JPH07179878A - Emulsion composition for lubrication and rust prevention of medical instrument - Google Patents
Emulsion composition for lubrication and rust prevention of medical instrumentInfo
- Publication number
- JPH07179878A JPH07179878A JP5346206A JP34620693A JPH07179878A JP H07179878 A JPH07179878 A JP H07179878A JP 5346206 A JP5346206 A JP 5346206A JP 34620693 A JP34620693 A JP 34620693A JP H07179878 A JPH07179878 A JP H07179878A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- emulsion composition
- lubrication
- lubricating oil
- rust prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F11/00—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
- C23F11/08—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids
- C23F11/10—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using organic inhibitors
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は人体への毒性が極めて低
く安全で、潤滑性、防錆性および耐硬水性に優れた、医
療器具の潤滑・防錆用乳化液組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an emulsion composition for medical device lubrication and rust prevention, which has extremely low toxicity to the human body, is safe, and is excellent in lubricity, rust resistance and hard water resistance.
【０００２】[0002]
【従来の技術】医療器具は通常、使用前に滅菌消毒を行
い、無菌状態で使用されるが、使用後に洗浄して錆など
を生じないように、かつ器具の関接部が平滑に動くよう
に、保存される。従来、金属製の医療器具（鋼製小
物）、特に手術用器具の関接部の潤滑剤として、流動パ
ラフィンあるいはシリコン油等を器具表面にそのまま塗
布またはスプレーすることが行われていた。しかしなが
ら、これらの方法では器具表面がべとついたり、高圧蒸
気滅菌しても耐熱性のある細菌芽胞が流動パラフィン等
の層に隠蔽されて生き残るという問題点があった。2. Description of the Related Art Medical instruments are usually sterilized before use and used in an aseptic condition. However, they should be cleaned after use to prevent rust and the joints of the instruments should move smoothly. Will be saved. Conventionally, liquid paraffin, silicone oil, or the like has been applied or sprayed as it is on the surface of a medical instrument (small steel article) made of metal, particularly as a lubricant for the joint portion of a surgical instrument. However, these methods have problems that the surface of the device is sticky and that the heat-resistant bacterial spores are hidden by the layer of liquid paraffin and survive even when sterilized by high-pressure steam.
【０００３】また、これらの問題点を回避する方法とし
ては、流動パラフィンをオレイン酸トリエタノールアミ
ン石けんと非イオン界面活性剤で乳化することにより、
油分を微粒子状で手術器具に付着する技術（特許公報平
３−１２８９０号）が挙げられるが、この方法では水道
水で希釈した場合、オレイン酸トリエタノールアミン石
けんが水の硬度成分と反応して金属石けんを生じ、潤滑
性能を減じるという問題点があった。As a method of avoiding these problems, liquid paraffin is emulsified with triethanolamine oleate soap and a nonionic surfactant,
There is a technique (patent publication No. 3-12890) for adhering oil in the form of fine particles to a surgical instrument. In this method, when diluted with tap water, triethanolamine oleate soap reacts with the hardness component of water. There is a problem that metal soap is generated and the lubrication performance is reduced.
【０００４】さらに、細工物の医療用器具はステンレス
加工の難しさから、鉄にメッキを施した製品が使用され
ており、これらの製品は使用を繰り返すことにより、メ
ッキにピンホールが生じ、この部分から金属の腐蝕が生
じ、ついにはメッキが完全にはがれ、器具全体が腐蝕す
るという問題点があった。[0004] Further, in medical instruments made of crafts, products plated with iron are used because of the difficulty of processing stainless steel. By repeating the use of these products, pinholes are generated in the plating, There was a problem that the metal was corroded from the portion, the plating was completely peeled off, and the entire equipment was corroded.
