JPH06254150A - Medical adhesive agent - Google Patents

Abstract

PURPOSE:To improve the adhesiveness for skin by allowing an adhesive layer to contain the adhesiveness applying resin. CONSTITUTION:The hydrophilic polymer used for adhesive composition comprises at least one kind selected from the group consisting of (cross-linked type) polyacrylic acid (salt), carboxymethyl-cellulose (salt), hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, polyvinyl alcohol, sodium alginate, polyvinyl pyrrolidone, methyl vinyl ether - maleic anhydride copolymer and gelatin. Water is used in 200-1200 pts.wt. for 100 pts.wt. hydrophilic polymer. The adhesiveness applying resin consists of at least one kind selected from the group consisting of rosin ester, hydrogen-added petroleum resin, and terpene group resin, and incorporated with 10-300 pts.wt. for 100 pts.wt. of hydrophilic polymer. Accordingly, the excellent adhesiveness for skin can be obtained.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a medical patch.

[0002]

2. Description of the Related Art Conventionally, various types of medical patches have been used. For example, Japanese Patent Application Laid-Open No. 3-67044 discloses a poultice containing a base polymer composed of a thermoplastic elastic material and a softening agent, a hydrophilic polymer aqueous solution composed of a hydrophilic polymer, a polyhydric alcohol and water, and a drug. ing.

However, since the poultice has a high water content, it has a problem of poor adhesion to the skin surface and peeling during use.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned drawbacks, and an object thereof is to exhibit good adhesiveness to the skin, and to be appropriately applied by applying it to a wound or a skin inflammation site. It gives a cooling sensation to keep the wound hydrated and moisturized to promote epidermal regeneration, absorbs excess body fluid that has exuded from the wound site, and is resistant to rash even after application for a long time. The object is to provide a medical patch that does not cause

[0005]

In the medical patch of the present invention, an adhesive layer is provided on one side of a support, and the adhesive layer comprises the hydrophilic polymer (a), water (b) and tackifier. It is formed from a pressure-sensitive adhesive composition composed of the resin (c).

Examples of the support include resin films of polyester, nylon, rayon, polyethylene, polyvinyl chloride, polyvinylidene chloride, polyethylene-vinyl acetate copolymer, polyurethane, etc .; cotton, polyester, rayon, polypropylene, etc. Woven or non-woven fabric;
Examples thereof include a laminate of the resin film and a woven or non-woven fabric.

The hydrophilic polymer (a) used in the pressure-sensitive adhesive composition includes polyacrylic acid (salt), cross-linked polyacrylic acid (salt), carboxymethyl cellulose (salt), hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose. , Polyvinyl alcohol, sodium alginate, polyvinylpyrrolidone,
One or more selected from the group consisting of methyl vinyl ether maleic anhydride copolymer and gelatin.

Examples of the above-mentioned polyacrylic acid salt, cross-linked polyacrylic acid salt and carboxymethyl cellulose salt include sodium salt.

In the pressure-sensitive adhesive composition, when the amount of water (b) is small, the moisture permeability of the pressure-sensitive adhesive layer is poor, and when it is large, it is included in the crosslinked structure formed in the hydrophilic polymer (a). Therefore, the amount is limited to 200 to 1,200 parts by weight, preferably 250 to 1,000 parts by weight, based on 100 parts by weight of the hydrophilic polymer (a).

The tackifying resin (c) used in the pressure-sensitive adhesive composition is at least one selected from the group consisting of rosin ester, hydrogenated petroleum resin and terpene resin.

In the pressure-sensitive adhesive composition, the tackifying resin (c)
If the amount is too small, the adhesive strength to the skin becomes insufficient, and if the amount is too large, the amount of the hydrophobic component becomes larger than the amount of the hydrophilic component, and sufficient moisture permeability and hygroscopicity cannot be obtained. (A) 10 per 100 parts by weight
To 300 parts by weight, preferably 15 to 250 parts by weight.

