JPH07149787A - Astringent and binding compound and preparation for medical and cosmetic use - Google Patents

Abstract

PURPOSE:To obtain an astringent and binding compound consisting of zinc glycyrrhizinate, zinc glycyrrhetinate, etc., having astringent action, hemostatic action, binding action of solid preparation and adhesive action to the skin and useful for high-quality medical and cosmetic preparation, etc. CONSTITUTION:This astringent and binding compound consisting of zinc glycyrrhizinate of formula (GZ)(Zn)y (GZ is glycyrrhizic acid; (y) is 0.01-3) or zinc glycyrrhetinate of formula (GT)(Zn)y (GT is glycyrrhetic acid; (y) is 0.01-1) and useful as a high-quality medical and cosmetic preparation is produced by dissolving glycyrrhizic acid of formula I or glycyrrhetic acid of formula II in ethanol-water (1:1), adding an aqueous solution of 1N potassium hydroxide to the solution under stirring, slowly adding an aqueous solution of zinc sulfate heptahydrate, heating the obtained mixture at 50 deg.C, cooling the mixture, collecting the produced precipitate by filtration, washing with water and finally drying the product.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an astringent / binding compound and a medicinal / cosmetic preparation used by being added to a drug, a quasi drug or a cosmetic.

[0002]

2. Description of the Related Art Generally, glycyrrhetinic acid (hereinafter referred to as GT
Abbreviated as -H. ) Or its glycoside glycyrrhizic acid (same as glycyrrhizin or glycyrrhizin,
Hereinafter, it is abbreviated as GZ-H. ) Is known to have many pharmacological actions as shown below, and is used in various pharmaceutical products, quasi drugs or cosmetics in the form of free acid or ammonium salt, potassium salt, sodium salt, higher alcohol ester, etc. It is compounded.

That is, the pharmacological actions of GZ-H or GT-H include water electrolytes of the adrenal cortex, glucose hormone-like action, estrogen-like action, antitussive action, anti-inflammatory action, antiallergic action, detoxification action, and high fat. It has been known so far that it has an effect of improving blood pressure and an effect of increasing the cyclic AMP concentration in gastric mucosal cells.

Therefore, GZ-H or GT-H is
Based on antitussive action, anti-inflammatory action, and antiallergic action, it is incorporated into cold remedies and antitussives as pharmaceuticals, and is also incorporated into fatigue-relieving nutrients due to experimental liver disorder recovery action, phospholipase A ₂ inhibitory action and the like.

Further, GZ-H or GT-H is blended in medicinal toothpaste as an agent for preventing alveolar pyorrhea, which is a quasi drug, and in medicated creams, lotions, etc. as an agent for preventing rough skin, and in addition, medicated hair. It is also added to tonics, medicated antiperspirants, and medicated baby powder.

Further, GZ-H or GT-H is a basic cosmetic such as massage cream, cleansing cream, emulsion, emollient cream, skin lotion,
In hair cosmetics, it is also used in cosmetics such as lotions, emulsions, bath powders, white powders, and make-up products as hair care products for whole body such as hair tonics, hair liquids and hair gels.

[0007]

However, the conventional GZ-
H or GT-H and derivatives thereof have no astringent action or hemostatic action as a pharmacological action, and there is a problem that even if these actions are found, they are very weak.

In addition to such pharmacological action,
Regarding the binding property effective for preventing cracks of powder molded tablets or cosmetics such as solid white powder, the conventional GZ-H
Alternatively, GT-H and these related compounds had no effect.

Furthermore, conventional GZ-H or GT-
H and these related compounds also have no effect on the adhesive property of improving the adhesive property to the skin in powdery cosmetics.

Therefore, the present invention provides a compound of glycyrrhizic acid or glycyrrhetinic acid type, which has an astringent action and a hemostatic action, and further has a binding action of a solid preparation, an adhesive action to the skin, that is, a binding action. Furthermore, it is an object to provide a high-quality medical / cosmetic preparation containing the same.

[0011]

In order to solve the above problems, in the present invention, an astringent / binding compound consisting of zinc glycyrrhizinate represented by the following formula 3
Alternatively, it is an astringent / binding glycyrrhizin compound represented by the following chemical formula 4 and consisting of zinc glycyrrhetinate.

