JPH07157417A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To obtain a dentifrice composition containing an oil-soluble licorice extract having high stability and exhibiting suppressed discoloration and change of odor with time. CONSTITUTION:This dentifrice composition is produced by adding 0.01-0.1wt.%, preferably 0.02-0.06wt.% of a higher fatty acid ester such as an ascorbic acid ester to a dentifrice composition containing an oil-soluble licorice extract. The fatty acid ester is especially preferably ascorbyl palmitate for a dentifrice composition containing calcium carbonate as the abrasive and ascorbyl dipalmitate for a composition containing hydrogen calcium phosphate as the abrasive. The oil-soluble licorice extract is prepared by drying licorice or a plant of the same genus, preferably the root of the plant, cutting the dried root to a proper size, adding a solvent such as methanol or ethanol, extracting by a conventional method, concentrating and drying the obtained extracted liquid, extracting the solid with a solvent such as ethyl acetate and concentrating and drying the obtained extract. The amount of the extract is usually 0.0005-10wt.%, preferably 0.005-5wt.% based on the dentifrice composition.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition containing an oil-soluble licorice extract and a higher fatty acid ester of ascorbic acid. More specifically, the above dentifrice has improved discoloration and odor during long-term storage. Agent composition.

[0002]

2. Description of the Related Art Conventionally, it has been known to mix an oil-soluble licorice extract with a dentifrice composition for the purpose of preventing periodontal disease and suppressing oral bacteria. However, a dentifrice composition containing an oil-soluble licorice extract has a problem of discoloration or odor over time, and it is desired to solve this problem.

[0003]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide a dentifrice composition containing an oil-soluble licorice extract, which is highly stable and has improved discoloration and odor over time. It is to be.

[0004]

Means for Solving the Problems As a result of intensive studies to achieve the above object, the present inventors have found that in a dentifrice composition containing an oil-soluble licorice extract, a higher fatty acid ester of ascorbic acid is further added. It has been found that the blending suppresses discoloration and odor over time, and has completed the present invention. Accordingly, the present invention relates to a dentifrice composition containing an oil-soluble licorice extract, which is characterized by containing a higher fatty acid ester of ascorbic acid.

Examples of the higher fatty acid ester of ascorbic acid used in the dentifrice composition of the present invention include palmitic acid ester, stearic acid ester, oleic acid ester, linoleic acid ester and linolenic acid ester of ascorbic acid. They may be monoesters or diesters. More specifically, examples thereof include ascorbyl palmitate, which is a palmitic acid monoester of ascorbic acid, and ascorbyl dipalmitate, which is a palmitic acid diester of ascorbic acid. These higher fatty acid esters of ascorbic acid are known as food additives or raw materials for cosmetics, and are commercially available. Such market products can be used in the present invention. The higher fatty acid ester of ascorbic acid in the dentifrice composition of the present invention is preferably blended in an amount of 0.01 to 0.1% by weight, more preferably 0.02 to 0.1% by weight, based on the total weight of the dentifrice composition. It is 0.06% by weight. Compounding amount is 0.01
If it is less than 10% by weight, the effect of the present invention cannot be obtained, and if it exceeds 0.1% by weight, discoloration of the higher fatty acid ester of ascorbic acid itself may become remarkable.

The oil-soluble licorice extract used in the dentifrice composition of the present invention may be one extracted by a conventional method. As its raw material, licorice or its homologous plants such as Glycyrrhiza glabra Linne, Glycyrrhiza inflata Ba
Licorice roots such as talin and stront can be used. As the extraction method, for example, licorice or its homologous plant, preferably its root is dried, and the extraction raw material divided into appropriate sizes is added with a solvent such as methanol or ethanol and subjected to an extraction treatment according to a conventional method to obtain an extract. After the extract is concentrated to dryness, a solvent such as ethyl acetate is added to this extract for extraction treatment, and the extract is concentrated to dryness to obtain the extract. The amount of the extraction solvent used is usually 1 to 10 times the amount of the extraction raw material. The extraction is usually done under boiling. The extraction time is usually 1 to 24 hours, preferably 2
It is suitable to set it to 10 hours. The extraction operation can also be repeated. The amount of the oil-soluble licorice extract extracted in the dentifrice composition of the present invention may be a conventionally used amount, and is usually 0.000 based on the total weight of the dentifrice composition.
It is from 05 to 10% by weight, more preferably from 0.005 to 5% by weight.

