JPH0737374B2 - Toothpaste - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice containing an adsorbent for preventing bad breath.

[0002]

2. Description of the Related Art Conventionally, oral refreshing agents and medicated dentifrices have been frequently used to prevent bad breath. In the mouth with medicated toothpaste,
In particular, polishing and cleaning the teeth will prevent alveolar pyorrhea, prevent the development and progression of tooth decay, and prevent bad breath.In addition, taking oral refreshing agents will cause drinking, nausea and vomiting, hangover, dizziness, bad breath, and mood. It is recognized that discomfort etc. will be resolved.

Commonly accepted ingredients for mouth-cooling agents include Acacia catechu, Amatia, Wikipedia, Licorice, Keihi, Koshiyo, Chinese sardine, Japanese citrus fruit, Japanese citrus fruit, red pepper, d-camphor, dl-camphor, chlorophyllin derivative, dl-. Menthol, l-menthol, peppermint oil, oyster grass, syringa, yakchi, dragon brain,
There are excipients such as fennel oil, nutmeg, juniper oil, cinnamon oil, saffron, rose oil, matcha tea and starch. The other components of the mouth-cooling agent include dehydroacetic acid, preservatives such as sodium dehydroacetate, antifungal agents, satsukaline, artificial sweeteners such as sodium, and other suitable flavors, flavoring agents, gold foil, silver foil, aluminum foil, There are garments such as red iron oxide.

Further, the components of medicinal dentifrice include azulene, allantoin, allantoin chlorohydroxyaluminum, allantoin dihydroxyaluminum, glycyrrhizinic acid, sodium polyphosphate, chlorophyrin derivative, stearyl alcohol, sodium carbonate, precipitated calcium carbonate, hinokitiol, fluorinated. There are sodium, polysorbate 80, other suitable emulsifiers such as sodium lauryl sulfate, sodium sweetener of Satsukaline, other sweeteners, calcium hydrogen phosphate for toothpaste, sodium monofluorophosphate, chlorhexidine hydrochloride, fragrances, pigments and the like. The malodorous substance in the mouth is removed and reduced by cleaning the mouth with a mouth-freshening agent or a medicated dentifrice containing these components, and the malodor is masked with the fragrance component to prevent bad breath.

Generally, the cause of bad breath is alcohol, tobacco, cheese,
Food and drink such as garlic, and small particles of food in the mouth
Decomposes by bacteria and enzymes to produce malodorous substances,
Suppurates tissue destroyed by stomatitis, glossitis, and gingivitis
It is said that it will cause bad breath. And that component is sulfurized
Hydrogen, methyl mercaptan, ammonia, trimethyl
Known to be min, free fatty acids, aldehydes, etc.
ing. On the other hand, there has been disclosed a dentifrice that contains any one of hydroxyapatite, aluminum silicate, and aluminum hydroxide. For example, regarding hydroxyapatite, JP-A-62-67013, JP-A-62-248487, and JP-A-62-2499.
No. 17 disclosed in Japanese and Hei 2-22214 discloses
ing. JP-A-62-249917 and JP-A-2
Hydroxyapatite described in JP-A-22214
Is mainly used as an abrasive to prevent tooth decay.
More effective when combined with a fluorine compound
Allowed to act, also the enzyme dextranase immobilized on its
Improves the effect of preventing decomposition. Aluminum silicate is disclosed in JP-A-61-76410.
There is. The aluminum silicate described in this publication is
It has high polishing and cleaning properties as an abrasive. Further, regarding aluminum hydroxide, JP-A-60-142912
JP-A-61-12611, JP-A-61-161
No. 15818, Japanese Patent Application Laid-Open No. 1-131023 , and Japanese Patent Application Laid-Open No. 2-207016.

[0006]

However, the above-mentioned mouth-cooling agent, medicated dentifrice, or dentifrice containing hydroxyapatite, aluminum silicate, or aluminum hydroxide disclosed in the above-mentioned publication contains various oral malodor components. It is not intended to be removed by adsorption. Particularly, JP-A-62-249917 containing any one of hydroxyapatite and the like.
The toothpaste disclosed in JP-A-2-22214 and the like only uses hydroxyapatite or the like as the main abrasive, and has almost no function of adsorbing sulfides.
Yes. Silicic acid described in JP-A-61-76410
Aluminum does not have the ability to exchange ions, causing stomatitis in the oral cavity,
Amine compound produced by bacteria in inflamed areas such as glossitis and ulcer areas
It does not have the function of adsorbing free fatty acids. In addition, JP-A 1-1
Boehmite-like aluminum hydroxide described in Japanese Patent No. 31023
Minium has the function of adsorbing phosphate ions
Other Japanese Patent Application Laid-Open Nos. 60-142912 and 61
-12611, JP-A-61-15818 and
And the hydroxides described in JP-A-2-207016.
Formaldehyde and acetaldehyde similar to luminium
It does not have the function of adsorbing aldehydes such as sodium chloride. JP-A-60
Aluminum hydroxide described in JP-A-142912
Has only a function as an abrasive. For this reason, an excellent adsorbent that selectively adsorbs and removes halitosis components has not been found yet, and the above-described action is insufficient with conventional adsorbents.