Alternatively, a medical preparation or cosmetic preparation is
It is composed of zinc glycyrrhizinate represented by the formula (3) below, zinc glycyrrhetinate represented by the formula (4) below, or a mixture of both.

[0013]

[Chemical 3]

[0014]

[Chemical 4]

The details will be described below. Zinc glycyrrhizinate represented by the formula (3) used in the present invention (hereinafter,
It is abbreviated as GZ-Zn. ) Is a compound in which the composition ratio of glycyrrhizic acid (C ₄₂ H ₆₂ O ₁₆ ) and zinc represented by the following chemical formula 5 is 1: 0.01 to 3: 1. This is because if the composition ratio of zinc is less than 0.01, the intended effect of the present invention cannot be obtained, and in view of the composition formula of the compound, the composition ratio of zinc cannot exceed 3.

[0016]

[Chemical 5]

Zinc glycyrrhetinate represented by the formula (4) used in the present invention (hereinafter abbreviated as GT-Zn) is glycyrrhetin (C ₃₀
H ₄₆ O ₄ ) and zinc have a composition ratio of 1: 0.01 to 1. This is because if the composition ratio of zinc is less than 0.01, the intended effect of the present invention cannot be obtained, and if it exceeds 1, it is impossible from the composition formula of the compound.

[0018]

[Chemical 6]

[0019]

【Example】

[Example 1] Preparation of GZ-Zn: 50 g of GZ-H was dissolved in 500 ml of ethanol water (1: 1) and stirred while stirring at 120
Add 1 ml of 1N potassium hydroxide aqueous solution, and further add 50
8.63 g of zinc sulfate heptahydrate dissolved in ml of water was gradually added. After heating to 50 ° C., it was cooled and the precipitate was filtered, washed with water and dried to obtain 36 g of GZ-Zn.

The infrared absorption spectrum of the obtained GZ-Zn was measured, and the wavelengths at which the maximum absorption was observed are shown in Table 1. In addition, the infrared absorption spectrum of GZ-H as a raw material was similarly examined, and the results are also shown in Table 1.

[0021]

[Table 1]

From the results shown in Table 1, 1732 cm ^-1 peculiar to free carboxylic acid was greatly reduced in GZ-Zn. In addition, the absorption of raw material GZ-H at 1647 cm ^-1 is GZ-Z.
a wide range becomes the n, maximum absorption was observed at 1640cm ^-1, also absorption of 1000~1200cm ^-1 found in the carbohydrate, it could also be confirmed in any way. From these, it is understood that the product is GZ-Zn which is a zinc salt of GZ-H.

With respect to the obtained GZ-Zn, its hemostatic action, astringent action, wound healing action, anti-inflammatory action, adhesive action,
The following experiment was conducted to confirm that there is a binding action.

[Hemostatic Confirmation Experiment] J. Soc. Cosmet. Ch
em. Japan., Vol. 24 (3), p187 (1991) Asanuma's method (improved
Bleeding method) was applied.

That is, male Wistar rats (body weight 200 to 250 g) fasted overnight were pentobarbital (8).
(0 mg / kg) intraperitoneally and anesthetized, then below ribs 2
A 2.5 cm circular peritoneum was used at the position of cm.

Immediately thereafter, euglobulin-SK mixture
An amount equivalent to 2 ml / kg was administered from the femoral vein of the left foot. Filter paper (2 x 2 cm) on the peritoneum that is bleeding quickly after administration
Then, 0.2 ml of the test solution was administered to the filter paper. Five minutes after the administration, the filter paper was removed, and a filter paper (1.5 × 3 cm) previously soaked in warm water at 37 ° C. was placed on the exposed surface to absorb the bleeding blood for 30 minutes. This filter paper was replaced every 30 minutes, and this operation was performed for 2 hours after the administration of the test solution.

The filter paper having absorbed the blood was put into a test tube containing 4 ml of water, and the blood was eluted by shaking in a water bath at 37 ° C. for 30 minutes. Measure the absorbance of this at 540 nm wavelength,
The amount of bleeding was taken every 30 minutes. That is, the amount of bleeding was evaluated by absorbance, and the results are shown in Table 2.

