JPH07126156A - Medicine-containing tacky sheet and packaging structure thereof - Google Patents

Abstract

PURPOSE:To obtain a medicine-containing tacky sheet forming unevenness in a support and/or a coating material, excellent in usability and not causing lowering of yield and increase of the cost. CONSTITUTION:This medicine-containing tacky sheet consists of a support, a medicine-containing tacky agent layer and a coating material laminated on the surface of this medicine-containing tacky agent layer. The sheet is obtained by forming unevenness on the surface opposite to the medicine-containing tacky agent layer side in the support and/or the exposed surface of the coating material. The unevenness is formed by pressing or printing or printing using ink formed of a foaming resin and then foaming this printed part or attaching or bonding organic or inorganic particles or powder or by a method using an unevenness-forming member laminated on the surface of the support and/or coating material. The sheet has high slipping property between the medicine- containing tacky sheet and sheet of support, coating material, etc., and the sheet is free from tackiness of a tacky sheet to the interior of package and capable of readily taking out the medicine-containing tacky sheet when used.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug-containing pressure-sensitive adhesive sheet used for transdermal administration of a drug and its packaging structure.

[0002]

2. Description of the Related Art In recent years, a transdermal absorption method in which a drug-containing adhesive sheet is attached to a living body has been adopted as a means for administering a drug into the living body. Such a drug-containing pressure-sensitive adhesive sheet is obtained by laminating a pressure-sensitive adhesive layer containing a drug for percutaneous absorption on one surface of a plastic support such as polyester or polyethylene, and coating the exposed pressure-sensitive adhesive layer surface with a coating material. It will be. In general, such a drug-containing pressure-sensitive adhesive sheet is individually packaged in a moisture-impermeable packaging material in order to prevent volatilization of the contained drug and prevent its influence on humidity.

In the case of packaging as described above, however, the pressure-sensitive adhesive may stick out from the end surface of the drug-containing pressure-sensitive adhesive sheet and adhere to the inner surface of the packaging material or the back surface of the support, making it difficult to take out the drug-containing pressure-sensitive adhesive sheet during use. is there.

In the adhesive layer, a plasticizer or a tackifier,
When a liquid component is contained, these substances exude from the end surface of the pressure-sensitive adhesive layer and adhere (wrap around) to the back surface of the support or the covering material and further to the inner surface of the packaging material, and as a result, to the inner surface of the packaging material. There is a problem that the drug-containing pressure-sensitive adhesive sheet is stuck and it becomes difficult to take out the drug-containing pressure-sensitive adhesive sheet.

Further, when it is necessary to temporarily accumulate the cut sheets in the manufacturing process of the sheet containing the drug-containing pressure-sensitive adhesive sheet, the support and the covering material, for the same reason as above,
There is also a problem that workability is significantly reduced due to poor slipperiness between the sheets.

To solve these problems, for example, a method of enlarging the size of the separator or providing a protruding portion, a so-called bank, on the outer peripheral edge of the increased separator can be mentioned.

[0007]

However, in the above method, the sticking out of the pressure-sensitive adhesive and the adhesion (wraparound) of the plasticizer or the like to the back surface of the separator can be prevented, but the adhesion of the plasticizer or the like (wraparound) to the support side is prevented. Cannot be prevented.

Although the above method is an effective method, the yield is reduced due to the large size of the release paper, and a special device is required to provide the protrusions on the outer peripheral edge of the separator, resulting in high cost. I have a problem.

The present invention has been completed in order to solve the above technical problems, and has a good slip property between sheets such as a drug-containing pressure-sensitive adhesive sheet, a support and a covering material, and to the inner surface of the packaging material. It is an object of the present invention to provide a drug-containing pressure-sensitive adhesive sheet and a packaging structure for the drug-containing pressure-sensitive adhesive sheet, which can be taken out very easily during use without sticking of the pressure-sensitive adhesive sheet, and which does not reduce the yield or the cost.

[0010]

Means for Solving the Problems As a result of repeated studies to achieve the above object, the present inventors have found that the side surface of the support opposite to the drug-containing pressure-sensitive adhesive layer side and / or the exposed surface of the coating material has unevenness. By forming the, the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material is substantially reduced in contact area to improve the slipperiness of the drug-containing pressure-sensitive adhesive sheet, the support, the sheet such as the covering material, and the drug-containing pressure-sensitive adhesive sheet The inventors have found that sticking is effectively prevented, and completed the present invention.