【０００５】[0005]
【発明が解決しようとする課題】本発明は上記問題点を
克服し、潤滑性、防錆性及び耐硬水性に優れ、しかも毒
性が極めて低い医療器具の潤滑・防錆用乳化液組成物を
提供することを目的とする。本発明者は、かかる目的を
達成すべく鋭意検討した結果、潤滑油分として液状脂肪
酸エステルおよび／またはホホバ油を用い、非イオン界
面活性剤で乳化することにより、安全であり、水道水の
硬度成分にも影響されることなく、優れた潤滑効果を発
揮し、しかもオレオイルザルコシンを配合することで、
メッキを施した医療器具の防錆にも優れた医療器具用潤
滑・防錆乳化液組成物が得られることを見出し本発明を
完成するに至った。DISCLOSURE OF THE INVENTION The present invention overcomes the above problems and provides an emulsion composition for lubrication and rust prevention of medical devices which is excellent in lubricity, rust prevention and hard water resistance and has extremely low toxicity. The purpose is to provide. The present inventor has conducted extensive studies to achieve such an object, and as a result, it is safe by using a liquid fatty acid ester and / or jojoba oil as a lubricating oil and emulsifying with a nonionic surfactant, and the hardness of tap water is high. It exerts an excellent lubricating effect without being affected by the ingredients, and by adding oleoyl sarcosine,
The inventors have found that a lubricating / rust-preventing emulsion composition for medical devices, which is excellent in rust-preventing plated medical devices, can be obtained, and completed the present invention.
【０００６】[0006]
【課題を解決するための手段】すなわち、本発明は、 (a) 潤滑油分１：ＲＣＯＯＲ′で表わされる液状脂肪酸
エスエル〔式中、Ｒは炭素数６乃至１８のアルキル基で
あり、Ｒ′はオクチルドデシル、イソプロピル、セチ
ル、又はブチルである〕 (b) 潤滑油分２：ホホバ油 (c) 防錆剤：オレオイルザルコシン (d) 乳化剤：非イオン界面活性剤 (e) アルカリ化剤：ジエタノールアミン を、(a) ＋(b) ＝５〜４０重量％ (c) ＝０．１〜１０重量％ (d) ＝１〜１５重量％ (e) ＝０．１〜２重量％ の配合割合で含有し、かつｐＨが７〜９であることを特
徴とする医療器具の潤滑・防錆用乳化液組成物を提供す
るものである。That is, the present invention relates to (a) a lubricating oil content 1: a liquid fatty acid ester represented by RCOOR '[wherein R is an alkyl group having 6 to 18 carbon atoms and R'is Is octyldodecyl, isopropyl, cetyl, or butyl] (b) Lubricating oil 2: Jojoba oil (c) Rust inhibitor: oleoyl sarcosine (d) Emulsifier: nonionic surfactant (e) Alkalineizer : Diethanolamine (a) + (b) = 5-40% by weight (c) = 0.1-10% by weight (d) = 1-15% by weight (e) = 0.1-2% by weight The present invention provides an emulsion composition for lubricating and rustproofing medical equipment, characterized in that it is contained in a ratio and has a pH of 7-9.
【０００７】本発明において使用される(a) 潤滑油分
１：ＲＣＯＯＲ′で表わされる液状脂肪酸エスエル〔式
中、Ｒは炭素数６乃至１８のアルキル基であり、Ｒ′は
オクチルドデシル、イソプロピル、セチル、又はブチル
である〕としては、例えばミリスチン酸イソプロピル、
パルミチン酸イソプロピル、オクタン酸セチル、ミリス
チン酸オクチルドデシル、パルミチン酸オクチル、ステ
アリン酸オクチル、ステアリン酸ブチルなどが挙げられ
るが、特にミリスチン酸イソプロピル、ミリスチン酸オ
クタデシルが好ましい。(A) Lubricating oil used in the present invention 1: Liquid fatty acid ester represented by RCOOR '[wherein R is an alkyl group having 6 to 18 carbon atoms, R'is octyldodecyl, isopropyl, Is cetyl or butyl], for example, isopropyl myristate,
Examples thereof include isopropyl palmitate, cetyl octanoate, octyl dodecyl myristate, octyl palmitate, octyl stearate, and butyl stearate, with isopropyl myristate and octadecyl myristate being particularly preferred.
【０００８】本発明において使用される(b) 潤滑油分
２：ホホバ油は無毒で優れた潤滑効果があり、(a) 潤滑
油分１とともに使用される。(a) 潤滑油分１と(b) 潤滑
油分２はそれぞれ単独でも、混合でも使用することがで
きるが、(a) ＋(b) の潤滑成分は、本発明の組成物中に
５〜３０重量％、好ましくは８〜２０重量％配合され
る。潤滑油分の配合割合が５重量％未満では潤滑効果が
乏しくなり、３０重量％を越えると乳化液の粘性が増
し、使用時に水に希釈する場合に溶解しにくくなる。(B) Lubricating oil component 2 used in the present invention: Jojoba oil is nontoxic and has an excellent lubricating effect, and is used together with (a) lubricating oil component 1. (a) Lubricating oil component 1 and (b) Lubricating oil component 2 can be used either individually or as a mixture, but the lubricating component of (a) + (b) can be used in the composition of the present invention in an amount of 5 to 5%. 30% by weight, preferably 8 to 20% by weight is blended. If the blending ratio of the lubricating oil component is less than 5% by weight, the lubricating effect will be poor, and if it exceeds 30% by weight, the viscosity of the emulsion will increase and it will be difficult to dissolve when diluted with water during use.