[0028]

[Table 2]

[Convergence Confirmation Experiment 1] Ten normal taste holders were swung with 20 ml of the test solution to examine whether the tongue was tight and the astringent sensation was present. This result is
The answers were the same for all 10 persons and are shown in Table 3. Those with astringent taste were evaluated as having an astringent effect, and those without an astringent effect were evaluated as having no astringent effect.

[0030]

[Table 3]

[Convergence Confirmation Experiment 2] 3 ml of a collagen aqueous solution (commercially available soluble collagen) was placed in a test tube, 1 ml of the test liquid was added thereto, and the mixture was gently stirred. Immediately after that, the presence or absence of precipitate formation was confirmed. In this case, those in which precipitation was observed due to alteration of the protein were evaluated as having an astringent action (+), and those in which no precipitation was observed were evaluated as having no astringent action (-), and the results are shown in Table 4.

[0032]

[Table 4]

[Wound healing action confirmation experiment] Journal of the Japanese Pharmacological Society
Vol. 100, 162 (1992) With reference to the method of Shimizu et al., The procedure was as follows. That is, male Hartley guinea pigs (body weight around 300 g) were anesthetized with Nembutal (30 mg).
/ Kg, i. p. ), The back part was shaved and disinfected, two incisions (1.5 cm) were made on the left and right with a scalpel, and the wound was sewn into two equal parts per wound with a silk thread. After making a cut 3
Width 1 cm and length 2 cm so that the cut will be 1 cm after day
The skin was removed. The test solution is dissolved or dispersed in physiological saline so as to be 2 mg / 0.4 ml / individual, and 0.1 ml / site around the wound site at a rate of 2 per wound.
It was subcutaneously administered once a day for 3 days to 4 sites in total.

To determine the degree of adhesion of the wound, the wound tension (g / cm) of the wound was measured with a rheometer. In addition,
The average value of the wound tensions at two locations on the left and right was taken as the wound resistance of one individual, and the results are shown in Table 5.

[0035]

[Table 5]

[Adhesion Action Confirmation Experiment] Powders having the compositions shown in Table 6 (Experimental Example A and Experimental Example B) were prepared, and a sensory test was conducted by 10 adults. That is, Experimental Example A
Alternatively, 0.2 g of Experimental Example B was applied to the forearm to judge the superiority or inferiority of the smooth and even adhesion, and the results are also shown in Table 6.

[0037]

[Table 6]

[Binding Action Confirmation Experiment] Powders having the compositions shown in Table 7 (Experimental Example C and Experimental Example D) were mixed, 0.5 g of each was placed in a tablet molding machine having a diameter of 16 mm, and a weight of 200 kg (100 kg). / Cm < ² >) for 1 minute and then brought to normal pressure.

The breaking strength of the obtained tablets was measured by a rheometer as a test material, and the results are shown in Table 7.

[0040]

[Table 7]

Comparative Example 1 A general reagent, dipotassium glycyrrhizinate (hereinafter abbreviated as GZ-K2), was used as Comparative Example 1. Except for using this GZ-K2 instead of GZ-Zn, the same hemostatic action as described above was obtained.
Each confirmation test of the astringent action / wound healing action was performed, and the results are shown in Table 2, Table 3, Table 4, and Table 5, respectively.

Comparative Example 2 Glycyrrhizic acid (GZ-H) as a general reagent was used as Comparative Example 2. Except that this GZ-H was used instead of GZ-Zn,
The above-mentioned wound healing action confirmation test was performed, and the results are also shown in Table 5.

Regarding Example 1 and Comparative Examples 1 and 2 described above, as is clear from the results in Table 2, Comparative Example 1 does not show a significant difference with respect to distilled water (control). In Example 1, a hemostatic effect was observed with a significant difference of P <0.05.

From the results of Table 3 or Table 4, it can be seen that Example 1 has a convergent property. In addition, from the results of Table 5,
In Comparative Example 1, no significant difference was observed with respect to physiological saline (control), but in Example 1, a significant difference of P <0.01 was observed, and the wound tension resistance was observed, indicating that it has a wound healing effect. .

From the results of the sensory test shown in Table 6, it was confirmed that the powder having the composition of Experimental Example B including Example 1 had a good adhesion action of GZ-Zn.

From the results shown in Table 7, the tablet of Experimental Example D containing Example 1 was 1.5 times or more stronger than that of Experimental Example C containing no Example 1.