The drug-containing pressure-sensitive adhesive sheet of the present invention comprises a support,
In a drug-containing pressure-sensitive adhesive sheet comprising a drug-containing pressure-sensitive adhesive layer and a coating material laminated on the surface of the drug-containing pressure-sensitive adhesive layer,
The support is characterized in that unevenness is formed on the side opposite to the drug-containing pressure-sensitive adhesive layer side and / or on the exposed surface of the coating material.

That is, the feature of the present invention resides in that in the drug-containing pressure-sensitive adhesive sheet, unevenness is formed on the side surface of the support opposite to the drug-containing pressure-sensitive adhesive layer side and / or the exposed surface of the covering material. The method of forming is not particularly limited.

The support is not particularly limited as long as it is formed in the form of a sheet or a film, but it is particularly preferable that it does not allow the evaporation of a drug or moisture to pass through. The body may be formed of a single layer or a laminated body of a plurality of layers.

Further, examples of the above-mentioned coating material include sheet-shaped or film-shaped material subjected to a peeling treatment, and specific examples thereof include known materials.

In the present invention, the support and / or the covering material may have irregularities formed by pressing.
Specifically, it is possible to employ a method in which unevenness is formed by subjecting the surface of the support and / or the covering material to a pressing treatment with, for example, a roll or a press stamped in a desired shape. As a result of being able to use existing equipment by modifying the press plate, etc., it is extremely economical.

In the present invention, embossing may be mentioned as another method for forming the unevenness of the support and / or the covering material by pressing. In this case, when unevenness is formed on the support and / or the covering material, there is no curved shape, that is, there is no corner portion in order to prevent a film or a sheet for forming the support and / or the covering material from having holes or scratches. It is desirable to form unevenness.

Further, in the drug-containing pressure-sensitive adhesive sheet of the present invention, the irregularities on the support and / or the covering material may be formed by printing. In this case, the unevenness on the support and / or the covering material is printed by using the ink formed of the foaming resin, and the one formed by the foaming of the printed portion is the kind and the mixing ratio of the foaming agent. Is advantageous because the amount of foaming, that is, the height of the irregularities can be arbitrarily changed by adjusting.

Further, in the drug-containing pressure-sensitive adhesive sheet of the present invention, irregularities in the support and / or the covering material are formed by adhering or adhering organic or inorganic particles or powder to the support and / or the covering material. It can also be something.

Examples of the organic particles include particles or powders formed of natural or synthetic materials. Among these, synthetic materials are preferable because particles or powders of stable quality can be obtained. Examples of the synthetic material include particles or powders made of a thermoplastic resin or a thermosetting resin.

In order to adhere or adhere the organic or inorganic particles or powders of the natural or synthetic material to the support and / or the coating material, for example, a method such as heat fusion or hot melt resin adhesion is used. Is adopted.

In the present invention, it is also advantageous to use a member formed by a concavo-convex forming member laminated on a support and / or a covering material. As the unevenness forming member, a support and / or
Or, it is not particularly limited as long as it gives unevenness to the surface of the covering material, but especially woven cloth or non-woven cloth is inexpensive, and if it is formed of thermoplastic resin, it can be easily laminated. desirable.

In the drug-containing pressure-sensitive adhesive sheet of the present invention,
In the unevenness of the support and / or the covering material, the ratio of the projections to the entire surface of the support and / or the covering material depends on the type and composition of the adhesive used. Therefore, it is not particularly limited, but in particular, it is desirable that this convex portion is 5 to 90% of the entire surface of the support and / or the covering material, and the area of the convex portion is
If it is less than 5%, the concave portion and the inner surface of the packaging material are likely to come into contact with each other, and as a result, the contact area with the drug-containing pressure-sensitive adhesive sheet, that is, the adhesive area or the adhesion area becomes large, and the drug-containing pressure-sensitive adhesive sheet becomes difficult to take out during use. Sometimes, on the other hand, 90%
If it exceeds, the convex portion and the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material are likely to contact each other, so that the contact area with the drug-containing pressure-sensitive adhesive sheet, that is, the adhesive area or the adhesion area becomes large and the drug-containing pressure-sensitive adhesive sheet is used. Sometimes it is difficult to take out, which is not preferable.

