JPH06510902A - Rfkbp:新規なプロリルイソメラーゼおよびラパマイシン/fk506結合タンパク質 - Google Patents
Rfkbp:新規なプロリルイソメラーゼおよびラパマイシン/fk506結合タンパク質Info
- Publication number
- JPH06510902A JPH06510902A JP4512051A JP51205192A JPH06510902A JP H06510902 A JPH06510902 A JP H06510902A JP 4512051 A JP4512051 A JP 4512051A JP 51205192 A JP51205192 A JP 51205192A JP H06510902 A JPH06510902 A JP H06510902A
- Authority
- JP
- Japan
- Prior art keywords
- rfkbp
- protein
- sequence
- binding
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69711391A | 1991-05-08 | 1991-05-08 | |
US697,113 | 1991-05-08 | ||
PCT/US1992/003993 WO1992019745A1 (fr) | 1991-05-08 | 1992-05-07 | Rfkbp: une nouvelle isomerase de prolyle et proteine de liaison de rapamycine/fk506 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH06510902A true JPH06510902A (ja) | 1994-12-08 |
Family
ID=24799862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4512051A Pending JPH06510902A (ja) | 1991-05-08 | 1992-05-07 | Rfkbp:新規なプロリルイソメラーゼおよびラパマイシン/fk506結合タンパク質 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0584217A1 (fr) |
JP (1) | JPH06510902A (fr) |
AU (1) | AU2007192A (fr) |
CA (1) | CA2102117A1 (fr) |
FI (1) | FI934901A0 (fr) |
HU (1) | HUT70259A (fr) |
WO (1) | WO1992019745A1 (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4388893A (en) * | 1992-05-20 | 1993-12-13 | Vertex Pharmaceuticals Incorporated | Method of detecting tissue-specific FK506 binding protein messenger RNAs and uses thereof |
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5846981A (en) * | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
US5482850A (en) * | 1993-10-29 | 1996-01-09 | New England Biolabs, Inc. | Method for identifying anti-parasitic compounds |
US5457182A (en) * | 1994-02-15 | 1995-10-10 | Merck & Co., Inc. | FK-506 cytosolic binding protein, FKBP12.6 |
IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US6218424B1 (en) | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
US6274602B1 (en) | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
EP1085853A1 (fr) | 1998-06-03 | 2001-03-28 | GPI NIL Holdings, Inc. | Compositions pour la croissance des cheveux a base d'amides et d'esters heterocycliques et utilisation de ces compositions |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
DE19907598A1 (de) * | 1999-02-22 | 2000-08-24 | Schulz Burkhard | DNA Sequenz kodierend ein FKBP ähnliches Protein, Plasmide, Bakterien, Hefen und Pflanzen enthaltend dieses Protein sowie Mutanten in Arabidopsis für dieses Gen, die in der Ausprägung der Pflanzenarchitektur, der Reaktion gegenüber Brassinosteroiden und ihren Verbindungen und durch Ethylen vermittelten Gravitropismus der Wurzel defekt sind |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
WO2008082984A2 (fr) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Réactif de lyse non dénaturante destiné à être utilisé en immunoessai de capture en solution |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
ES2405364T3 (es) | 2006-12-29 | 2013-05-30 | Abbott Laboratories | Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera |
ES2393135T3 (es) | 2006-12-29 | 2012-12-18 | Abbott Laboratories | Ensayo mejorado para fármacos inmunosupresores |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0379549B1 (fr) * | 1988-06-23 | 1995-12-27 | Associates Of Cape Cod, Inc. | Proteine de liaison d'endotoxines et ses utilisations |
DE69013015T2 (de) * | 1989-01-19 | 1995-05-11 | Merck & Co Inc | Protein aus dem Cytosol, das FK-506 binden kann. |
WO1991004321A1 (fr) * | 1989-09-25 | 1991-04-04 | President And Fellows Of Harvard College | Recepteur pour fk-506 |
-
1992
- 1992-05-07 WO PCT/US1992/003993 patent/WO1992019745A1/fr not_active Application Discontinuation
- 1992-05-07 EP EP19920911933 patent/EP0584217A1/fr not_active Withdrawn
- 1992-05-07 CA CA 2102117 patent/CA2102117A1/fr not_active Abandoned
- 1992-05-07 JP JP4512051A patent/JPH06510902A/ja active Pending
- 1992-05-07 HU HU9303164A patent/HUT70259A/hu unknown
- 1992-05-07 AU AU20071/92A patent/AU2007192A/en not_active Abandoned
-
1993
- 1993-11-05 FI FI934901A patent/FI934901A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2007192A (en) | 1992-12-21 |
CA2102117A1 (fr) | 1992-11-09 |
HU9303164D0 (en) | 1994-03-28 |
WO1992019745A1 (fr) | 1992-11-12 |
HUT70259A (en) | 1995-09-28 |
EP0584217A1 (fr) | 1994-03-02 |
FI934901A (fi) | 1993-11-05 |
FI934901A0 (fi) | 1993-11-05 |
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