JPH0647528B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial field of application> The present invention relates to cosmetics having excellent skin-beautifying effects and moisturizing effects.

<Prior Art> When the eggshell membrane of avian egg is used to cover a wound due to burns or the like, the eggshell membrane adheres to the wound and promotes epithelial formation of the skin. As is clear from this, the eggshell membrane has a good wound healing effect.

Although this mechanism is not yet clear, it is not only due to passive action such as suppression of exudate from the wound site by the eggshell membrane and prevention of bacterial infection, but unknown active ingredient is leached from the eggshell membrane and directly or It is speculated that this may be indirectly due to an active action such as promoting the proliferation of fibroblasts.

Therefore, it is highly expected that youthful skin can be obtained by incorporating eggshell membranes into cosmetics and activating epidermal cells and fibroblasts.

In order to meet that expectation, as disclosed in Japanese Patent Publication No. 56-11682, cosmetics containing a soluble egg shell membrane have been proposed.

<Problems to be Solved by the Invention> However, the cosmetics according to the above proposals have a weak skin-beautifying effect and do not fully meet expectations.

Therefore, it is desired to develop a cosmetic having a beautiful skin effect and a moisturizing effect by exerting a synergistic effect by using a soluble egg shell membrane in combination with other active ingredients, but such research has not been conducted yet.

In view of such circumstances, it is an object of the present invention to provide a cosmetic having an excellent skin beautifying effect and a moisturizing effect.

<Means for Solving the Problems> As a result of intensive research to achieve the above-mentioned object, the present inventor has found that a cosmetic composition in which a soluble eggshell membrane and sphingolipid are used in combination has a beautiful skin effect and a moisturizing effect. The present invention has been completed.

The cosmetic of the present invention is characterized by containing a soluble egg shell membrane and a sphingolipid.

In the present invention, the soluble eggshell membrane refers to a membrane (egg shell membrane) attached to the inside of the eggshell of an avian egg such as chicken eggs and quail eggs (eggshell membrane) solubilized in fresh water or alcohol, and specifically, the eggshell The membrane is solubilized with an acid agent, an alkaline agent, an organic solvent, an oxidizing / reducing enzyme, or the like. Since such a soluble eggshell membrane is not generally commercially available, an example of a method for obtaining a soluble eggshell membrane by treating the eggshell membrane with an acid, an alkali or the like by a conventional method will be shown here.

First, the eggshell membrane is decomposed in an alkaline water-containing organic solvent. Here, the alkaline hydrous organic solvent is caustic soda,
Aqueous solution 70-40 (weight%; hereinafter the same)% with an alkali agent such as caustic potash to make the alkali concentration 0.2-3.0 N, and a water-soluble organic solvent 30 such as methanol, ethanol, acetone, etc. -60% is mixed. . Appropriate conditions for the decomposition treatment are 30 to 60 ° C. and 1 to 8 hours.

Next, the solution of the soluble eggshell membranes is obtained by neutralizing and passing the obtained decomposition solution. Incidentally, if this solution is dried by a conventional method, a powdery soluble egg shell membrane is obtained.

On the other hand, in the present invention, the sphingolipid is a complex lipid having sphingoid as a common component and is not particularly limited in the present invention, but ceramide, cerebroside, sphingomyelin and derivatives thereof are preferable. This sphingolipid is used in various animals and plants such as pigs,
It is widely present in the epidermis of cattle, horses, etc., brain, or in eggs, soybeans, etc., but in the present invention, its origin is not limited, whether natural or synthetic.

Examples of the cosmetics of the present invention include hair nourishing agents, scalp agents, hair styling agents, lotions, creams, emulsions, packs and rinses.

In order to obtain the cosmetic of the present invention, the soluble egg shell membrane and the glycerophospholipid may be added to ordinary cosmetic raw materials, and the cosmetic may be prepared by a conventional method.

Here, the usual cosmetic raw material, depending on the type of cosmetics, for example, oil, water, surfactants, moisturizers, ultraviolet absorbers, alcohols, chelating agents, colorants, preservatives, colorants, fragrances , Antioxidants, etc.