【０００９】本発明において使用される(c) 防錆剤：オ
レオイルザルコシンは毒性が低く優れた防錆効果があ
り、さらに潤滑・防錆用乳化液の乳化安定性を向上させ
る効果を有する。 (c) 防錆剤：オレオイルザルコシンは本発明の組成物中
に０．１〜１０重量％、好ましくは０．５〜５重量％配
合される。オレオイルザルコシンの配合割合が０．１重
量％未満では防錆効果を期待できず、１０重量％を越え
ると経済的でない。(C) Anticorrosion agent used in the present invention: Oleoyl sarcosine has a low toxicity and an excellent anticorrosion effect, and further has an effect of improving the emulsion stability of an emulsion for lubrication and anticorrosion. . (c) Anticorrosion agent: Oleoyl sarcosine is incorporated in the composition of the present invention in an amount of 0.1 to 10% by weight, preferably 0.5 to 5% by weight. If the blending ratio of oleoyl sarcosine is less than 0.1% by weight, the anticorrosive effect cannot be expected, and if it exceeds 10% by weight, it is not economical.
【００１０】本発明において使用される(d) 乳化剤：非
イオン界面活性剤は、潤滑油分の乳化剤であり、例えば
ポリオキシエチレン（１〜２０モル）アルキルエーテ
ル、ポリオキシエチレン（１〜２０モル）アルキルフェ
ニルエーテル、ポリオキシエチレンポリオキシプロピレ
ンブロックポリマー、ポリオキシエチレンソルビタン脂
肪酸エステル、テトラオレイン酸ポリオキシエチレンソ
ルビット、ソルビタン脂肪酸エステル、ポリエチレング
リコール脂肪酸エステル、ポリオキシエチレン硬化ヒマ
シ油等が挙げられる。 (d) 乳化剤：非イオン界面活性剤は本発明の組成物中に
１〜１５重量％、好ましくは３〜１０重量％配合され
る。The (d) emulsifier: nonionic surfactant used in the present invention is an emulsifier for the lubricating oil component, such as polyoxyethylene (1 to 20 mol) alkyl ether and polyoxyethylene (1 to 20 mol). ) Alkyl phenyl ethers, polyoxyethylene polyoxypropylene block polymers, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit tetraoleate, sorbitan fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene hydrogenated castor oil and the like. (d) Emulsifier: The nonionic surfactant is incorporated in the composition of the present invention in an amount of 1 to 15% by weight, preferably 3 to 10% by weight.
【００１１】(e) アルカリ化剤：ジエタノールアミンは
本発明の組成物中に０．１〜２．０重量％配合され、乳
化液のｐＨを７〜９に調整する。乳化液のｐＨが７未満
になると防錆効果が乏しくなり、９を越えると刺激性が
強くなり医療器具に使用しにくくなる。(E) Alkalizing agent: Diethanolamine is mixed in the composition of the present invention in an amount of 0.1 to 2.0% by weight to adjust the pH of the emulsion to 7 to 9. If the pH of the emulsion is less than 7, the anticorrosive effect becomes poor, and if it exceeds 9, the irritation becomes strong and it becomes difficult to use it in medical instruments.
【００１２】なお、本発明の組成物は本発明の効果を損
わない範囲で防腐剤、殺菌剤、酸化防止剤等を任意に添
加することができる。The composition of the present invention may optionally contain a preservative, a bactericidal agent, an antioxidant and the like within a range that does not impair the effects of the present invention.
