JPH0683033U - Adhesive tape - Google Patents

Abstract

(57) [Summary] [Purpose] An adhesive tape that does not peel off even when it is applied to a flexion such as a joint for a long time. A pressure-sensitive adhesive tape having a pressure-sensitive adhesive layer on one surface of a support, the support being made of a non-woven fabric having a basis weight of 10 to 600 g / m ² , and a heat-sealing portion having a constant width on the peripheral edge of the support. Is provided, and the area of the heat-sealed portion is 1 of the surface area of the support.
Corresponds to ~ 50%.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to an adhesive tape mainly used for medical purposes.

[0002]

[Prior art]

 BACKGROUND ART Adhesive tapes used for medical purposes are used for protection of wound skin or for containing various drugs in an adhesive layer for therapeutic purposes. Especially when adhesive tape used for treatment of joint pain is applied to joints such as knees and elbows for a long time, the adhesive tape may have a tensile force due to flexion and extension of joints, or a frictional force with clothes. To work.

Due to such a frictional force, peeling occurs on the peripheral portion of the adhesive tape attached to the skin surface, and once peeling occurs, continuous friction with clothes causes the peeling to proceed in a chain to form a curl. There was a problem that it turned up and finally the entire adhesive tape peeled off.

As a measure against such a problem, the following various methods have been studied. Japanese Utility Model Publication No. 63-742 discloses a method of rolling the periphery of a soft resin foam sheet support having closed cells by heat treatment to form an extremely thin edge. However, it is difficult to completely prevent peeling due to friction with clothes by forming an extremely thin edge, and since the resin foam sheet with closed cells has extremely poor air permeability, the skin gets wet during application. It is not preferable as an adhesive tape support because it may cause a rash or a rash.

Further, Japanese Utility Model Laid-Open No. 3-6431 discloses an adhesive tape in which a peripheral portion of a support is coated with an adhesive having a higher strength than other portions. However, such an adhesive tape has a manufacturing method. There was a problem that it became complicated and difficult to mass-produce.

Further, Japanese Utility Model Publication No. 61-164225 discloses an adhesive tape in which a belt-shaped reinforcing base material is laminated on a peripheral portion or a corner portion of a support. Had a problem that the manufacturing method was complicated and mass production was difficult.

[0007]

[Problems to be solved by the device]

 The present invention has been made in view of the above problems, and an object of the present invention is to provide an adhesive tape that does not peel off even when it is attached to a bending portion such as a joint for a long time.

[0008]

[Means for Solving the Problems]

 The adhesive tape of the present invention has a non-woven fabric as a support and an adhesive layer provided on one surface of the support.

The pressure-sensitive adhesive used in the pressure-sensitive adhesive layer is not particularly limited as long as it exhibits pressure-sensitive adhesiveness at room temperature, and examples thereof include acrylic-based, rubber-based, and silicone-based pressure-sensitive adhesives. To be

Examples of the acrylic pressure-sensitive adhesive include (meth) acrylic acid alkyl ester monomers obtained from aliphatic alcohols having 1 to 18 carbon atoms and (meth) acrylic acid, N-vinyl-2-pyrrolidone and other functional groups. A copolymer with a polymerizable monomer is preferable.

Examples of the (meth) acrylic acid alkyl ester monomer include methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, isobutyl (meth) acrylate, and (meth) acrylic acid. Hexyl, octyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, isooctyl (meth) acrylate, decyl (meth) acrylate, isodecyl (meth) acrylate, lauryl (meth) acrylate, (meth ) Stearyl acrylate and the like can be mentioned, and one kind or two or more kinds thereof are used.

When the proportion of N-vinyl-2-pyrrolidone in the above-mentioned copolymer is low, the drug release-accelerating effect is not sufficiently exerted, and when it is high, the tackiness is insufficient. .

Examples of the other functional monomer include a monomer having a hydroxyl group, a monomer having an amide group, a monomer having an amino group, and the like.

