JPH06321734A - Make-up cosmetic - Google Patents

Abstract

PURPOSE:To obtain a make-up cosmetic effective for treating pimple, containing hinokitiol. CONSTITUTION:This make-up cosmetic contains 0.001-10.0wt.%, preferably 0.01-5.0wt.% of hinokitiol, a well-known antimicrobial agent. In the case where the cosmetic is an emulsion composition, a mixture of a nonionic surfactant having >=7 HLB value, preferably POE hardened castor oil and a POE alkyl ether is added as an emulsifying agent to the emulsion composition to preferably show treating effect on pimple and stability. By mixing hinokitiol, treating effect on pimple can be obtained without being influenced by other components such as oil content, pigment and powder. The cosmetic also has excellent stability and effect on Propionibacterium acnes, a pimple causing bacterium continuously existing on the skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to makeup cosmetics effective for treating acne.

[0002]

BACKGROUND OF THE INVENTION Acne is one of the skin diseases, the cause of which has not been completely elucidated, but it is generally said that it is caused by excessive sebum secretion, keratinization of hair follicles, and bacteria in hair follicles. Creams and ointments containing drugs suitable for the purpose of solving these problems are expected as acne treatment products.

In drug substance, hinokitiol and photosensitizer 2
Antibacterial agents such as No. 01, sulfur, and berberine exert extremely high antibacterial activity in vitro against Propionibacterium acnes, which is a skin-resident acne bacterium. However, at present, only the lotion and water-dispersed products are effective as products, not the emulsified products or powder-containing products. Therefore, a product which is actually added to a cream, an ointment or an emulsion and is effective as a therapeutic agent for acne is very useful. Further, if it can be applied to a foundation system, it will be very interesting as a foundation effective for treating acne while hiding the redness of acne. On the other hand, the oil-in-water emulsion composition is an important formulation as an external preparation for the skin, such as a refreshing feeling to use, and it is useful to impart an acne treatment effect to this formulation.

[0004]

DISCLOSURE OF THE INVENTION The present inventors have diligently studied to obtain an excellent acne treatment effect in makeup cosmetics. As a result, when hinokitiol is used among various drugs, oil, pigment, powder, etc. The inventors have found that the above object can be achieved without being affected by other components, the stability is also good, and that it is effective against Propionibacterium acnes bacteria, and the present invention has been completed. Furthermore, it has been found that the use of a nonionic surfactant having HLB of 7 or more as an emulsifier is more effective.

[0005]

That is, the present invention relates to a makeup cosmetic composition containing hinokitiol.

The structure of the present invention will be described in detail below. Hinokitiol is a known antibacterial agent, and the content thereof is 0.001 to 1 in the makeup cosmetic of the present invention.
It is 10.0% by weight, preferably 0.01 to 5.0% by weight. If it is less than 0.01% by weight, the effect is not sufficient.

In the present invention, when the makeup cosmetic is in the form of an emulsion composition, the emulsifier used may be any of a cationic surfactant, an anionic surfactant and a nonionic surfactant.

However, among the surfactants, HLB
It is preferable to combine nonionic surfactants having (Note 1) of 7 or more from the viewpoint of acne treatment effect and stability.

To give a concrete example, polyoxyethylene (hereinafter abbreviated as POE) sorbitan monooleate, PO
POE sorbitan fatty acid esters such as E sorbitan monostearate and POE sorbitan tetraoleate, P
OE sorbit moonolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE
POE sorbit fatty acid esters such as sorbit monostearate, POE glycerin monostearate, P
POE glycerin fatty acid esters such as OE glycerin monoisostearate, POE glyceryl triisostearate, POE castor oil, POE hydrogenated castor oil, P
POE hydrogenated castor oil derivatives such as OE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE propylene glycol fatty acid ester, P
Examples include POE alkyl ethers such as OE fatty acid amide, sucrose fatty acid ester, POE behenyl ether, and POE cetyl ether, alkyl ethoxydimethylamine oxide, and trioleyl phosphoric acid.

Among them, POE having HLB of 7 or more
It is preferable to add hydrogenated castor oil and POE alkyl ethers, and it is most preferable to add POE (60 mol) hydrogenated castor oil and POE (30 mol) cetyl ether. The blending amount is 0.001 to 10.0% by weight, and particularly preferably 0.1 to 3.0% by weight.

(Note 1) The HLB value of the nonionic surfactant is calculated by the Kawakami equation of the following equation 1.

[0012]

## EQU1 ## HLB = 7 + 11.7 log (Mw / Mo) (where Mw represents the molecular weight of the hydrophilic group and Mo represents the molecular weight of the lipophilic group).