The object of the present invention is to provide hydrogen sulfide, methylmerca.
Butane, ammonia, trimethylamine, free fatty acids,
It is to provide a dentifrice capable of selectively adsorbing and removing a plurality of components of halitosis components such as aldehydes in the mouth.

[0008]

To achieve the above object, according to the solution to ## dentifrice such present invention is intended to include any two or more of the synthetic hydroxyapatite synthetic aluminum silicate and aluminum hydroxide. Synthetic hydroxyapatite
Is a fine powder having an average particle size of 0.5 to 5 μm ,
And, the inside of the powder has a pore size of 16 to 20 angstrom.
With a diameter of 80-100 angstroms
Crystallinity of 65-
It is 80% porous. In addition, synthetic aluminum silicate
SiO ₂ / Al ₂ O ₃ molar ratio is 2.5 to 25
Molar ratio of exchangeable alkali metal ions to Al ₂ O ₃
And 0.05 to 3 are contained. Furthermore, aluminum hydroxide is
-Mite-like aluminum hydroxide having the general formula AlO (O
H) · nH ₂ 0 (but represented by 0 ≦ n <1), the surface
The amount of active OH groups is 0.2 to 1.0 meq / g and BET
Specific surface area of 200 m ² / g or more and 5 angst
Design so that many pores with a pore size near the loam are distributed.
It is a manufactured porous body. Synthetic Hydroxy of Toothpaste of the Present Invention
The content of siapatite is 10% by weight or less based on all components.
The amount of synthetic aluminum silicate is 20
The content of aluminum hydroxide is less than 100% by weight.
It is 30% by weight or less of the content .

The present invention will be described in detail below. The synthetic hydroxyapatite of the present invention is a completely new substance,
As described above, it is a fine porous powder. This synthetic hydroxyapatite reacts in a solution containing sulfide during synthesis.
16 to 20 by repeating the refining by desorption baking
Angstroms and 80-100 Angstrom holes
The pore size distribution increases, and this pore size distribution excels particularly in the adsorption power of hydrogen sulfide and methyl mercaptan.

Further, the synthetic aluminum silicate of the present invention is
"Ammonium ion-selective adsorbent" filed by one of the applicants (Japanese Patent Laid-Open No. 3-249940). This synthetic aluminum silicate selectively adsorbs ammonium ions in water and has an excellent effect on raising live fish or treating pollution.
Play . As a result of further researches by the present inventors on the use thereof, it was found that this synthetic aluminum silicate has adsorption ability for trimethylamine for amine compounds and allyl sulfide for sulfides in addition to the above-mentioned ammonia. It is one of the contained components. That is, this synthetic key
Aluminum oxide has an ion-exchange capacity and can be applied to solid surfaces.
The sodium ion replaces trimethylamine,
Some free fatty acids are fixed as aluminum salts.
As a result, the synthetic aluminum silicate becomes
Bacteria are produced by protecting the inflamed area and ulcer area such as inflammation and glossitis with a film.
Adsorbs amine compounds and free fatty acids
It relieves pain and prevents bad breath.

Further, the aluminum hydroxide of the present invention is a crystalline compound "boehmite-like aluminum hydroxide" (patented by one of the applicants), which is a crystalline compound having an excellent function as an oral phosphate ion adsorbent. Kaihei 1-13
It is an improved substance of 1023). Japanese Patent Laid-Open No. 1-131023
Boehmite-like aluminum hydroxide disclosed in Japanese Patent Publication No.
It is represented by the general formula AlO (OH) · nH ₂ 0 (where 0 ≦ n <1), and the amount of active OH groups on the surface is 0.2 to 1.0 meq /
and BET specific surface area of 200 m ² / g or more. In addition to the above characteristics, the aluminum hydroxide of the present invention is produced so that the pores are distributed in the vicinity of 5 angstroms, and is excellent in adsorbing aldehydes such as formaldehyde and acetaldehyde.
Aldehydes on the active OH groups on the surface of aluminum hydroxide
Is added to form a methylol compound,
It is presumed that excellent adsorption ability will occur.