Examples of the monomer having a hydroxyl group include hydroxyalkyl (meth) acrylate such as 2-hydroxyethyl (meth) acrylate and hydroxypropyl (meth) acrylate. Examples of the amide group-containing monomer include acrylamides such as acrylamide, dimethyl acrylamide and diethyl acrylamide; alkoxymethyl (meth) acrylamides such as N-ethoxymethyl acrylamide and N-butoxymethyl acrylamide; and diacetone acrylamide. Examples of the monomer having an amino group include dimethylaminoethyl acrylate and the like.

Examples of functional monomers other than the above include vinyl acetate, vinyl acrylate, styrene, α-methylstyrene, vinyl chloride, acrylonitrile, ethylene, propylene, butadiene and the like.

The proportion of the other functional monomer in the above copolymer is preferably 49% by weight or less.

If desired, a polyfunctional monomer may be added to the acrylic pressure-sensitive adhesive. Addition of such a polyfunctional monomer causes a slight amount of cross-linking between the produced copolymers and increases the cohesive force of the adhesive, so that there is almost no relation to the properties of the adhered site or the amount of sweat. In addition, it is possible to prevent adhesive residue when the adhesive tape is peeled off, and to suppress skin irritation.

Examples of the above polyfunctional monomers include di (meth) acrylates obtained by reacting (meth) acrylic acid with polymethylene glycols such as hexamethylene glycol and octamethylene glycol; polyethylene glycol and polypropylene glycol. (Meth) acrylates obtained by reacting polyalkylene glycols such as (meth) acrylic acid; tri (meth) acrylates such as trimethylolpropane tri (meth) acrylate and glycerin tri (meth) acrylate; Examples include tetra (meth) acrylates such as pentaerythritol tetra (meth) acrylate. These polyfunctional monomers may be used alone or in combination of two or more.

When the amount of the polyfunctional monomer added is small, the effect of improving the internal cohesive force due to crosslinking is small, and when the amount is large, the acrylic adhesive causes gelation and adversely affects the diffusion and release of the drug. 0.005 to 0 .. based on 100 parts by weight of the copolymer. 5 parts by weight is preferred.

The above-mentioned rubber-based pressure-sensitive adhesive is not particularly limited as long as it has a pressure-sensitive adhesive property at room temperature, but includes, for example, a base polymer such as natural rubber, synthetic rubber, rubber elastic body and a tackifying resin. Is preferred.

Examples of the synthetic rubber include styrene-isoprene block copolymers such as styrene-isoprene block copolymers and styrene-isoprene-styrene block copolymers; styrene-butadiene block copolymers and styrene-butadiene-styrene. Block copolymers, styrene-ethylene-butadiene-styrene block copolymers, and other styrene-butadiene block copolymers.

Examples of the rubber elastic body include polyisoprene, polybutene, polyisobutylene, and ethylene-vinyl acetate copolymer.

Examples of the tackifying resin include rosin-based resins, polyterpene resins, coumarone-indene resins, petroleum-based resins, and terpene-phenol resins.

In the rubber-based pressure-sensitive adhesive composition, when the amount of the tackifying resin is small, the internal cohesive force is high and the adhesive force is insufficient, and when the amount is large, the internal cohesive force is decreased and cohesive failure occurs. 20 to 200 parts by weight is preferable with respect to parts.

The rubber-based pressure-sensitive adhesive composition may include, if necessary, a softening agent such as liquid polybutene, mineral oil, lanolin, liquid polyisoprene, and liquid polyacrylate; a filler such as titanium oxide; butylhydroxyltoluene and the like. Anti-aging agents and the like may be added.

The silicone-based pressure-sensitive adhesive is not particularly limited as long as it has pressure-sensitive adhesive properties at room temperature, and examples thereof include those containing polydimethylsiloxane as a main component.

Further, a plasticizer, a filler, an antiaging agent, etc. may be added to the acrylic, rubber and silicone pressure-sensitive adhesives, if necessary.

The material of the non-woven fabric used for the above-mentioned support is not particularly limited as long as it does not impair the performance of the adhesive tape and has heat fusion properties, and examples thereof include polyethylene terephthalate, polyester, polyolefin and acetic acid. Examples thereof include vinyl-vinyl chloride copolymer, polyamide, ethylene-vinyl acetate copolymer, plasticized polyvinyl chloride, polyvinylidene chloride, rayon and the like.

