JPH0640857A - Hair-growing agent - Google Patents

Abstract

PURPOSE:To provide a hair-growing agent having excellent hair-growing effect. CONSTITUTION:The hair-growing agent contains a condensation product of hydrolyzed collagen protein and a fatty acid or its salt as an active component. The hair-growing effect can be further improved by compounding the active component with other hair-growing component and/or a component having skin capillary dilating action.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growing agent containing a condensate of a hydrolyzate of collagen protein and a fatty acid or a salt thereof as an active ingredient.

[0002]

BACKGROUND OF THE INVENTION Condensates of collagen protein hydrolysates and fatty acids or salts thereof are anionic protein-based surfactants, which have protective action, moisturizing action and softening action on skin and hair. Cage, soap, shampoo, conditioner,
It is used in cosmetics for hair, creams, emulsions, face washes, lipsticks, lip balms, etc. On the other hand, conventional hair-growth agents include those that are expected to have a hair-growth effect by inhibiting the activation of male hormones or increasing blood flow in capillaries, for example, having an odd carbon chain length of 5 to 25 carbon atoms. A hair-growing agent containing an aliphatic monohydric alcohol or an esterified product or an etherified product thereof as an active ingredient is known (Japanese Patent Publication No. 63-41364).

[0003]

However, the hair-growing agents known in the past are not yet sufficient in their hair-growing effect, and therefore, the development of a hair-growing agent having excellent effects has been eagerly awaited.

[0004]

SUMMARY OF THE INVENTION The inventors of the present invention have
As described above, the present invention has been completed by finding that a condensate of a hydrolyzate of collagen protein and a fatty acid or a salt thereof, which is used by being blended in cosmetics and hair agents, etc., exhibits an excellent hair-growing effect.

The hair restorer of the present invention contains a condensate of a hydrolyzate of collagen protein and a fatty acid or a salt thereof as an active ingredient.

The hydrolyzate of collagen protein in the condensate of hydrolyzate of collagen protein and fatty acid, which is the active ingredient of the hair-growth agent of the present invention, is mainly used for acid, alkali and enzyme of bovine or porcine bone and skin, respectively. Alternatively, it is a polypeptide obtained by hydrolysis in the presence of a combination, and is also called hydrolyzed collagen, which is used in cosmetics and the like.

The fatty acid in the condensate of the hydrolyzate of collagen protein and the fatty acid, which is the active ingredient of the hair restorer of the present invention, is a saturated fatty acid (eg, enanthic acid, caprylic acid, pelargonic acid, capric acid, undecyl acid, lauric acid). , Tridecyl acid, myristic acid, pentadecyl acid,
Palmitic acid, peptadecyl acid, stearic acid, isostearic acid, nonadecanoic acid, arachidic acid, behenic acid, etc., unsaturated fatty acids (for example, undecylenic acid, oleic acid, elaidic acid, cetoleic acid, erucic acid, brassic acid, linoleic acid, linolenic acid) Acid, arachidonic acid, stearic acid, etc.) and coconut oil fatty acid. Among these, isostearic acid, undecylenic acid, oleic acid and coconut oil fatty acid are preferable.

Examples of preferable salts of the condensate of collagen protein hydrolyzate and these fatty acids include inorganic or organic salts. Examples of the inorganic salts include alkali metal salts (eg sodium salt, potassium salt, etc.). Examples of the organic salt include triethanolamine salt, aminomethylpropanol salt, aminomethylpropanediol salt and the like.

Condensates of hydrolysates of collagen protein and fatty acids and salts thereof which are preferably used in the hair restorer of the present invention include isostearoyl hydrolyzed collagen, undecylenoyl hydrolyzed collagen, oleoyl hydrolyzed collagen and coconut oil fatty acid. Included are hydrolyzed collagen and their above-mentioned inorganic and organic salts.

