JPH0648319B2 - Radioisotope automatic dispensing device and automatic dispensing method - Google Patents

Description

TECHNICAL FIELD The present invention relates to a radioisotope automatic dispensing apparatus and an automatic dispensing method for reducing exposure of an operator, and more specifically, to a radioisotope solution. After measuring the specific activity and adjusting the specific activity to a prescribed value by diluting with physiological saline solution, the operator automatically injects a prescribed amount of radioisotope solution into the labeled vial containing the drug. TECHNICAL FIELD The present invention relates to a radioisotope automatic dispensing apparatus and an automatic dispensing method that reduce the exposure to radiation.

[Prior Art] When a drug labeled with a radioisotope (hereinafter abbreviated as RI) (hereinafter abbreviated as a labeled drug) is injected into the human body, it is selectively selected in a specific tissue or organ of the human body depending on the type of the labeled drug. Gather in. By observing this with an appropriate detection device, physiological or pathophysiological information of the tissue or organ of interest can be obtained.

Although many nuclides are used as the RI for labeling, technetium-99m (Tc-99m) is most often used. By the way, Tc-99m is a daughter nuclide of Mo-99, but since it has a short half-life of 6 hours, it contains Mo-99 and its daughter nuclide Tc-99m, and only Tc-99m should be selectively taken out. The RI solution containing Tc-99m is taken out from a device called "Techne Generator" which can be used whenever necessary. However, the specific activity of the RI solution taken out from the techne generator differs depending on the elapsed time since the techne generator was manufactured and the manufacturer. Therefore, in order to prepare a predetermined amount of the labeled drug, the specific activity of the RI solution must be measured correctly. Further, it may be necessary to dilute the RI solution with a physiological saline solution to adjust it to a predetermined specific activity.

Conventionally, in the preparation of a labeling drug, the radioactivity intensity of an RI vial containing an RI solution is measured, while the amount of the solution in the RI vial is visually measured and the specific radioactivity is determined from the amount and the radioactivity intensity. After the measurement, the required amount of RI solution was collected by an injection needle or the like and manually injected into a vial containing a drug.

Such handling of RI by hand has a drawback in that the cumulative radiation exposure dose due to long-term work is large, and there is a risk of serious damage to the human body.

Therefore, as a device for improving the manual handling and reducing the exposure dose to the worker, a device described in Japanese Patent Laid-Open No. 59-51400 is known.

According to this device, a technetium vial containing a solution of technetium and a saline vial containing a physiological saline solution are actuated by a flow rate controller arranged in the middle of the injection route to act as a marker containing a drug. A predetermined amount of technetium solution or physiological saline solution is automatically injected into the vial. Therefore, this radioisotope automatic injection device has an advantage that the radiation dose of the operator is considerably reduced.

[Problems to be Solved by the Invention] However, in the apparatus described in Japanese Patent Laid-Open No. 59-51400, there is no specific activity measuring means for technavial, and it is necessary to use a separate device before using the apparatus. Measured by
It needs to be calculated.

Further, in this device, there is only one labeled vial, and when preparing a plurality of labeled compounds, it is necessary to remove the dispensed labeled vial and set the labeled vial in another container again. Therefore, the exposure during these operations cannot be avoided, and the operation becomes extremely complicated.

[Means for Solving Problems] The present invention has been made in view of the above conventional problems, and according to the present invention, a radioisotope vial containing a radioisotope solution and a saline containing a saline solution are provided. In a radioisotope automatic dispensing device mainly consisting of a vial and a labeled vial containing a drug into which a predetermined amount of the radioisotope solution and physiological saline solution is automatically injected, a predetermined amount is sucked from the radioisotope vial and the saline diet vial. Measuring means for measuring the amount of the solution, a dilution vial into which the solution having the measured amount of the solution is injected, a radiation detector for measuring the radioactivity intensity of the dilution vial, and the measuring means from the radioisotope vial Injection of radioisotope solution into the dilution vial by Calculation means for calculating the specific activity of the radioisotope solution from the amount and the radiation intensity measured by the radiation detector, and a predetermined amount of the solution in the dilution vial from the saline vial to the dilution vial by the measuring means. Adjusting means for adjusting the specific activity of the radioisotope, and a radioisotope automatic dispensing device comprising: a radioisotope vial containing a radioisotope solution; and a saline vial containing a physiological saline solution,
In the automatic dispensing method of a radioisotope solution using a radioisotope automatic dispensing device mainly consisting of a labeled vial containing a drug into which a predetermined amount of the radioisotope solution and physiological saline solution is automatically injected, (a) While measuring the amount of the solution by sucking a predetermined amount of the radioisotope solution from the radioisotope vial, inject the radioisotope solution into the dilution vial, and (b) measure the radioactivity of the radioisotope solution injected into the dilution vial. Measured, (c) calculating the specific activity of the radioisotope solution from the injection amount of the radioisotope solution injected into the dilution vial and the radiation intensity of the radioisotope solution, and based on the obtained calculation results A predetermined amount of physiological saline solution is collected from the vial into the diluted vial and Automatic dispensing method radioisotope, characterized by adjusting the specific activity of the solution interpretation vial is provided.