As the above-mentioned support, a non-woven fabric made of polyethylene terephthalate, polyester, polyolefin, rayon or the like is used from the viewpoints of drug non-migration property, chemical resistance, moisture resistance, dimensional stability, dyeability, price and the like. preferable.

When the unit weight of the above-mentioned non-woven fabric becomes smaller, the thickness becomes thinner, so that the rigidity cannot be improved by the heat fusion treatment described later, and peeling during sticking cannot be prevented. There so reduced, it is limited to 10~600g / m ^2.

A heat-sealing portion is provided on the peripheral portion of the support by heating and pressurizing the support with a constant width. By forming such a heat-sealed part, the surface of the fibers that make up the non-woven fabric are melted, and adjacent fibers are fused and the rigidity of the support is improved, so peeling from the peripheral edge of the adhesive tape is prevented. To be done. It is preferable that such a heat-sealed portion is continuously provided on the entire peripheral portion of the support.

When the area of the heat-sealing portion is small, the peeling of the adhesive tape cannot be prevented, and when it is large, the adhesive tape gives a feeling of strangeness that follows the skin, and is therefore 1 to 50% of the surface area of the support. It is preferably 5 to 40%.

For example, when the size of the support is a rectangle of 10 × 14 cm ² , the heat-sealed portion is 1. The width is preferably 6 to 12.7 mm and is preferably provided continuously to the peripheral portions of the four sides.

Examples of the heat fusion method include a method in which the nonwoven fabric is heated to the melting temperature of the fibers and pressed. The heating temperature and pressure during heat fusion are determined by the melting temperature of the fibers that make up the non-woven fabric.If the heating temperature and pressure are low, the fusion of the fibers will be insufficient, and if the heating temperature and pressure are high, the fibers will be excessively fused. As a result, the rigidity becomes too high and the fiber breaks, so 100 to 300 ° C. and 0.5 to 50 kg / cm ² are generally preferable.

The heat-sealing portion may be provided either before or after the pressure-sensitive adhesive layer is formed on the support.

In order to protect the pressure-sensitive adhesive layer of the pressure-sensitive adhesive tape, release paper may be laminated on the pressure-sensitive adhesive layer. Examples of the release paper include those obtained by subjecting the surface of a polyethylene terephthalate film to silicon treatment, and those obtained by subjecting the polyethylene surface of a laminate of paper and polyethylene to silicone. The thickness of the release paper is preferably 1000 μm or less and 20 to 200 μm.

The adhesive layer of the adhesive tape may contain various drugs for the purpose of treatment. The drug is not particularly limited as long as it can penetrate the skin, and examples thereof include nonsteroidal antipyretic and antiphlogistic analgesics, steroidal antiinflammatory drugs, vasodilators, hypertensive / arrhythmic agents, antihypertensive agents, antitussive and antitussive agents. , Antitumor agents, local anesthetics, hormones, asthma / nasal allergy treatments, antihistamines, anticoagulants, antispasmodics, cerebral circulation / metabolic agents, antidepressants / anxiolytics, vitamin D preparations, hypoglycemic agents, Antiulcer agents, hypnotics, muscle relaxants, constituent substances and the like can be mentioned.

The non-steroidal antipyretic and anti-inflammatory analgesics include indomethacin, ketoprofen, aspirin, acetaminophenone, diclofenac sodium, ibuprofen, sulindac, naproxen, ferfenamic acid, ibufenac, fenbufen, alclofenac, phenylbutazone, Mefenamic acid, benzdac, piroxicam, flurbiprofen, pentazocine, buprenorphine hydrochloride, butorphanol tartrate and the like can be mentioned.

Examples of the above-mentioned steroidal anti-inflammatory agents include hydrocortisone, prednisolone, fluocinolone acetonide, fludroxycortide, methylprednisolone, hydrocortisone acetate, triamcinolone acetonide, dexamethasone, betamethasone acetate, and yoshi. Examples include diflucortron herbate, clobetasol propionate, fluocinonide, and the like.

