JPH0640884A - Whitening cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having high skin whitening effect, also excellent in safety and stability, containing an extract of alfalfa. CONSTITUTION:The cosmetic containing 0.01-10 (pref.0.1-1) wt.%, on a solid basis, of an alfalfa extract obtained by adding 2-20 wt.times of a solvent such as water or methanol to dried or raw weeds of Medicago sativa, Medicago, media, etc., each belonging to Medicago hispida followed by extraction at 5-90 deg.C.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition containing an extract of alfalfa (including medicated cosmetic compositions which are quasi drugs, the same applies hereinafter).

[0002]

2. Description of the Related Art Generally, when the skin is irradiated with ultraviolet rays from sunlight, melanin is remarkably produced in pigment cell melanocytes in the skin and the skin tends to be blackened.
Prevention of blackening of the skin caused by such sunburn,
In addition, ascorbic acid, hydrogen peroxide, glutathione, colloidal sulfur, hydroquinone, kojic acid, cinnamic aldehyde, quercetin, quercetin, and other substances conventionally used in cosmetics for the purpose of removing spots and freckles caused by the deposition of melanin pigments. Catechins and the like are known.
However, these whitening ingredients have poor stability in the prescription system, and, for example, coloring and off-flavor due to decomposition may occur.
In terms of percutaneous absorption, the effect and efficacy are insufficient,
In addition, various problems and issues such as safety problems still remain.

[0003]

Therefore, an object of the present invention is to provide a whitening cosmetic composition which has a high whitening effect and is excellent in safety and stability.

[0004]

Means for Solving the Problems As a result of intensive studies for many years in view of such circumstances, the present inventors have found that the extract of alfalfa has a high whitening effect and is excellent in safety and stability. The present invention was completed based on this. So far, attempts have been made to apply the extract of alfalfa to skin cosmetics, but both are as moisturizing ingredients and emollient ingredients, and are related to whitening cosmetic ingredients as whitening ingredients and their whitening efficacy. No research has been done. That is, the present invention relates to a whitening cosmetic composition containing an extract of alfalfa.

The present invention will be described in detail below. The alfalfa used in the present invention is also referred to as rosin, and it is a medusa of the family of the family Lepidoptera:
L.), Medicago media Per
s.), Medicago falcata
L.) and the like may be used.

In the present invention, a solvent is first added to dried alfalfa grass or raw grass to extract, but the solvent to be used is not particularly limited as long as it is a solvent capable of efficiently extracting a whitening effect component from alfalfa. As specific examples, water, methanol, ethanol, isopropyl alcohol, n-butanol, ethyl acetate, acetone, xylene, toluene, benzene, chloroform, propylene glycol, 1,3-butylene. Examples thereof include glycol, glycerin and the like, and a mixed solution thereof, but propylene glycol and 1,3-butylene glycol are preferably used. Further, the extraction temperature and the amount of the extraction solvent are not particularly limited, but usually 5 to 90 ° C. and about 2 to 20 times the amount.

Further, after removing the insoluble matter by filtration, centrifugation or decantation, if necessary, decolorization,
For the purpose of deodorization, it is possible to use an adsorbent such as activated carbon, activated clay, silica gel, activated alumina synthetic resin or the like, or fractionate, purify or concentrate by solvent fractionation, reverse osmosis membrane, ion exchanger or the like. The obtained extract can be pulverized in the liquid form as it is or by a method such as vacuum concentration, spray drying or freeze drying.

When the safety of the extract of alfalfa used in the whitening cosmetic composition of the present invention was tested, it was found to be a practical problem in terms of acute toxicity, skin irritation, skin sensitization and mutagenicity. No points were observed, confirming the high safety.

Further, the stability of the extract of alfalfa used in the whitening cosmetic composition of the present invention will be described in Examples 5-1 below.
When the whitening cosmetic of No. 0 was stored at 40 ° C. for 6 months, the properties and physicochemical properties were tested, and it was confirmed that there was no change and the stability with time was high.

