JPH07116020B2 - Liquid crystal type external base - Google Patents
Liquid crystal type external baseInfo
- Publication number
- JPH07116020B2 JPH07116020B2 JP62123349A JP12334987A JPH07116020B2 JP H07116020 B2 JPH07116020 B2 JP H07116020B2 JP 62123349 A JP62123349 A JP 62123349A JP 12334987 A JP12334987 A JP 12334987A JP H07116020 B2 JPH07116020 B2 JP H07116020B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid crystal
- crystal structure
- poe
- present
- external base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K19/54—Additives having no specific mesophase characterised by their chemical composition
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/52—Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives with special physical aspect: solvents, solid particles
- C09K2019/528—Surfactants
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は、液晶型外用基剤に関するものであり詳しくは
高級アルコールを含む特定成分からなる液晶構造体をと
ることにより透明感があり硬度の温度依存性が少なく優
れた経時安定性を有し，塗布時のべたつきがなくさっぱ
りした使用感を得ることを特徴とする液晶型外用基剤に
関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial application] The present invention relates to a liquid crystal type external base material, and more specifically, a liquid crystal structure composed of a specific component containing a higher alcohol is used to provide a transparent feeling and hardness. The present invention relates to a liquid crystal type external base material which has a low temperature dependency, excellent stability over time, and is free from stickiness during application and provides a refreshing feeling of use.
［従来の技術］ 高級アルコールは外用基剤として広く一般に利用されて
いる。例えば，吸水性軟膏や親水性軟膏等の乳剤性軟膏
では，高級アルコールの配合によりさっぱりした使用感
を付与できるとともに，系の増粘を促し軟膏の安定性を
高める効果が期待できる。また，この効果は高級アルコ
ールが軟膏中で液晶構造体をとることによることがよく
知られている。[Prior Art] Higher alcohols are widely used as a base for external use. For example, in an emulsified ointment such as a water-absorbent ointment or a hydrophilic ointment, the effect of enhancing the viscosity of the system and enhancing the stability of the ointment can be expected by adding a higher alcohol to give a refreshing feeling. It is also well known that this effect is due to the higher alcohol taking a liquid crystal structure in the ointment.
［発明が解決しようとする問題点］ しかしながら，高級アルコールはあくまでも乳化安定助
剤として用いられるものであり，高級アルコールの液晶
構造体は非常に不安定であり，高級アルコールだけで外
用基剤を得ようとすると耐温性特に高温側である40℃前
後の安定性が悪く液晶構造の破壊によるパール様の光沢
を持つ結晶の析出，粘度低下等の問題を引き起こした。
これらの欠点を解決する方法としては高級アルコールの
配合量を抑えパラフィン，ワセリン等常温で固体の炭化
水素類を配合したり，アラビアゴム，カルボキシビニル
ポリマー，ヒドロキシプロピルセルロース等の水溶性高
分子を利用する場合があるが，これらの添加物を利用す
ると液晶構造体は白濁して液晶特有の透明感が失われ
る。さらに，系の安定性を向上させるためにこれらの添
加剤を多量に使用した場合，べたつきが増してさっぱり
した使用感が得られない。[Problems to be Solved by the Invention] However, higher alcohols are used only as an emulsion stabilizing aid, and the liquid crystal structure of higher alcohols is very unstable. This resulted in problems such as poor temperature resistance, especially around 40 ° C, which is the high temperature side, and precipitation of crystals with a pearly luster due to the destruction of the liquid crystal structure and a decrease in viscosity.
As a method to solve these drawbacks, the amount of higher alcohol is reduced and paraffin, petrolatum, and other solid hydrocarbons are blended at room temperature, and water-soluble polymers such as gum arabic, carboxyvinyl polymer, and hydroxypropyl cellulose are used. However, when these additives are used, the liquid crystal structure becomes cloudy and the transparency characteristic of the liquid crystal is lost. Furthermore, when a large amount of these additives is used in order to improve the stability of the system, the stickiness increases and a refreshing feeling is not obtained.