The make-up cosmetic composition according to the present invention contains a drug, a moisturizer, a thickener, a preservative,
Dispersant, fragrance, pigment, UV absorber, pigment, powder (talc, kaolin, sericite, muscovite, synthetic mica, phlogopite, calcium carbonate, silica, alumina, aluminum silicate, magnesium silicate, magnesium carbonate, Inorganic pigments such as barium sulfate and boron nitride; spherical organic powders such as spherical nylon, spherical polymethylmethacrylate, spherical polyethylene and spherical fluororesin; titanium dioxide,
White pigments such as zinc oxide; inorganic red pigments such as iron oxide (iron oxide) and iron titanate; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide, carbon black, and low order titanium oxide. Organic pigments such as Red No. 201, Orange No. 203, Yellow No. 205, Blue No. 401, Green No. 3, etc .;
Etc.), preservatives, fragrances, surfactants, oils (vegetable oils, fatty acids, higher alcohols, esters of fatty acids and higher alcohols, liquid oils such as silicone oil, liquid hydrocarbon oils; carnauba wax, candelilla wax, paraffin wax, Ingredients generally used in makeup cosmetics such as ceresin, microcrystalline wax, synthetic hydrocarbon wax, polyethylene wax, hydrogenated castor oil, solid fat (wax) such as refined lanolin, semisolid oil, etc. may be blended. it can.

The makeup cosmetic composition of the present invention may be in any form such as powder solid form, oily solid form, water-in-oil type or oil-in-water type.

[0015]

The present invention will be described in more detail with reference to the following examples. The present invention is not limited to this.
The blending amount is% by weight.

Example 1 Emulsion foundation wt% 1) Purified water Residue 2) Ethanol (95%) 5.0 3) Hinokitiol 0.05 4) Preservative proper amount 5) Propylene glycol 8. 06) Triethanolamine 1.0 7) Bentonite 1.5 8) Pigment proper amount 9) Titanium dioxide 6.0 10) Talc 6.0 11) Kaolin 3.0 12) Stearic acid 2.0 13) Cetyl alcohol 0.3 14) Liquid paraffin 20.0 15) Propylene glycol monostearate 1.5 16) POE (60 mol) hydrogenated castor oil 0.3 17) Perfume proper amount 1) -8) The mixture was heated and mixed with, and mixed and pulverized 9) to 12) were added thereto, and the mixture was uniformly dispersed with a homomixer and kept at 70 ° C. (aqueous phase). Separately, 13) to 17) were dissolved by heating at 70 ° C. (oil phase), the aqueous phase and the oil phase were mixed and emulsified by a homomixer, and then cooled to obtain an oil-in-water emulsion foundation.

Further, the control agents described below were used as Example 2 and Comparative Examples 1 to 3, and the blending amount was corrected with ion-exchanged water.

Example 2 From Example 1, POE (20 mol) sorbitan monolaurate was blended instead of POE hardened (60 mol) castor oil.

Comparative Example 1 Photosensitive element No. 201 (0.05%) was blended in place of the hiokitiol of Example 1.

Comparative Example 2 Salicylic acid (0.
1%).

Comparative Example 3 Instead of the thiothiol of Example 1, phenol was used.
(0.1%) was blended.

Example 3 Emulsion foundation 1) Purified water Residue 2) Propylene glycol 10.0 3) Ethanol 5.0 4) Hinokitiol 2.0 5) Triethanolamine 1.0 6) Pigment Appropriate amount 7) Titanium dioxide 6.0 8) Talc 6.0 9) Kaolin 3.0 10) Beeswax 3.0 11) Squalane 10.0 11) Stearyl alcohol 5.0 13) Stearic acid 10.0 14) Propylene Glycol monostearate 3.0 15) POE (5 mol) cetyl ether 3.0 16) Perfume proper amount 17) Preservative, antioxidant proper amount 1) -5) Each component was heated and mixed at 70 ° C. . 6) to 9) which had been mixed and pulverized were added to this, dispersed uniformly with a homomixer, and kept at 70 ° C. (aqueous phase). Separately 10) to 17) at 70 ℃
It melted by heating (oil phase). The aqueous phase and the oil phase were mixed and emulsified with a homomixer and then cooled to obtain an emulsified foundation.

Further, the following control agents were prepared as Comparative Examples 4 to 6, and the blending amount was corrected with ion-exchanged water.

Comparative Example 4 Photosensitive element No. 201 (0.1%) was blended in place of the hinokitiol of Example 3.

Comparative Example 5 Instead of the hinokitiol of Example 3, salicylic acid (0.
5%).

Comparative Example 6 Instead of the hinokitiol of Example 3, phenol (0.
5%).

Example 4 Emulsion foundation 1) Purified water Residue 2) Propylene glycol 3.0 3) Polyethylene glycol 400 2.0 4) Ethanol 5.0 5) Hinokitiol 0.01 6) Triethanolamine 1.0 7) Pigment proper amount 8) Titanium dioxide 6.0 9) Talc 6.0 10) Kaolin 3.0 11) Cetanol 1.5 12) Stearic acid 0.1 13) Palmitic acid 0.1. 1 14) Liquid lanolin 1.0 15) Squalane 2.0 16) Isopropyl myristate 1.0 17) Glyceryl monostearate 1.5 18) POE (60 mol) hydrogenated castor oil 0.5 1) -6) Each component was heated and mixed at 70 ° C. 7) to 10) which were mixed and pulverized were added thereto, and the mixture was uniformly dispersed with a homomixer and kept at 70 ° C. (aqueous phase). 11) ~ 18) separately 70 ℃
It melted by heating (oil phase). The aqueous phase and the oil phase were mixed and emulsified with a homomixer and then cooled to obtain an emulsified foundation.