Examples of the vasodilator include diltiazem, diltiazem hydrochloride, verapamil, pentaerythritol tetranitrate, dipyridamole, isosorbide dinitrate, nifedipine, nitroglycerin and the like.

Examples of the above-mentioned hypertensive / arrhythmic agents include propanol, atenolol, pindolol, quinidine sulfate, ajmaline, alprenol hydrochloride, metoprolol tartrate, nadolol, timolol maleate, disopyramide and the like.

Examples of the above-mentioned blood pressure lowering agents include clonidine hydrochloride, captopril, prazosin hydrochloride, penbutrol sulfate, guanabenz acetate, guanfansin hydrochloride, bunazosin hydrochloride, eranbryl maleate, arotinol hydrochloride, bunitrolol hydrochloride and the like.

Examples of the above antitussive and antitussive agents include, for example, procaterol hydrochloride, terbutaline sulfate, fenoterol hydrobromide, tulobuterol hydrochloride, ambroxol hydrochloride, pirbuterol hydrochloride, mabuterol hydrochloride, clenbuterol hydrochloride, trimetquinol hydrochloride, formo fumarate. Examples include terol.

Examples of the above-mentioned antitumor agent include 5-fluorosiluracil, 1- (2-tetrahydrofuryl) -5-fluorosiluracil, mitomycin C, and the like, and the above anesthetics include benzocaine and procaine. , Lidocaine, tetracaine and the like.

Examples of the hormone agent include steroid hormones such as estrogen, estradiol, testosterone, progesterone and prostaglandin, and peptide hormones such as insulin.

Examples of the above-mentioned therapeutic agent for asthma / nasal allergy include ketotifen fumarate, azelastine hydrochloride, sodium chromoglylate, and the like, and examples of the above antihistamines include cycloheptazine hydrochloride, diphenhydramine hydrochloride, fenbenzamine, mequitazine. Etc.

Examples of the anticoagulant include heparin and the like, and examples of the antispasmodic include scopolamine, clofluperol and the like.

Examples of the cerebral circulation / metabolism improving agent include vinpocetine, flunarizine hydrochloride, nicardipine hydrochloride, brovincamine fumarate, dihydroergotoxine mesylate, ifenprodil tartrate, isoxuprine hydrochloride and the like.

Examples of the above antidepressant / anxiolytic agents include maprotiline hydrochloride, etizolam, diazepam, bromazepam, amitriptyline hydrochloride, mianserin hydrochloride and the like, and examples of vitamin D preparations include alfacalcidol, ergocalciferol. Etc.

Examples of the hypoglycemic agent include glibenclamide and gliclazide, and examples of the anti-ulcer agent include clevobride malate, famotidine, glycopyrronium bromide and the like.

Examples of the sleeping agent include phenobarbital, amobarbital, etc., examples of the muscle relaxant include eperisone, eperisone hydrochloride, etc., and examples of the antibiotic include tetracycline, Examples include chloramphenicol.

The content of the above-mentioned drug in the pressure-sensitive adhesive layer varies depending on the type of the drug, the transdermal preparation, etc., but when the content is low, the drug effect is not exhibited, and when the content is high, the drug is deposited in the pressure-sensitive adhesive layer or at room temperature. Since the adhesiveness of the pressure-sensitive adhesive layer is insufficient, the amount is usually preferably 1 to 50% by weight.

Examples of the method for producing the above-mentioned pressure-sensitive adhesive tape include a usual method for producing a pressure-sensitive adhesive tape, for example, a solvent coating method, a hot melt coating method, an emulsion coating method, an electron beam coating method and the like. To manufacture an adhesive tape by a solvent coating method, for example, various kinds of drugs, additives, etc. are dissolved or dispersed in a solvent, if necessary, and the resulting solution or dispersion is applied to the surface of the support. A method of forming a pressure-sensitive adhesive layer by directly coating and drying it on.