本発明者らはこうした事情に鑑み，炭化水素類や水溶性
高分子類を使用しなくとも経日による結晶転移や硬度の
変化がなく，しかもさっぱりした使用感で透明感のある
安定な高級アルコールの液晶型外用基剤を得るべく鋭意
研究を重ねた結果高級アルコール，脂肪酸，親油性非イ
オン界面活性剤，親水性非イオン界面活性剤，多価アル
コール及び水から得られる安定な高級アルコールの液晶
型外用基剤が上記目的を達せられることを見出し，この
知見に基づいて本発明を完成した。In view of these circumstances, the present inventors have found that, even without using hydrocarbons or water-soluble polymers, there is no crystal transition or hardness change with time, and a stable higher alcohol with a refreshing feeling and transparency. As a result of earnest research to obtain a liquid crystal type external base material, a stable higher alcohol liquid crystal obtained from higher alcohols, fatty acids, lipophilic nonionic surfactants, hydrophilic nonionic surfactants, polyhydric alcohols and water The present invention has been completed based on the finding that a base for external use of a mold can achieve the above object.
［問題を解決する手段］ すなわち，本発明は高級アルコール，高級アルコールに
対し重量で0.1〜0.8倍量の脂肪酸，親油性非イオン界面
活性剤，親水性非イオン界面活性剤，多価アルコール及
び水からなり、炭化水素および水溶性高分子を配合しな
いことを特徴とする透明な液晶型外用基剤である。[Means for Solving Problems] That is, the present invention relates to higher alcohols, 0.1 to 0.8 times by weight of fatty acids, higher amounts of fatty acids, lipophilic nonionic surfactants, hydrophilic nonionic surfactants, polyhydric alcohols and water. It is a transparent liquid crystal external base material which is characterized by containing no hydrocarbon and water-soluble polymer.
以下，本発明について詳述する。Hereinafter, the present invention will be described in detail.
本発明で用いられる高級アルコールは炭素数14〜22の飽
和高級アルコールが挙げられる。これらは単独または二
種以上を組み合わせて使用される配合量は本発明により
得られる液晶構造体全量に対し通常１〜15重量％（以
下，単に％で示す）。好ましくは３〜10％の範囲で配合
される。１％より少ない場合には当該液晶構造体を形成
せず,15％を越える場合には液晶構造体の高温安定性が
悪くなり経日による白濁及び結晶の析出がみられる。Examples of the higher alcohol used in the present invention include saturated higher alcohols having 14 to 22 carbon atoms. These are used singly or in combination of two or more, and the compounding amount is usually 1 to 15% by weight (hereinafter, simply indicated by%) based on the total amount of the liquid crystal structure obtained by the present invention. It is preferably blended in the range of 3 to 10%. When it is less than 1%, the liquid crystal structure is not formed, and when it exceeds 15%, the high temperature stability of the liquid crystal structure is deteriorated and white turbidity and precipitation of crystals are observed over time.
本発明で用いられる脂肪酸は炭素数14〜22の飽和，不飽
和いずれでもよい直鎖又は分枝鎖の脂肪酸がもちいられ
る。これらは単独又は二種以上を組み合わせて使用され
る配合量は本発明に使用される高級アルコールに対して
重量で0.1〜0.8倍量である。当倍量未満では液晶構造体
は白濁し，当倍量を越えると結晶が析出する。The fatty acid used in the present invention is a linear or branched fatty acid having 14 to 22 carbon atoms which may be saturated or unsaturated. These are used alone or in combination of two or more, and the compounding amount is 0.1 to 0.8 times by weight with respect to the higher alcohol used in the present invention. If it is less than the equimolar amount, the liquid crystal structure becomes cloudy, and if it exceeds the equimolar amount, crystals are precipitated.