In addition, Comparative Examples 7 to 9 were prepared using the following control agents, and the compounding amount was corrected with ion-exchanged water.

Comparative Example 7 Photosensitizer No. 201 (0.01%) was blended in place of the hinokitiol of Example 4.

Comparative Example 8 Instead of the hinokitiol of Example 4, salicylic acid (0.
1%).

Comparative Example 9 Instead of the hinokitiol of Example 4, phenol (0.
1%).

Example 5 Solid powder foundation 1) Sericite 70.0 2) Titanium dioxide 10.0 3) Pigment proper amount 4) Preservative proper amount 5) Hinokitiol 0.05 6) Squalane 5.0 7) Dimethylpolysiloxane 5.0 8) Sorbitan fatty acid ester 1.0 9) Perfume proper amount 6) The oil component of 9) is mixed and dissolved, and 5) is added and uniformly dissolved, and the powder component of 1) to 4) is added. The mixture was added, mixed and crushed, and then stamped on a metal plate to obtain a solid foundation.

Comparative Example 10 Correction was performed with sericite instead of the hinokitiol of Example 5.

Example 6 Powder solid white powder 1) Talc 80.0 2) Sericite 10.0 3) Muscovite 5.0 4) Preservative proper amount 5) Pigment proper amount 6) Hinokitiol 0.05 7) Squalane 3. 08) Liquid paraffin 1.0 9) Sorbitan fatty acid ester 1.0 10) Perfume proper amount 7) The mixed components of 10) are mixed and dissolved, and 6) is added and uniformly dissolved 1) to 5 ) Was added, mixed and crushed, and then stamped on a gold plate to obtain a solid white powder.

Comparative Example 11 Sericite was corrected in place of the hinokitiol of Example 6.

Example 7 Powder solid blusher 1) Talc 45.0 2) Muscovite 35.0 3) Titanium dioxide 5.0 4) Zinc oxide 5.0 5) Pigment proper amount 6) Preservative proper amount 7) Hinokitiol 0 .05 8) Liquid paraffin 5.0 9) Dimethylpolysiloxane 3.0 10) Sorbitan fatty acid ester 1.0 11) Perfume proper amount 8) to 11) are mixed and dissolved, and 7) is added to homogeneity. A mixture of the dissolved powder components 1) to 6) was added, and after mixing and crushing, a gold dish was punched to obtain a solid blusher.

Comparative Example 12 Sericite was corrected in place of the hinokitiol of Example 7.

Example 8 Oily foundation 1) Kaolin 10.0 2) Nylon powder 15.0 3) Sericite 15.0 4) Squalane 20.0 5) Pigment proper amount 6) Hinokitiol 0.05 7) Squalane 20.0 8) Dimethyl polysiloxane 15.0 9) Sorbitan fatty acid ester 1.0 10) Wax 10.0 11) Perfume proper amount 6) -9).
6) was added and uniformly dissolved. The powder components 1) to 5) were added thereto, dispersed at 80 ° C., wet pulverized with a TK mill, added with 10) and mixed at 90 ° C., and then filled in a metal plate to obtain an oily foundation.

Comparative Example 13 Correction was performed with sericite instead of the hinokitiol of Example 8.

<Measurement of antibacterial activity against acne bacteria (1)>
The antibacterial activity of the emulsified foundation was measured by the paper disc method. That is, on the surface of GAM agar medium (manufactured by Nissui Pharmaceutical Co., Ltd.)
erium acnes ATCC 11827) was inoculated at 10 ⁴ CFU / cm ² and a 50 μl sample impregnated paper disk (8 mm diameter, manufactured by ADVANTEC) was left on the surface of the medium. After anaerobically culturing this at 37 ° C for 48 hours,
The antibacterial activity was judged by the presence or absence of a growth inhibition zone around the paper disk. The results are shown in Table 1.

[0041]

[Table 1]

(⊚: a growth inhibition zone is widely recognized, ◯: a growth inhibition zone is recognized, ×: no growth inhibition zone is recognized)

<Measurement of antibacterial activity against acne bacteria (2)>
The liquid solid culture method was used to evaluate the antibacterial activity of powder solid foundation, powder solid white powder, powder solid blusher, and oily foundation. That is, the antibacterial activity was determined by inoculating a 10% sample solution (solvent was sterile water) with acne bacteria and measuring the viable cell count at 37 ° C over time. The results are shown in Table 2.

[0044]

[Table 2]

[0045]

The makeup cosmetics containing hinokitiol of the present invention have an excellent acne treatment effect.
As a result, the prescription range of the composition for treating acne is expanded, and a composition having not only a therapeutic effect but also a makeup effect can be obtained. Further, despite the presence of powders, emulsifiers, etc., the acne treatment effect is maintained without deactivating hinokitiol.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Ki Sakurai 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture Shiseido Daiichi Research Center

Claims (2)

[Claims] 1. A makeup cosmetic containing hinokitiol. 2. The makeup cosmetic composition according to claim 1, further comprising a nonionic surfactant having an HLB of 7 or higher.