【００１３】本発明の組成物は、医療器具（特に手術用
器具）の潤滑・防錆剤として使用されるが、該器具を数
分間以上浸漬して使用する場合には５〜２０重量％の濃
度に希釈して使用される。また、全自動で器具の予選、
洗浄、すすぎ、防錆・潤滑、乾燥を行う場合（例えばジ
ェットウオッシャーＭＵ−５０００〈シャープ製〉を使
用）には、０．１〜５重量％の濃度に希釈して使用され
る。The composition of the present invention is used as a lubricant / rust preventive for medical instruments (particularly surgical instruments). When the instrument is dipped for several minutes or more and used, it is contained in an amount of 5 to 20% by weight. It is used after diluting to a concentration. Also, fully automatic equipment qualification,
When performing cleaning, rinsing, rust prevention / lubrication, and drying (for example, using Jet Washer MU-5000 <made by Sharp>), it is diluted to a concentration of 0.1 to 5% by weight and used.
【００１４】[0014]
【実施例】以下、本発明を実施例により具体的に説明す
るが、本発明はこれらに限定されるものではない。EXAMPLES The present invention will now be specifically described with reference to examples, but the present invention is not limited thereto.
【００１５】実施例 １ ミリスチン酸オクチルドデシル９重量％、ホホバ油１重
量％、モノオレイン酸ポリオキシエチレンソルビタン
（２０ＥＯ）２重量％、テトラオレイン酸ポリオキシエ
チレンソルビット（６０ＥＯ）２重量％、オレオイルザ
ルコシン２重量％を激しく撹拌しながら精製水８１．４
重量％を加え、さらに０．６重量％のジエタノールアミ
ンを加えると、ｐＨ８．０の安定な乳化液が得られた。Example 1 9% by weight of octyldodecyl myristate, 1% by weight of jojoba oil, 2% by weight of polyoxyethylenesorbitan monooleate (20EO), 2% by weight of polyoxyethylenesorbit tetraoleate (60EO), oleoyl oil 21.4% sarcosine with 81.4% purified water with vigorous stirring
Addition of wt% followed by addition of 0.6 wt% of diethanolamine gave a stable emulsion with pH 8.0.
【００１６】実施例 ２ ミリスチン酸イソプロピル１０重量％、ホホバ油２重量
％、モノオレイン酸ポリオキシエチレンソルビタン（２
０ＥＯ）２重量％、ポリオキシエチレン硬化ヒマシ油
（６０ＥＯ）２重量％、オレオイルザルコシン２重量％
を激しく撹拌しながら精製水８１．４重量％を加え、さ
らに０．６重量％のジエタノールアミンを加えると、ｐ
Ｈ８．０の安定な乳化液が得られた。Example 2 Isopropyl myristate 10% by weight, jojoba oil 2% by weight, polyoxyethylene sorbitan monooleate (2
0EO) 2% by weight, polyoxyethylene hydrogenated castor oil (60EO) 2% by weight, oleoyl sarcosine 2% by weight
With vigorous stirring, 81.4% by weight of purified water was added, and further 0.6% by weight of diethanolamine was added.
A stable emulsion of H8.0 was obtained.
【００１７】比較例 １ ミリスチン酸オクチルドデシル３重量％、ホホバ油１重
量％、モノオレイン酸ポリオキシエチレンソルビタン
（２０ＥＯ）０．８重量％、テトラオレイン酸ポリオキ
シエチレンソルビット（６０ＥＯ）０．８重量％、オレ
オイルザルコシン１重量％を激しく撹拌しながら精製水
９３．１重量％を加え、さらに０．３重量％のジエタノ
ールアミンを加えると、ｐＨ８．０の安定な乳化液が得
られた。Comparative Example 1 Octyldodecyl myristate 3% by weight, jojoba oil 1% by weight, polyoxyethylene sorbitan monooleate (20EO) 0.8% by weight, tetraoleate polyoxyethylene sorbit (60EO) 0.8% by weight. %, 1% by weight of oleoyl sarcosine was added with vigorous stirring to 93.1% by weight of purified water, and further 0.3% by weight of diethanolamine was added to obtain a stable emulsion having a pH of 8.0.
【００１８】比較例 ２ ミリスチン酸イソプロピル９重量％、ホホバ油１重量
％、モノオレイン酸ポリオキシエチレンソルビタン（２
０ＥＯ）２重量％、テトラオレイン酸ポリオキシエチレ
ンソルビット（６０ＥＯ）２重量％、オレオイルザルコ
シン０．０５重量％を加え、さらに０．１重量％のジエ
タノールアミンを加えると、ｐＨ８．０の安定な乳化液
が得られた。Comparative Example 2 Isopropyl myristate 9% by weight, jojoba oil 1% by weight, polyoxyethylene sorbitan monooleate (2
0EO) 2% by weight, polyoxyethylene sorbitol tetraoleate (60EO) 2% by weight, oleoyl sarcosine 0.05% by weight, and 0.1% by weight of diethanolamine were added to stabilize the pH of 8.0. An emulsion was obtained.
