably 1 to 100 parts by weight of mugwort and 5 to 2 of cabbage.
It is 00 parts by weight.
【0022】本発明において、刺梨単独、または、刺
梨、ヨモギ及びキャベツから選ばれる2種以上を添加す
る動物用基礎飼料は、任意のものを使用することができ
る。これらの基礎飼料の原料として例示されるものは、
穀類例えばとうもろこし、マイロ、小麦粉を、そうこう
類として例えば脱脂米ぬか、ふすまを、動物質性飼料と
して例えば魚粉、脱脂乳を、植物油かす類例えば大豆油
かすを、その他例えば炭酸カルシウム、リン酸カルシウ
ム、食塩、ビタミンB2、DLメチオニン、塩化コリン、
硫酸マンガン、乾燥硫酸鉄、ヨウ素酸カルシウム、硫酸
銅、乾燥硫酸亜鉛、サッカリンナトリウムなどであっ
て、これらを配合して製造される。これらの原料の配合
割合は、施されるべき動物に応じて種々変更、改変され
る。In the present invention, any basal feed for animals may be used as the basal feed for veterinary animals to which sashimi alone or two or more kinds selected from sashimi, mugwort and cabbage are added. Examples of raw materials for these basic feeds are:
Grains such as corn, mylo and wheat flour, such as defatted rice bran and bran as malaria, fish meal and skim milk as animal-based feed, vegetable oil meal such as soybean oil meal, and others such as calcium carbonate, calcium phosphate, salt and vitamins B 2, DL methionine, choline chloride,
Manganese sulfate, dried iron sulfate, calcium iodate, copper sulfate, dried zinc sulfate, sodium saccharin and the like are produced by mixing these. The blending ratio of these raw materials is variously changed and modified according to the animal to be treated.
【0023】これら基礎飼料に刺梨単独、または、刺
梨、ヨモギ及びキャベツから選ばれる2種以上を組み合
わせて添加配合して飼料を製造する場合には基礎飼料に
対して少なくとも例えば刺梨単独、または、刺梨、ヨモ
ギ及びキャベツのエキス乾燥重量として 0.001重量%以
上の割合で配合することが望ましく、さらに好ましくは
0.01 重量%以上の割合で配合するのがよい。In the case of producing a feed by adding sashimi alone or two or more kinds selected from sashimi, mugwort and cabbage to these basic feeds to produce a feed, at least, for example, pears alone, Alternatively, it is desirable to add 0.001% by weight or more as a dry weight of pears, mugwort and cabbage extract, and more preferably
It is recommended to add it in a proportion of 0.01% by weight or more.
【0024】本発明の改良飼料、つまり、刺梨単独、ま
たは、刺梨、ヨモギ及びキャベツから選ばれる2種以上
を含有する飼料を施すべき動物には、家畜、家禽、ペッ
ト類、魚介類などが包含される。家畜としては豚、牛、
馬、ヤギ、羊、兎などを、家禽としては、にわとり、う
ずら、七面鳥、あひるなどを、ペット類としては犬、猫
などを、魚介類としてブリ、タイ、ヒラメ、フグ、シマ
アジ、カンパチ、サケ、コイ、ウナギ、アユ、マス、イ
ワナ、エビなどを例示することができる。Animals to which the improved feed of the present invention, that is, pears alone or a feed containing two or more kinds selected from pears, mugwort and cabbage, are to be fed, livestock, poultry, pets, seafood and the like. Is included. As domestic animals, pigs, cows,
Horses, goats, sheep, rabbits, poultry such as chickens, quail, turkeys, ducks, pets such as dogs and cats, seafood such as yellowtail, Thailand, flounder, blowfish, horse mackerel, amberjack, salmon. , Carp, eel, sweetfish, trout, char, shrimp and the like.
【0025】次に実施例をあげて本発明を具体的に説明
するが、この実施例によって本発明が限定されるもので
はない。Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.
