CN113061479B - Lubricant for transparent medical equipment and preparation method thereof - Google Patents
Lubricant for transparent medical equipment and preparation method thereof Download PDFInfo
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- CN113061479B CN113061479B CN202110336113.9A CN202110336113A CN113061479B CN 113061479 B CN113061479 B CN 113061479B CN 202110336113 A CN202110336113 A CN 202110336113A CN 113061479 B CN113061479 B CN 113061479B
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- lubricant
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- 239000000314 lubricant Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 12
- 239000002199 base oil Substances 0.000 claims abstract description 11
- 239000003899 bactericide agent Substances 0.000 claims abstract description 10
- 239000000654 additive Substances 0.000 claims abstract description 9
- 230000000996 additive effect Effects 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 5
- 239000004288 Sodium dehydroacetate Substances 0.000 claims description 5
- 229920000570 polyether Polymers 0.000 claims description 5
- 229940079839 sodium dehydroacetate Drugs 0.000 claims description 5
- 235000019259 sodium dehydroacetate Nutrition 0.000 claims description 5
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005187 foaming Methods 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 230000001050 lubricating effect Effects 0.000 abstract description 9
- 238000005406 washing Methods 0.000 abstract description 3
- 241000519995 Stachys sylvatica Species 0.000 description 9
- 238000005461 lubrication Methods 0.000 description 5
- 239000006260 foam Substances 0.000 description 4
- 239000010687 lubricating oil Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000013556 antirust agent Substances 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229910000975 Carbon steel Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000010962 carbon steel Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M173/00—Lubricating compositions containing more than 10% water
- C10M173/02—Lubricating compositions containing more than 10% water not containing mineral or fatty oils
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
- C10M2207/10—Carboxylix acids; Neutral salts thereof
- C10M2207/12—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to acyclic or cycloaliphatic carbon atoms
- C10M2207/121—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to acyclic or cycloaliphatic carbon atoms having hydrocarbon chains of seven or less carbon atoms
- C10M2207/122—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to acyclic or cycloaliphatic carbon atoms having hydrocarbon chains of seven or less carbon atoms monocarboxylic
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/1033—Polyethers, i.e. containing di- or higher polyoxyalkylene groups used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/105—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing three carbon atoms only
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Lubricants (AREA)
Abstract
The invention belongs to the technical field of medical washing, and particularly relates to a lubricant for transparent medical instruments and a preparation method thereof. The lubricant for the transparent medical instrument consists of the following components: water-soluble base oil, additive, antirust bactericide and water; the lubricant is colorless and transparent, and is soluble in water and alcohol. The lubricant is transparent and visible, is completely water-soluble, and has excellent lubricating performance.
Description
Technical Field
The invention belongs to the technical field of medical washing, and particularly relates to a lubricant for transparent medical instruments and a preparation method thereof.
Background
Most of the lubricants for medical instruments are milky white, and obvious white spots can remain after cleaning and drying. The main reason is that the main component of the white lubricating oil is white oil, the white oil is emulsified by an emulsifier and compounded by other auxiliary materials to form water-soluble white lubricating oil, but white spots are separated out from the white lubricating oil after the white lubricating oil is dried. In addition, the use liquid is opaque, so that the instrument cannot be visualized during manual instrument treatment, and operation is inconvenient.
Although the water-soluble lubricating antirust agent disclosed in patent No. CN104531321A for surgical instruments and the preparation method thereof solve the problem of residual white spots, the lubricating effect of the propylene glycol and the methoxypolyethylene glycol applied to the water-soluble lubricating antirust agent for the surgical instruments is not good enough for the medical instruments.
Therefore, there is a need for a lubricant for medical devices, which can solve the problem of white spots after the lubricant is dried, has excellent lubricating performance, and most importantly, can be used for visualizing the devices during use.
Disclosure of Invention
The invention aims to provide a lubricant for transparent medical instruments, which is transparent and visible, completely water-soluble and excellent in lubricating performance, and a preparation method thereof aiming at the defects.
The technical scheme of the invention is as follows: a lubricant for transparent medical instruments, which consists of the following components: water-soluble base oil, additives, antirust bactericides and water; the lubricant is colorless and transparent, and is soluble in water and alcohol.