The outline of the configuration of the present invention will be described below with reference to FIG. 1 corresponding to the embodiment.

An RI vial 1 containing the RI stock solution, for example, a syringe 2 which is a volume measuring device composed of a cylinder and a piston mechanism such as a syringe, a saline vial 3 containing a saline solution, an RI stock solution and a physiological saline solution. The dilution vials 4 to be transferred are connected to each other by a tube 5. Flow path opening / closing valves 6 to 6 are provided in the middle of the tube 5. The piston 2 of the syringe 2 is a drive device 7
It is designed to be driven linearly. The radioactivity intensity of the dilution vial 4 is measured by the radiation detector 15.

In the middle of the tube 5 that connects the RI vial 1 and the syringe 2, a liquid shortage detector 8 that detects the presence or absence of the solution in the tube is provided. A pressure detector 9 for detecting the pressure inside the tube is provided in the middle of the tube connecting the syringe 2 and the dilution vial 4.

Tube 5 (5, 5 ...) Through which solution or gas flows
The flow path system mainly composed of is attached to the seat as an integrated piping unit.

The labeled vials 10 to 10 into which a predetermined amount of RI solution and physiological saline solution are injected are lead shield containers 11 to 10 respectively.
Cartridge 1 that is a portable frame that is placed in 11
It is stored in 2.

The other ends of the tubes 5 to 5 inserted into the labeled vials 10 to 10 and connected to the injection needles 18 to 18 for supplying and exhausting the gas in the vials are connected to the overflow bag 13. The entire device is controlled by the computer device 14.

[Operation] In the apparatus configured as described above, the dilution vial 4 is empty before the operation of the apparatus, the piston 2 of the syringe 2 is pushed to the bottom of the syringe 2, and the open / close valves 6 to 6 are
Are all closed.

When the operation of the device is started, after the opening / closing valve 6 is opened, the piston 2 is pulled out by a predetermined stroke by the drive device 7, whereby a predetermined amount of RI stock solution is collected from the RI vial 1 into the syringe 2. Next, the on-off valve 6 is closed, and after the on-off valve 6 is opened, the piston 2 is pushed to the bottom of the syringe 2 by the drive device 7 to inject a predetermined amount of the RI stock solution into the dilution vial 4. . The radioactivity of the predetermined amount of the RI stock solution injected into the dilution vial 4 is measured by the radiation detector 15. The radioactivity intensity per unit volume of the RI solution in the dilution vial 4, that is, the ratio, is obtained by taking the solution amount injected into the dilution vial 4 and the measured radioactivity intensity into the computer device 14 by a known method and performing a calculation process. You can know the radioactivity.

The liquid shortage detector 8 detects whether or not a solution is contained in the tube 5, and is a known detector such as a light transmission type sensor, and the injection needle 18 in the RI vial 1 is used.
It is used as a means for knowing the end point when the RI undiluted solution up to the upper end is transferred to the dilution vial 4 or similarly for knowing the lack of the RI undiluted solution when transferring a predetermined amount.

Here, when the RI solution having the known solution amount and specific activity measured above is contained in the dilution vial 4 and the specific activity is desired to be adjusted by dilution, the piston 2
Is opened at the bottom of the syringe 2 and only the on-off valve 6 is opened, and the piston 2 is pulled out by the drive device 7 for a predetermined stroke, whereby a predetermined amount of the physiological saline solution is collected from the saline vial 3 into the syringe 2.

Next, the on-off valve 6 is closed, and after the on-off valve 6 is opened,
By pushing the piston 2 to the bottom of the syringe 2, a predetermined amount of physiological saline solution is injected into the dilution bias 4, the RI solution in the dilution vial 4 is diluted, and the specific activity is adjusted.