The dentifrice composition of the present invention is not limited in its form and may be a toothpaste composition or a liquid dentifrice composition. The dentifrice composition of the present invention can be produced according to a conventional method. Further, it may contain additives commonly used in dentifrice compositions, such as abrasives, wetting agents, foaming agents, thickeners, flavors, sweeteners and preservatives, and various active ingredients. The amounts of these additives and various active ingredients to be compounded may be those normally used. In the present invention, more specifically, an oil-soluble licorice extract extract-containing dentifrice composition containing calcium carbonate is blended with ascorbyl palmitate, and an oil-soluble licorice extract extract-containing dentifrice composition containing calcium hydrogen phosphate is added. It is particularly preferred to incorporate ascorbyl dipalmitate.

Specific examples of additives and other components used in the dentifrice composition of the present invention are shown below. Abrasive: calcium carbonate, calcium hydrogen phosphate, hydroxyapatite, tricalcium phosphate, aluminum hydroxide, calcium pyrophosphate, silicic acid etc. Wetting agent: glycerin, sorbitol, propylene glycol, polyethylene glycol, dipropylene glycol, 1,3 -Butylene glycol, maltitol, etc. Blowing agents: sodium lauryl sulfate, N-lauroyl-L
-Sodium glutamate, sodium lauroyl sarcosine, nonionic surfactant, etc. Thickening agent: hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium polyacrylate, xanthan gum, etc. Preservative: paraoxybenzoic acid ester, alkyldiaminoethylglycine hydrochloride, etc. Sweetness Food: sodium saccharin, stevioside, etc. Fragrance: menthol, anethole, limonene, isoamyl acetate, carvone, methyl salicylate, thymol,
Spearmint oil, peppermint oil, lemon oil, cinnamon oil,
Other ingredients such as clove oil, eucalyptus oil: tocopherol acetate, isopropylmethylphenol, sodium chloride, allantoin, glycyrrhizinic acid and its salts, guaiazulene and its salts, fluorides, chlorhexidines, edetate, etc.

[0009]

EFFECTS OF THE INVENTION The dentifrice composition of the present invention is a highly stable dentifrice composition containing an oil-soluble licorice extract which is suppressed in discoloration and odor change over time.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. [Preparation of oil-soluble licorice extract] Licorice (Glycyrrhiza gl
abra Linne) and licorice (Glycyrrhiza inflata Batali)
To 1 kg of each root of n), 10 liters of absolute ethanol was added and extraction was carried out under reflux for 5 hours. The obtained extract was concentrated under reduced pressure and dried, and then 10 liters of ethyl acetate was added to this ethanol extract and extraction was carried out under reflux for 5 hours.
The ethyl acetate extract was concentrated under reduced pressure and dried to obtain about 30 g of extracts A and B, respectively.

Example A toothpaste composition was prepared according to a conventional method using the oil-soluble licorice extract extracts A and B described above and having the compositions shown in Tables 1 and 2 below. Further, the discoloration and odor of these toothpaste compositions with time were subjected to sensory evaluation as follows. The results are also shown in Tables 1 and 2. The blending amount of each component in the table is shown in% by weight based on the total weight of the dentifrice composition.

(Evaluation of discoloration) A dentifrice composition was placed at 40 ° C. for 8 hours.
A sample stored for a week and returned to room temperature was visually compared with a dentifrice composition having a similar composition immediately after preparation. The evaluation criteria and judgments are as follows. Evaluation Criteria Judgment No change in color tone is observed 〇 Some change in color tone is slightly recognized △ Change in color tone is significantly recognized × (Evaluation of odor) Samples prepared by storing the dentifrice composition at 40 ° C for 8 weeks and returning it to room temperature are prepared. Immediately after, the dentifrice composition having the same composition was compared by 5 panelists, and evaluated based on the following criteria, and the average score was evaluated by 5 panelists. Less rate Average determination of change score 4 points 3 points change No change of the reference odor is one point changes there are two points changes with little significant decision five 3.0 or 〇 2.0 or 3.0 △ 1.0 Greater than or equal to less than 2.0 ×

[0012]

[Table 1] ──────────────────────────────────── Component Ingredients Examples 1 2 3 4 5 6 7 8 ──────────────────────────────────── Concentrated glycerin 48 48 48 48 48 48 48 48 ─── ───────────────────────────────── Carboxymethyl 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Sodium cellulose ───── ─────────────────────────────── Calcium carbonate 35 35 35 35 35 35 35 35 ───────── ─────────────────────────── Hydroxyapatite 5 5 5 5 5 5 5 5 ────────────── ─────────────────────── Oil-soluble licorice extract A 0.05 0.05 0.05 0.05--- -〃 B----0.05 0.05 0.05 0.05 ──────────────────────────────────── Ester 1 ^{* 1} 0.03 0.06--0.03 0.06--──────────────────────────────────── Ester 2 ^{* 2-} -0.03 0.06--0.03 0.06 ──────────────────────────────────── N-lauroyl-L- 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 Sodium glutamate ──────────────────────────────────── 1,3-butylene Glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ──────────────────────────────────── Perfume 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ──────────────────────────────────── Purified water Residual residue Residual residue Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining ──────────────────────────────────── Judgment ○ ○ △ △ ○ ○ △ △ ──────────────────────────────────── Judgment of odor ○ ○ △ △ ○ ○ △ △ ──────────────────────────────────── * 1 Ascorbyl palmitate * 2 Ascorbyl dipalmitate