[Example 2] Preparation of GT-Zn: To 50 g of GT-H, 1000 ml of water was added, and 210 ml of 0.5N potassium hydroxide in ethanol solution was added with stirring.
Then, 15.01 g of zinc sulfate heptahydrate dissolved in water was gradually added. After heating to 50 ° C., it was cooled, the precipitate was filtered, washed with water and dried to obtain 52 g of GT-Zn.

The infrared absorption spectrum of the obtained GT-Zn was measured, and the wavelengths at which the maximum absorption was observed are shown in Table 8. In addition, the infrared absorption spectrum of the raw material GT-H was similarly examined, and the results are also shown in Table 8.

[0049]

[Table 8]

From the results shown in Table 8, 1705 cm ^-1 peculiar to free carboxylic acid disappeared in GT-Zn. Further, the absorption at 1663 cm ^-1 of the starting material GT-H was broadened with GT-Zn, and the maximum absorption was observed at 1647 cm ^-1 .
From these facts, the product is G, which is a zinc salt of GT-H.
It can be seen that it is T-Zn.

The following experiments were conducted to confirm that the obtained GT-Zn has hemostatic action, wound healing action, anti-inflammatory action, adhesive action and binding action. The confirmation tests of the adhesion action and the binding action were carried out under the same conditions as in the test method described above, and the results are summarized in Table 9 (adhesion action confirmation experiment) and Table 10 (binding action confirmation experiment), respectively. .

[0052]

[Table 9]

[0053]

[Table 10]

[Wound healing action confirmation experiment] Journal of the Japanese Pharmacological Society
Vol. 100, 162 (1992) By applying the method of Shimizu et al., It was performed as follows. That is, male Hartley guinea pigs (body weight around 300 g) were anesthetized with Nembutal (30 mg).
/ Kg, i. p. ), The back part was shaved and disinfected, two incisions (1.5 cm) were made on the left and right with a scalpel, and the wound was sewn into two equal parts per wound with a silk thread. After making a cut 3
Width 1 cm and length 2 cm so that the cut will be 1 cm after day
The skin was removed. The test solution was dispersed with white petrolatum so that the amount of the test solution was 2 mg / 0.4 ml / individual, and an amount of 0.2 ml per wound was applied to the wound center once a day for 3 days.

In order to determine the degree of adhesion of the incision, the wound tension resistance (g / cm) of the wound was measured with a rheometer. In addition,
The average value of the wound tension at two locations on the left and right was taken as the wound tension resistance of one individual, and the results are shown in Table 11.

[0056]

[Table 11]

[Anti-inflammatory action confirmation test] Keio Medical Science 44 (1), p
17 (1967) According to the method of Tomizawa et al. That is, 150 g
The test solution was dispersed in 1.0% polysorbate and sesame oil before and after using male and female Wistar rats, and subcutaneously administered to the back of the rat at a rate of 500 mg / 2.0 ml / kg for 7 consecutive days. Examined.

The method for evaluating the anti-inflammatory effect in this case is rat
Using a foot test, 0.1 ml of 10% formalin-physiological saline was subcutaneously administered to one hindpaw of the rat, and the average value of increase in paw volume after 1 hour, 2 hours, 3 hours was calculated. The inhibition rate of the test solution administration group with respect to the control was calculated, and Table 1
Shown in 2.

[0059]

[Table 12]

[Hemostatic action confirmation experiment] J. Soc. Cosmet. Ch
em. Japan., Vol. 24 (3), p187 (1991) Asanuma's method (improved
Bleeding method) was applied.

That is, male Wistar rats (body weight 200 to 250 g) fasted overnight were pentobarbital (8).
(0 mg / kg) intraperitoneally and anesthetized, then below ribs 2
A 2.5 cm circular peritoneum was used at the position of cm.

Immediately thereafter, euglobulin-SK mixture
An amount equivalent to 2 ml / kg was administered from the femoral vein of the left foot. Place a filter paper (2 x 2 cm) on the peritoneum that is bleeding quickly,
After 10 minutes, the filter paper was removed and 100 mg of the test product was applied. Immediately thereafter, a filter paper (1.5 × 3 cm) which had been soaked in warm water at 37 ° C. in advance was placed on the exposed surface to absorb the bleeding blood for 30 minutes. This filter paper was replaced every 30 minutes, and this operation was performed from 1 hour and 30 minutes after the application of the test product.