【００１９】比較例 ３ 比重０．８３、動粘度５５ＣＳＴ（１００°Ｆ）の液状
パラフィン１８重量％、トリエタノールアミン４．５重
量％、ポリエチレングリコール６００モノオレエート２
重量％、ポリエチレングリコール４００ジオレエート２
重量％およびオレイン酸３重量％をとり、激しく撹拌し
ながら精製水７０．５重量％を加えると、ｐＨ８．８の
安定な乳化液が得られた。Comparative Example 3 18% by weight of liquid paraffin having a specific gravity of 0.83 and a kinematic viscosity of 55 CST (100 ° F.), 4.5% by weight of triethanolamine, and polyethylene glycol 600 monooleate 2
% By weight, polyethylene glycol 400 dioleate 2
% By weight and 3% by weight of oleic acid were added, and 70.5% by weight of purified water was added with vigorous stirring to obtain a stable emulsion having a pH of 8.8.
【００２０】以上の各乳化液（実施例１〜２、比較例１
〜３）について潤滑性・防錆性および耐硬水性試験を行
った。以下に、各乳化液の試験方法を示す。Each of the above emulsions (Examples 1 and 2, Comparative Example 1)
3) were subjected to lubricity / rust prevention and hard water resistance tests. The test method of each emulsion is shown below.
【００２１】〔潤滑性試験〕各乳化液の１０重量％およ
び１重量％水溶液を１ｌ調整し、これらの各水溶液中に
洗浄済みの手術用鉗子を５分間浸漬した。その後手術用
鉗子を引き上げ、乾燥機（１０５℃）にて３０分間乾燥
し、手術用鉗子の潤滑性を評価した。この時の評価基準
は以下の通りである。 Ａ：潤滑性が極めて良好で、関接部の動きが極めてスム
ーズ。 Ｂ：潤滑性が良好で、関接部の動きはスムーズ。 Ｃ：潤滑性がやや劣り、関接部の動きが少し堅い。 Ｄ：潤滑性がなく、関接部の動きがかなり堅い。[Lubricity test] 1 liter of 10% by weight and 1% by weight aqueous solution of each emulsion was prepared, and washed surgical forceps were immersed in each of these aqueous solutions for 5 minutes. After that, the surgical forceps were pulled up and dried for 30 minutes by a dryer (105 ° C.), and the lubricity of the surgical forceps was evaluated. The evaluation criteria at this time are as follows. A: The lubricity is extremely good, and the movement of the joint is extremely smooth. B: The lubricity is good, and the joint part moves smoothly. C: Lubricity is slightly inferior, and movement of joints is a little stiff. D: There is no lubricity, and the movement of the joint is quite firm.
【００２２】〔防錆試験〕各乳化液の１０重量％および
１重量％水溶液を５ｍｌ調整し、これらを均一に研磨し
た圧延鋼板（厚さ１ｍｍ、３５ｍｍ×５０ｍｍ）に滴下
し、４８時間後の防錆性を評価した。この時の評価基準
は以下の通りである。 Ａ：全く錆は発生していない。 Ｂ：若干錆が発生している。 Ｃ：全面に錆が発生している。[Rust prevention test] 5 ml of 10% by weight and 1% by weight aqueous solution of each emulsion was prepared and dropped on a uniformly polished rolled steel plate (thickness 1 mm, 35 mm x 50 mm), and after 48 hours. The rust resistance was evaluated. The evaluation criteria at this time are as follows. A: No rust was generated. B: Some rust is generated. C: Rust is generated on the entire surface.
【００２３】〔耐硬水性試験〕各乳化液をイオン交換水
と全硬度１００ＣａＣＯ3 ｐｐｍの水にて、１重量％の
水溶液に調整し、イオン交換水及び全硬度１００ＣａＣ
Ｏ3 ｐｐｍの各水溶液の濁り具合を比較した。この時の
評価基準は以下の通りである。 Ａ：両方とも濁り具合に全く差が認められない。 Ｂ：明らかに全硬度１００ＣａＣＯ3 ｐｐｍの水溶液に
濁りが認められる。[Hard water resistance test] Each emulsion was adjusted to a 1% by weight aqueous solution with ion-exchanged water and water having a total hardness of 100 CaCO 3 ppm to prepare ion-exchanged water and a total hardness of 100 CaC.
