JPH0647333U - Patch - Google Patents

Abstract

(57) [Abstract] [Purpose] Prevents skin irritation caused by drugs by supporting and fixing affected areas such as low back pain, tendon sheath, and muscle pain to provide heat retention and absorbing water that evaporates from the skin due to sweating and the like. , A patch with excellent adhesive strength and medicinal effect. [Structure] On a support A made of a foam, a water-absorbent sheet B containing 10 to 70 g / m ² of a water-soluble polymer and having a thickness of 5 to 100 μm, and a support C made of a non-woven fabric or a woven fabric are arranged in this order. It is laminated to form a laminate, and a plaster layer containing a medicinal component is formed on the support C side of the laminate.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to an adhesive patch, and more particularly to an adhesive patch having excellent supporting and fixing properties and heat retaining properties, and having improved stuffiness during application.

[0002]

[Prior art]

 Conventionally, various types of patches have been developed and put into practical use. For example, in JP-A-63-145222, a patch comprising a support a made of a foam, a support b made of a woven fabric or a non-woven fabric, and a paste b intermittently applied to the support b. Is disclosed.

However, the use of the above-mentioned patch suppresses evaporation of sweat from the skin and causes water to stay on the surface of the skin. It is known that such water softens the skin and increases skin irritation caused by drugs. Further, there is a problem that the adhesive force of the patch is reduced due to the moisture on the skin surface, and the patch peels off during use.

In order to avoid such skin irritation, a method of improving the air permeability of the patch to promote the evaporation of water can be considered. However, if the air permeability is excessively given, generally the patch is kept warm. There was a problem that the effect decreased.

Further, in order to promote water evaporation, a woven fabric such as suf, muslin, cotton cloth, or a napped fabric, or a non-woven fabric, or a thin film is used as the support, so that the support has good heat retention and ventilation. The one that has been imparted with the property and water absorption is used.

[0006] However, such a support does not have a function of fixing or supporting the affected part, and also has a weak back and cannot maintain its own form. Therefore, there is a problem in that the plaster surface of the patch bends during sticking, the plaster surface sticks to each other, and sticking becomes difficult.

[0007]

[Problems to be solved by the device]

 The present invention has been made in view of the above problems, and an object thereof is to support and fix affected areas such as low back pain, tendon sheath, and muscle pain to provide heat retention and absorb water evaporated from the skin due to sweating or the like. By doing so, it is to provide a patch that prevents skin irritation by a drug and exhibits excellent adhesive strength and drug effect.

[0008]

[Means for Solving the Problems]

 The present invention will be described in detail below. The support A used in the present invention is a foam. Examples of the foam include polyethylene, polyethylene-vinyl acetate copolymer and mixtures thereof, and foams such as polypropylene, polyvinyl chloride, polystyrene, and polyurethane.

As the foam, either closed cells or open cells can be used, but when the water vaporization effect is required, open cells are preferable as long as the heat retention is not impaired. Further, the foaming ratio of the foam can be 5 to 50 times, but 10 to 25 times is preferable for the purpose of use of the present invention.

The thickness of the support A is preferably 0.5 to 10 mm, more preferably 0.5 to 4 mm.

Further, in order to improve air permeability, the support A may be provided with a through hole in the thickness direction.

By using the foam having the above-mentioned properties, it is possible to give the support A a heat retaining effect and a supporting effect as well as a light weight, cushioning property and stretchability.

The foam used for the above-mentioned support A is obtained by, for example, mixing the above resin with a foaming agent, a cross-linking agent (however, not necessary in the case of radiation cross-linking), and if necessary, a functional monomer or the like. After molding into an appropriate shape such as a sheet, heat it to a temperature above the decomposition temperature of the cross-linking agent and below the decomposition temperature of the foaming agent to crosslink it, and then heat above the decomposition temperature of the foaming agent to expand it. Alternatively, it is produced by a method of simultaneously performing crosslinking and foaming. In the case of radiation crosslinking, a foam is produced by irradiating with radiation and crosslinking, followed by heat foaming.