本発明で用いられる非イオン界面活性剤は,HLB値７以下
の親油性非イオン界面活性剤及びHLB値10以上の親水性
非イオン界面活性剤であり親油性非イオン界面活性剤と
親水性非イオン界面活性剤を組み合わせて使用する。親
油性非イオン界面活性剤としては，グリセリルモノステ
アレート，グリセリルジステアレート，グリセリルモノ
オレエート，グリセリルジオレエート，ジグリセリルモ
ノステアレート，ジグリセリルモノオレエート，ジグリ
セリルモノイソステアレート，ジグリセリルジオレエー
ト，ジグリセリルジイソステアレート等のグリセリン脂
肪酸エステルやポリオキシエチレン（以下,POEと略す）
２モル付加モノステアレート等のポリエチレングリコー
ル脂肪酸エステルやポリオキシエチレン３〜10モル付加
硬化ヒマシ油等を挙げることが出来る。これらは単独ま
たは二種以上を組み合わせて使用される。配合量は本発
明により得られる液晶構造体全量に対し通常0.1〜5.0
％，好ましくは0.5〜2.0％である。0.1％より少ない場
合には液晶構造体の高温安定性が悪くなり経日による白
濁及び結晶の析出がみられ,5％を越えると適度な硬度が
得られない。親水性非イオン界面活性剤としては，デカ
グリセリルモノステアレート，デカグリセリルモノオレ
エート，デカグリセリルモノイソステアレート等のデカ
グリセリン脂肪酸エステルやPOE10〜55モル付加ポリエ
チレングリコールモノステアレート,POE10モル付加ポリ
エチレングリコールモノオレエート等のPOE付加型ポリ
エチレングリコール脂肪酸エステルやPOE15モル付加グ
リセリルモノステアレート,POE15モル付加グリセリルモ
ノオレエート等のPOEグリセリン脂肪酸エステルやPOE20
〜60モル付加硬化ヒマシ油等を挙げることができる。こ
れらは単独又は二種以上を組み合わせて使用される。こ
のうちPOE付加型ポリエチレングリコール脂肪酸エステ
ルとPOE付加型硬化ヒマシ油の組み合わせが特に好まし
い。配合量は本発明により得られる液晶構造体全量に対
し通常１〜15％，好ましくは３〜10％の範囲で配合され
る。１％より少ない場合には液晶構造体は白濁し,15％
を越える場合には当該液晶構造体を形成しない。The nonionic surfactant used in the present invention is a lipophilic nonionic surfactant having an HLB value of 7 or less and a hydrophilic nonionic surfactant having an HLB value of 10 or more. Used in combination with an ionic surfactant. Lipophilic nonionic surfactants include glyceryl monostearate, glyceryl distearate, glyceryl monooleate, glyceryl dioleate, diglyceryl monostearate, diglyceryl monooleate, diglyceryl monoisostearate, diglyceryl monostearate Glyceryl fatty acid esters such as glyceryl dioleate and diglyceryl diisostearate, and polyoxyethylene (hereinafter abbreviated as POE)
Examples thereof include polyethylene glycol fatty acid esters such as 2 mol addition monostearate and polyoxyethylene 3 to 10 mol addition hydrogenated castor oil. These are used alone or in combination of two or more. The compounding amount is usually 0.1 to 5.0 with respect to the total amount of the liquid crystal structure obtained by the present invention.
%, Preferably 0.5 to 2.0%. When it is less than 0.1%, the high temperature stability of the liquid crystal structure is deteriorated and white turbidity and precipitation of crystals are observed, and when it exceeds 5%, an appropriate hardness cannot be obtained. Examples of hydrophilic nonionic surfactants include decaglyceryl fatty acid esters such as decaglyceryl monostearate, decaglyceryl monooleate, and decaglyceryl monoisostearate, and POE 10-55 mol added polyethylene glycol monostearate, POE 10 mol added polyethylene. POE-added polyethylene glycol fatty acid ester such as glycol monooleate or POE 15 mole-added glyceryl monostearate, POE 15 mole-added POE glycerin fatty acid ester such as glyceryl monooleate or POE 20
-60 mol addition hardened castor oil etc. can be mentioned. These are used alone or in combination of two or more. Of these, a combination of POE-added polyethylene glycol fatty acid ester and POE-added hydrogenated castor oil is particularly preferable. The compounding amount is usually 1 to 15%, preferably 3 to 10% with respect to the total amount of the liquid crystal structure obtained by the present invention. When it is less than 1%, the liquid crystal structure becomes cloudy and 15%
If it exceeds, the liquid crystal structure is not formed.