The content of the soluble eggshell membrane is preferably 0.01 to 10% of the total amount of the cosmetic raw material in terms of dry matter, and the content of sphingolipid is preferably 0.001 to 5%.

In either case, if the blending amount is too small, the water-retaining effect of the obtained cosmetic tends not to be expected, and if it is too large, the resulting cosmetic tends to be sticky, which is not desirable.

<Example> (1) Preparation of Soluble Eggshell Membrane After breaking eggs of shell eggs to remove the egg liquid, the obtained egg liquid with the eggshell membrane is put into fresh water, and the eggshell is manually removed to remove the eggshell. A film was obtained. Then, the obtained eggshell membrane was immersed in a 1% hydrochloric acid aqueous solution for 1 hour to dissolve the minute eggshell attached to the eggshell membrane, washed with water and dried in the sun to obtain a dried eggshell membrane.

To 100 g of the dried eggshell membrane thus obtained, 1200 ml of 2N aqueous sodium hydroxide solution and 800 ml of absolute ethanol were added.
ml was added, and the eggshell membrane was solubilized by treatment at 40 ° C. for 5 hours with stirring.

Next, the obtained liquid is separated with a cloth filter, neutralized,
After desalting and freeze-drying, 53 g of a powdery soluble eggshell membrane was obtained.

(2) Production of cream The following raw materials were prepared.

-Raw material A (oil phase) cerebroside 0.2% beeswax 2.0 stearic acid 5.0 stearyl alcohol 5.0 reduced lanolin 2.0 squalane 20.0 sorbitan monostearate 3.0 polyoxyethylene sorbitan monostearate 3.0 Raw Material B (Aqueous Phase Part) Powdery Soluble Eggshell Membrane 0.5% 1,3-butylene glycol 5.0 Methylparaben 0.1 Purified Water 54.2 Oil Phase Part of Raw Material A and Water Phase of Raw Material B After heating and melting the parts, the raw material A was mixed with the raw material B, emulsified and cooled to produce a cream.

<Test example> Test example 1 (moisturizing test) The following three types of samples were prepared.

Test group: cream obtained in Example 1 Control group 1: cream obtained by removing soluble eggshell membrane from the formulation of Example 1 Control group 2: cream obtained by removing cerebroside from the formulation of Example 1 Control group 3: implementation Cream excluding soluble eggshell membrane and cerebroside from the formulation of Example 1 Next, a glass weighing bottle (inner diameter 45 mm) in which 20 g of each of the above samples was separately packed was prepared, and the temperature was maintained with the opening of the bottle open. After storing in a thermostat at 37 ° C. and a humidity of 60% for one month, the water loss of each sample was measured and the water retention capacity of each sample was measured. The results shown in Table 1 were obtained.

The water retention capacity was calculated by the following formula.

From the results shown in Table 1, it was confirmed that when the soluble eggshell membrane and cerebroside were used in combination (test group), the moisturizing properties were higher than when used alone (control groups 1 and 2). It was

Test Example 2 (Cosmetic Effect) The following samples were prepared.

Test plot: Cream obtained in Example (1) Control plot 1: Cream used in Control plot 1 of Test Example 1 Control plot 2: Cream used in Control plot 2 of Test Example 1 Next, from age 30 to 45 3 30-year-old girls, 10 for each
The samples were divided into groups and each of the above three kinds of samples was applied to the face once a day for morning and evening, and then the makeup effect was observed. The results shown in Table 2 were obtained.

In the table, “good” means that it is better than before use, “good” means that it is slightly better, and “not good” does not change, and the numerical values correspond to 10 test subjects in one group. Indicates the number of persons.

From the results shown in Table 2, when the soluble eggshell membrane and cerebroside as the sphingolipid are used in combination (test group), the skin-beautifying effect and the moisturizing effect are better than those when used alone (control groups 1 and 2). It was recognized that the feeling was high.

<Effects of the Invention> As described above, the cosmetic of the present invention contains the soluble eggshell membrane and the sphingolipid, and therefore has excellent skin-beautifying effect and moisturizing effect.

Claims (1)

[Claims] 1. A cosmetic comprising a soluble eggshell membrane and a sphingolipid blended therein.