JPH06505245A - Topical soap gel formulation - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Topical Sequenkel formulation The present invention describes the application of cosmetic and pharmaceutical active substances based on soap gels. A molded, especially stick-like formulation for The formulation exhibits excellent dimensional stability and good transportability, and contains virtually no lower alcohols. Regarding compounds.

Soaps as carriers for topically applied cosmetic and pharmaceutical active substances Gels have been known for some time. Soaps usually contain aqueous lower alcohols and Sodium stearate gel in glycol and glycol has been used. Unfortunately , such gels are generally too hard and leave only a small amount on the skin when applied to the skin. The disadvantage is that only 100% of products can be transported. This kind of soap gel arrangement In order to improve the transportability of the compound, U.S. Patent No. 2,900,306 describes It is suggested to mix in water-soluble myristic acid soap. In other literature, To improve gel time L7, reduce syneresis and stickiness, fatty acid esters and recommends the addition of ethylene oxide and propylene oginate condensates to National Patent No. 4617185). These additives have the desired effect on formulation clarity. There are some things that do not have undesirable effects.

Therefore, the problem that the present invention seeks to solve is high transparency, high dimensional stability and Provides a molded soap gel formulation that exhibits sufficient transportability when in contact with skin and skin It is to be.

According to the present invention, this problem is solved by using an alkali metal soap gel based gel. Cl6-22 fatty acid mixture in the state of metal soap 3-10% by weight 3-6 charcoal Polyol having elementary atoms and 2 to 6 hydroxyl groups 30 to 90% by weight water 1 to 3 0% by weight, and contains cosmetic or pharmaceutical active substances and, if desired, other typical auxiliaries, The fatty acid mixture Straight chain saturated fatty acids 60-95% by weight Branched saturated fatty acids 5-40% by weight A soap for the topical application of cosmetic and medicinal substances, characterized in that it contains solved by gel formulation.

As a result of the presence of branched fatty acid soaps, the formulation While maintaining its hardness, it melts instantly and to a limited extent when it comes into contact with the skin. Due to its lubricious properties, thin films of the formulation can be easily applied to the skin.

Suitable direct fatty acids include palmitic acid, stearic acid, arachidic acid, behenic acid, or or industrial mixtures consisting of these fatty acids in raw form, such as hydrogenated coconut oil fatty acids. or hydrogenated tallow fatty acids. Preferably stearic acid is used.

Suitable branched saturated fatty acids include, for example, 2-hequinrudecanoic acid, 2-octyldodecanoic acid, or other branched fatty acids having 16 to 22 carbon atoms.

However, isostearic acid is particularly suitable. Isostearic acid as raw and liquid is understood to be a mixture of branched isomers of stearic acid, a dimeric unsaturated fatty acid by hydrogenation of isomeric liquid monomeric fatty acids that form as by-products in can be obtained. This isostearic acid and other branched fatty acids are American Oil Chemists Society (J, Am, Oil, Ch. eIl, SOC,) November 1979 (Vol. 56), pp. 823A-827A. It is detailed.

In other words, such branched fatty acids are mixtures whose main components are methyl-branched isomers. It is a compound. Isostearic acid is a commercially available product, for example Em-Sol (Em ersol) 875 [Henkel Corp.] product name It's on sale.

Mixtures of straight-chain and branched fatty acids may be composed entirely or mostly of alkali metal salts (alkali metal salts). The sodium soap is preferred.

However, free unsaponified fatty acids can be added in a certain proportion, e.g. There is no problem even if the content is on the order of 0.01 to 0.5% by weight.

Amount ratio of straight chain fatty acids to branched fatty acids in the fatty acid mixture used in the present invention affects the hardness of the soap gel formulation and its transportability. Isosteari Increasing the content reduces hardness and increases skin delivery. However, this These parameters are also influenced by the total fatty acid content in the gel. Preferably, the fatty acid mixture is used in an amount of 5 to 8% by weight. The fatty acid mixture is Consisting of 80-95% by weight of stearic acid and 5-20% by weight of branched saturated fatty acids It is preferable.

Suitable polyols having 3 to 6 carbon atoms and 2 to 6 hydroxyl groups are e.g. tylene glycol, 1,2-propylene glycol, 1,3-propylene glyco 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol Tylene glycol, glycerin, erythritol, pentaerythritol, tri Methylolpropane, sorbitol, anhydrous sorbitol, cyclohexane trio It is inositol. propylene glycol and glycerin individually, or used in mixtures with sorbitol and/or butylene glycol It is particularly preferable. These polyols are used for the entire soap gel formulation. Preferably, it is present in a total amount of 70-90% by weight. Particularly desirable functional characteristics are As Liol, glycerin 10-80% by weight, propylene glycol 10-8% 0% by weight, and sorbitol and/or 1,4-butylene glycol 5~ Obtained when 20% by weight of the mixture is present.

A transparent soap gel that is particularly dimensionally stable and exhibits favorable delivery properties on the skin. The formulation is Fatty acid mixture in the form of sodium soap 5-8% by weight glycerin, 1.2- Propylene glycol, 1,3-propylene glycol or sorbitol with them Mixture with tall and/or 1,4-butylene glycol 70-90% by weight %,and Water 5-25% by weight Contains.