A crosslinking agent may be added to the pressure-sensitive adhesive composition for the purpose of increasing the degree of crosslinking of the hydrophilic polymer (a) and increasing the viscosity of the pressure-sensitive adhesive composition.

Examples of the cross-linking agent used in the pressure-sensitive adhesive composition include magnesium chloride, magnesium carbonate,
Magnesium compounds such as magnesium hydroxide; calcium compounds such as calcium chloride, calcium carbonate, calcium hydroxide and calcium sulfate; zinc compounds such as zinc hydroxide and zinc oxide; aluminum such as alum, aluminum sulfate, aluminum hydroxide and aluminum chloride. Compounds: sodium compounds such as sodium carbonate, sodium hydroxide and the like, which may be used alone 2
You may use together 1 or more types.

In the above-mentioned pressure-sensitive adhesive composition, when the amount of the crosslinking agent is small, a sufficient crosslinked structure is not formed in the hydrophilic polymer (a), and when the amount is large, the hydrophilic polymer (a) is agglomerated, so that the hydrophilicity is high. 0. 100 parts by weight of polymer (a).
05 to 100 parts by weight is preferable, and 0.1 is more preferable.
~ 80 parts by weight.

Further, the pressure-sensitive adhesive composition may further contain a moisturizer, if necessary, to the extent that the effects of the present invention are not impaired.
A pH adjuster, an antioxidant, a filler and the like may be added.

Examples of the moisturizers include glycerin, propylene glycol, sorbitol, 1,3-butylene glycol, polyethylene glycol and sodium lactate. These moisturizers may be used alone or in combination. The above may be used together.

Examples of the pH adjusting agent include sodium hydroxide, potassium hydroxide, lactic acid, acetic acid, citric acid and the like.

Examples of the above-mentioned antioxidant include butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), gallic acid esters such as propyl gallate, nordihydroguaiaretic acid (NDGA) and thiodipropionic acid. , Tocopherol and the like.

Examples of the filler include kaolin,
Examples thereof include titanium oxide, talc, calcium carbonate, magnesium carbonate, silicate, silicic acid, aluminum hydrate, barium sulfate, calcium sulfate and calcium sulfite.

The constitution of the medical patch of the present invention is as described above, but a drug may be contained in the pressure-sensitive adhesive layer if necessary.

Examples of the above-mentioned agents include sterilizing and disinfecting agents,
Anti-smear and scald drug, Purulent disease drug, healing promoter, burn drug, parasitic skin disease drug, antihistamine,
Antiallergic agents, analgesics, antibiotics, etc. may be mentioned, and if necessary, camphor, menthol, methyl salicylate,
Anti-itch, such as difendramine hydrochloride; hemostatic agents and the like may be added.

Examples of the sterilizing and disinfecting agent include acrinol and mercury curochrome solution, and examples of the anti-smear and cracking agents include glycerin, tocopherol acetate, glycyrrhetinic acid, methyl salicylate, mustard extract, vanillylamide nonylate and the like.

Examples of the purulent disease agent include sulfamethoxazole sodium, and examples of the healing accelerator include bucladesine sodium, tocoretinate, calf blood extract, lysozyme chloride, aluminum chlorohydroxy allantoinate. , Bendazac, aldioxa and the like.

As the burn drug, tincture oil, chitin,
Examples thereof include chitosan, and examples of the drug for parasitic skin diseases include thiantol, sulfur, phenol, decanium chloride, clotrimazole and the like.

Examples of antihistamines include chlorpheniramine maleate and diphenhydramine.

Examples of the analgesic include xylocaine, dibucaine hydrochloride and the like, and examples of the antibiotic include kanamycin monosulfate, streptomycin sulfate, oxytetracycline hydrochloride and the like.

The above drugs may be used alone or in combination of two or more kinds. The drug does not have to be completely dissolved in the pressure-sensitive adhesive layer, and may be dispersed in the pressure-sensitive adhesive layer.