【0026】[0026]
【実施例】生のヨモギの葉3kgを水15リットルに浸漬
し、30分間煮沸熱抽出後、ろ過し、得られたろ液を
1.8kgになるまで加熱濃縮し、エキスを得る。そし
て、このエキスを噴霧乾燥により粉末化し、ヨモギのエ
キス乾燥粉末を得た。また、キャベツも同様に粉末化
し、キャベツのエキス乾燥粉末を得た。そして、丸善製
薬株式会社より販売されている商品名、刺梨エキスパウ
ダーMF(刺梨エキス30%、デキストリン70%品)
を1500g、そして前記ヨモギのエキス乾燥粉末67
5g、キャベツのエキス乾燥粉末225gを混合し、刺
梨、ヨモギ及びキャベツのエキス混合粉末2400gを
得た。得られた混合粉末をブタに抗生剤と共に投与し
た。[Examples] 3 kg of fresh mugwort leaves were immersed in 15 liters of water, subjected to boiling heat extraction for 30 minutes, filtered, and the obtained filtrate was heated and concentrated to 1.8 kg to obtain an extract. Then, this extract was powdered by spray drying to obtain a dry extract of mugwort. Further, cabbage was similarly pulverized to obtain a cabbage extract dry powder. And the brand name sold by Maruzen Pharmaceutical Co., Ltd., Pear extract powder MF (30% of pear extract, 70% of dextrin)
1500 g, and the above-mentioned wormwood extract dry powder 67
5 g and 225 g of the cabbage extract dry powder were mixed to obtain 2400 g of a mixed pear, mugwort and cabbage extract mixed powder. The obtained mixed powder was administered to pigs together with antibiotics.
【0027】[0027]
【試験例】さらに試験例によって、本発明の効果を具体
的に説明する。以下の試験例では、上記実施例で製造し
た刺梨、ヨモギ及びキャベツのエキス乾燥粉末、つまり
重量比で2:3:1で混合したものを用いた。また、表
1、2において、χ2 検定を行い、表中の「*」および
「**」は各々危険率p<0.05およびp<0.01を表す。[Test Examples] Further, the effects of the present invention will be specifically described with reference to test examples. In the following test examples, dried pears, mugwort and cabbage extract dry powders produced in the above examples, that is, mixed in a weight ratio of 2: 3: 1 were used. In addition, in Tables 1 and 2, χ 2 test was performed, and “*” and “**” in the table represent the risk factors p <0.05 and p <0.01, respectively.
【0028】(試験例1)SLC:ICR雄性マウス各
々4匹(週齢5〜6、体重25〜33g )に抗生物質ア
モキシシリン(AMPC)10mg/kgと刺梨、ヨモギ及
びキャベツのエキス乾燥粉末を表1に示すような配合比
で経口投与し、2時間後に採血した。そしてこの血清中
のAMPC濃度を測定し、AMPC単独投与区と比較、
検定した。血清中のAMPC濃度はSarcina luteas(グ
ラム陽性AMPC感受性菌)菌株を用い、ディスク法に
より測定した(試験例2も同様に測定した)。Test Example 1 SLC: 4 male ICR mice each (5-6 weeks old, 25-33 g body weight) were treated with 10 mg / kg of the antibiotic amoxicillin (AMPC) and dried powder of pear, mugwort and cabbage extract. Oral administration was performed at the compounding ratio shown in Table 1, and blood was collected 2 hours later. Then, the AMPC concentration in the serum was measured and compared with the AMPC single administration group,
It was certified. The AMPC concentration in serum was measured by the disc method using Sarcina luteas (Gram-positive AMPC-sensitive bacterium) strain (Test Example 2 was also measured).
【0029】[0029]
【表1】 [Table 1]
【0030】表1より、AMPCと刺梨の配合区、およ
び、AMPCと刺梨、ヨモギ及びキャベツのエキス配合
区では、明らかにAMPC単独投与区に比べ用量依存的
に吸収改善効果が見られた。From Table 1, in the combination group of AMPC and pears, and in the combination group of AMPC and pears, mugwort and cabbage extract, the absorption improving effect was clearly seen in a dose-dependent manner as compared with the administration group of AMPC alone. .
【0031】(試験例2)SPF雄性豚各6頭(1ケ月
齢、体重約15Kg)にAMPC10mg/kg単独及び刺
梨、ヨモギ及びキャベツのエキス乾燥粉末30mg/kgを
配合して飼料に添加、給飼し0.5、1、2、3、6時
間後に採血した。その血清中のAMPC濃度を測定しA
MPC単独のものと配合のものを比較した。飼料の組成
は表3に示すとおりである。(Test Example 2) AMPC 10 mg / kg alone and 6 mg of dried pear, mugwort and cabbage extract powder were added to each of 6 SPF male pigs (1 month old, body weight: about 15 kg) and added to the feed. Blood was collected 0.5, 1, 2, 3, and 6 hours after feeding. Measure the AMPC concentration in the serum and
The MPC alone and the compounded one were compared. The composition of the feed is shown in Table 3.