The filter paper containing the absorbed blood was placed in a test tube containing 4 ml of water, and the mixture was immersed in a 37 ° C. water bath for 30 minutes to elute the blood and then filtered. The absorbance at a wavelength of 540 nm was measured and used as the amount of bleeding every 30 minutes. That is, the amount of blood loss was evaluated by absorbance, and the results are shown in Table 13.

[0064]

[Table 13]

Comparative Example 3 A general reagent stearyl glycyrrhizinate: C ₄₈ H ₈₂ O ₄ (hereinafter abbreviated as GT-St) was used as Comparative Example 3. This GT-St is GT
The confirmation test of the above-mentioned wound healing action and anti-inflammatory action was performed in exactly the same manner except that it was used in place of -Zn, and the results are shown in Table 9 and Table 12, respectively.

Comparative Example 4 Glycyrrhetinic acid (GT-H) as a general reagent was used as Comparative Example 4. Except that this GT-H was used in place of GT-Zn,
Confirmation tests of the above-described wound healing action, anti-inflammatory action, and hemostatic action were performed, and the results are shown in Table 11 (wound healing), Table 12 (anti-inflammatory), and Table 13 (hemostatic), respectively.

From the results shown in Table 11, Comparative Example 3 and Comparative Example 4 had a greater wound resistance than white petrolatum (control), but no significant difference was observed. However, in Example 2, a significant difference was observed at P <0.05, and it can be said that there is a wound healing action.

From the results shown in Table 9, it was confirmed that the powder having the composition of Experimental Example F including Example 2 had a good effect of adhering GT-Zn.

From the results shown in Table 10, the tablet of Experimental Example H including Example 2 has a strength 1.5 times or more that of Experimental Example G which does not include Example 2 and strongly binds the powder. You can see that

As is clear from the results shown in Table 12, the degree of anti-inflammatory action was Comparative Example 4 <Comparative Example 3 <Example 2, and GT-St was 1.34 times as much as GT-H in the same amount.
The effect of GT-Zn was 1.44 times.

From the results shown in Table 13, Comparative Example 4 showed no significant difference from the control (no administration), while Example 2 showed a hemostatic effect with a significant difference of P <0.05.

Next, examples of medical and cosmetic preparations will be described below. All the mixing ratios are parts by weight (hereinafter, simply referred to as parts).

Example 3 (1) Macrogol 4000 500 parts (2) Macrogol 400 460 parts (3) GZ-Zn 10 parts (4) Purified water 30 parts Total 1000 parts (1) to (4) After heating at 65-70 ° C to dissolve,
Macrogol ointment was prepared by cooling and stirring until it solidified. When the obtained ointment was applied to slight scratches, a hemostatic effect was observed.

Example 4 (1) White ointment 700 parts (2) GZ-Zn 50 parts (3) GT-Zn 250 parts Total 1000 parts (1) to (3) were heated to 65 to 70 ° C. After melting,
An ointment was prepared by cooling and stirring until it solidified. When the obtained ointment was applied to the ulcer surface, the affected area was protected, absorption of secretions and dryness of the affected area were observed.

Example 5 (1) Starch 450 parts (2) GZ-Zn 50 parts (3) GT-Zn 500 parts Total 1000 parts (1)-(3) are mixed until uniform and sprayed. Was prepared. When the obtained spray was applied to the wound site, the affected area was protected, secretion of secretions and dryness of the affected area were observed.

Example 6 (1) Sesame oil 500 parts (2) Polysorbate 20 50 parts (3) GZ-Zn 50 parts (4) GT-Zn 400 parts 1000 parts in total (1) to (4) uniformly A liniment agent was prepared by mixing until the mixture became uniform. When the obtained liniment agent was applied to the burned site, it protected the affected area, absorbed secretions, dried the affected area, and disappeared inflammation.

Example 7 (1) Glycerin fatty acid ester 900 parts (2) GZ-Zn 50 parts (3) GT-Zn 50 parts Total 1000 parts (1) to (3) are heated to 65 to 70 ° C. Then, the mixture was stirred until it became uniform, and molded by a suppository molding machine. When the obtained suppository was inserted through the anus of a person with hemorrhoidal disease, the effect of protecting the hemorrhoidal area, absorbing secretions, drying the affected area, eliminating inflammation, and stopping hemostasis was observed.