To manufacture the adhesive tape by the hot melt coating method, for example, various drugs, additives and the like are heated and melted to the adhesive, if necessary, and mixed, and the melt is directly applied to the surface of the support. Examples include a method of forming a pressure-sensitive adhesive layer by contact coating and cooling and solidification. The melt may be coated on a release paper, and the pressure-sensitive adhesive layer obtained after cooling and solidification may be transferred and adhered to a support.

The thickness of the above-mentioned pressure-sensitive adhesive layer varies depending on the purpose of use, but when the thickness becomes thin, the tackiness becomes insufficient, and when it becomes thick, the skin followability of the pressure-sensitive adhesive tape is impaired. Therefore, the thickness is preferably 10 to 100 μm.

For the purpose of protecting the obtained pressure-sensitive adhesive layer, a release paper such as a polyethylene terephthalate film having one surface subjected to a release treatment may be laminated on the pressure-sensitive adhesive layer.

[0057]

【Example】

 Embodiments of the present invention will be described below. (Example 1) [Preparation of acrylic pressure-sensitive adhesive and drug-containing pressure-sensitive adhesive] 187.5 parts by weight of 2-ethylhexyl acrylate (75% by weight) and 62.5 parts by weight of N-vinyl-2-pyrrolidone (25 Was added to a separable flask, and 250 parts by weight of ethyl acetate was added so that the monomer concentration in the initial stage of polymerization was 50% by weight. This solution was heated to 80 ° C. under a nitrogen atmosphere, and a solution of 1 part by weight of lauroyl peroxide dissolved in 100 ml of ethyl acetate as a polymerization initiator was added little by little to carry out polymerization for 8 hours to obtain a solid content concentration of 41. A 7% by weight acrylic adhesive ethyl acetate solution was obtained. Aspirin was dissolved in the ethyl acetate solution of the acrylic pressure-sensitive adhesive so that the aspirin content was 17% by weight based on the solid content of the acrylic pressure-sensitive adhesive to obtain a drug-containing pressure-sensitive adhesive solution.

A 25 μm-thick polyethylene terephthalate (hereinafter referred to as PET) film was coated with the above-mentioned drug-containing pressure-sensitive adhesive solution on a release paper whose one side was subjected to a silicone release treatment, and then dried at 60 ° C. for 30 minutes to give a 100 μm-thick film. An adhesive layer was formed. This pressure-sensitive adhesive layer was adhered to one side of a polyester / polyolefin non-woven fabric having a basis weight of 60 g / m ² (“ED-6” manufactured by Japan Vileen Co., Ltd.), at 120 ° C., pressure 1 kg / cm ² , speed 2 m / min. After heat lamination, it was punched into a size of 10 × 14 cm ² to obtain an adhesive film having an adhesive layer. Then, the peripheral edges of the four sides of this adhesive film are heat-pressed with a width of 5 mm at a temperature of 200 ° C. and a pressure of ² kg / cm ² to heat-bond them to a heat-melting amount corresponding to 6.3% of the support surface area. An adhesive tape provided with a dressing part was obtained.

Example 2 16 parts by weight of styrene-isoprene-styrene block copolymer (SIS) (“Califlex TR1107” manufactured by Shell Chemical Co., Ltd.), 5 parts by weight of polybutene (manufactured by Nippon Oil Co., Ltd., average molecular weight 1350), 36.5 parts by weight of an alicyclic saturated hydrocarbon resin (“ALCON P90” manufactured by Arakawa Chemical Co., Ltd.) and 0.6 parts by weight of butylhydroxytoluene were placed in a mixing tank and heated to 150 ° C. under nitrogen substitution and mixed. To obtain a rubber adhesive. 97.35 parts by weight of the above-mentioned rubber-based adhesive, 2 parts by weight of crotamiton, 0.15 parts by weight of 1-menthol and indomethacin were placed in a mixing tank and heated to 120 ° C. under nitrogen substitution and mixed to obtain a drug-containing adhesive. It was