The pressure detector 9 is means for detecting whether the tube 5 is properly set in each of the on-off valves 6 to 6, whether the on-off valve operates properly, or whether the tube 5 is leak-free. For example, when only the on-off valve 6 is opened to collect a predetermined amount of air into the syringe 2, all the on-off valves other than 6 are closed and the piston 2 is pushed down by a predetermined amount, if a predetermined pressure is not reached, something is abnormal. It is shown that.

[Examples] The present invention will be described in detail below based on the examples shown in the drawings.

FIG. 1 shows an outline of an embodiment of the present invention, which includes an RI vial section A, a volume measuring section B, a radiation detecting section C, a saline vial section D, a labeled vial section E, a flow path control section F, and an overflow. It is mainly composed of a bag portion G.

In FIG. 1, RI vial 1 and drain vial 1
6. The labeled vials 10 to 10 are contained in lead containers 11 to 11 for shielding radiation.

Each vial is pierced with an injection needle 18-18 for collecting or injecting a solution and an injection needle 18-18 for discharging or introducing gas in the vial.

The flow path opening / closing valves 6 to 6 that form the flow path control unit F press the tube 5 or loosen the
The flow path of the solution or gas inside is controlled to be opened or closed.

The volume measuring unit B is composed of a syringe 2 using a syringe and a driving device 7 using a pulse motor for linearly driving the piston 2 of the syringe.

The radiation detection unit C is composed of a dilution vial 4 and a well-type radiation device 15.

The labeled vial section E is composed of a portable cartridge 12 in which the lead shield containers 11 to 11 respectively containing the labeled vials 10 to 10 can be set. The labeling vials 10 to 10 are inserted with injection needles 18 to 18 for injecting a solution body or gas connected to the tube 5. Further, the injection needles 18 to which are inserted to discharge the gas in the vial are connected to the overflow bag 13 which is a buffer container through the tubes 5 to 5, respectively. This prevents contamination within the device when the solution overflows. In addition, overflow bag 1
The tube 3 is open to the atmosphere through the tube 5. If necessary, spacers 19 are provided on the bottoms of the lead shielding containers 11 to 11 so that the caps of the labeled vials have the same height.
Has been inserted.

Liquid shortage detector 8 for detecting the presence or absence of the solution in the tube 5 in the middle of the tube 5 connecting the syringe 2 and the injection needle 18 for collecting the RI stock solution inserted in the RI vial 1.
However, one end of the tube branched from the middle of the tube connecting the cylinder 2 and the dilution vial 4 is connected to the pressure detector 9 and is used as a means for detecting an abnormality in the tube system.

Injection needle 18 for introducing or discharging gas into the vial
Nos. 18 to 18 are connected to the tubes 5 to 5, respectively, and communicate with the atmosphere through filters 17 to 17 connected to the other ends of the tubes 5 to 5.

RI vial 1 and its lead shielding container 11, syringe 2 and its piston 2, saline vial 3, dilution vial 4,
The drain vial 16 and its lead shielding container 11, the piping unit 20, and the cartridge 12 are each attachable to and detachable from a main body device (not shown).

After the dispensing operation to each labeling vial is completed, the RI solution remaining in the dilution vial 4 is transferred to the drain vial 16 via the silage 2.

The RI automatic pipetting device according to the present invention is controlled by a computer device 14 mainly composed of a microcomputer or a personal computer and an interface such as a signal acquisition of a detector, an opening / closing valve, a driving device and the like. The role of the computer device 14 is to receive input of set values for operating the device from an operator, control the drive device 7 for measuring the amount of solution, calculate specific activity,
Control of each switch necessary for dispensing a predetermined amount of RI solution into the labeled vials 10 to 10, operation control based on various operation command buttons (not shown), and display of calculation result and operation state. Is the main one.

Next, with reference to the drawings, the operation and operation of the radioisotope automatic dispensing apparatus of the embodiment shown in FIG. 1 will be described according to the procedure thereof.

I. A predetermined number of labeled vials 10 are set in the cartridge 12.

・ Injection needle 18 for injecting and degassing each labeled vial 10.
, 18 ... are set.

・ The labeled vial 10 to be dispensed at once is cartridge 12
Set to. (Maximum 5) II. The piping unit 20 is set in the dispensing device.

・ Set the tube 5 on the pinch valves 6, 6 ...

-Set the labeled vial cartridge 12.

・ Injection needles 18, 18 ..., 18 of the labeled vial 10
, 18 are connected to predetermined tubes 5, 5, 5 ...

The injection vials 18, 18 are similarly connected to the drain vial 16 and the dilution vial 4.