Example 8 (1) GZ-Zn 10 parts (2) GT-Zn 30 parts (3) Talc 897 parts (4) Kaolin 60 parts (5) Perfume 1 part (6) Methylparaben 2 parts Total 1000 Parts (1) to (6) were mixed until uniform to prepare a spray (a powder for preventing eczema, etc.). The obtained dusting agent on the neck,
It was effective in preventing eczema when it was applied to chest, back, armpits, and other areas that secrete a lot of sweat. Moreover, when it was applied to the site where sweat rash was already present, the affected area was protected, and secretion of secretions and dryness of the affected area were observed.

Example 9 (1) GZ-Zn 5 parts (2) GT-Zn 0.5 parts (3) Talc 81.15 parts (4) Kaolin 5 parts (5) Titanium dioxide 3 parts (6) Zinc oxide 5 parts (7) Iron oxide 0.05 part (8) Perfume 0.1 part (9) Methylparaben 0.2 part Total 100 parts (1) to (9) are mixed until uniform and powdered white powder ( Was prepared. The obtained white powder had very good adhesion to the skin.

Example 10 (1) GZ-Zn 0.5 part (2) GT-Zn 5 part (3) Talc 61.7 part (4) Kaolin 5 part (5) Titanium dioxide 8 part (6) Zinc oxide 1 part (7) Iron oxide 0.5 part (8) Magnesium carbonate 3 parts (9) Perfume 0.1 part (10) Methylparaben 0.2 part (11) Liquid paraffin 5 parts (12) Silicone oil (5cs) ) 5 parts (13) sorbitan sesquioleate 3 parts (14) glycerin 2 parts 100 parts in total (1) to (14) were mixed until uniform and pressure-molded with a molding machine to obtain a solid white powder. The obtained solid white powder had a stable quality without cracking at room temperature for more than half a year, and had a feeling of use that sweat was suppressed, and it was hard to remove and had good adhesion.

Example 11 (1) Ethanol 50 parts (2) Purified water 49.4 parts (3) GZ-Zn 0.5 part (4) Methylparaben 0.1 part Total 100 parts (1) and (2) ) Was mixed and (3) and (4) were added and dissolved to prepare an antiperspirant lotion. The obtained antiperspirant lotion suppressed sweat and had a refreshing and good feeling of use.

Example 12 (1) GZ-Zn 5 parts (2) GT-Zn 10 parts (3) Talc 74.8 parts (4) Methylparaben 0.2 parts (5) Silicone oil (5cs) 10 parts A total of 100 parts (1) to (5) were mixed until uniform to obtain an antiperspirant powder. When this antiperspirant powder was applied to areas such as the sides that secrete a lot of sweat, the applied area was dried and
The smell of sweat was suppressed and it was a good feeling to use.

Example 13 (1) Ethanol 15 parts (2) Glycerin 2 parts (3) Butylene glycol 5 parts (4) Methylparaben 0.1 part (5) Perfume 0.1 part (6) Polyoxyethylene curing Castor oil (50 EO) 0.1 part (7) GZ-Zn 0.1 part (8) Purified water 77.6 parts Total 100 parts (1) to (6) are stirred until uniform. And (7) and (8) were added and dissolved to obtain an astringent lotion. The resulting astringent lotion had a good feeling of use due to its astringency.

Example 14 (1) Ethanol 50 parts (2) Butylene glycol 5 parts (3) Perfume 0.1 part (4) Methylparaben 0.2 part (5) Polyoxyethylene hydrogenated castor oil (50EO) .) 0.1 part (6) GZ-Zn 0.1 part (7) Purified water 44.5 parts Total 100 parts (1) to (5) are stirred until they are homogeneously dissolved, and (6) ) And (7) were added and dissolved to obtain an aftershaving lotion. The obtained aftershaving lotion has astringent, hemostatic and anti-inflammatory effects,
It had a refreshing feel and had a good feel after shaving.