In addition to the above drugs, aloe extract, mugwort extract and the like may be added.

A pressure-sensitive adhesive layer is formed by applying the above-mentioned pressure-sensitive adhesive composition onto a support by a conventionally known method. However, if the thickness of the pressure-sensitive adhesive layer becomes thin, it is difficult to apply it to the support. As the thickness increases, the cost increases, so
500 μm is preferable, and more preferably 50 to 300 μm.
m. After coating the pressure-sensitive adhesive composition on a support, if necessary, 30 to 90 ° C., more preferably 35 to 70 ° C.
May be dried in.

Release paper may be laminated to protect the pressure-sensitive adhesive layer. As release paper, polyester film, polypropylene film, polyethylene coated paper,
Polyethylene-coated glassine paper or the like with one surface treated with silicon is used.

[0031]

The medical patch of the present invention contains a tackifying resin such as a rosin ester and a terpene resin in the pressure-sensitive adhesive layer, and thus exhibits good adhesion to the skin. In addition, the medical patch of the present invention, when applied to cutaneous sites such as cuts, abrasions, burns and irritation due to sunburn and skin irritation such as heat rash,
The water in the water-soluble polymer in the adhesive layer gives a good cooling effect and promotes healing by keeping the wound site in an appropriate moist environment. Further, in the medical patch of the present invention, since a cross-linking structure of hydrophilic polymers is formed in the pressure-sensitive adhesive layer, no adhesive residue occurs when peeled from the application site.

[0032]

EXAMPLES Examples of the present invention will be described below. (Example 1) 60 parts by weight of cross-linked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and sodium carboxymethyl cellulose ("Serogen" manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.) 4
500 parts by weight of water, hydrogenated petroleum resin ("Emulsion AM-1002" manufactured by Arakawa Chemical Co., Ltd.) 10 parts by weight relative to 0 parts by weight
An adhesive composition consisting of parts by weight is applied to a polyurethane film support to form an adhesive layer having a thickness of 200 mμ,
A polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

(Example 2) 70 parts by weight of sodium polyacrylate ("Aronbis" manufactured by Nippon Pure Chemical Co., Ltd.) and hydroxypropyl cellulose ("Shin-Etsu HP" manufactured by Shin-Etsu Chemical Co., Ltd.)
C ”) 30 parts by weight, 500 parts by weight of water, terpene-based resin (“ YS resin Px ”manufactured by Yasuhara Chemical Co., Ltd.) 7
A polyester woven fabric support was coated with 0 parts by weight of a pressure-sensitive adhesive composition to form a pressure-sensitive adhesive layer having a thickness of 200 mμ, and a polypropylene film subjected to a one-sided silicone release treatment was laminated on the pressure-sensitive adhesive layer as release paper. A medical patch was obtained.

(Example 3) 70 parts by weight of hydroxyethyl cellulose ("Fujichemi HEC" manufactured by Fuji Chemical Co., Ltd.) and 30 parts by weight of sodium alginate ("Kimitsu algin" manufactured by Kimitsu Chemical Co., Ltd.), 500 parts by weight of water and rosin ester ( Arakawa Chemical Co., Ltd. "Super Ester E-72"
0 ") 100 parts by weight of a pressure-sensitive adhesive composition is applied to a nylon film support to form a pressure-sensitive adhesive layer having a thickness of 200 mμ, and the polyethylene-coated glassine paper having a one-sided silicone release treatment is peeled off from the pressure-sensitive adhesive layer. It was laminated as paper to obtain a medical patch.