The soap gel formulations of the invention can be used for topical application of cosmetic and pharmaceutical active substances. use Cosmetic and pharmaceutical active substances are added to soap gel formulations for individual application. Mix in the required dosage. Cosmetic active substances within the scope of the invention are, for example, antibacterial agents, deodorants, skin moisturizers, antiperspirants, hair removers, dyes and perfumes. substances, as well as cosmetic oils. Pharmaceutically active substances within the scope of the invention are for example antibiotics, corticoids, local anesthetics, and other substances used for skin disorders. Ru. The amount of cosmetic and pharmaceutical substances incorporated is generally 11 to 5 times the total formulation. It is on the order of % by weight, preferably in the range of 0.1 to 1% by weight.

In a particularly preferred embodiment, the soap gel formulation of the invention is used as a stick deodorizer. Use as. In the present invention, desorbed as a cosmetic active substance in such products. Odor substances are present. Suitable deodorizing substances include, for example, antibacterial agents, e.g. Lichloro-2'-hydroxydiphenyl ether [Irgasan] n) DP300], chlorhexidine digluconate or phenoxyethano deodorized antibacterial essential oils, farnesol, lipase inhibitors, such as trier citrate. chill or triacetin, astringents such as sodium aluminum chlorohydroxide Droxylactate, and other known body deodorants or antiperspirants.

In addition to the active substances mentioned, the soap gel formulation of the invention is characterized by its appearance and storage Other auxiliaries may be included to improve stability. Such auxiliaries are, for example, complexes. additives, antioxidants, preservatives, fragrances, colorants, brighteners, pearl pigments or fine particle igneous It is silica. Turbidity and crystallization during storage can be reduced by adding water-soluble salts, preferably sodium chloride. of about 0.1 to 0.3% by weight of the soap gel formulation. It has also been discovered that this can be prevented by adding it as an auxiliary agent. The total amount of auxiliaries is , in an amount not exceeding 5% by weight of the total soap gel formulation, preferably from about 1 to Present in an amount of 3% by weight.

Preferably, the soap gel formulations of the present invention do not contain lower alcohols.

However, if desired up to 10% by weight of a lower alcohol, such as ethanol or Isopropatool may be incorporated into the formulation.

The soap gel formulation of the present invention consists of combining a polyol, water and fatty acid mixture in a container. A mixture obtained by mixing while heating to about 50 to 90°C to obtain an alkali metal hydroxide is added in the form of a concentrated aqueous solution to form a clear solution and the saponification of the fatty acids is completed. It is best produced by stirring until the Then the active substance and Auxiliary agents may be incorporated sequentially during cooling. Finally, the product is heated to a temperature above the gel formation temperature. Pour into a mold such as a stick tube and heat to solidify into a dimensionally stable gel. Leave to cool to ℃.

The invention is illustrated by the following examples.

Example A soap gel formulation having the composition shown in Table I was prepared as follows.

Polyol, water and fatty acids were mixed in a container and heated to 70°C. The resulting mixture When sodium hydroxide is added little by little to the paste, the paste becomes transparent through saponification. became homogeneous. After adding other auxiliaries and perfume oils, stick the paste into The mixture was poured into a tube and allowed to cool to +20°C.

A soap gel stick with good dimensional stability and very favorable transportability is obtained. It was done.

international search report Continuation of front page (51) Int, C1,' Identification symbol Internal office reference number A 61 K 7/15 5 8615-4C7/48 9051-4C A61L 9101 Z 7167-4CI

Claims (5)

[Claims] 1. 3-10% by weight of a C16-22 fatty acid mixture in the form of an alkali metal soap; 30-90% by weight of polyols having 3-6 carbon atoms and 2-6 hydroxyl groups, 1-30% by weight of water, and Contains cosmetic or pharmaceutical active substances and, if desired, other typical auxiliaries; The fatty acid mixture contains 60-95% by weight of straight-chain saturated fatty acids and 5-40% by weight of branched saturated fatty acids. For topical application of cosmetic and pharmaceutical active substances, characterized in that it contains % by weight gel-based soaps of alkali metal soaps, especially in stick form, for Gel formulation. 2. The straight chain saturated fatty acid is stearic acid, and the branched saturated fatty acid is isostearin. 2. Soap gel formulation according to claim 1, characterized in that it is an acid. 3. Glycerin and/or propylene glycol or is the combination of these substances with sorbitol and/or 1,4-butylene glycol. characterized in that the mixture is present in a total amount of 70 to 90% by weight relative to the entire formulation The soap gel formulation according to claim 1 or 2. 4. As polyols: 10-80% by weight of glycerin, 1% by weight of propylene glycol 0-80% by weight, and sorbitol and/or 1,4-butylene glycol 4. Any one of claims 1 to 3, characterized in that 5 to 20% by weight of the mixture is present. The soap gel formulation described in. 5. Fatty acid mixture in sodium soap form 5-8% by weight, polyol 70-8% 90% by weight, Water 5-25% by weight The soap gel formulation according to any one of claims 1 to 4, characterized in that it contains thing.