The dilution vial 4 is set in the well type radiation detector 15.

-Connect the syringe 2 to the tube 5 and set it in the drive device 7.

III. ... Leakage and blockage test of on-off valves 6, 6 ... and pipes-By pressing a predetermined button of the computer device 14, the dispensing device performs the following operation.

All the on-off valves 6, 6 ... Are closed, air is pressurized with the syringe 2, and leakage is tested from the value of the pressure sensor.

The opening / closing valves 6, 6 ... Are sequentially opened / closed, the pressure is detected, and the operation of the opening / closing valves 6, 6 ... Is tested.

IV. Key-in the data to be dispensed into the computer device 14-Enter the target radioactivity, volume, vial size, drug amount and nuclide name of each labeled vial 10.

After the input is completed, the computer device 14 calculates the specific activity and volume of the RI solution injected into each labeled vial 10.

V. Set the raw food vial 3.

VI. RI vial 1 taken out from techne generator
Set.

VII. Start of dispensing ・ By pressing a predetermined button of the computer device 14, the dispensing device performs the following operation.

Aspirate the RI stock solution from the RI vial 1 with the syringe 2,
Transfer to dilution vial 4.

Calculate the volume of RI stock solution from the syringe 2 cycle.

Radioactivity intensity measurement of RI stock solution.

The RI stock solution is diluted and mixed with a physiological saline solution according to the highest specific activity to be injected into the labeling vial 10.

Calculate and inject the RI solution into the labeled vial 10.

A predetermined amount of physiological saline solution for adjusting the concentration and cleaning the duct is injected into the labeling vial 10.

Air is sucked by the syringe 2, and the residual liquid in the pipeline is sent to the corresponding labeled vial 10 by air.

The above operations 1 to 2 are repeated for the other labeled vials 10.

In addition, when making the thing whose specific activity is very lower than others, the RI solution is further diluted, mixed, and finally dispensed.

When the dispensing is completed, the inside of the pipe line is sucked by the syringe 2 for each system, and the residual liquid content in the injection needles 18, 18 ... Is sent to the drain vial 16.

The end of dispensing is displayed on the computer device 14.

The dispensing contents are printed on the printer each time.

FIG. 2 shows another embodiment of the automatic radioisotope dispensing apparatus according to the present invention.

The difference from the above-mentioned embodiment is that the radiation detector 15 is movable by a driving mechanism (not shown), the dilution vial 4 is housed in a removable lead shielding container 11, and the radioactivity is reduced. For the purpose of measurement, holes are made in the bottom of the lead shielding containers 11 to 11.

The main operation of this embodiment, which is different from the above-described embodiments, will be described below.

In the operation of measuring the amount of the RI stock solution in the RI vial 1 and moving it into the dilution vial 4, the radiation detector 1
5 moves to the liquid shortage detection unit 22 and detects the presence or absence of the solution in the tube 5 by the decrease in the radioactivity intensity. During the operation of measuring the radioactivity intensity of the dilution vial 4, the radiation detector 15 moves to the bottom of the dilution vial 4. A predetermined amount of RI solution is added from the dilution vial 4 to the labeling vial 10 respectively.
After dispensing to 10 to 10, it can move to the lower part of 10 to 10 one by one, and each radioactivity intensity can be measured.

FIG. 3 shows an embodiment of the piping unit 20 in which most of the tubes 5, 5, ... Are fixed on the seat 23 so as to facilitate the attachment / detachment operation of the tubes 5, 5.

The connectors 21 to 21 are connectors to the injection needles 18 to 18, respectively. The connectors 21, 21 are connectors for the syringe 2 and the pressure detector 9, respectively.

[Effects of the Invention] As described above, according to the radioisotope automatic dispensing apparatus and the automatic dispensing method of the present invention, by providing the syringe for measuring the amount of the solution and the dilution vial, the known volume can be stored in the dilution vial. Since the RI stock solution can be injected, the specific activity of the RI stock solution can be correctly known by measuring its radioactivity intensity. Also, by injecting a physiological saline solution into a vial diluted in a predetermined amount by the syringe. The specific activity can be adjusted.

Further, by providing the liquid shortage detector, the liquid shortage can be detected when the RI undiluted solution is measured and transferred from the RI vial to the dilution vial, so that the volume can be correctly known.

Further, since a pressure detector is provided in the middle of the tube, an abnormality such as a leak in the tube system can be detected. On the other hand, by integrating the tube system as a piping unit, the tube can be easily attached and detached.