(Example 4) 70 parts by weight of cross-linked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and 30 parts by weight of sodium carboxymethyl cellulose ("Serogen" manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.) and 800 parts of water. Parts by weight, 100 parts by weight of glycerin, 50 parts by weight of hydrogenated petroleum resin ("Emulsion AM-1002" manufactured by Arakawa Chemical Co., Ltd.), and 30 parts by weight of sodium carbonate as a cross-linking agent are applied to a polyester film support. Then thickness 20
A pressure-sensitive adhesive layer having a thickness of 0 mμ was formed, and a polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

Example 5 70 parts by weight of polyvinylpyrrolidone ("Kollidon" manufactured by BASF Japan Ltd.) and 30 parts by weight of methyl vinyl ether maleic anhydride copolymer ("GANTREZ AN" manufactured by Gokyo Sangyo Co., Ltd.) were used. An adhesive composition comprising 600 parts by weight of distilled water, 10 parts by weight of magnesium chloride as a cross-linking agent and 50 parts by weight of a terpene-based resin (“YS resin Px” manufactured by Yasuhara Chemical Co., Ltd.) was applied on a polyethylene-vinyl acetate copolymer film support. Was applied to form a pressure-sensitive adhesive layer having a thickness of 250 μm, and a polypropylene film having a one-sided silicone release treatment was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

Example 6 80 parts by weight of crosslinked polyacrylic acid (“Hibiswako” manufactured by Wako Pure Chemical Industries, Ltd.) and 20 parts by weight of polyvinyl alcohol (“Hosefimer” manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) were added to water. An adhesive composition comprising 500 parts by weight, glycerin 100 parts by weight, rosin ester (“Super Ester E-720” manufactured by Arakawa Chemical Co., Ltd.) 20 parts by weight, and aluminum chloride 0.1 part by weight as a cross-linking agent was used as a polyurethane film support. 20 on the top
A pressure-sensitive adhesive layer having a thickness of 0 μm was formed, and a polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

Example 7 50 parts by weight of cross-linked polyacrylic acid (“Hibiswako” manufactured by Wako Pure Chemical Industries, Ltd.), 20 parts by weight of polyvinylpyrrolidone (“Kollidon” manufactured by BSF Japan) and sodium carboxymethyl cellulose (first) 500 parts by weight of water, 200 parts by weight of glycerin, hydrogenated petroleum resin (Emulsion AM-10 manufactured by Arakawa Chemical Co., Ltd.) per 30 parts by weight of “Serogen” manufactured by Kogyo Seiyaku Co., Ltd.
02 ") 50 parts by weight, sodium carbonate 30 as a crosslinking agent
50 parts by weight of Aldioxa (“Carmicha granules” manufactured by Taisho Pharmaceutical Co., Ltd.), which is a healing promoter as a drug, and acrinol (“Acrinol solution” manufactured by Ebis Co., Ltd.), which is a disinfectant.
An adhesive composition consisting of 1 part by weight is applied onto a cotton woven fabric support to form an adhesive layer having a thickness of 300 μm, and the adhesive layer is a polyester film which has been subjected to one-sided silicone release treatment as release paper. The layers were laminated to obtain a medical patch.

(Example 8) 70 parts by weight of polyvinylpyrrolidone ("Kolidone" manufactured by BSF Japan) and 30 parts by weight of methyl vinyl ether-maleic anhydride copolymer ("GANTREZ AN" manufactured by Gokyo Sangyo Co., Ltd.) , Glycerin 50 parts by weight, distilled water 400 parts by weight, aluminum chloride 0.1 part by weight as a cross-linking agent, terpene-based resin (“YS resin Px” manufactured by Yasuhara Chemical Co., Ltd.) 50
A pressure-sensitive adhesive composition consisting of 1 part by weight of a disinfectant acrinol (“ACINOL liquid” manufactured by Ebisu Co., Ltd.) as a drug and applied on a polyester non-woven fabric support to give a thickness of 300
A pressure-sensitive adhesive layer having a thickness of μm was formed, and a polypropylene film subjected to a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

(Example 9) 40 parts by weight of cross-linked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and 60 parts by weight of sodium carboxymethyl cellulose ("Serogen" manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.) and 800 parts of water. Parts by weight, 100 parts by weight of glycerin, 50 parts by weight of hydrogenated petroleum resin (“Emulsion AM-1002” manufactured by Arakawa Chemical Co., Ltd.), 30 parts by weight of sodium carbonate as a cross-linking agent, and hydrocortisone acetate as a drug (made by Taisho Pharmaceutical Co., Ltd.). "Coleton") 2 parts by weight of a pressure-sensitive adhesive composition is applied on a rayon non-woven fabric support to form a pressure-sensitive adhesive layer having a thickness of 300 μm, and the polyester film subjected to a silicone release treatment on one side is peeled off from the pressure-sensitive adhesive layer. It was laminated as paper to obtain a medical patch.