【0032】[0032]
【表2】 [Table 2]
【0033】[0033]
【表3】 [Table 3]
【0034】表2より、投与後0.5〜6時間後におい
ても、明らかにAMPC単独投与区に比べ吸収改善効果
が見られた。From Table 2, even after 0.5 to 6 hours after the administration, the absorption improving effect was clearly seen as compared with the AMPC single administration group.
【0035】上記の試験から、本発明にかかる抗生剤吸
収改善剤及び飼料は、優れた抗生物質の吸収改善作用を
有するため、抗生物質の投与量を削減することができる
ということが示唆された。従って、本発明の価値は非常
に高い。From the above-mentioned test, it was suggested that the antibiotic absorption improver and the feed according to the present invention have an excellent antibiotic absorption-improving action, so that the dose of the antibiotic can be reduced. . Therefore, the value of the present invention is very high.
Claims (6)
た2種以上を含有する抗生剤吸収改善剤。2. An antibiotic absorption improver containing two or more kinds selected from piercing pears, mugwort and cabbage.
生剤吸収改善剤。3. An antibiotic absorption improver containing pears, mugwort and cabbage.
物用飼料。4. A veterinary feed which improves absorption of antibiotics containing pears.
た2種以上を添加した抗生剤吸収を改善する動物用飼
料。5. An animal feed for improving absorption of antibiotics, which comprises two or more selected from prickly pears, mugwort and cabbage.
生剤吸収を改善する動物用飼料。6. A feed for animals which improves absorption of antibiotics by adding pears, mugwort and cabbage.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5206808A JPH0741427A (en) | 1993-07-30 | 1993-07-30 | Antibiotic absorption improver and feed |
TW082108253A TW391878B (en) | 1992-10-07 | 1993-10-06 | Pharmaceutical composition or feedstuff comprising at least one of rosa roxburghii, artemisiae argyi folium and brassica oleracea var. capitata l. |
EP93307988A EP0592220B1 (en) | 1992-10-07 | 1993-10-07 | Pharmaceutical composition or feedstuff containing a plant substance |
DE69329769T DE69329769D1 (en) | 1992-10-07 | 1993-10-07 | Medicinal or animal feed containing vegetable material |
US08/333,079 US5556624A (en) | 1992-10-07 | 1994-11-01 | Method of immunopotentiating and protecting an animal from E. coli infections using a combination of Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. |
US08/433,312 US5556625A (en) | 1992-10-07 | 1995-05-03 | Pharmaceutical composition comprising Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. used to reduce the symptoms of diarrhea |
US08/438,503 US5628998A (en) | 1992-10-07 | 1995-05-10 | Method for improving amoxicillin absorption in mammals by administering the amoxicillin to the mammal in combination with Rosa roxburghii, Artemisiae argyi folium and/or Brassica oleracea var. capitata L. |
US08/438,494 US5624671A (en) | 1992-10-07 | 1995-05-10 | Method for increasing egg production rate, egg weight or eggshell strength by administering a composition containing the plants Rosa roxburghii, Artemisiae argyi folium and Brassica oleracea var. capitata L. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5206808A JPH0741427A (en) | 1993-07-30 | 1993-07-30 | Antibiotic absorption improver and feed |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH0741427A true JPH0741427A (en) | 1995-02-10 |
Family
ID=16529436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5206808A Pending JPH0741427A (en) | 1992-10-07 | 1993-07-30 | Antibiotic absorption improver and feed |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0741427A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100430403B1 (en) * | 2001-12-07 | 2004-05-03 | 거창군 | Livestock feed added with wormwood and Hanwoo meat bred by the feed |
KR100904396B1 (en) * | 2007-10-24 | 2009-06-26 | 주식회사 알앤엘바이오 | Compositon for Increasing Milk Production Containing Artemisia capillaris |
-
1993
- 1993-07-30 JP JP5206808A patent/JPH0741427A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100430403B1 (en) * | 2001-12-07 | 2004-05-03 | 거창군 | Livestock feed added with wormwood and Hanwoo meat bred by the feed |
KR100904396B1 (en) * | 2007-10-24 | 2009-06-26 | 주식회사 알앤엘바이오 | Compositon for Increasing Milk Production Containing Artemisia capillaris |
JP2010537664A (en) * | 2007-10-24 | 2010-12-09 | アールエヌエル バイオ カンパニー リミテッド | Composition for increasing milk production of livestock containing wormwood |
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