This drug-containing pressure-sensitive adhesive was heated to 120 ° C., and a thickness of 200 μm was obtained by using a hot melt coater (manufactured by Meltex) on a 25 μm-thick PET film-treated release paper treated with silicon on one side. , Evenly spread on one surface of a polyester non-woven fabric having a basis weight of 100 g / m ² (“EL-5500” manufactured by Japan Vilene Co., Ltd.) and brought into close contact with it, then at 70 ° C., pressure of 2 kg / cm ² , and speed of 2 m / min. After heat lamination, it was punched out into a size of 10 × 14 cm ² to obtain an adhesive film having an adhesive layer. Then, the peripheral edges of the four sides of this adhesive film were heat-bonded by hot-pressing at a width of 7 mm and a pressure of 10 kg / cm ² at 200 ° C. to obtain 22. An adhesive tape provided with a heat-sealed portion corresponding to 6% was obtained.

Example 3 A support is a polyolefin nonwoven fabric having a basis weight of 300 g / m ² (“ED-300M” manufactured by Japan Vilene Co., Ltd.), a drug is flurbiprofen, and an adhesive layer has a thickness of 300 μm. An adhesive film was obtained in the same manner as in Example 2 except for the above. Then, the peripheral edges of the four sides of this pressure-sensitive adhesive film are heat-sealed by heating and pressing at a width of 10 mm and a pressure of 20 kg / cm ² at 200 ° C. The adhesive tape provided was obtained.

Comparative Example 1 An adhesive tape was obtained in the same manner as in Example 1 except that the peripheral portion of the support was not heat-sealed.

Comparative Example 2 The same procedure as in Example 2 was carried out except that the peripheral edges of the four sides of the adhesive film were heat-sealed by heating and pressing at a width of 15 mm at 200 ° C. and a pressure of 20 kg / cm ^2. An adhesive tape was obtained.

[Evaluation of Adhesive Tape] With respect to the adhesive tapes (10 × 14 cm ² ) obtained in the above Examples and Comparative Examples, human skin migration and adhesiveness were evaluated by 5 adult male evaluators. The results are shown in Table 1. (1) Human skin migration test After removing the release paper from the adhesive tape and applying it to the evaluator's inner arm for 24 hours, the drug content remaining on the removed adhesive tape was quantified and the drug content before application was included. The transferability of the drug to human skin was determined from the difference in the amount. The residual drug content was determined by punching out the peeled adhesive tape into a circle with a diameter of 2 cm, extracting this with 30 ml of tetrahydrofuran containing a certain amount of diphenyl, collecting the supernatant, and using high performance liquid chromatography. Was determined by the internal standard method.

(2) Adhesion Test The release paper of the adhesive tape was removed and attached to the knee joint of the evaluator, and the peeling of the adhesive tape due to friction with clothes, flexion and extension of the knee, etc. was judged according to the following criteria, and the adhesion was evaluated. The sex was evaluated by the average score of 5 evaluators. <Evaluation Criteria> 3 points: No peeling occurred even after 24 hours from application. 2 points: Peeling occurred 12 to 24 hours after application. 1 point: Peeling occurred 6 to 12 hours after application. 0 points: Peeling occurred within 6 hours after application.

[0066]

[Table 1]

[0067]

[Effect of device]

 The adhesive tape of the present invention is as described above, and by providing the heat-sealing portion on the peripheral portion of the support, peeling does not occur even if it is attached to a bent portion such as a joint for a long time. It is preferably used as an adhesive tape for treating pain.

[Brief description of drawings]

FIG. 1 is a perspective view showing an embodiment of the present invention.

FIG. 2 is a sectional view showing an embodiment of the present invention.

[Explanation of symbols]

 1 Support 2 Adhesive Layer 3 Release Paper 4 Thermal Fusion Part

Claims (1)

[Scope of utility model registration request] 1. A pressure-sensitive adhesive tape having a pressure-sensitive adhesive layer on one side of a support, the support being made of a non-woven fabric having a basis weight of 10 to 600 g / m ² , wherein the peripheral edge of the support is heat-melted with a constant width. A pressure-sensitive adhesive tape comprising a bonding portion, wherein the area of the heat-sealing portion corresponds to 1 to 50% of the surface area of the support.