(Example 10) 30 parts by weight of hydroxyethyl cellulose ("Fujichemi HEC" manufactured by Fuji Chemical Co., Ltd.) and 70 parts by weight of sodium carboxymethyl cellulose ("Serogen" manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) were used, and 500 parts of water was added.
Parts by weight, 100 parts by weight of glycerin, 20 parts by weight of rosin ester ("Super Ester E-720" manufactured by Arakawa Chemical Co., Ltd.), 10 parts by weight of sodium carbonate as a cross-linking agent, and bucladesine sodium as a healing accelerator as a drug (Daiichi Pharmaceutical Co., Ltd.). "Actin Ointment" manufactured by K.K.), 10 parts by weight of a pressure-sensitive adhesive composition is applied on a polypropylene non-woven fabric support to form a pressure-sensitive adhesive layer having a thickness of 300 μm, and a polyester film treated on one side with silicon is formed on the pressure-sensitive adhesive layer. It was laminated as a release paper to obtain a medical patch.

Example 11 Water was added to 80 parts by weight of crosslinked polyacrylic acid (“Hibiswako” manufactured by Wako Pure Chemical Industries, Ltd.) and 20 parts by weight of polyvinyl alcohol (“Hosefimer” manufactured by Nippon Synthetic Chemical Industry Co., Ltd.). 500 parts by weight, glycerin 100 parts by weight, rosin ester (“Super Ester E-720” manufactured by Arakawa Chemical Co., Ltd.) 20 parts by weight, sodium carbonate 10 parts by weight as a cross-linking agent, and bucladesine sodium (first drug as a healing accelerator as a drug. 10 parts by weight of a pressure-sensitive adhesive composition manufactured by Pharmaceutical Industries Co., Ltd.) is applied onto a polyurethane film support to form a pressure-sensitive adhesive layer having a thickness of 200 μm, and the pressure-sensitive adhesive layer is treated with a silicone coating on one side thereof. Glassine paper was laminated as a release paper to obtain a medical patch.

(Comparative Example 1) The abrasion site was disinfected with Mercurochrome solution, the wound site was covered with gauze, and the gauze was fixed with an adhesive tape.

(Comparative Example 2) 60 parts by weight of crosslinked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and 40 parts by weight of sodium carboxymethyl cellulose ("Serogen" manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) were added to water. 180 parts by weight and hydrogenated petroleum resin ("Emulsion AM-1" manufactured by Arakawa Chemical Co., Ltd.
002 ") 10 parts by weight of a pressure-sensitive adhesive composition is applied on a polyurethane film support to form a pressure-sensitive adhesive layer having a thickness of 200 μm, and a polyethylene-coated glassine paper treated with a silicone release on one side is formed on the pressure-sensitive adhesive layer. It was laminated as a release paper to obtain a medical patch.