Example 15 (1) Purified water 59.7 parts (2) Polyvinyl alcohol 15 parts (3) Ethanol 20 parts (4) Glycerin 5 parts (5) Perfume 0.05 parts (6) Polyoxyethylene Hardened castor oil (50 EO) 0.1 part (7) Methylparaben 0.1 part (8) GZ-Zn 0.05 part Total 100 parts 100 parts heated to 80 ° C. (2) is stirred. While adding,
It was completely dissolved. Then, it was cooled and uniformly dissolved (3)
(8) Add at 50 ° C., stop cooling and stirring at 35 ° C. to obtain a pack material. The obtained pack material was a pack that was refreshed without causing pores to spread too much.

Example 16 (1) Glycerin 20 parts (2) Disodium phosphate 40 parts (3) Calcium carbonate 15 parts (4) GT-Zn 0.2 parts (5) N-lauroyl sarcosine sodium 1. 5 parts (6) Methyl paraben 0.2 part (7) Fragrance 0.5 part (8) Purified water 22.6 parts Total 100 parts Knead (2) to (7) in sequence with (1) heated to 80 ° C. Then, (8) was added and kneaded to obtain a toothpaste.
The toothpaste obtained has an astringent action and an anti-inflammatory action,
It was suitable for preventing and treating alveolar pyorrhea.

Example 17 (1) Sorbitan monostearate 3 parts (2) Polyoxyethylene sorbitan Monostearic acid (20 EO) 2 parts (3) Titanium dioxide 1 part (4) Iron trioxide 0. 1 part (5) GZ-Zn 1 part (6) Stearic acid 15 parts (7) Cetanol 5 parts (8) Squalane 3 parts (9) Octyldodecyl myristate 3 parts (10) Purified lanolin 3 parts (11) Glycerin 10 Parts (12) butylene glycol 5 parts (13) methylparaben 0.2 parts (14) butylparaben 0.1 parts (15) purified water 46.6 parts (16) triethanolamine 2 parts total 100 parts (1) and ( Put (3) to (5) in 2) and knead.
(6) to (14) were heated to 80 ° C., (1) to (5) were added while stirring, and further heated to 80 ° C. (1
Add 5) and (16). Then, it was cooled to 35 ° C. with stirring to obtain a base cream. The obtained base cream had astringent action and anti-inflammatory action as well, and was a base cream that was comfortable to the skin without sweating.

Example 18 (1) Potassium soap base 40 parts (2) Polyoxyethylene cetyl ether (25 EO) 4 parts (3) Propylene glycol 10 parts (4) Glycerin 10 parts (5) Maltitol 2 parts (6) Purified lanolin 1.5 parts (7) Methylparaben 0.2 parts (8) Butylparaben 0.1 parts (9) Sodium lauryl sulfate 1 part (10) Purified water 30.8 parts (11) GT- Zn 0.2 parts (12) Fragrance 0.2 parts Total 100 parts (1) to (9) are heated and dissolved at 80 ° C., 80 ° C. (10) is added thereto, and the mixture is stirred and homogenized, and then stirred. While cooling to 45 ° C., (11) and (12) were added, and stirring and cooling were continued to 35 ° C. to obtain a face wash. The obtained face wash,
After washing, it was moist and had a very refreshing feel.

[0089]

[Effect] As described above, the present invention is an astringent / binding compound consisting of zinc glycyrrhizinate or zinc glycyrrhetinate having a predetermined chemical composition, or a medical composition composed of a single compound or a mixture of both compounds. Since it is used as a cosmetic or cosmetic preparation, it has the advantage of being a compound or a medical or cosmetic preparation having astringent and hemostatic effects, binding of solid pharmaceuticals and cosmetics, and adhesion to the skin.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI technical display location A61K 31/70 ADA 9454-4C

Claims (4)

[Claims] 1. An astringent / binding compound comprising zinc glycyrrhizinate represented by the following formula 1. [Chemical 1] 2. An astringent / binding compound consisting of zinc glycyrrhetinate represented by the following chemical formula 2. [Chemical 2] 3. A medical preparation comprising the zinc glycyrrhizinate represented by the formula of Formula 1 of claim 1 or the zinc glycyrrhetinate represented by the formula of Formula 2 of claim 2 alone or in a mixture of both. 4. A cosmetic preparation comprising zinc glycyrrhizinate represented by the formula of formula 1 of claim 1, zinc glycyrrhetinate represented by the formula of formula 2 of claim 2, or a mixture of both.