The amount of the alfalfa extract used in the whitening cosmetic composition of the present invention may be appropriately changed depending on the degree of symptoms, product form, frequency of use, etc. %, Preferably 0.1 to 1% by weight. If it is less than 0.01% by weight, even if the whitening cosmetic composition of the present invention is applied to the skin, the percutaneous absorption amount does not reach the optimum amount for exhibiting the whitening effect, and if it is 10% by weight or more, no increase in the effect is observed. , Not economically appropriate.

In the whitening cosmetic composition of the present invention, in addition to the alfalfa extract described above, other whitening ingredients may be used in combination.
Oils and fats, polyhydric alcohols, lower alcohols, thickeners, ultraviolet absorbers / scattering agents, antiseptics, antioxidants, chelating agents, pH adjusters, fragrances, dyes, water and the like can be appropriately added.

Specific examples of these additive components are as follows. As the surfactant, polyoxyethylene (hereinafter abbreviated as POE-) octyldodecyl alcohol,
POE-2-decyl PO such as tetradecyl alcohol
P such as E-branched alkyl ether, POE-oleyl alcohol ether, POE-cetyl alcohol ether
OE-alkyl ether, sorbitan monooleate,
POE such as sorbitan monoisostearate, sorbitan ester such as sorbitan monolaurate, POE-sorbitan monooleate, POE-sorbitan monoisostearate, POE-sorbitan monolaurate
-Glycerin fatty acid ester such as sorbitan ester, glyceryl monooleate, glyceryl monostearate, glyceryl monomyristate, POE-glyceryl monooleate, POE-glyceryl monostearate,
POE-glyceryl fatty acid ester such as POE-glyceryl monomyristate, POE-dihydrocholesterol ester, POE-hardened castor oil, POE-hardened castor oil, POE-hardened castor oil fatty acid ester such as isostearate, POE-octylphenol ether, etc. POE-alkyl aryl ether, glycerol monoisostearate, glycerol ester such as glycerol monomyristate, POE-glycerol monoisostearate, POE-glycerol ether such as POE-glycerol monomyristate, diglyceryl monostearate, decaglyceryl Non-iodine such as polyglycerin fatty acid ester such as decasterate, decaglyceryl decaisostearate, diglyceryl diisostearate Surfactants, myristic acid, stearic acid, palmitic acid, behenic acid, isostearic acid, potassium higher fatty acids such as oleic acid, sodium, diethanolamine, triethanolamine, salts such as amino acids, the alkali salts of ether carboxylic acids,
Anionic surfactants such as N-acyl amino acid salts, N-acyl sarconates, higher alkyl sulfonates, etc., cationic amines such as alkyl amine salts, polyamines, amino alcohol fatty acid organic silicone resins, alkyl quaternary ammonium salts, etc. Agents or amphoteric surfactants such as lecithin and betaine derivatives.

The oils and fats include castor oil, olive oil,
Cocoa oil, camellia oil, palm oil, wax, jojoba oil, grape seed oil, avocado oil and other vegetable oils, mink oil, egg yolk oil and other animal oils, beeswax, whale wax, lanolin, carnauba wax, candelilla wax, etc. Waxes, liquid paraffin, squalene, microcrystalline wax, ceresin wax, paraffin wax, hydrocarbons such as petrolatum, lauric acid, myristic acid, stearic acid,
Natural and synthetic fatty acids such as oleic acid, isostearic acid, behenic acid, cetanol, stearyl alcohol,
Natural and higher alcohols such as hexyldecanol, octyldecanol, and lauryl alcohol; esters such as isopropyl myristate, isopropyl parimiate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate.

As the polyhydric alcohol, ethylene glycol, polyethylene glycol, propylene glycol,
Polyglycerin such as 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, glycerin, diglycerin, triglycerin, tetraglycerin, glucose, maltose, maltose, sucrose, fructose, xylitolose, sorbitol, maltotri Aus, threitol, erythritol, etc.