本発明で用いられる多価アルコールとしては，例えば，
エチレングリコール，ジエチレングリコール，トリエチ
レングリコール，ポリエチレングリコール，プロピレン
グリコール，ジプロピレングリコール，ヘキシレングリ
コール,1,3−ブチレングリコール，グリセリン，ジグリ
セリン，ポリグリセリン，グルコース，ソルビトール，
マルチトール等が挙げられる。これらは単独又は二種以
上を組み合わせて使用される。配合量は本発明により得
られる軟膏全量に対し通常１〜30％，好ましくは５〜20
％の範囲で配合される。１％より少ない場合，液晶構造
体の高温安定性が悪くなり経日とともに白濁し,30％を
越える場合には当該液晶構造体を形成しない。Examples of the polyhydric alcohol used in the present invention include, for example,
Ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, 1,3-butylene glycol, glycerin, diglycerin, polyglycerin, glucose, sorbitol,
Maltitol etc. are mentioned. These are used alone or in combination of two or more. The compounding amount is usually 1 to 30%, preferably 5 to 20% based on the total amount of the ointment obtained by the present invention.
It is blended in the range of%. When it is less than 1%, the high temperature stability of the liquid crystal structure becomes poor and becomes cloudy over time, and when it exceeds 30%, the liquid crystal structure is not formed.
本発明において液晶構造体とは高級アルコールの均一一
層のラメラー構造であり，この均一一層構造を破壊しな
い限りにおいて油分を配合することができる。In the present invention, the liquid crystal structure is a lamellar structure of higher alcohol having a uniform layer, and an oil component can be blended as long as the uniform layer structure is not destroyed.
本発明で用いられる油分は化粧品，医薬品，食品等の業
界で一般に利用されている油分の中で常温において液状
を呈するものを挙げることができる。これらは単独又は
二種以上を組み合わせて使用される。Examples of the oil component used in the present invention include those which are liquid at room temperature among the oil components generally used in the fields of cosmetics, pharmaceuticals, foods and the like. These are used alone or in combination of two or more.
油分の配合量は本発明により得られる液晶構造体全量に
対し通常0.01〜20％，好ましくは0.01〜10％である。20
％を越えて油分を配合した混合は，良好な液晶構造体を
得るために大量の界面活性剤を配合しなければならず安
全性，使用性の観点から好ましくない。The oil content is usually 0.01 to 20%, preferably 0.01 to 10%, based on the total amount of the liquid crystal structure obtained by the present invention. 20
Mixing with an oil content in excess of 10% is not preferable from the viewpoint of safety and usability because a large amount of surfactant must be added in order to obtain a good liquid crystal structure.
［実施例］ 以下，本発明を実施例によって説明する。[Examples] Hereinafter, the present invention will be described with reference to Examples.
実施例１〜３ 表１内に示したようにセタノールとステアリン酸の比が
1:0.2の実施例１では透明感のある液晶構造体が得ら
れ，高温安定性も良好であった。それに対し，ステアリ
ン酸の比が該比以下の比較例１では，透明感のある液晶
構造体は得られなかった。また，該比以上の比較例２で
は高温安定性が悪く結晶が析出した。さらに親油性非イ
オン界面活性剤を配合しなかった比較例３でも高温安定
性が悪かった。また，スクワランを配合した比較例４で
は透明性が悪かった。Examples 1-3 As shown in Table 1, the ratio of cetanol to stearic acid is
In Example 1 of 1: 0.2, a transparent liquid crystal structure was obtained, and the high temperature stability was also good. In contrast, in Comparative Example 1 in which the ratio of stearic acid was less than the ratio, a transparent liquid crystal structure could not be obtained. Further, in Comparative Example 2 in which the ratio was not less than this, the high temperature stability was poor and crystals were precipitated. Further, in Comparative Example 3 in which the lipophilic nonionic surfactant was not added, the high temperature stability was poor. Further, in Comparative Example 4 in which squalane was mixed, the transparency was poor.
実施例2,3については透明性及び高温安定性良好なもの
であった。In Examples 2 and 3, the transparency and the high temperature stability were good.
（実施例１〜3,比較例１〜４の製法） 表中〜，を70℃で加熱溶解し油相とし，これに
，を加熱混合した水相を加え，これを室温まで攪拌
冷却して表中実施例１〜３及び比較例１〜４を得た。 (Manufacturing methods of Examples 1 to 3 and Comparative Examples 1 to 4) In Tables 1 to 3 were dissolved by heating at 70 ° C to form an oil phase, to which an aqueous phase obtained by heating and mixing was added, and the mixture was stirred and cooled to room temperature. Examples 1 to 3 and Comparative Examples 1 to 4 in the table were obtained.
実施例４ ％ セトステアリルアルコール 6 パルミチン酸 0.5 ステアリン酸 0.5 シリコンオイル 2 ジグリセリンジイソステアレート 2 POE60モル硬化ヒマシ油 2 POE45モルポリエチレングリコール モノステアレート 2 ソルビトール 5 1,3−ブチレングリコール 10 精製水 残部 実施例５ ％ セトステアリルアルコール 5 ステアリン酸 1 シリコンオイル 2 アジピン酸ジイソプロピル 2 グリセリンモノステアレート 0.5 POE50モル硬化ヒマシ油 2 POE45モルポリエチレングリコール モノステアレート 2 エタノール 10 1,3−ブチレングリコール 10 精製水 残部 実施例６ ％ セトステアリルアルコール 5 ステアリン酸 1 シリコンオイル 2 オリーブ油 10 グリセリンモノステアレート 2.5 POE50モル硬化ヒマシ油 2 POE45モルポリエチレングリコール モノステアレート 2 グリセリン 10 ジプロピレングリコール 5 精製水 残部 実施例７ ％ セトステアリルアルコール 6 ステアリン酸 1.2 オレイン酸 2 アジピン酸ジイソプロピル 2 グリセリンモノステアレート 0.8 POE50モル硬化ヒマシ油 2 POE45モルポリエチレングリコール モノステアレート 2 グリセリン 5 1,3−ブチレングリコール 10 精製水 残部 （実施例4,5,6,7の製法） 〜の油相を70℃で加熱溶解し，そこへ70℃で加熱混
合した〜の水相を加え，これをホモミキサー，超音
波乳化器，マントンガウリン乳化器等で処理し，その後
室温で攪拌冷却して本発明品を得た。Example 4% cetostearyl alcohol 6 palmitic acid 0.5 stearic acid 0.5 silicone oil 2 diglycerin diisostearate 2 POE 60 mol hydrogenated castor oil 2 POE 45 mol polyethylene glycol monostearate 2 sorbitol 5 1,3-butylene glycol 10 purified water balance balance Example 5% cetostearyl alcohol 5 Stearic acid 1 Silicon oil 2 Diisopropyl adipate 2 Glycerine monostearate 0.5 POE 50 mol Hardened castor oil 2 POE 45 mol Polyethylene glycol monostearate 2 Ethanol 10 1,3-butylene glycol 10 Purified water balance Example 6% cetostearyl alcohol 5 stearic acid 1 silicone oil 2 olive oil 10 glycerine monostearate 2.5 POE 50 mole hydrogenated castor oil 2 POE 45 mole polyethylene glycol monostearate 2 glycerin 10 Dipropylene glycol 5 Purified water Remainder Example 7 %% cetostearyl alcohol 6 Stearic acid 1.2 Oleic acid 2 Diisopropyl adipate 2 Glycerin monostearate 0.8 POE 50 mol Hydrogenated castor oil 2 POE 45 mol Polyethylene glycol monostearate 2 Glycerin 5 1,3- Butylene glycol 10 Purified water balance (production method of Examples 4,5,6,7) The oil phase of ~ was dissolved by heating at 70 ° C, and the aqueous phase of ~ mixed by heating at 70 ° C was added thereto, and this was mixed with a homomixer. , An ultrasonic emulsifier, a Mantongaurin emulsifier, etc., and then stirred and cooled at room temperature to obtain the product of the present invention.
実施例４〜７の発明品は，透明性及び高温安定性良好な
ものであった。The invention products of Examples 4 to 7 had good transparency and high-temperature stability.
［発明の効果］ 以上の実施例でわかるように本発明は，経日による結晶
転移や硬度の変化がなく，しかもさっぱりした使用感で
透明感のある安定な高級アルコールの液晶型外用基剤で
ある。[Effects of the Invention] As can be seen from the above examples, the present invention is a stable higher alcohol liquid crystal type external base material which has no crystal transition or hardness change over time and has a refreshing feeling and transparency. is there.