(Comparative Example 3) 60 parts by weight of crosslinked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and sodium carboxymethyl cellulose ("C manufactured by Daicel Chemical Co., Ltd."
MC Daicel ") 40 parts by weight, and 1600 parts by weight of water and 10 parts by weight of hydrogenated petroleum resin (" Emulsion AM-1002 "manufactured by Arakawa Chemical Co., Ltd.) are coated on a polyester nonwoven fabric support. Then thickness 300
A pressure-sensitive adhesive layer having a thickness of μm was formed, and a polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

Comparative Example 4 70 parts by weight of sodium polyacrylate ("Aronbis" manufactured by Nippon Pure Chemical Co., Ltd.) and hydroxypropyl cellulose ("Shin-Etsu HP" manufactured by Shin-Etsu Chemical Co., Ltd.)
C ") 30 parts by weight, 500 parts by weight of water, terpene resin (" YS resin Px "manufactured by Yasuhara Chemical Co., Ltd.) 4
A pressure-sensitive adhesive composition consisting of 00 parts by weight is applied onto a rayon non-woven fabric support to form a pressure-sensitive adhesive layer having a thickness of 300 μm,
A polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

Comparative Example 5 70 parts by weight of sodium polyacrylate (“Aronbis” manufactured by Nippon Pure Chemical Co., Ltd.) and hydroxypropyl cellulose (“Shin-Etsu HP” manufactured by Shin-Etsu Chemical Co., Ltd.)
C ") 30 parts by weight, 500 parts by weight of water and a terpene resin (" YS resin Px "manufactured by Yasuhara Chemical Co., Ltd.)
A pressure-sensitive adhesive composition consisting of 400 parts by weight was coated on an ethylene-vinyl acetate copolymer film support to give a thickness of 200.
A pressure-sensitive adhesive layer having a thickness of μm was formed, and a polyethylene-coated high-quality paper having a silicone release treatment on one side was laminated as a release paper on the pressure-sensitive adhesive layer to obtain a medical patch.

(Comparative Example 6) 70 parts by weight of crosslinked polyacrylic acid ("Hibiswako" manufactured by Wako Pure Chemical Industries, Ltd.) and sodium carboxymethyl cellulose ("C" manufactured by Daicel Chemical Industries, Ltd.)
MC Daicel ") 30 parts by weight, 800 parts by weight of water, 100 parts by weight of glycerin, 50 parts by weight of hydrogenated petroleum resin (" Emulsion AM-1002 "manufactured by Arakawa Chemical Co., Ltd.) and 0.01 parts by weight of sodium carbonate as a crosslinking agent. Part of the adhesive composition onto a cotton woven fabric support to give a thickness of 3
A pressure-sensitive adhesive layer having a thickness of 00 μm was formed, and a polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

(Comparative Example 7) 70 parts by weight of polyvinylpyrrolidone ("Kolidone" manufactured by BSF Japan) and 30 parts by weight of methyl vinyl ether-maleic anhydride copolymer ("GANTREZ AN" manufactured by Gokyo Sangyo Co., Ltd.) , Glycerin 100 parts by weight, distilled water 600 parts by weight,
120 parts by weight of aluminum chloride as a cross-linking agent and a terpene-based resin (“YS resin Px” manufactured by Yasuhara Chemical Co., Ltd.)
A pressure-sensitive adhesive composition comprising 50 parts by weight is applied to the woven side of a cotton woven cloth and a polyurethane film laminated support to give a thickness of 30.
A pressure-sensitive adhesive layer having a thickness of 0 μm was formed, and a polyester film having a silicone release treatment on one side was laminated on the pressure-sensitive adhesive layer as release paper to obtain a medical patch.

(Comparative Example 8) 2% by weight of a non-woven fabric made of sodium carboxymethyl cellulose (made by Asahi Kasei Corporation)
Immerse in a hexane solution of silicone rubber dispersion (“SD8001 dispersion” manufactured by Toray Silicone Co., Ltd.) for 1 minute, leave it at room temperature for 30 minutes, and then, on silicone release paper, 20 wt% polyether type urethane (Dainichi Seika) A tetrahydrofuran / dimethylformamide mixed solution of "Leathermin P-2045R" manufactured by the company) was applied using an applicator to form a film. Immediately after the application, the above-mentioned nonwoven fabric was placed on the wet layer, allowed to stand at room temperature for 15 minutes, and then cured in an oven at 55 ° C for at least 1 hour to obtain a medical patch.