Thickeners include sodium alginate,
Xanthan gum, aluminum silicate, quince seed extract, tragacanth gum, starch, collagen, natural macromolecules such as sodium hyaluronate, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, soluble starch, semi-synthetic macromolecules such as chaotic cellulose, carboxy Synthetic polymeric substances such as vinyl polymers and polyvinyl alcohol.

As the ultraviolet absorber, para-aminobenzoic acid, 2-ethoxyethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, butylmethoxybenzoylmethane, glyceryl-mono-2-ethylhexanoyl-di-paramethoxy. Benzophenone, digaroyl trioleate, 2-2'-dihydroxy-4-methoxybenzophenone, ethyl-4-bishydroxypropylaminobenzoate, 2-ethylhexyl-2-cyano-
3,3'-diphenyl acrylate, ethylhexyl paramethoxycinnamate, 2-ethylhexyl salicylate, glyceryl paraaminobenzoate, homomethyl salicylate, methyl orthoaminobenzoate, 2-hydroxy-4-methoxybenzophenone, amyl-para-dimethylaminobenzoate, 2-Phenylbenzimidazole-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and the like. Preservatives include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4.
4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, benzalkonium chloride, hinokitiol, resorcin, ethanol and the like. Examples of antioxidants include tocopherol, ascorbic acid, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid, and propyl gallate.

Examples of chelating agents include sodium edetate and sodium citrate. As other whitening ingredients,
Kojic acid, arbutin, etc.

Some of these additive components have a function of further improving the effectiveness of the skin cosmetic of the present invention by enhancing the stability or transdermal absorbability of the essential components of the present invention. In addition, the dosage form is arbitrary, and may be any soluble type, emulsion type, powder dispersion type, etc., and is widely used for basic cosmetics such as lotions, emulsions, creams and packs, as well as makeup cosmetics such as foundations. Available. Next, the present invention will be described based on test examples and examples, but the present invention is not limited to these.

[0019]

EXAMPLES Example 1. Preparation of alfalfa extract 4 kg of propylene glycol was added to 1 kg of dried alfalfa grass, and the mixture was stirred and extracted at 60 ° C. for 3 hours. Then, 100 g of diatomaceous earth was added and filtered. Further, 100 g of activated carbon was added to the filtrate and the mixture was stirred for 1 hour and then filtered to obtain 4 kg of an extract.

Example 2. Method for preparing alfalfa extract 6 kg of xylene is added to 1 kg of alfalfa dried grass, and the mixture is extracted with stirring at room temperature for 2 hours and then filtered. Further, 200 g of silica gel was added to the filtrate, stirred for 1 hour, filtered, concentrated under reduced pressure to remove xylene, and dissolved in 3 kg of squalane to obtain an extract.

Example 3. Preparation method of alfalfa extract 30 kg of ethanol was added to 8 kg of alfalfa raw grass, and the mixture was extracted with stirring at room temperature for 3 hours and then centrifuged. Further, the supernatant is added with 100 g of a synthetic resin adsorbent (Amberlite XAD-2).
Is passed through a column packed with and is concentrated under reduced pressure to remove ethanol to obtain 200 g of an extract.

Example 4. Method for preparing alfalfa extract 1 kg of alfalfa dried grass was mixed with 5 kg of 1,3-butylene glycol / water mixture (1: 1), stirred and extracted at 80 ° C for 2 hours, and then 100 g of diatomaceous earth was added and filtered. To do. Further, the filtrate is concentrated with a reverse osmosis membrane (NaCl inhibition rate 10%) to obtain 1 kg of an extract.

Test Example 1. Melanin production inhibitory effect test in cultured cells of alfalfa extract 2 × 10 ⁵ B16 mouse melanoma cells were cultured in a culture dish with a diameter of 6 cm using 10% fetal calf serum-added Eagle's MEM medium and 5% carbonic acid. Under air containing gas
It was cultured at 37 ° C for 6 days. The cells were detached with Dulbecco's phosphate buffer containing 0.025% trypsin, the number of cells was measured, and centrifugation was performed to visually compare the degree of whitening of the cells.