[0013]

[Table 2] ──────────────────────────────────── Component Example 9 10 11 12 13 14 15 16 ──────────────────────────────────── Concentrated glycerin 48 48 48 48 48 48 48 48 ─── ───────────────────────────────── Carboxymethyl 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Sodium cellulose ───── ─────────────────────────────── Calcium hydrogen phosphate 35 35 35 35 35 35 35 35 ─────── ───────────────────────────── Hydroxyapatite 5 5 5 5 5 5 5 5 ──────────── ───────────────────────── Oil-soluble licorice extract A 0.05 0.05 0.05 0.05-- --〃 B----0.05 0.05 0.05 0.05 ───────────────────────────────────── Ester 1 ^{* 1} 0.03 0.06--0.03 0.06--──────────────────────────────────── Ester 2 ^{* 2} --0.03 0.06--0.03 0.06 ──────────────────────────────────── N-lauroyl-L- 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 Sodium glutamate ──────────────────────────────────── 1,3- Butylene glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ──────────────────────────────────── Perfume 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ──────────────────────────────────── Purified water Residual residue Remaining Remaining Remaining Remaining Remaining Remaining Remaining Remaining ──────────────────────────────────── Judgment △ △ ○ ○ △ △ ○ ○ ──────────────────────────────────── Odor judgment △ △ ○ ○ △ △ ○ ○ ──────────────────────────────────── * 1 Ascorbyl palmitate * 2 Ascorbyl dipalmitate

[0014]

COMPARATIVE EXAMPLE As a comparative example, a toothpaste composition having the composition shown in Table 3 below was prepared by a conventional method, and sensory evaluation was conducted in the same manner as in the above-mentioned Examples. The results are also shown in Table 3. The blending amount of each component in the table is% by weight based on the total weight of the dentifrice composition.
Indicated by.

[0015]

[Table 3] ──────────────────────────────────── Component Comparative Examples 1 2 3 4 5 6 7 8 ──────────────────────────────────── Concentrated glycerin 48 48 48 48 48 48 48 48 ─── ───────────────────────────────── Carboxymethyl 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Sodium cellulose ───── ─────────────────────────────── Calcium carbonate 35 35--35 35 35 35 ────────── ─────────────────────────── Calcium hydrogen phosphate--35 35----─────────── ───────────────────────── Hydroxyapatite 5 5 5 5 5 5 5 5 ──── ─────────────────────────────── Oil-soluble licorice extract A 0.05-0.05-0.05 0.05--〃 B-0.05- 0.05--0.05 0.05 ──────────────────────────────────── Vitamin E----0.03 0.06 0.03 0.06 ──────────────────────────────────── N-Lauroyl-L- 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 Sodium glutamate ──────────────────────────────────── 1,3-butylene glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ──────────────────────────────────── Fragrance 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ── ────────────────────────────────── Purified water Residual residue Residual residue Re-remain Re-remain Re-remain Re-remain Re-remain ──────────────────────────────────── Discoloration judgment × × × × △ △ △ △ △ ──────────────────────────────────── Judgment of bad smell × × × × × × × × ─────────────────────────────────────

From the results shown in Tables 1 to 3 above, in the dentifrice composition of the present invention, the conventional dentifrice compositions containing the oil-soluble licorice extract extract (Comparative Examples 1 to 4) and antioxidants were used. Compared with the oil-soluble licorice extract extract-containing dentifrice compositions (Comparative Examples 5 to 8) containing vitamin E, which is known as an agent, it is clear that both discoloration and odor over time are suppressed. is there.

Claims (3)

[Claims] 1. A dentifrice composition containing an oil-soluble licorice extract, wherein the dentifrice composition contains a higher fatty acid ester of ascorbic acid. 2. The dentifrice composition according to claim 1, wherein the higher fatty acid ester of ascorbic acid is ascorbyl palmitate. 3. The dentifrice composition according to claim 1, wherein the higher fatty acid ester of ascorbic acid is ascorbyl dipalmitate.