JPH0653155B2 - Autotransfusion set - Google Patents

Description

TECHNICAL FIELD The present invention relates to an autologous blood transfusion set capable of simultaneously transfusing stored blood and collecting fresh blood.

[Prior Art and Problems] Currently, blood collected in a plastic bag is used for transfusion within 21 days, but actually collected blood is used up to about 7 days. If the storage period becomes long, hemolysis in blood and formation of microaggregates will proceed, and it is not preferable to use these bloods for blood transfusion, and it is desirable to use the collected blood for blood transfusions as soon as possible.

Furthermore, at present, the amount of blood that can be collected from a donor at one time is 400
There is a limit of ml to 500 ml. This is because collecting a large amount of blood from a donor at one time has a large effect on the living body (anemia, decrease in blood components, etc.) in consideration of the balance of body fluid balance. Moreover, there is a risk of infection of syphilis, hepatitis, etc. with fresh blood of others, and establishment of autologous blood transfusion is being promoted.

[Means for Solving Problems] In order to solve the above problems and safely and efficiently carry out blood transfusion and blood collection, the present invention basically (1) the liquid introduction needle 7a and the connecting pipe 8 , 9 and drip tube 11 (2) Connection tube 13a and filters 14a, 15 inside
blood transfusion member 3a including drip tube 12a loaded with a and 16a and equipped with blood introduction needle 17a (3) Blood transfusion needle 20a, connecting pipes 21 and 22, and mixed injection unit 2
Blood transfusion member 4 composed of 3a and 24a (4) Connection pipes 27 and 28 and cleaning liquid storage member 6 composed of waste liquid bag 26 (5) Via connection pipe 37a and connection pipe 38a loaded with communication piece 39a Parent bag 3 in which child bag 36a is connected
Blood storage member 5a and each of these constituent members 2, 3a, 4, 5
The present invention provides an autotransfusion set in which a and 6 are integrally connected via connecting pipes 41, 42, and 43.

[Operation] With the above configuration, the transfusion member 2 is filled with physiological saline into the transfusion member 3a. Fresh blood is collected from the donor through the transfusion member 4 and introduced into the blood storage member 5a. Water is dropped into the blood transfusion member 4 The blood preserved by the blood donor is transfused to the blood donor via the blood transfusion member 3a and the blood transfusion member 4 The following steps are repeated to collect blood so as not to burden the blood donor. And blood transfusion are performed in good balance with each other without excess or deficiency, and at the end, an autologous blood transfusion without loss of physical strength of the blood donor by supplementing the blood donor with an electrolyte solution from a mixed injection part provided in the middle of the blood collection member 4. Is to do.

[Example] FIG. 1 is a schematic view showing an example of the autologous blood transfusion set 1 of the present invention. The autologous blood transfusion set 1 basically includes an infusion member 2, blood transfusion members 3a and 3b, a blood transfusion member 4 and a blood storage member 5
The cleaning liquid storage member 6 includes a and 5b.

The liquid transfusing member 5 is loaded with a liquid introducing needle 7a in which a needle 7c made of stainless steel or the like is implanted in a needle base 7b, connecting pipes 8 and 9 made of flexible polyvinyl chloride, etc., and a filter 10 made of polyamide such as nylon. The drip tube 11 is made of polyvinyl chloride or the like. The transfusion member 3a is a drip tube 12 made of polyvinyl chloride or the like.
The drip cylinder 12a comprises a connecting pipe 13a made of flexible polyvinyl chloride or the like a and a filter 1 made of polyethylene terephthalate or the like having different pore sizes inside.
4a, 15a, 16a are loaded, and a blood introducing needle 17a made of polycarbonate or the like and a connecting pipe 18a made of polyvinyl chloride or the like with the connecting pipe 13a are attached to the ends.
The blood transfusion member 4 includes a needle base 20 that is made of stainless steel or the like.
The blood collection needle 20a, which is implanted in c and has the rotary blade 20d attached to the needle base 20c, and the connecting pipes 21 and 22 made of flexible polyvinyl chloride or the like are provided between the two connecting pipes 21 and 22. Mixed injection parts 23a, 24a made of polycarbonate and having puncturing buttons 23b, 24b made of silicone rubber embedded therein are installed.