[0024]

[Table 1]

The results are shown in Table 1. All of the alfalfa extracts of the present invention had a stronger whitening effect on B16 mouse melanoma cells than kojic acid, which has been known to have a melanin production-inhibiting effect. Further, in the present test, the cells whitened by the alfalfa extract were re-cultured without adding the test substance, and as a result, the cells became black, the melanin production inhibitory effect of the alfalfa extract was reversible, and It was confirmed that the growth was not adversely affected.

Test Example 2. A test for treatment of melasma of alfalfa extract A panel of 40 subjects suffering from melasma, half of the 20 subjects was the cream of Example 5 described below, and the remaining 20 subjects was the extract of Example 5 from alfalfa. The cream (comparative example) having the formulation except for was applied to the face every day for 3 months, and the lightening effect after use was evaluated. (Judgment Criteria) Effective: Pigmentation was considerably thinned Fairly: Pigmentation was slightly thinned Invalid: Pigmentation did not change

[0027]

[Table 2]

The results are shown in Table 2. The whitening cosmetic composition of the present invention of Example 5 showed a significant therapeutic effect on liver spots.

Example 5. Whitening cream Stearic acid 2.0 (%) Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Polyoxyethylene (25) cetyl alcohol 3.0 Lipophilic glyceryl monostearate 2. 0 Propylene glycol 5.0 Extract of Example 1 2.0 Perfume, preservative Suitable amount Purified water Total amount 100

Example 6. Whitening cream Beeswax 6.0 (%) Cetanol 5.0 Reduced lanolin 8.0 Squalane 37.5 Fatty acid glycerin 4.0 Lipophilic monoglyceryl monostearate 2.0 Polyoxyethylene (20) sorbitan monolaurate 2.0 Propylene glycol 5.0 Extract of Example 2 0.5 Perfume, preservative Suitable amount Antioxidant Suitable amount Purified water Total amount 100

Example 7. Whitening lotion Glycerin 5.0 (%) Propylene glycol 4.0 Oleyl alcohol 0.1 Polyoxyethylene (20) sorbitan monolaurate ester 1.5 Polyoxyethylene (20) lauryl ether 0.5 Ethanol 10.0 Example Extract of 3 0.02 Fragrance, antiseptic Suitable amount UV absorber Suitable amount Purified water Total amount 100

Example 8. Whitening emulsion Stearic acid 0.2 (%) Cetanol 1.5 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 10.0 Polyoxyethylene (10) monooleate 2.0 Glycerin 3.0 Propylene glycol 5.0 Triethanolamine 1.0 Extract of Example 1 0.1 Fragrance, preservative Appropriate amount Purified water Total amount 100

Example 9. Whitening pack Polyvinyl alcohol 15.0 (%) Sodium carboxymethyl cellulose 5.0 5.0 Propylene glycol 3.0 Ethanol 10.0 Extract of Example 2 1.0 Fragrance, preservative Suitable amount Purified water Total amount 100

Example 10. Whitening foundation Stearic acid 2.4 (%) Propylene glycol monostearate 2.0 Cetostearyl alcohol 0.2 Liquid lanolin 2.0 Liquid paraffin 3.0 Isopropyl myristate 8.5 Carboxymethylcellulose sodium 0.2 Bentonite 0.5 Propylene glycol 4.0 Triethanolamine 1.1 Titanium oxide 8.0 Talc 4.0 Extract of Example 4 0.01 Perfume, preservative Suitable amount Purified water Total amount 100

[0035]

As described in detail above, the present invention provides a whitening cosmetic composition having a higher whitening effect than the conventionally known whitening cosmetic compositions and having excellent safety and stability.

Claims (1)

[Claims] 1. A whitening cosmetic composition comprising an alfalfa extract.