The turbidity of each aqueous solution of O 3 ppm was compared. The evaluation criteria at this time are as follows. A: There is no difference in turbidity in both cases. B: Obviously, turbidity is observed in an aqueous solution having a total hardness of 100 CaCO 3 ppm.
【００２４】以下に各乳化液（実施例１〜２、比較例１
〜３）の試験結果を示す。Each emulsion (Examples 1 and 2 and Comparative Example 1) is described below.
~ 3) shows the test results.
【００２５】 [0025]
【００２６】表１の試験結果から明らかなように、本発
明の組成物は潤滑性、防錆性が低濃度で優れ、かつ希釈
する水の水質に対して影響を受けないものであることが
わかった。As is clear from the test results shown in Table 1, the composition of the present invention is excellent in lubricity and rust prevention at low concentrations and is not affected by the water quality of the water to be diluted. all right.
【００２７】なお、以下に実施例１の乳化液の安全性試
験についての結果を示す。 急性毒性試験（ＬＤ50試験）マウス ４０ｍｌ／ｋｇ以上 皮膚一次刺激性 異常が認められない 変異原性試験 異常が認められない 目粘膜刺激性 異常が認められないThe results of the safety test of the emulsion of Example 1 are shown below. Acute toxicity test (LD 50 test) Mice 40 ml / kg or more Primary skin irritation No abnormalities observed Mutagenicity test No abnormalities Eye mucous membrane irritation abnormalities not observed
【００２８】[0028]
【発明の効果】本発明の医療器具の潤滑・防錆用乳化液
組成物は毒性が極めて低く安全で、しかも潤滑効果、防
錆効果に優れるものであり、さらに希釈する水の水質の
影響を受けないものである。EFFECT OF THE INVENTION The emulsion composition for lubrication and rust prevention of medical devices of the present invention has extremely low toxicity and is safe, and is excellent in lubrication effect and rust prevention effect. It is not received.
─────────────────────────────────────────────────────
─────────────────────────────────────────────────── ───
【手続補正書】[Procedure amendment]
【提出日】平成５年１２月２９日[Submission date] December 29, 1993
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】請求項１[Name of item to be corrected] Claim 1
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【手続補正２】[Procedure Amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００６[Correction target item name] 0006
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【０００６】[0006]
【課題を解決するための手段】すなわち、本発明は、 （ａ）潤滑油分１：ＲＣＯＯＲ′で表わされる液状脂肪
酸エステル〔式中、Ｒは炭素数６乃至１８のアルキル基
であり、Ｒ′はオクチルドデシル、イソプロピル、セチ
ル、又はブチルである〕 （ｂ）潤滑油分２：ホホバ油 （ｃ）防錆剤：オレオイルザルコシン （ｄ）乳化剤：非イオン界面活性剤 （ｅ）アルカリ化剤：ジエタノールアミン を、（ａ）＋（ｂ）＝５〜４０重量％ （ｃ）＝０．１〜１０重量％ （ｄ）＝１〜１５重量％ （ｅ）＝０．１〜２重量％ の配合割合で含有し、かつｐＨが７〜９であることを特
徴とする医療器具の潤滑・防錆用乳化液組成物を提供す
るものである。Means for Solving the Problems That is, the present invention is, (a) lubricating oil 1: RCOOR liquid fatty es te le wherein represented by ', R is an alkyl group having 6 to 18 carbon atoms, R'is octyldodecyl, isopropyl, cetyl, or butyl] (b) Lubricating oil content 2: Jojoba oil (c) Rust preventive: oleoyl sarcosine (d) Emulsifier: nonionic surfactant (e) Alkali Agent: diethanolamine, (a) + (b) = 5-40% by weight (c) = 0.1-10% by weight (d) = 1-15% by weight (e) = 0.1-2% by weight The present invention provides an emulsion composition for lubricating / rust-preventing medical devices, characterized in that it is contained at a blending ratio of 5 and has a pH of 7-9.