In the drug-containing pressure-sensitive adhesive sheet of the present invention,
In the unevenness of the support and / or the covering material, the pitch of the convex portions is 0.1 to 20 mm and the height is 2 μm to 1 mm, to prevent sticking or adhesion of the drug-containing pressure-sensitive adhesive sheet, and heat seal portion. It is advantageous from the viewpoint of ensuring the airtightness or bulkiness.

In the packaging structure for a drug-containing pressure-sensitive adhesive sheet of the present invention, in order to achieve the above-mentioned object, the drug-containing pressure-sensitive adhesive sheet described above is packaged in a packaging material having an inner surface having irregularities.

As a method for forming irregularities on the inner surface of the packaging material, the same method as the method for forming irregularities on the surface of the support and / or the covering material is adopted.

In this case, in the unevenness of the inner surface of the packaging material, the pitch of the convex portions is 0.1 to 20 mm and the height is 2 μm to 1 mm, so that the drug-containing pressure-sensitive adhesive sheet is prevented from sticking or sticking, It is useful from the viewpoint of ensuring the airtightness of the heat-sealed portion or bulkiness, and in particular, the height of the convex portion is preferably in the range of 2 to 900 μm, and more preferably in the range of 2 to 800 μm. If the height is less than 2 μm, it may be meaningless to provide a convex portion from the viewpoint of preventing the drug-containing pressure-sensitive adhesive sheet from sticking or adhering, while if it exceeds 1 mm, its formation becomes difficult. However, it is not preferable from the viewpoints of securing the airtightness of the heat-sealed portion or making it bulky, and cost.

[0027]

The drug-containing pressure-sensitive adhesive sheet of the present invention is a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a coating material laminated on the surface of the drug-containing pressure-sensitive adhesive layer. Since unevenness is formed on the side opposite to the layer side and / or the exposed surface of the covering material, the substantial contact area between the drug-containing adhesive sheet and the inner surface of the packaging material is reduced, that is, the drug-containing adhesive sheet and the packaging material are The adhesive area or the adhered area with the inner surface is reduced, so that the drug-containing adhesive sheet can be taken out very easily during use.

Further, in the packaging structure for a drug-containing pressure-sensitive adhesive sheet of the present invention, since the drug-containing pressure-sensitive adhesive sheet is packaged in a packaging material having irregularities formed on the inner surface, the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material are Since the substantial contact area with the drug-containing pressure-sensitive adhesive sheet is further reduced, that is, the pressure-sensitive adhesive area between the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material or the adhesion area is further reduced, and the drug-containing pressure-sensitive adhesive sheet can be taken out very easily during use. .

[0029]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will now be described in detail with reference to the accompanying drawings, but the present invention is not limited thereto.

FIG. 1 is a perspective view showing a drug-containing pressure-sensitive adhesive sheet according to an embodiment of the present invention from the support side, FIG. 2 is a perspective view showing the coating material side, and FIG. X '
It is sectional drawing in a line.

4 to 7 are perspective views showing other embodiments of the drug-containing pressure-sensitive adhesive sheet of the present invention.

1 to 3, a drug-containing pressure-sensitive adhesive sheet 1 of the present invention comprises a support 2 made of various plastic sheets, non-woven fabrics, metal foils, or composite sheets thereof.
And a pressure-sensitive adhesive layer 3 mainly composed of a polymer such as acrylic, rubber, silicone, vinyl ether or the like containing a known drug for percutaneous absorption capable of being transdermally absorbed into the body, and a plastic It is composed of a laminated structure with a coating material 4 such as a sheet or paper having a surface subjected to a peeling treatment.

In this case, the drug-containing adhesive sheet 1 of the present invention
As shown in FIG. 3, the supporting member 2 and the covering material 4 are formed with unevenness 5 on the inner surface by pressing from the outer surface.

That is, the support 2 is placed on a support plate having a smooth surface.
Alternatively, a method in which the covering material 4 is placed and the unevenness 5 is formed by pressing the surface of the support body 2 and the covering material 4 from the outside with a roll or a press plate stamped in a predetermined shape It is extremely economical because existing equipment can be used by modifying rolls or press plates.

In place of the above method, the adhesive layer 3 and the coating material 4 are sequentially laminated on the support 2 to form the drug-containing adhesive sheet 1, and then a roll or press stamped in a predetermined shape from both sides. The unevenness 5 may be formed all at once on the surfaces of the support 2 and the covering 4 by a plate or the like.