The cleaning liquid storage member 6 comprises waste liquid bags 26 made of flexible polyvinyl chloride or the like and connecting pipes 27, 28 made of flexible polyvinyl chloride or the like as well as male lures at the ends of the connecting pipes 27, 28. 29 and 30 are mounted and connected via a connecting pipe 31 made of silicone rubber or the like.
A check valve 33 made of flexible polyvinyl chloride or silicone rubber is attached to the waste liquid inlet 32 of the waste liquid bag 26.

The blood storage member 5a includes a parent bag 35a and a child bag 36.
A connecting piece 39a made of polycarbonate or the like is mounted inside the connecting tube 37a.

These constituent members 2, 3a, 3b, 4, 6, 5a, 5
b, connecting pipes 9, 13a, 13b and 21, 2 respectively
Connection pipes 41, 42, 43 made of polyvinyl chloride or the like are connected via 2, 27, 28, 37a, 37b, 40.

Roller clamps A, B, C made of polypropylene or the like for the connecting pipes 9, 13a, 13b Dura clamps D, E, F made of polypropylene or the like for the connecting pipes 22, 27, 40 Polypropylene for the connecting pipes 37a, 37b The slide clamps G and H are attached.

The liquid introduction needle 7a, the blood introduction needle 17a, and the blood collection needle 20a are capped with needle caps 101, 102, 103 made of polypropylene or the like so as not to come into contact with the outside air.

Next, a method of using the present invention will be described with reference to FIG.

(1) Priming operation Roll clamps A, B, C and Jura clamps D, E,
F is closed and the liquid introduction needle 7a is connected to a container (not shown) in which physiological saline is enclosed. While the roll clamp A is opened and the drip tube 11 is pumped, the physiological saline is introduced up to a predetermined liquid level in the drip tube 11. When the liquid level reaches a predetermined level, the roll clamp B is opened, and physiological saline is further introduced into the drip tube 12a through the connecting pipe 13a. When the liquid level reaches a predetermined level, the roll clamp C is further opened to similarly introduce the physiological saline into the drip tube 12b up to the predetermined liquid level.

Then, open the Jura clamps D, E, and F, adjust the opening degree of the roll clamp A, add physiological saline solution, and draw the air in the connecting pipes 40, 27, 28 together with the physiological saline solution in the waste bag 26. Then, the clamps D, E and F are closed and the priming is completed.

(2) First Blood Collection The communication piece 39a of the connecting tube 37a is cut to open the slide clamp G, and the blood collection needle 20a is punctured by the donor to open the Jura clamp E.

Blood flows into the parent bag 35a through the blood transfusion needle 20a and the connecting tubes 21, 22, 37a.

When the collection of a predetermined amount of blood is completed, the slide clamp G is closed, the roll clamps A and D are opened, and physiological saline is dripped from the infusion member 2 into the blood transfusion member 4 through the connecting pipe 40. This can prevent blood from stagnating and coagulating in the blood transfusion member 4 before the next operation is performed.

At this time, the blood collection needle 20a is left punctured by the donor. This is to maintain the closed system until blood transfusion and blood collection are completed.

(3) Blood transfusion operation A blood bag (not shown) in which blood was previously stored and stored by the previous blood collection is attached to the blood introduction needle 17a of the blood transfusion member 13a.
Connect to.

Close roll clamp A, open roll clamp B,
Blood is transfused to the donor via the connecting tubes 13a, 40, 22, 21 and the blood transfusion needle 20a. The blood transfusion rate at this time is about 60 ml /
min (to the extent that a continuous thread does not fall down along the drip core) is preferable.

When the blood transfusion in the blood bag (not shown) is completed, the roll clamp B is closed.

The roll clamp A is opened again, and physiological saline is introduced into the blood transfusion member 4 in order to prevent the blood remaining in the blood transfusion member 4 from coagulating.