Further, since the labeled vial contained in the lead shielding container can be housed in the portable cartridge, the labeled vial can be easily set in the main body device, and the exposure during the transportation of the cartridge can be reduced.

The measurement of the specific activity of the RI stock solution, the adjustment of dilution, and the dispensing of the RI solution into the labeled vials are automatically performed after each vial is set in the main unit, so the radiation exposure of workers is minimized. Can be suppressed.

[Brief description of drawings]

FIG. 1 is a block diagram showing an embodiment of the present invention, FIG. 2 is a block diagram showing another embodiment of the present invention, and FIG. 3 is an implementation of a piping unit in which a tube is fixed on a seat and integrated. It is a block diagram which shows an example. 1 ... RI vial, 2 ... syringe, 3 ... saline vial, 4 ... dilution vial, 7 ... driving device, 8 ... out of liquid detector, 9 ... pressure detector, 10-10 ... label Vials 11-11 ... Lead shielding container, 12 ...
Cartridge, 13 ... Overflow bag, 14 ...
… Computer device, 15 …… Radiation detector, 16 ……
Drain vial, 17 ... Filter, 19 ... Spacer, 20 ... Piping unit.

Front page continued (72) Inventor Masaaki Tanaka 1-12-32 Nishihonmachi, Ube City, Yamaguchi Prefecture Ube Research Co., Ltd. Ube Laboratory (72) Inventor Masao Matsuno 1-12-32 Nishihonmachi, Yamaguchi Prefecture Ube Kosan Co., Ltd. Ube Laboratory (56) References AZ-107N techne dispenser catalog and instruction manual (Distributor Chiyoda Security Products Co., Ltd., Anzai Sogyo Co., Ltd.) Issued in October 1984

Claims (7)

[Claims] 1. A radioisotope vial containing a radioisotope solution, a saline vial containing a physiological saline solution, and a labeled vial containing a drug into which a predetermined amount of the radioisotope solution and a physiological saline solution is automatically injected. In a radioisotope automatic dispensing device mainly consisting of, a measuring means for measuring a solution amount by aspirating a predetermined amount from the radioisotope vial and a saline vial, and a diluting vial into which the solution in which the solution amount is measured is injected, A radiation detector for measuring the radioactivity intensity of the dilution vial, and a radioisotope from the injection amount of the radioisotope solution injected from the radioisotope vial into the dilution vial by the measuring means and the radiation intensity measured by the radiation detector. Measure the specific activity of the solution A radioisotope, comprising: a calculating means for calculating, and a adjusting means for adjusting a specific activity of the solution in the diluted vial by collecting a predetermined amount from the saline vial into the diluted vial by the measuring means. Automatic dispensing device. 2. The automatic radioisotope dispensing device according to claim 1, further comprising a liquid shortage detecting means provided in the middle of a tube connecting the radioisotope vial and the measuring means for measuring the amount of the solution. 3. The automatic radioisotope dispensing apparatus according to claim 1, further comprising a pressure detecting means in the middle of a tube connecting the measuring means for measuring the amount of the solution and the dilution vial. 4. The automatic radioisotope dispensing apparatus according to claim 1, wherein a tube through which a solution or gas flows is attached to and integrated with a sheet. 5. The automatic radioisotope dispensing apparatus according to claim 1, wherein a plurality of lead shielding containers for accommodating the labeled vials are attached to a portable frame body. 6. The radioisotope according to claim 1, wherein the other end of the tube connected to an injection needle for supplying and exhausting gas inside the vial inserted into the labeled vial is connected to a buffer container. Automatic dispensing device. 7. A radioisotope vial containing a radioisotope solution, a saline vial containing a physiological saline solution, and a labeled vial containing a drug into which predetermined amounts of the radioisotope solution and the physiological saline solution are automatically injected. In the automatic dispensing method of the radioisotope solution using the radioisotope automatic dispensing device mainly consisting of (a) while measuring the solution amount by sucking a predetermined amount of the radioisotope solution from the radioisotope vial into the dilution vial. Injecting the radioisotope solution, (b) measuring the radioactivity intensity of the radioisotope solution injected into the dilution vial, (c) the injection amount of the radioisotope solution injected into the dilution vial and the radioisotope solution Ratio of radioisotope solution from radiation intensity of Radioactivity characterized by calculating radioactivity and adjusting a specific activity of the solution in the dilution vial by collecting a predetermined amount of physiological saline solution from the saline vial to the dilution vial based on the obtained calculation result. Automatic isotope dispensing method.