The shape of the unevenness 5 is not particularly limited, but specifically, for example, as shown in FIG. 1, it is formed in a dot shape over the entire surface, or as shown in FIGS. 2 and 7. In addition, the surface of the coating material 4 is engraved with irregularities 5 of a repeating pattern of specific characters such as company name and handling method, or the irregularities 5 are formed in a grid pattern as shown in FIG. As shown in FIG.
As shown in FIG. 5, the unevenness 5 can be formed in a pear-skin pattern, or can be formed in a wavy line shape (not shown), and can be formed in a combination thereof.

As a method of forming the unevenness 5, a method of adhering or adhering organic or inorganic particles or powders to the support 2 and / or the coating material 4 by heat fusion or hot melt resin is adopted. To be done. In addition to the above, the adhesion of the particles or powder includes pressing and fixing the support 2 and / or the coating material 4, the compounding of the matting agent to the film, and the sand matting. is there.

In the packaging structure of the drug-containing pressure-sensitive adhesive sheet 1 of the present invention, in order to achieve the above-mentioned object, the drug-containing pressure-sensitive adhesive sheet 1 is packaged in a packaging material 6 having irregularities 5 formed on the inner surface. It is a thing.

That is, FIG. 8 is a perspective view showing an embodiment of the packaging structure of the drug-containing adhesive sheet 1 of the present invention, and FIG. 9 is shown in FIG.
3 is an enlarged cross-sectional view taken along line YY 'of FIG.

In FIGS. 8 and 9, the packaging material 6 used for packaging the drug-containing adhesive sheet 1 of the present invention is
As shown in FIG. 9, when the packaging material 6 is pressed from the outer surface, the unevenness 7 is formed on the inner surface thereof.

By the way, the drug-containing adhesive sheet 1 of the present invention
In the packaging structure, the above-mentioned drug-containing pressure-sensitive adhesive sheet 1 is packaged in a specific packaging material 6, and therefore the description of the drug-containing pressure-sensitive adhesive sheet 1 will be omitted because it is redundant.

The material for producing the packaging material 6 is not particularly limited as long as it is in the form of a film or sheet, but a material having heat sealability is preferable. From this viewpoint, Specifically, a packaging material using a heat-sealable plastic sheet such as polyethylene, surlyn, an ethylene vinyl acetate copolymer, an ethylene vinyl alcohol copolymer, or hytron can be used. In particular, in order to prevent volatilization or decomposition of the drug for transdermal absorption contained in the drug-containing pressure-sensitive adhesive sheet 1 to be contained, it is preferable to laminate an impermeable film such as a polyester film or a metal foil.

Needless to say, a permeable sheet such as paper or non-woven fabric may be laminated as long as the drug does not vaporize or decompose. The thickness of the film-shaped or sheet-shaped material is usually about 10 to 200 μm.

Further, in this packaging structure, the drug-containing pressure-sensitive adhesive sheet 1 is packaged in the packaging material 6 having the irregularities 7 formed on the inner surface, so that the drug-containing pressure-sensitive adhesive sheet 1 and the inner surface of the packaging material 6 are separated from each other. The substantial contact area is further reduced, that is, the adhesive area or the adhered area between the drug-containing pressure-sensitive adhesive sheet 1 and the inner surface of the packaging material 6 is further reduced, and the drug-containing pressure-sensitive adhesive sheet 1 can be taken out very easily during use.

[0045]

The drug-containing pressure-sensitive adhesive sheet of the present invention comprises a support, a drug-containing pressure-sensitive adhesive layer, and a coating material laminated on the surface of the drug-containing pressure-sensitive adhesive layer. Since unevenness is formed on the side opposite to the pressure-sensitive adhesive layer side and / or the exposed surface of the covering material, the substantial contact area between the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material is reduced, that is, the drug-containing pressure-sensitive adhesive sheet and the packaging material. The adhesive area or the adhesive area with the inner surface of the material is reduced, and as a result, the drug-containing adhesive sheet or the adhesive sheet easily sticking out of the adhesive from the end surface,
Even when a drug-containing pressure-sensitive adhesive sheet in which a plasticizer or a liquid component is easily exuded is packaged, it becomes difficult for the drug-containing pressure-sensitive adhesive sheet to be adhered or adhered to the inner surface of the packaging material. Of.