Comparative Example 9 A solution prepared by dissolving 17 parts by weight of polyvinylidene fluoride powder (“Kynar K301” manufactured by Mitsubishi Petrochemical Co., Ltd.) in 72 parts by weight of acetone and 8 parts by weight of dimethylfolinamide was placed on a polyethylene terephthalate film. After casting, it is immersed in a 1,1,2-trifluoroethane bath for 5 minutes, dried and the average pore size is 0.45μ.
Thus, a polyvinylidene fluoride porous film having a thickness of m and a film thickness of 135 μm was obtained. A plasma-initiated surface graft polymerization of N, N-dimethylacrylamide onto this film was performed to obtain a hydrophilic polyvinylidene fluoride film.

[Evaluation of medical patch] For each of the 20 types of samples obtained in the above Examples and Comparative Examples, 5 samples per sample
An adult male person evaluates the following items (1) to (6),
The results are shown in Tables 1 and 2. (1) Pain at the time of replacement When the sample was applied to the wound for 12 hours and peeled off, the person who did not feel any pain and judged that he / she did not hurt the wound filled in the score 1 and felt the pain or the wound. The person judged to be injured entered 0 points, and the total points of 5 persons are shown in Tables 1 and 2. (2) Feeling of sticking While the sample was stuck to the wound for 12 hours, the person who judged that it did not peel off wrote a score of 1 and the person who judged that it did peeled off wrote 0 points and the total of 5 people. The points are shown in Tables 1 and 2. (3) Healing effect The sample was applied to the wound site for 12 hours, and the person who judged that healing without suppuration entered a score of 1, and the person who judged that healed did not enter 0 points and 5 people The total points are shown in Tables 1 and 2. (4) Moisture on the wound While the sample was applied to the wound for 12 hours, the person who judged that there was moderate moisture permeability and did not have heat on the wound filled in the score 1 and the person who judged that there was heat Enter 0 points and 5
The total points of persons are shown in Tables 1 and 2. (5) Absorption of excess exudate from the wound The person who judged that the appropriate wet condition was maintained so that the wound healed promptly while the sample was applied to the wound for 12 hours filled in the score 1. However, the person who judged that the wet state was not maintained filled in 0 points, and the total points of 5 persons were shown in Table 1 and Table 2.
It was shown to. (6) Prosthetic property While the sample was applied to the wound for 12 hours, a person who absorbed sweat, bodily fluids, etc., caused no one, and judged that there was no glue residue A person who judged that there was adhesive residue filled in 0 points, and the total points of 5 persons are shown in Table 1 and Table 2.

[0053]

[Table 1]

[0054]

[Table 2]

[0055]

The composition of the medical patch of the present invention is as described above, exhibits good adhesion to the skin, remarkably reduces skin irritation and skin damage, and has cuts, abrasions, and burns. Also, wounds such as inflammation due to sunburn, bruise, not only keep the wound in a hydrated wet state and promote epidermal regeneration by applying it to a skin inflammation site such as atopy,
It does not cool the inflammation of the wound, absorbs excess exudate from the wound site, etc., and does not cause adhesive residue when peeling.

Claims (1)

[Claims] 1. A medical patch comprising a support and a pressure-sensitive adhesive layer provided on one surface thereof, wherein the pressure-sensitive adhesive layer comprises (a) polyacrylic acid (salt), crosslinkable polyacrylic acid (salt), and carboxy. Methyl cellulose (salt), hydroxypropyl cellulose,
100 parts by weight of one or more hydrophilic polymers selected from the group consisting of hydroxyethyl cellulose, methyl cellulose, polyvinyl alcohol, sodium alginate, polyvinyl pyrrolidone, methyl vinyl ether-maleic anhydride copolymer and gelatin, (b) water 200 to 1 , 2
00 parts by weight and (c) 10 to 300 parts by weight of a tackifying resin selected from the group consisting of rosin esters, hydrogenated petroleum resins and terpene-based resins. Characteristic medical patch.