(4) Second blood sampling The communication piece 39b is cut to open the clamp H and the clamp E.

Blood is introduced into the parent bag 35b through the blood transfusion needle 20a and the connecting tubes 21, 22, 37b.

After collecting a predetermined amount of blood, the clamp E is closed and the clamp A is opened, and physiological saline is dropped from the transfusion member 2 to the transfusion member 4.

(5) Termination The clamp E is closed and the electrolyte solution prepared in advance is replenished to the supplier through the mixed injection part 23a, the connecting pipe 21, and the blood transfusion needle 20a.

Finally, the connecting pipes 37a and 37b are hermetically welded by a welder, the blood storage members 5a and 5b are separated, and stored at 4 ° C. for use in the next blood transfusion.

As another embodiment of the autologous blood transfusion set of the present invention, the numbers of blood transfusion members and blood storage members can be appropriately combined.

For example (1) Two blood transfusion members (3a, 3b) and three blood storage members (5a, 5b, 5c) (see Fig. 2) (2) Three blood transfusion members (3a, 3b, 3c) and three blood Storage members (5a, 5b, 5c) (see FIG. 3) (3) Three infusion members (3a, 3b, 3c) and four blood storage members (5a, 5b, 5c, 5d) (see FIG. 4) The following modes are possible.

Furthermore, ten types of embodiments can be implemented by combining the number of blood storage members (5a to 5d) and the capacities of the parent bags (38a to 38d) in the blood storage members (5a to 5d).

As shown in Table 1, the blood collection pattern can be combined according to the donor's health condition and physical strength to determine the preparatory blood volume before blood collection.

Next, specific examples of each part of the autotransfusion set of the present invention will be described.

When there are two or more pairs of blood transfusion members, a plurality of connecting pipes 63a and 63b having blood introducing needles 62a and 62b attached thereto may be attached to one drip tube 61 as shown in Fig. 5 (a). good. Alternatively, as shown in FIG. 5 (b), the connecting tube 64 of the infusion member may be attached to the drip tube 61 together with the connecting tubes 63a and 63b.

As a result, the number of parts can be reduced by the amount of the deleted drip tube.

A specific mode of the check valve 33 formed in the cleaning liquid storage member 6 is shown in FIGS. 6 and 7. (A) is a top view, (b) is an AA sectional view and a BB sectional view of (a).

The check valve 64 of FIG. 6 is formed by stacking two sheets of flexible polyvinyl chloride 65 on top of each other and forming the end 66 as a heat seal.

The check valve 67 shown in FIG. 7 is generally called a "duck's beak valve" and is integrally formed of flexible polyvinyl chloride or silicone rubber. 68 is a beak portion formed thinly.

By mounting these check valves 64, 67 on the waste liquid inlet 32 of the waste liquid bag 26, after introducing the cleaning liquid into the waste liquid bag 26, when pressure is applied from the outside of the waste liquid bag 26, the external pressure is reversed. Seats 65, 65 of stop valve 64 or beak 68 of check valve 67
Since it works in the direction of crushing, the used cleaning solution does not re-enter the inside of the autotransfusion set and hygiene is maintained.

The male lures 29, 30 attached to the ends of the connecting pipes 27, 28 of the cleaning liquid storage member 6 are used as follows.

When the blood transfusion needle 20a punctures a blood donor and collects blood, if a problem such as blood cell clogging occurs inside the needle 20b of the blood transfusion needle 20a, remove the connecting tube 31 to expose the male luer 30. Then, for example, as shown in FIG. 9, the blood collecting needle 71 is connected to the female luer 72 of the blood collecting needle 71 prepared for a spare, and the blood collecting needle 71 is punctured by the donor.

Blood is introduced into the main bag 35a of the blood storage member 5a via the connecting pipes 27 and 37a. On the contrary, the blood collection needle 20a is connected to the other male luer 29 and used for waste liquid treatment.

Various filters 14a, 15 loaded inside the drip tube 12a
The pore sizes of a and 16a are 210 μ, 160 μ, and
The size is 35μ, which is small from the blood inlet to the outlet. As a result, it is possible to completely prevent microaggregates in blood from entering the autotransfusion set.