【手続補正３】[Procedure 3]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００７[Correction target item name] 0007
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【０００７】本発明において使用される（ａ）潤滑油分
１：ＲＣＯＯＲ′で表わされる液状脂肪酸エステル〔式
中、Ｒは炭素数６乃至１８のアルキル基であり、Ｒ′は
オクチルドデシル、イソプロピル、セチル、又はブチル
である〕としては、例えばミリスチン酸イソプロピル、
パルミチン酸イソプロピル、オクタン酸セチル、ミリス
チン酸オクチルドデシル、パルミチン酸オクチル、ステ
アリン酸オクチル、ステアリン酸ブチルなどが挙げられ
るが、特にミリスチン酸イソプロピル、ミリスチン酸オ
クチルドデシルが好ましい。[0007] The (a) a lubricating oil for use in the invention 1: RCOOR 'liquid fatty es in Te Le [formula represented by, R is an alkyl group having 6 to 18 carbon atoms, R' is octyl dodecyl, Isopropyl, cetyl, or butyl], for example, isopropyl myristate,
Isopropyl palmitate, cetyl octanoate, octyldodecyl myristate, octyl palmitate, octyl stearate, although such butyl stearate, in particular isopropyl myristate, myristyl O
Cutyl dodecyl is preferred.
【手続補正４】[Procedure amendment 4]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１３[Correction target item name] 0013
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【００１３】本発明の組成物は、医療器具（特に手術用
器具）の潤滑・防錆剤として使用されるが、該器具を数
分間以上浸漬して使用する場合には５〜２０重量％の濃
度に希釈して使用される。また、全自動で器具の予洗、
洗浄、すすぎ、防錆・潤滑、乾燥を行う場合（例えばジ
ェットウオッシャーＭＵ−５０００〈シャープ製〉を使
用）には、０．１〜５重量％の濃度に希釈して使用され
る。The composition of the present invention is used as a lubricant / rust preventive for medical instruments (particularly surgical instruments). When the instrument is dipped for several minutes or more and used, it is contained in an amount of 5 to 20% by weight. It is used after diluting to a concentration. In addition, the pre-washing of the instrument in a fully automatic,
When performing cleaning, rinsing, rust prevention / lubrication, and drying (for example, using Jet Washer MU-5000 <made by Sharp>), it is diluted to a concentration of 0.1 to 5% by weight and used.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ１０Ｍ 105:68 105:62 105:34 107:34） Ｃ１０Ｎ 30:00 Ｃ 30:12 40:06 ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Office reference number FI technical display location C10M 105: 68 105: 62 105: 34 107: 34) C10N 30:00 C 30:12 40:06
Claims (2)
る液状脂肪酸エスエル〔式中、Ｒは炭素数６乃至１８の
アルキル基であり、Ｒ′はオクチルドデシル、イソプロ
ピル、セチル、又はブチルである〕 (b) 潤滑油分２：ホホバ油 (c) 防錆剤：オレオイルザルコシン (d) 乳化剤：非イオン界面活性剤 (e) アルカリ化剤：ジエタノールアミン を、(a) ＋(b) ＝５〜４０重量％ (c) ＝０．１〜１０重量％ (d) ＝１〜１５重量％ (e) ＝０．１〜２重量％ の配合割合で含有し、かつｐＨが７〜９であることを特
徴とする医療器具の潤滑・防錆用乳化液組成物。(A) Lubricating oil content 1: Liquid fatty acid ester represented by RCOOR '[wherein R is an alkyl group having 6 to 18 carbon atoms, and R'is octyldodecyl, isopropyl, cetyl, or butyl. (B) Lubricating oil 2: Jojoba oil (c) Rust preventive: oleoyl sarcosine (d) Emulsifier: nonionic surfactant (e) Alkalinizer: diethanolamine, (a) + (b ) = 5 to 40% by weight (c) = 0.1 to 10% by weight (d) = 1 to 15% by weight (e) = 0.1 to 2% by weight, and the pH is 7 to 9. An emulsion composition for lubrication and rust prevention of medical equipment, which is No. 9.