15-25 parts by weight of water-soluble base oil; 5-10 parts of an additive; 0.5-1 part of antirust bactericide.
The water-soluble base oil is DOW DOW product water-soluble polyether and does not contain paraffin and organic silicon. The base oil is colorless and transparent, has reliable safety and can not threaten the health of patients.
The additive is a low-foaming surfactant polypropylene glycol. The adopted polypropylene glycol has low foam surface activity, can increase the solubility of the water-soluble base oil in water, and can not remain after lubrication.
The antirust bactericide is food-grade sodium dehydroacetate. The antirust bactericide has a strong inhibiting effect on bacteria and also has an antirust effect.
The preparation method of the lubricant for the transparent medical instrument comprises the following steps:
(1) preparing a premix A: firstly, adding water-soluble base oil into a reactor, and then adding an additive to dissolve completely to obtain a premix A;
(2) preparing a premix B: adding the antirust bactericide into water to dissolve to obtain a premix B;
(3) preparing a lubricant: and (3) mixing the premix A obtained in the step (1) with the premix B obtained in the step (2) to obtain the lubricant.
The invention has the beneficial effects that: the lubricant for the transparent medical instrument is a colorless transparent lubricant, and white spots cannot be remained on the surface of the instrument after cleaning; can have better compatibility with human tissues; and has good lubricating property. When the lubricant is used for soaking lubricating instruments, visualization is realized, the instrument state is easy to observe, and the operation is convenient.
Drawings
FIG. 1 is a comparison of the lubricant for transparent medical devices of the present invention with a currently available lubricant; wherein, the first left is purified water, the second left is the transparent lubricant stock solution of the invention, and the first right is the ordinary milky lubricant stock solution.
FIG. 2 is a comparison of the lubricant for transparent medical devices of the present invention with a lubricant currently available on the market; wherein the left picture is the using state of the milky lubricant, and the right picture is the using state of the transparent lubricant.
Detailed Description
The present invention will be described in detail by examples.
Example 1
The lubricant for the transparent medical instrument comprises the following components in parts by weight: 20 parts of DOW DOW product water-soluble polyether, 10 parts of low-foam surfactant polypropylene glycol, 0.5 part of food grade sodium dehydroacetate and the balance of water; the lubricant is colorless and transparent, and is soluble in water and alcohol.
The preparation method of the lubricant for the transparent medical instrument comprises the following steps:
(1) preparing a premix A: firstly, adding water-soluble base oil into a reactor, and then adding an additive to dissolve completely to obtain a premix A;
(2) preparing a premix B: adding the antirust bactericide into water for dissolving to obtain a premix B;
(3) preparing a lubricant: and (3) mixing the premix A obtained in the step (1) with the premix B obtained in the step (2) to obtain the lubricant.
As is apparent from FIG. 1, the lubricant for transparent medical devices according to the present invention has transparency comparable to that of purified water.
As can be seen from FIG. 2, the lubricant is diluted in a simulated hand-wash mode, and the lubrication process of the medical device can be clearly seen during use of the lubricant according to the present invention.
Example 2
The lubricant for the transparent medical instrument comprises the following components in parts by weight: 18 parts of DOW DOW product water-soluble polyether, 10 parts of low-foam surfactant polypropylene glycol, 0.5 part of food grade sodium dehydroacetate and the balance of water; the lubricant is colorless and transparent, and is soluble in water and alcohol.
The preparation method is the same as example 1.
Example 3
The lubricant for the transparent medical instrument comprises the following components in parts by weight: 18 parts of DOW DOW product water-soluble polyether, 10 parts of low-foam surfactant polypropylene glycol, 1 part of food grade sodium dehydroacetate and the balance of water; the lubricant is colorless and transparent, and is soluble in water and alcohol.
The preparation method is the same as example 1.
The lubricants described in examples 1 to 3 were subjected to performance measurement. The method comprises the measurement of lubricating performance, whether white spots remain, corrosivity and bacteriostatic activity.
1. The lubricants described in embodiments 1 to 3 were used to lubricate the same joint of the same medical instrument, and the ratio of the reduction in the dynamic friction force and the static friction force before and after lubrication was counted. The results show a significant reduction in kinetic and static friction, as shown in table 1.