The dentifrice of the present invention is prepared by blending any two or more of the above three kinds of adsorbents, and other known dentifrice ingredients such as calcium carbonate, hydroxyethyl cellulose, glycerin, a foaming agent and a fragrance. It is a mixture. The reason for mixing two or more kinds is that one kind is not enough to remove the halitosis components present in the mouth. The compounding amount of synthetic hydroxyapatite is 1 in all components so that the 3 kinds of adsorbents can function effectively.
0% by weight or less, the compounding amount of synthetic aluminum silicate is 20% by weight or less in all components, and the compounding amount of aluminum hydroxide is 30% by weight or less in all components . Immediately
Then, the dentifrice of the present invention is blended with the above three kinds of adsorbents.
The amount depends on the bulk specific gravity of each adsorbent, the amount of water absorption, and used alone.
Check the 3 points of the amount remaining in the mouth after using the prototype toothpaste.
Make a tentative decision with a low price, check the effect with an actual adsorption test, and finally
It was decided. The bulk ratio of synthetic hydroxyapatite
The weight is 80-100 ml / 10 g, which are large particles,
A toothpaste made by adding water only will add up to about 20% by weight.
It is possible to add. When 20% by weight is added
Has a large amount that remains in the mouth after brushing teeth and should be observed with an endoscope.
Then, a white film was formed all over the tongue and oral mucosa, and remained.
It makes me feel uncomfortable. Therefore synthetic hydroxyapata
The amount of Ito blended was such that there was no residual feeling after use and no irritation.
It is also possible to add other two components for the purpose of adsorbing an appropriate amount on the mucosal surface.
Considering this, it is determined to be 10% by weight or less. Also synthetic silicic acid
Aluminum has a bulk specific gravity of about 50 to 60 ml / 10 g.
It is an amorphous bulky powder, and it can be kneaded with water by itself.
The maximum amount that can be formed into a tongue is about 33% by weight. Only
20% by weight or less considering the feeling of use and addition of other two components
You can decide below. Furthermore, aluminum hydroxide is boehmite.
It is crystalline and has a bulk density of about 30ml / 10g.
The maximum amount of powder that can be kneaded into paste with water only is
It is about 40% by weight. Increases the amount of adsorption and enhances the deodorant effect
It is advisable to add as much as possible 3 components
30% by weight or less considering the addition of the other two components
It is used as the main ingredient of the toothpaste of the present invention to improve the adsorption effect.
You can get it.

[0013]

In the dentifrice thus formulated, synthetic hydroxyapatite mainly adsorbs hydrogen sulfide and methyl mercaptan, synthetic aluminum silicate mainly adsorbs ammonia, trimethylamine and allyl sulfide and free fatty acid, and aluminum hydroxide Formaldehyde,
It mainly adsorbs aldehydes such as acetaldehyde.

[0014]

As described above, the toothpaste of the present invention in which any two or more of the above three kinds of adsorbents are blended has a bad odor in the mouth as compared with the conventional toothpaste. Since the ingredients are selectively adsorbed, if the inside of the mouth is washed with this toothpaste, the malodorous ingredients are removed, and an excellent effect of preventing bad breath is exhibited.

[0015]

EXAMPLES Next, examples of the present invention will be described together with comparative examples in order to show specific embodiments of the present invention. The examples described below do not limit the technical scope of the present invention. <Examples 1 to 5> Purified water was added to the compounding ingredients shown in Table 1 to make 100%, and this was uniformly stirred and kneaded to prepare dentifrice. <Comparative Example 1> To the toothpaste, purified water was added to the compounding ingredients shown in Table 1 to make 100%, and this was uniformly stirred and kneaded.

<Adsorption Test and Results> 5 g of the dentifrices prepared in Examples 1 to 5 and Comparative Example 1 were placed in 300 ml of each airtight container of hydrogen sulfide, methyl mercaptan, ammonia, trimethylamine, allyl sulfide and acetaldehyde of known concentrations. The concentration decrease 24 hours after the addition was measured.

As shown in Tables 2 to 7, it was found that the dentifrices of Examples 1 to 5 exhibited excellent adsorption power of the halitosis component as compared with the dentifrice of Comparative Example 1.

[0018]

[Table 1]

[0019]

[Table 2]

[0020]

[Table 3]

[0021]

[Table 4]

[0022]

[0023]

[Table 6]

[0024]

[Table 7]

 ─────────────────────────────────────────────────── --- Continuation of the front page (56) References JP-A-1-131023 (JP, A) JP-A 60-142912 (JP, A) JP-A 61-76410 (JP, A) JP-A 62- 67013 (JP, A) JP-A-2-22214 (JP, A)

Claims (1)

[Claims] 1. When all components are 100% by weight, 10
% By weight of synthetic hydroxyapatite and 20 wt% or less
Toothpaste acids formulated with any two or more of the synthetic aluminum silicate and 30% by weight of aluminum hydroxide under
The average particle size of the synthetic hydroxyapatite is
Fine powder of 0.5 to 5 μm and inside the powder
Pores having a pore size of 16 to 20 Å and 80
There are many pores with a pore size of ~ 100 Å.
Porous body having a crystallinity of 65 to 80% produced so as to be clothed
, And the said synthetic aluminum silicate is a SiO ₂ / Al ₂ O ₃
It has a molar ratio of 2.5 to 25 and is ion-exchangeable.
The molar ratio of potassium metal ion to Al ₂ O ₃ is 0.05 to 3
The aluminum hydroxide contains boehmite-like hydroxide
An aluminum, the general formula _{AlO (OH) · nH 2 0} ( where 0
≦ n <1), and the amount of active OH groups on the surface is 0.
2-1.0 meq / g and BET specific surface area of 200 m
² / g or more and a pore size near 5 angstroms
It is a porous body that has a large number of pores
Toothpaste characterized by: