JPH0687271U - Liquid container - Google Patents

Abstract

(57) [Summary] [Purpose] To provide a plastic liquid container capable of maintaining a chemical solution such as an amino acid solution in a substantially oxygen-free state for a certain period of time. [Structure] A resin inner bag filled with an amino acid solution is enclosed in a resin outer bag, and a deoxidizer is placed in a space between the inner bag and the outer bag. Since the resin material is oxygen permeable, oxygen in the air permeates the outer bag, but is absorbed by the oxygen scavenger and prevented from entering the amino acid solution in the inner bag. Further, the space between the inner bag and the outer bag may be filled with an inert gas or may be evacuated.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to a liquid container containing a drug solution such as an amino acid solution.

[0002]

[Prior art]

 In recent years, a high-calorie infusion method has been widely used in which all nutrients required by the living body are ingested through a vein. The high calorie infusion method is applied to a wide range of cases where oral ingestion such as gastrointestinal suture insufficiency or gastrointestinal transit disorder is inadequate or impossible, or when oral intake such as inflammatory bowel disease or severe diarrhea is not preferable. This is the case when high calorie supplementation that exceeds enteral supplementation such as burns and severe trauma is desired, and when the specificity of metabolism due to diseases such as liver failure / kidney failure and glycogen storage disease is applied.

The high-calorie infusion used in the high-calorie infusion method basically contains all the nutrients necessary for the living body in an appropriate amount. That is, it is a multi-component infusion containing sugars, amino acids, main electrolytes, trace metals and vitamins. However, it is currently impossible to commercialize a composite liquid containing all of these in terms of mixability and stability. Therefore, the following three methods are currently used. (1) Use a commercially available basic solution for high calorie infusion. This basic solution is a high-concentration glucose solution mixed with the main electrolyte, and when used, it is mixed with amino acids and added with vitamins and insufficient electrolyte. (2) A commercially available hypertonic glucose solution and an amino acid solution are mixed, or these are combined and administered. (3) Prepare the basic solution for high-calorie infusion or glucose solution independently in a pharmacy formulation room.

That is, in any case, the amino acid solution is mixed with the basic solution for high calorie infusion or the hypertonic glucose solution. The amino acid solutions currently on the market include those containing glass beads and those containing plastic containers.

Of the essential amino acids contained in the amino acid solution, tryptophan has an indole nucleus in the side chain, and when other amino acids, saccharides, and aldehydes coexist in the presence of O ₂ , these tryptophans form carbonyl groups. It condenses with the indole nucleus and becomes colored. In order to prevent the condensation of this tryptophan with other amino acids, sugars and aldehydes, the amino acid solution is N ₂ substituted. If it is in a glass bottle, once it is replaced with N ₂ , the glass does not permeate gas, so the state where O ₂ is not substantially present in the amino acid solution is maintained for a long period of time. can do.

[0006]

[Problems to be solved by the device]

However, in plastic containers, most plastic materials are gas permeable, so even if O ₂ in the container is replaced with N ₂ once, it will not be stored during high pressure steam sterilization or during storage. There was a problem that O ₂ gas in the air permeated into the amino acid solution through the plastic container and was colored.

[0007]

[Means for Solving the Problems]

 Therefore, the present invention solves the above-mentioned drawbacks of the prior art, and provides a liquid container that is made of plastic and can maintain a chemical solution such as an amino acid solution in a substantially oxygen-free state for a certain period of time. To aim.

That is, the liquid container according to the present invention has a double structure of a resin inner bag for filling a chemical solution and a resin outer bag for enclosing the liquid, and is installed in a space formed between the inner bag and the outer bag. It is characterized in that an oxygen agent is enclosed in the space to form a space layer that is maintained in an anoxic state for a certain period of time to prevent oxygen in the air from entering the inner bag.

Oxygen in the air can permeate through the plastic forming the outer bag and enter the space between the inner bag and the outer bag, but since it is absorbed by the oxygen scavenger placed in this space, This space remains substantially anoxic. Therefore, although the inner bag is also made of plastic, it is possible to prevent oxygen from entering the drug solution, which is the content.

Furthermore, the space between the inner bag and the outer bag can be filled with an inert gas or the space can be evacuated.

[0011]

【Example】

 An amino acid solution container according to an embodiment of the present invention is shown in FIG. In this amino acid liquid container 1, a plastic inner bag 2 containing an amino acid liquid 5 is enclosed in a plastic outer bag 3, and a space formed between the inner bag 2 and the outer bag 3. An oxygen absorber 4 is placed in the.

The method for producing the amino acid liquid container 1 is as follows. That is, when the inner bag 2 is filled with the amino acid solution 5 through the outlet 6, nitrogen gas is simultaneously blown into the inner bag 2 so that the inner bag 2 is filled with oxygen so that oxygen does not exist in the inner bag 2. (Not shown). The inner bag 2 thus filled with the amino acid solution 5 is subjected to autoclave high-pressure steam sterilization.

In high-pressure steam sterilization treatment, air is usually sent into the autoclave in order to increase the pressure in the autoclave, but the oxygen present in the air causes the amino acid solution 5 to color during autoclave sterilization. Therefore, instead of air, nitrogen gas is sent into the autoclave to raise the pressure.

After sterilization, the inner bag 2 filled with the amino acid solution 5 is accommodated in the outer bag 3 together with the oxygen scavenger 4, and then the end portion of the outer bag 3 is sealed. At this time, the space formed between the inner bag 2 and the outer bag 3 may be filled with nitrogen gas or may be evacuated.

When sterilization is performed in a tower autoclave, the water may be replaced with nitrogen. Also, when performing sterilization with a funnel, replace the water with nitrogen.

As another manufacturing method, after the inner bag 2 filled with the amino acid solution 5 is obtained as described above, the inner bag 2 is put in the outer bag 3 together with the oxygen scavenger 4 and the end of the outer bag 3 is filled. Seal the part. At this time, similarly, the space formed between the inner bag 2 and the outer bag 3 may be filled with nitrogen gas or may be evacuated.

Next, this is sterilized by an autoclave. In the case of this method, since the oxygen absorber 4 is already enclosed in the space between the inner bag 2 and the outer bag 3, the air in the autoclave can be increased in the same manner as in the conventional method in order to increase the pressure in the autoclave. You can send it in. Of course, nitrogen gas may be fed in as in the above case. Also, when sterilizing with a tower autoclave or a funnel mat, it may be carried out in the same manner as in the conventional method, or the water may be replaced with nitrogen in the same manner as described above.

Any deoxidizing agent 4 may be used. For example, a deoxidizing agent containing iron as a main component and deoxidizing into iron oxide by contact with oxygen is used. As an example, a product commercially available from Mitsubishi Gas Chemical Co., Inc. under the trade name of "Ageless" is used.

Examples of the plastic material forming the inner bag 2 include olefin resins such as polyethylene and polypropylene, soft polyvinyl chloride resin, ethylene-vinyl acetate resin and the like.

Examples of the plastic material forming the outer bag 3 include olefin resins such as polyethylene and polypropylene, soft polyvinyl chloride resins, ethylene-vinyl acetate resins, styrene resins and polyesters.

[0021]

[Effect of device]

 According to the present invention, even though it is a plastic container, the content liquid such as the amino acid liquid can be maintained in the anoxic state for a long period of time, and the color reaction of the amino acid due to oxygen can be prevented and stable. The amino acid solution can be stored in the state.

Since it is made of plastic, it is lightweight and convenient for transportation, and since it is transparent, the state of the content liquid can be easily confirmed.

[Brief description of drawings]

FIG. 1 is a schematic view of a liquid container according to an embodiment of the present invention.

[Explanation of symbols]

 1 Liquid container 2 Inner bag 3 Outer bag 4 Oxygen absorber 5 Amino acid liquid 6 Discharge port

Claims (3)

[Scope of utility model registration request] 1. A double structure of a resin-made inner bag for filling a chemical solution and a resin-made outer bag for wrapping the same, wherein an oxygen scavenger is enclosed in a space formed between the inner bag and the outer bag. A liquid container characterized in that the space is a space layer that is maintained in an oxygen-free state for a certain period of time, and is configured to prevent oxygen in the air from entering the inner bag. 2. The liquid container according to claim 1, wherein the space is filled with an inert gas. 3. The liquid container according to claim 1, wherein the space is evacuated.