The hair restorer of the present invention comprises a condensate of a collagen protein hydrolyzate and a fatty acid, which is an active ingredient, or a salt thereof, and various types of bases such as emulsions, creams,
It is produced by mixing with a base such as lotion, hair tonic, or hair liquid by a conventional method.

The concentration of the active ingredient in these various preparations is
Although not particularly limited, it is usually 0.01 to 20% by weight, preferably 0.5 to 10% by weight.

The hair restorer of the present invention includes, in addition to a condensate of a hydrolyzate of collagen protein and a fatty acid or a salt thereof, n-pentadecyl nicotinate having a hair-restoring action,
n-pentadecyl nicotinate-N-oxide, n-
By blending pentadecanoic acid glyceride, cepharanthin, etc., and carpronium chloride, which has a skin peripheral vasodilatory effect, assembly extract, vitamin E nicotinate, benzyl nicotinate, etc., the hair growth effect is further promoted. The concentration of the component having a hair-growing action and the component having a skin peripheral vasodilatory action in the above-mentioned preparation when blended is not particularly limited, but is usually 0.001 to 10% by weight in the former and 0.01 in the latter. To 10% by weight.

[0013]

[Effect] Next, the effect of the hair restorer of the present invention will be described with reference to test examples. Test Example 1 Test solution (1) 99% containing 5% 25% hexadecyl isostearate solution of isostearoyl hydrolyzed collagen
Ethanol solution (2) 99% ethanol solution containing 5% 25% hexadecyl isostearate solution of isostearoyl hydrolyzed collagen and 5% n-pentadecyl nicotinate (3) 99% ethanol solution (control) Test method As a test animal, 6-week-old male C ₃ H / He mice (1
Group 10 to 15 animals were preliminarily bred for 1 week, and on the day before the test, the skin surface of about 8 cm ² of the back of the animal was injured with an electric clipper for animals (Natsume Seisakusho Co., Ltd.) under ether anesthesia. Shred to prevent it. The test solution is applied to each back skin of the hair-removed animal once a day using lint cloth or the like every day except Saturday and Sunday. The hair regrowth is evaluated based on the change with time of the area ratio (hair regrowth rate) of the hair regrowth part to the hair removing part. Test results

[Table 1] As is clear from the above test results, the hair-growing agent of the present invention exhibits an excellent hair-growing action, and when used in combination with other hair-growing agents, further superior hair-growing action.

Test Example 2 Test Liquid (4) Emulsion of Example 8 (5) (5) Emulsion of Example 9 (6) (6) Emulsion of Example 10 (7) 60% ethanol solution (control) Test Method Test Example 1 Do the same as. Test results

[Table 2] As is apparent from the above test results, the hair-growing agent of the present invention exhibits an excellent hair-growing action, and is used in combination with another component having a hair-growing action (milky lotion of Example 8) or a component having a skin peripheral vasodilator action. In combination with (the emulsion of Example 9),
It also exhibits an excellent hair-growth effect.

[0015]

[Examples] The hair-growing agent of the present invention will be described in more detail below with reference to Examples. Example 1 To 99% ethanol, a 25% hexadecyl isostearate solution of isostearoyl-hydrolyzed collagen and a fragrance were added and stirred, and then purified water was added to obtain a lotion having the following composition. Weight% Isostearoyl Hydrolyzed Collagen 25% Hexadecyl Isostearate Solution 599% Ethanol 90 Purified Water 4.5 Perfume 0.5

Example 2 A lotion preparation was obtained in the same manner as in Example 1 except that potassium undecylenoyl hydrolyzed collagen was used instead of the 25% hexadecyl isostearate solution of isostearoyl hydrolyzed collagen.