The water-absorbent sheet B used in the present invention is, for example, one obtained by mixing a fiber or pulp made of cotton, rayon, or polyester with a water-soluble polymer and molding it into a sheet by pressing or the like. Can be mentioned.

Examples of the water-soluble polymer include polyacrylic acid and salts thereof, starch acrylate, polymers of polyacrylic acid and polyvinyl alcohol, carboxymethyl cellulose and the like.

When the content of the water-soluble polymer in the water-absorbent sheet B is small, the water-absorbing effect is not exhibited, and when it is large, the sticking feeling is deteriorated. Therefore, the content is limited to 10 to 70 g / m ² .

The thickness of the water-absorbent sheet B is limited to 5 to 100 μm because the water-absorbing sheet B has no water-absorbing effect when it is thin and the sticking feeling is poor when it is thick.

The support C used in the present invention is made of non-woven fabric or woven fabric. The support C preferably has a water supply / transpiration effect and a heat retention effect from the purpose of use, and examples thereof include non-woven fabric or woven fabric such as flannel, cotton, silk, polyester, nylon.

As the above-mentioned support C, it is possible to use from a thin material such as gauze having a coarse texture to a thick material having a thickness of 2 mm as long as it has an appropriate texture gap.

By using the support C as described above, the plaster layer, which will be described later, penetrates into the fabric, an anchor effect is generated, the adhesion with the support C is strengthened, and the plaster layer is peeled from the support C. To prevent the plaster from remaining on the skin after use.

The laminate used in the present invention is obtained by adhering the support A, the water-absorbent sheet B and the support C with an adhesive or heat-sealing with a heat-fusible sheet.

The plaster used in the present invention is composed of a composition containing a medicinal component and an adhesive.

As the above-mentioned medicinal components, salicylates such as methyl salicylate and glycol salicylate; various herbal medicines such as arnica, yellow oak, aloe, sanshin and chamomile; anti-inflammatory analgesics such as indomethacin, ketoprofen and flurbiprofen; Antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate; other drugs commonly used as external medicines such as camphor, menthol, peppermint oil, thymol, capsicum extract, vanillamide nonylate, vitamin E, etc. .

The above-mentioned pressure-sensitive adhesive may be any pharmaceutically acceptable one, and any conventionally known pressure-sensitive adhesive can be used. For example, acrylic pressure-sensitive adhesive, rubber pressure-sensitive adhesive, silicone pressure-sensitive adhesive, urethane pressure-sensitive adhesive. Examples thereof include pressure sensitive adhesives, and solvent type, emulsion type, hot melt type and the like can be used.

The above-mentioned acrylic pressure-sensitive adhesive is a pressure-sensitive adhesive mainly composed of alkyl (meth) acrylate and is a copolymer of a functional monomer or a polyfunctional monomer copolymerizable with acrylic (meth) acrylate. It may be.

Examples of the alkyl (meth) acrylate include methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, dodecyl (meth) acrylate. Acrylate and the like can be cited. When the number of carbon atoms of the alkyl group of the acrylate is small, the cohesive force is improved, but the tackiness is decreased, and when the carbon number is large, the cohesive force is improved but the cohesive force is lowered. Those are preferable.

Examples of the functional monomer include (meth) acrylic acid, 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycidyl methacrylate, N-methylol (meth) acrylamide, and N-butoxymethyl acrylamide. Etc.

If these functional monomers are copolymerized, they are cross-linked by metal salts such as sodium hydroxide and calcium hydroxide, isocyanate, epoxy resin, melamine resin, urea resin, ammonium, etc., and the adhesive is aggregated. You can improve your strength.