また，本発明品は油溶性薬物を安定に配合することがで
きるため，各種医薬品の基剤として利用することができ
るものである。Further, since the product of the present invention can be stably blended with an oil-soluble drug, it can be used as a base for various pharmaceuticals.
Claims (1)
量で0.1〜0.8倍量の脂肪酸，親油性非イオン界面活性
剤，親水性非イオン界面活性剤，多価アルコール及び水
からなり、炭化水素および水溶性高分子を配合しないこ
とを特徴とする透明な液晶型外用基剤。1. A higher alcohol, which comprises 0.1 to 0.8 times the weight of a fatty acid, a lipophilic nonionic surfactant, a hydrophilic nonionic surfactant, a polyhydric alcohol and water, and a hydrocarbon and a water-soluble substance. A transparent liquid crystal external base material which is characterized by not containing a hydrophilic polymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62123349A JPH07116020B2 (en) | 1987-05-20 | 1987-05-20 | Liquid crystal type external base |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62123349A JPH07116020B2 (en) | 1987-05-20 | 1987-05-20 | Liquid crystal type external base |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63287718A JPS63287718A (en) | 1988-11-24 |
| JPH07116020B2 true JPH07116020B2 (en) | 1995-12-13 |
Family
ID=14858367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62123349A Expired - Lifetime JPH07116020B2 (en) | 1987-05-20 | 1987-05-20 | Liquid crystal type external base |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07116020B2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2709666B1 (en) * | 1993-09-07 | 1995-10-13 | Oreal | Cosmetic or dermatological composition consisting of an oil-in-water emulsion based on oily globules provided with a lamellar liquid crystal coating. |
| EP0833606B1 (en) * | 1995-06-22 | 2003-10-01 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
| JP5599127B2 (en) * | 2001-07-30 | 2014-10-01 | ホーユー株式会社 | Depigmenting agent composition, hair dye composition and hair straightener composition |
| JP4832036B2 (en) * | 2004-09-22 | 2011-12-07 | 花王株式会社 | Skin cleanser |
| JP5147098B2 (en) * | 2005-06-03 | 2013-02-20 | マルホ株式会社 | Liquid crystal emulsified composition |
| JP4918251B2 (en) * | 2005-12-02 | 2012-04-18 | 株式会社ナリス化粧品 | Cosmetics containing liquid crystal composition |
| JP3987552B2 (en) * | 2005-12-22 | 2007-10-10 | 憲司 中村 | Method for producing liquid crystal emulsion composition |
| JP3987551B2 (en) * | 2005-12-22 | 2007-10-10 | 憲司 中村 | Method for producing liquid crystal emulsion composition |
| EP2193798A1 (en) * | 2007-09-10 | 2010-06-09 | Maruho Co., Ltd. | Liquid crystal emulsion-type pharmaceutical composition containing cyclosporine, and method of treating cutaneous disease therewith |
| JP5614921B2 (en) * | 2008-06-17 | 2014-10-29 | 株式会社セプテム総研 | Liquid crystal lamellar cosmetic composition and cosmetic containing the same |
| JP2013049635A (en) * | 2011-08-30 | 2013-03-14 | Hoyu Co Ltd | Liquid crystal structure for moisturizing skin, and skin care composition |
| JP6355296B2 (en) * | 2013-04-09 | 2018-07-11 | ホーユー株式会社 | Skin preparation for external use |
| JP6713255B2 (en) * | 2015-06-23 | 2020-06-24 | ポーラ化成工業株式会社 | LCD cosmetics |
| KR20190093562A (en) * | 2016-12-01 | 2019-08-09 | 마루호 코 엘티디 | Medical external preparations |
| JP7162544B2 (en) * | 2019-01-29 | 2022-10-28 | 株式会社 資生堂 | Cloudy cosmetics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5784729A (en) * | 1980-11-13 | 1982-05-27 | Matsumoto Seiyaku Kogyo Kk | Water holding base and preparation thereof |
-
1987
- 1987-05-20 JP JP62123349A patent/JPH07116020B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63287718A (en) | 1988-11-24 |
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