Example 3 99% ethanol was mixed and stirred with coconut oil fatty acid hydrolyzed collagen triethanolamine, polyoxypropylene butyl ether, propylene glycol, polyoxyethylene hydrogenated castor oil derivative and perfume, and then purified water was added thereto. A hair liquid composition having the following composition was obtained. Weight% Coconut oil fatty acid hydrolyzed collagen Tri ethanolamine 3 99% ethanol 50 polyoxypropylene butyl ether 10 propylene glycol 5 polyoxyethylene hydrogenated castor oil derivative 0.5 (80 mol of ethylene oxide adduct) fragrance 0.5 purified water 31.0

Example 4 A coconut oil fatty acid hydrolyzed collagen A oleoyl hydrolyzed collagen was used in place of triethanolamine to obtain a hair liquid agent in the same manner as in Example 3.

Example 5 25% hexadecyl isostearate solution of isostearoyl-hydrolyzed collagen, cepharanthin, glycyrrhizinic acid and perfume were added to 99% ethanol and stirred to obtain a lotion having the following composition. Weight% Isostearoyl Hydrolyzed Collagen 25% Hexadecyl Isostearate Solution 3 Cepharanthin 0.002 Glycyrrhizic Acid 0.02 99% Ethanol 96.478 Perfume 0.5

Example 6 In the same manner as in Example 5, a lotion having the following composition was obtained. Weight% Isostearoyl Hydrolyzed Collagen 25% Hexadecyl Isostearate Solution 5 Vitamin E Nicotinate 0.3 L-Menthol 0.15 99% Ethanol 94.05 Perfume 0.5

Example 7 In the same manner as in Example 5, a lotion having the following composition was obtained. Weight% Isostearoyl Hydrolyzed Collagen 25% Hexadecyl Isostearate Solution 5 n-Pentadecyl Nicotinate-N-Oxide 599% Ethanol 89.5 Perfume 0.5

Example 8 (Phase A) 25% Solution of Isostearoyl Hydrolyzed Collagen in Hexadecyl Isostearate 2 Cepharanthin 0.002 Glyceryl tricaprate 5 Glyceryl monostearate 2.7 Diethanolamine cetylphosphate 0.3 (Phase B) Weight% Fragrance 0.5 Purified water 89.498 Phase A is heated to 80 ° C to melt, Phase B heated to 80 ° C is added to mix and emulsify, and the mixture is cooled to room temperature with stirring to obtain an emulsion. It was

Example 9 An emulsion having the following composition was obtained in the same manner as in Example 8. % By weight Isostearoyl hydrolyzed collagen 25% hexadecyl isostearate solution 2 Benzyl nicotinate 0.1 Glyceryl tricaprate 5 Glyceryl monostearate 2.7 Diethanolamine cetyl phosphate 0.3 Perfume 0.5 Purified water 89.4

Example 10 An emulsion having the following composition was obtained in the same manner as in Example 8. Weight% Isostearoyl Hydrolyzed Collagen 25% Hexadecyl Isostearate Solution 2 Glyceryl tricaprate 5 Glyceryl monostearate 2.7 Diethanolamine cetyl phosphate 0.3 Perfume 0.5 Purified water 89.5

Claims (5)

[Claims] 1. A hair restorer comprising a condensate of a hydrolyzate of collagen protein and a fatty acid or a salt thereof as an active ingredient. 2. The hair-growth agent according to claim 1, further comprising another component having a hair-growth action and / or a component having a skin peripheral vasodilatory action. 3. The hair restorer according to claim 2, wherein the other component having a hair-restoring action is n-pentadecyl nicotinate, n-pentadecyl nicotinate-N-oxide, n-pentadecanoic acid glyceride or cepharanthin. 4. A component having a skin peripheral vasodilatory action,
The hair restorer according to claim 2 or 3, which is carpronium chloride, assembly extract, vitamin E nicotinate or benzyl nicotinate. 5. A condensate of a collagen protein hydrolyzate and a fatty acid is isostearoyl hydrolyzed collagen,
The hair restorer according to any one of claims 1 to 4, which is undecylenoyl hydrolyzed collagen, oleoyl hydrolyzed collagen or coconut oil fatty acid hydrolyzed collagen.