The polyfunctional monomer is copolymerized to improve the cohesive force of the pressure-sensitive adhesive, and examples thereof include 1,6-hexane glycol dimethacrylate, tetraethylene glycol diacrylate, and trimethylolpropane trichloride. Examples thereof include acrylate, divinylbenzene, divinyltoluene, diallyl phthalate, diallylmaleate, diallyl adipate, diallyl glycolate, triallyl isocyanurate, and diethylene glycol bisallyl carbonate.

Further, a vinyl compound copolymerizable with an alkyl (meth) acrylate may be copolymerized, and examples of the vinyl compound include vinyl acetate, acrylonitolyl, styrene, N-vinyl-2-pyrrolidone and the like. Can be mentioned.

The above-mentioned acrylic pressure-sensitive adhesive has an alkyl (meth) acrylate as a main component, and the other components may be appropriately determined depending on the required performance. Generally, the functional monomer is used in the pressure-sensitive adhesive. Copolymerized up to 20% by weight, preferably 1 to 10% by weight. The polyfunctional monomer is generally 0.005-0.5% by weight. The vinyl compound is generally copolymerized in an amount of 50% by weight or less, preferably 40% by weight or less.

Particularly, 2-ethylhexyl acrylate is preferably a copolymer of 55 to 89.5% by weight, N-vinyl-2-pyrrolidone 45 to 10% by weight, and a polyfunctional monomer 0.005 to 0.5% by weight. .

Needless to say, a tackifier, a filler and the like may be added to the acrylic pressure-sensitive adhesive within the pharmaceutically acceptable range.

Examples of the rubber-based adhesive include natural rubber, styrene-butadiene rubber, polyisobutylene, styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, styrene-olefin-styrene block copolymer. An adhesive containing a rubber such as a coalesce, which is generally added with a tackifier such as rosin, hydrogenated rosin, rosin ester, terpene resin, terpene phenol resin, petroleum resin, coumarone resin, coumarone-indene resin. It becomes.

Further, almond oil, olive oil, camellia oil, persic oil, peanut oil, sesame oil, soybean oil, mink oil, corn oil, safflower oil, coconut oil, castor oil and other oils, oleic acid, liquid paraffin, etc. It may be added.

Excipients may be added to the plaster as required, and examples of the excipients include those commonly used in external preparations such as kaolin, bentonite, titanium oxide and zinc white. Is mentioned.

The plaster is applied to the support C side of the laminate to form a plaster layer.

As a method for applying the plaster, a usual method for applying an adhesive tape is adopted, and examples thereof include a solution application method and a hot melt application method.

In the case of the solution coating method, the paste is uniformly mixed, spread on a release paper (or a support C of the laminate) and the solvent is dried, and then the support C (or release paper) is used. The patch of the present invention can be obtained by a method of laminating.

In the case of the hot melt coating method, the pressure-sensitive adhesive component other than the medicinal component is heated and stirred under nitrogen substitution at 120 to 180 ° C. to dissolve, and then cooled to 100 to 150 ° C. A medicinal ingredient is added and mixed uniformly to obtain a plaster. Then, the patch of the present invention is obtained by a method of spreading the paste on release paper (or support C of the laminate) with a hot melt coater and laminating the support C (or release paper).

The above-mentioned release paper is used for the purpose of protecting the pressure-sensitive adhesive layer. Examples of such release paper include polypropylene film, polyester film, polyethylene-coated high-quality paper, polyolefin-coated glassine paper and the like with silicone on one side. It is used after release treatment.

The plaster layer may be formed on the entire surface of the support C so as to be a continuous layer, or may be formed as a discontinuous layer such as a spot shape, a stripe shape, or a lattice shape.

[0043]

【Example】

Embodiments of the present invention will be described below. (Example 1) [Production of Laminated Body] A 2 mm-thick polyethylene foam (foaming ratio: 15 times, closed cells) was coated with an acrylic pressure-sensitive adhesive, and a thickness of 30 g / m ^{2 of} starch acrylate was mixed. After adhering a 70 μm rayon fiber water-absorbent sheet (basis weight 70 g / m ² ), heat-melt the low-density polyethylene film in a dot shape on the water-absorbent sheet, and then add the thickness to the polyethylene film. A 70 μm thick polyester nonwoven fabric (basis weight: 70 g / m ² ) was superposed and laminated to obtain a laminate.