イソプロピルまたはミリスチン酸オクチルドデシルであ
ることを特徴とする請求項１記載の医療器具の潤滑・防
錆用乳化液組成物。2. The emulsion composition for lubrication and rust prevention of a medical device according to claim 1, wherein the liquid fatty acid ester is isopropyl myristate or octyldodecyl myristate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5346206A JP2694629B2 (en) | 1993-12-22 | 1993-12-22 | Emulsion composition for lubrication and rust prevention of medical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5346206A JP2694629B2 (en) | 1993-12-22 | 1993-12-22 | Emulsion composition for lubrication and rust prevention of medical equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07179878A true JPH07179878A (en) | 1995-07-18 |
| JP2694629B2 JP2694629B2 (en) | 1997-12-24 |
Family
ID=18381835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5346206A Expired - Fee Related JP2694629B2 (en) | 1993-12-22 | 1993-12-22 | Emulsion composition for lubrication and rust prevention of medical equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2694629B2 (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002285361A (en) * | 2001-03-22 | 2002-10-03 | Chubu Kiresuto Kk | Anticorrosives for magnesium-containing metallic material and corrosion inhibition method therefor |
| WO2003035809A1 (en) * | 2001-10-26 | 2003-05-01 | The Nisshin Oillio, Ltd. | Rubricating oil composition |
| JP2007039764A (en) * | 2005-08-04 | 2007-02-15 | Nippon Oil Corp | Rust-preventive oil composition |
| WO2008041569A1 (en) * | 2006-10-03 | 2008-04-10 | Kurita Water Industries Ltd. | Corrosion inhibitor and method of inhibiting corrosion |
| JP2011074498A (en) * | 2011-01-04 | 2011-04-14 | Jx Nippon Oil & Energy Corp | Rust-preventive oil composition |
| JP2011525210A (en) * | 2008-06-20 | 2011-09-15 | スリーエム イノベイティブ プロパティズ カンパニー | Medical aqueous lubricant emulsion or cleaning apparatus and method |
| CN106566642A (en) * | 2016-10-31 | 2017-04-19 | 邓集叶 | Mechanical cooling liquid and preparation method thereof |
| CN106566614A (en) * | 2016-10-31 | 2017-04-19 | 邓集叶 | Mechanical hydraulic oil and preparation method thereof |
| CN109181837A (en) * | 2018-09-20 | 2019-01-11 | 南京巨鲨显示科技有限公司 | A kind of aqueous lubricating oil and its preparation method and application |
| CN109957436A (en) * | 2017-12-22 | 2019-07-02 | 北京易护宜科技有限公司 | A kind of medical equipment lubricating and antirust agent rinsing oily phase transfer performance with heat |
| CN113801723A (en) * | 2021-09-26 | 2021-12-17 | 南通科星化工股份有限公司 | Environment-friendly type total synthetic metal cutting fluid |
-
1993
- 1993-12-22 JP JP5346206A patent/JP2694629B2/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002285361A (en) * | 2001-03-22 | 2002-10-03 | Chubu Kiresuto Kk | Anticorrosives for magnesium-containing metallic material and corrosion inhibition method therefor |
| JP4704589B2 (en) * | 2001-03-22 | 2011-06-15 | 中部キレスト株式会社 | Anticorrosive for magnesium-containing metal materials and anticorrosion treatment method |
| WO2003035809A1 (en) * | 2001-10-26 | 2003-05-01 | The Nisshin Oillio, Ltd. | Rubricating oil composition |
| JP2007039764A (en) * | 2005-08-04 | 2007-02-15 | Nippon Oil Corp | Rust-preventive oil composition |
| WO2008041569A1 (en) * | 2006-10-03 | 2008-04-10 | Kurita Water Industries Ltd. | Corrosion inhibitor and method of inhibiting corrosion |
| JP2011525210A (en) * | 2008-06-20 | 2011-09-15 | スリーエム イノベイティブ プロパティズ カンパニー | Medical aqueous lubricant emulsion or cleaning apparatus and method |
| JP2011074498A (en) * | 2011-01-04 | 2011-04-14 | Jx Nippon Oil & Energy Corp | Rust-preventive oil composition |
| CN106566642A (en) * | 2016-10-31 | 2017-04-19 | 邓集叶 | Mechanical cooling liquid and preparation method thereof |
| CN106566614A (en) * | 2016-10-31 | 2017-04-19 | 邓集叶 | Mechanical hydraulic oil and preparation method thereof |
| CN109957436A (en) * | 2017-12-22 | 2019-07-02 | 北京易护宜科技有限公司 | A kind of medical equipment lubricating and antirust agent rinsing oily phase transfer performance with heat |
| CN109181837A (en) * | 2018-09-20 | 2019-01-11 | 南京巨鲨显示科技有限公司 | A kind of aqueous lubricating oil and its preparation method and application |
| CN113801723A (en) * | 2021-09-26 | 2021-12-17 | 南通科星化工股份有限公司 | Environment-friendly type total synthetic metal cutting fluid |
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|---|---|
| JP2694629B2 (en) | 1997-12-24 |
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