The filters 14a, 15a and 16a are laminated and welded in the drip tube, and 16a is attached to the lower end of the drip tube by welding.

14a, 15a and 16a are collectively laminated and attached to the inner surface of the drip tube by welding.

As described above, the drip tube 12a can be loaded.

In the blood storage member 5a (the parent bag 35 via the connecting pipe 38a
The child bag 36a (attached to a) is used when the blood collected in the parent bag 35a is sampled for a blood test or the like. It is especially useful for blood tests that require large sample volumes.

As described above, while repeating blood transfusion and blood collection, it is performed so that the blood collection amount is relatively large, and the donor is given a replacement fluid corresponding to the amount of blood collected from the donor.
The burden on the donor is small.

Further, the number of liquid introduction needles 7a, the blood introduction needles 17a, and the blood collection needles 20a, which are attached to the autotransfusion set of the present invention, and the connecting tubes.
Shapes of 41, 42, 43 and respective constituent members 2, 3a, 4, 5a,
The material of 6 can be arbitrarily set according to the purpose of use.

[Effects of the Invention] As described above, the autotransfusion set of the present invention transfuse blood collected from a donor without loss of freshness, and at the same time, equilibrium the blood in an amount equal to or greater than the amount transfused from the donor. Since it is possible to collect blood without disturbing the balance of the above, and these can be used in a recycling system, it is particularly suitable for the preservation and self-transfusion of the donor's own blood.

Since the constituent members (1) to (5) are integrally connected, the operation can be performed in the closed system, so that hygiene can be ensured.

It is an excellent invention having the effects of the above.

[Brief description of drawings]

FIG. 1 is a schematic diagram showing the basic configuration of the autotransfusion set of the present invention. 2, 3 and 4 are schematic views showing another embodiment of the autotransfusion set of the present invention. FIG. 5 (a) is a schematic view showing another embodiment of the infusion member constituting the autotransfusion set. FIG. 5B is a schematic view showing another embodiment of the liquid transfusing member and the blood transfusing member. 6 and 7 show an embodiment of the check valve mounted on the cleaning liquid storage member, (a) is a plan view,
(B) is sectional drawing of (a). FIG. 8 is an enlarged view of the vicinity of the connection pipe of the cleaning liquid storage member. FIG. 9 is a schematic view showing an example of how to use the male luer of the cleaning liquid storage member. In the figure, 1 is an autotransfusion set, 2 is a transfusion member, 3 is a transfusion member, 4 is a transfusion member, 5a and 5b are blood storage members, 6 is a cleaning liquid storage member, 11, 12a and 12b are drip tubes, 7a.
Is a liquid introduction needle, 17a is a blood introduction needle, 20a is a blood collection needle, 23a and 24a are mixed injection parts, 26 is a waste liquid bag, 2
9 and 30 are male lures, 31 is a connecting pipe, 33 is a check valve,
35a and 35b are parent bags, 36a and 36b are child bags, 39a and 39b are communicating pieces, 41, 42 and 43 are connecting pipes, 8, 9, 13a, 13b, 21, 22, 27,
28, 37a, 37b, 38a, 38b are connecting pipes, A,
B and C are roll clamps, D, E and F are Jura clamps, and G and H are slide clamps.

Claims (1)

[Claims] 1. An autologous blood transfusion set used for collecting a predetermined amount of blood from a blood donor and storing it in advance, and collecting a new predetermined amount of blood from the blood donor. (1) A transfusion member composed of a liquid introduction needle, a connecting pipe and an infusion tube (2) A blood transfusion member composed of an infusion tube having a connecting tube and a filter loaded therein and a blood introduction needle attached (3) Blood collection Blood collection member composed of needle, connecting pipe and mixed injection part (4) Washing liquid storage member consisting of connecting pipe and waste bag (5) Connecting bag loaded with connecting piece and child bag connected via connecting pipe Blood storage member composed of a parent bag An autologous blood transfusion set characterized in that the above (1) to (5) are integrally connected via a connecting pipe.