TABLE 1 Friction force reduction before and after lubrication proportional table
2. The lubricants described in examples 1 to 3 were cleaned and dried by an automatic cleaning and sterilizing machine and hand washing, respectively, and then white spot measurement was performed. The results showed no white spots, as shown in Table 2.
TABLE 2 white spot determination after lubrication
3. The lubricants described in examples 1-3 were each tested for microbial corrosion challenge for 28 days. The results show that the antibacterial agent has extremely strong antibacterial effect on microorganisms, and the antibacterial effect is shown in table 3.
TABLE 3 microbial 28-day preservative challenge test results Table (CFU/mL)
4. The lubricants of the embodiments 1 to 3 are respectively subjected to corrosivity measurement on copper, aluminum, carbon steel and stainless steel according to the use concentration, and the evaluation criterion is GB/T38498-. The results showed that there was essentially no corrosion, see table 4.
TABLE 4 Metal corrosivity test
Claims (2)
1. The lubricant for the transparent medical instrument is characterized by comprising the following components: the water-soluble base oil is DOW DOW product water-soluble polyether and does not contain paraffin and organic silicon; the additive is low-foaming surfactant polypropylene glycol; the antirust bactericide is food-grade sodium dehydroacetate; water; the lubricant is colorless and transparent, and is dissolved in water and alcohol; 15-25 parts by weight of water-soluble base oil; 5-10 parts of an additive; 0.5-1 part of antirust bactericide.
2. A method for preparing the lubricant for transparent medical devices of claim 1, comprising the steps of:
(1) preparing a premix A: firstly, adding water-soluble base oil into a reactor, and then adding an additive to dissolve completely to obtain a premix A;
(2) preparing a premix B: adding the antirust bactericide into water for dissolving to obtain a premix B;
(3) preparing a lubricant: and (3) mixing the premix A obtained in the step (1) with the premix B obtained in the step (2) to obtain the lubricant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110336113.9A CN113061479B (en) | 2021-03-29 | 2021-03-29 | Lubricant for transparent medical equipment and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110336113.9A CN113061479B (en) | 2021-03-29 | 2021-03-29 | Lubricant for transparent medical equipment and preparation method thereof |
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| Publication Number | Publication Date |
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| CN113061479A CN113061479A (en) | 2021-07-02 |
| CN113061479B true CN113061479B (en) | 2022-09-23 |
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| CN114703010A (en) * | 2022-02-25 | 2022-07-05 | 上海皕滢生物科技有限公司 | Water-based emulsion lubricant for medical instruments and preparation method thereof |
| CN116286162B (en) * | 2023-03-03 | 2024-07-30 | 山东新华莎罗雅生物技术有限公司 | Lubricating rust-proof quick-drying agent and preparation method thereof |
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| KR20140024069A (en) * | 2009-05-01 | 2014-02-28 | 온코자임 파마 인코포레이티드 | Pentamidine combinations for treating cancer |
| CN104073323B (en) * | 2013-12-05 | 2016-08-31 | 老肯医疗科技股份有限公司 | A kind of lubricant being applicable to medicine equipment and preparation method |
| CN105567399B (en) * | 2016-01-18 | 2018-11-09 | 清华大学 | Water base titanic alloy machining liquid and its application |
| CN106085577A (en) * | 2016-06-06 | 2016-11-09 | 南京巨鲨显示科技有限公司 | A kind of medical apparatus and instruments soluble oil and preparation method thereof |
| CN107034003A (en) * | 2017-04-19 | 2017-08-11 | 清华大学 | Ultralow bubble total synthesis water-base lubricating fluid |
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Address after: No. 1618 Dexing North Avenue, Tianqu Industrial Park, Tianqu Sub district Office, Decheng District, Dezhou City, Shandong Province, 253000 Patentee after: SHANDONG ANJIE HI-TECH DISINFECTION TECHNOLOGY Co.,Ltd. Address before: 253000 Dezhou Tianqu Industrial Park, Shandong Province 268 Dexing North Road Patentee before: SHANDONG ANJIE HI-TECH DISINFECTION TECHNOLOGY Co.,Ltd. |
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