[Preparation of plaster] 100 parts by weight of styrene-isoprene-styrene block copolymer rubber (ABA block copolymer rubber), 80 parts by weight of alicyclic resin, 100 parts by weight of liquid paraffin Put in a dissolution tank, heat and stir at 150-180 ° C to make the whole uniform, prepare an adhesive, and then add 6 parts by weight of glycol salicylate, 1 part by weight of sanshin and 0.07 parts by weight of capsicum extract. The uniformly mixed medicinal components were added to the above-mentioned adhesive and stirred until the whole became uniform to prepare a plaster.

[Preparation of adhesive patch] A release paper is attached to the raw material attachment portion of the coating machine, and a plaster is applied in a groove having a width of 10 mm in the circumferential direction of the coating roll. It was rolled on a release paper, and the paste was applied on the release paper in a stripe shape so as to have a thickness of 150 to 250 μm, a width of 10 mm, and an interval of 10 mm. Then, the non-woven fabric surface of the above-mentioned laminated body was placed on the plaster coated on the release paper, and after pressing through a pinch roll, it was cut into 200 × 100 mm to obtain a preparation of a patch.

[Evaluation of Performance of Patch] The above-mentioned preparation was attached to a human body suffering from back pain, and the following performance evaluations 1) to 4) were performed. 1) Feeling of use The results were shown on Table 1 after being attached to the lumbar regions of 27 men and women (16 men, 11 women) and evaluated based on the following evaluation criteria. (1) Stimulation is strong and it irritates and hurts. (2) It feels warm and very comfortable. (3) Warm and comfortable. (4) The warmth is weak and unsatisfactory. (5) I don't feel any warmth.

2) Supporting effect 27 pieces of males and females (16 males, 11 females) were affixed to the lumbar region, and the results were shown in Table 1 based on the following evaluation criteria. (1) The waist is firmly fixed. (2) The waist is fixed compared to when nothing is attached. (3) I feel that my waist is supported somehow. (4) There is no sense of fixation. (5) I feel stiff and feel strange.

3) Peelability Affixed to the lumbar regions of 27 men and women (16 men, 11 women) and evaluated based on the following evaluation criteria, and the results are shown in Table 1. (1) No residue of the plaster was observed on the skin after peeling. (2) The skin was slightly sticky after peeling. (3) The rest of the plaster was partially seen. (4) The plaster was peeled from the back.

4) Effect on sweat Five males adhered to their waists and ran, and evaluated based on the following criteria. The results are shown in Table 1. (1) There was no particular change in stickability. (2) It was slightly sticky. (3) Skin was rash. (4) It peeled off due to sweat.

Example 2 A polyethylene foam having a thickness of 2 mm (foaming ratio: 15 times, closed cells) was provided with 2000 through-holes having an opening area of 3 mm ² (pore diameter 1 mm) per 100 cm ^{2 and} a thickness of 7 μm. The low-density polyethylene film of No. 1 was heat-melted and placed, a water-absorbent sheet similar to that of Example 1 was laminated thereon, and a rubber-based adhesive was applied onto this sheet, and then the same as Example 1. The polyester non-woven fabric of was laminated and laminated to obtain a laminate. The same plaster as in Example 1 was applied to this laminate to prepare a patch preparation, and the same performance evaluation as in Example 1 was performed. The results are shown in Table 1.