Further, in the packaging structure for a drug-containing pressure-sensitive adhesive sheet of the present invention, since the drug-containing pressure-sensitive adhesive sheet is packaged in a packaging material having irregularities formed on the inner surface, the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material are Substantially less contact area with, that is, the adhesive area between the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material or the adhesion area is further reduced, and as a result, a drug-containing pressure-sensitive adhesive sheet from which adhesive sticking out from the end face easily occurs, Even when a drug-containing pressure-sensitive adhesive sheet in which a plasticizer or liquid component easily exudes is packed, it becomes difficult to stick or adhere to the inner surface of the packaging material, so that it becomes easier to take out when using the encapsulated drug-containing pressure-sensitive adhesive sheet. It has an effect.

[Brief description of drawings]

FIG. 1 is a perspective view showing a drug-containing pressure-sensitive adhesive sheet according to an embodiment of the present invention from the support side.

FIG. 2 is a perspective view showing the drug-containing pressure-sensitive adhesive sheet of FIG. 1 from the coating material side.

FIG. 3 is a cross-sectional view taken along line XX ′ of FIG.

FIG. 4 is a perspective view showing a drug-containing pressure-sensitive adhesive sheet according to another embodiment of the present invention from the support side.

5 is a perspective view showing the drug-containing pressure-sensitive adhesive sheet of FIG. 4 from the coating material side.

FIG. 6 is a perspective view showing a drug-containing pressure-sensitive adhesive sheet according to still another embodiment of the present invention from the support side.

FIG. 7 is a perspective view showing the drug-containing pressure-sensitive adhesive sheet of FIG. 6 from the coating material side.

FIG. 8 is a perspective view showing a packaging structure of a drug-containing pressure-sensitive adhesive sheet according to an example of the present invention.

9 is a cross-sectional view taken along line YY 'of FIG.

[Explanation of symbols]

 1 Drug-Containing Adhesive Sheet 2 Support 3 Adhesive Layer 4 Covering Material 5 Unevenness 6 Packaging Material 7 Unevenness 8 Heat Seal Section

Front page continuation (72) Inventor Saburo Otsuka 1-2 1-2 Shimohozumi, Ibaraki City, Osaka Prefecture Nitto Denko Corporation

Claims (11)

[Claims] 1. A drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a coating material laminated on the surface of the drug-containing pressure-sensitive adhesive layer, the side opposite to the drug-containing pressure-sensitive adhesive layer side of the support and / or Alternatively, a drug-containing pressure-sensitive adhesive sheet, wherein unevenness is formed on the exposed surface of the covering material. 2. The drug-containing pressure-sensitive adhesive sheet according to claim 1, wherein the unevenness of the support and / or the covering material is formed by pressing. 3. The drug-containing pressure-sensitive adhesive sheet according to claim 1, wherein the irregularities of the support and / or the covering material are formed by printing. 4. The drug-containing adhesive according to claim 3, wherein the unevenness of the support and / or the covering material is printed by using an ink formed of a foaming resin and is formed by foaming of the printed portion. Sheet. 5. The drug-containing pressure-sensitive adhesive sheet according to claim 1, wherein the irregularities of the support and / or the covering material are formed by adhering or adhering organic or inorganic particles or powders. 6. The drug-containing pressure-sensitive adhesive sheet according to claim 1, wherein the unevenness of the support and / or the covering material is formed by an unevenness forming member laminated on the surface of the support and / or the covering material. 7. The drug-containing pressure-sensitive adhesive sheet according to claim 6, wherein the unevenness forming member is a woven fabric or a non-woven fabric. 8. In the unevenness of the support and / or the covering material, this convex portion is 5 of the entire surface of the support and / or the covering material.
The content of the drug-containing pressure-sensitive adhesive sheet according to any one of claims 1 to 7, which is about 90%. 9. The drug according to claim 1, wherein in the unevenness of the support and / or the covering material, the pitch of the convex portions is 0.1 to 20 mm and the height is 2 μm to 1 mm. Containing adhesive sheet. 10. A packaging structure for a drug-containing pressure-sensitive adhesive sheet, wherein the drug-containing pressure-sensitive adhesive sheet according to any one of claims 1 to 9 is packaged in a packaging material having irregularities formed on the inner surface. 11. The unevenness on the inner surface of the packaging material, wherein the pitch of the convex portions is 0.1 to 20 mm and the height is 2 μm.
The packaging structure for a drug-containing pressure-sensitive adhesive sheet according to claim 10, which has a size of ˜1 mm.