Example 3 On a polyethylene foam (thickness: 15 times, closed cells) having a thickness of 2 mm in which 7800 through holes each having an opening area of 0.8 mm ² (hole diameter: 0.5 mm) were provided per 100 cm ^2. A low-density polyethylene film having a thickness of 7 μm and having 2000 through holes having an opening area of 3 mm ² (hole diameter 1 mm) per 100 cm ² was heat-melted and placed, and the same water-absorbing property as in Example 1 was placed on the film. After laminating the sheets, a rubber adhesive was applied onto the sheets, and the same polyester nonwoven fabric as in Example 1 was superposed and laminated to obtain a laminated body. The same paste as in Example 1 was applied to this laminate to prepare a patch preparation, and the same performance evaluation as in Example 1 was performed. The results are shown in Table 1.

Example 4 On a polyethylene foam (thickness: 25 times, open cell: 3 mm thick) having 20 through holes with an opening area of 154 mm ² (hole diameter: 14 mm) per 100 cm ² , (opening area: 3 mm A low-density polyethylene film having a thickness of 7 μm and having 2000 through holes of ² (hole diameter 1 mm) per 100 cm ² was heat-melted and placed, and the water-absorbent sheet similar to that of Example 1 was laminated on the film. Then, a low-density polyethylene film having a thickness of 7 μm was heat-melted and placed in a dot shape on this sheet, and the same polyester nonwoven fabric as in Example 1 was laminated to obtain a laminate. After applying the same plaster as in Example 1 to prepare a patch preparation, the same performance evaluation as in Example 1 was performed, and the results are shown in Table 1.

Example 5 A low-density polyethylene film having a width of 5 mm and a thickness of 7 μm was placed on a polyethylene foam having a thickness of 2 mm (foaming ratio: 15 times, open cells) in a grid pattern having a size of 200 mm × 100 mm. And a 190 mm × 90 mm water absorbent sheet similar to that of Example 1 was inserted into each lattice and the polyester nonwoven fabric similar to that of Example 1 was heated and melted to obtain a laminated laminate. The same plaster as in Example 1 was applied to this laminate to prepare a patch preparation, and the same performance evaluation as in Example 1 was performed. The results are shown in Table 1.

Comparative Example 1 A patch preparation was prepared in the same manner as in Example 1 except that a 4 mm-thick flannel (flexibility 19 mm according to JIS L1005) simple substance was used instead of the laminate. After that, the same performance evaluation as in Example 1 was performed, and the results are shown in Table 1.

Comparative Example 2 A 2 mm-thick polyethylene foam (foaming ratio: 15 times, open cells) was coated with an acrylic adhesive, and a water-absorbing sheet similar to that in Example 1 was laminated. After preparing a patch preparation in the same manner as in Example 1 except that the body was obtained, the same performance evaluation as in Example 1 was performed, and the results are shown in Table 1.

Comparative Example 3 A low-density polyethylene film having a thickness of 7 μm was melted and placed in a dot shape on a polyethylene foam having a thickness of 2 mm (foaming ratio: 15 times, open cells), and the test was performed on this film. A patch preparation was prepared in the same manner as in Example 1 except that the same polyester nonwoven fabric as in Example 1 was laminated to obtain a laminate, and the same performance evaluation as in Example 1 was performed. Is shown in Table 1.

[0057]

[Table 1]

[0058]

[Effect of device]

 The patch of the present invention provides a heat-retaining effect by supporting and fixing affected areas such as low back pain, tendon sheath, and muscle pain, and also absorbs water evaporating from the skin due to sweating, etc., to prevent skin irritation by the drug, Exhibits excellent adhesive strength and medicinal effect.

[Brief description of drawings]

FIG. 1 is a schematic sectional view showing an embodiment of the patch of the present invention.

[Explanation of symbols]

 1 Support A 2 Water-absorbent sheet B 3 Support C 4 Plaster layer 5 Release paper

Claims (1)

[Scope of utility model registration request] 1. A support A made of a foamed material, containing a water-soluble polymer in an amount of 10 to 70 g / m ^{2, and having} a thickness of 5 to 100 μm.
Water absorbent sheet B, support C made of non-woven fabric or woven fabric
However, the patch is formed by laminating in this order to form a laminate, and a plaster layer containing a medicinal component is formed on the support C side of the laminate.