CN115400231A - Conductive medical adhesive and preparation method and application thereof - Google Patents
Conductive medical adhesive and preparation method and application thereof Download PDFInfo
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- CN115400231A CN115400231A CN202110584793.6A CN202110584793A CN115400231A CN 115400231 A CN115400231 A CN 115400231A CN 202110584793 A CN202110584793 A CN 202110584793A CN 115400231 A CN115400231 A CN 115400231A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J9/00—Adhesives characterised by their physical nature or the effects produced, e.g. glue sticks
- C09J9/02—Electrically-conducting adhesives
Abstract
The invention provides a conductive medical adhesive and a preparation method and application thereof. The raw materials for preparing the conductive medical adhesive comprise the following components in parts by weight: 15-50 parts of gelatin, 0.1-3 parts of conductive agent and 20-50 parts of modifier. The preparation method comprises the following steps: (1) Mixing gelatin, a conductive agent and water, and solidifying to obtain hydrogel; (2) And (2) modifying the hydrogel obtained in the step (1) and a modifier to obtain the conductive medical adhesive. The conductive medical adhesive prepared by the invention has better conductivity and adhesiveness, and better biocompatibility, and is suitable for being used as wound surface sealing materials or bonding repair materials for peripheral nerve injury.
Description
Technical Field
The invention belongs to the technical field of biomedical materials, and particularly relates to a conductive medical adhesive and a preparation method and application thereof.
Background
With the rapid development of economic level and the promotion of medical health industry, the requirements of patients on operation service and postoperative wound appearance are continuously improved. In recent years, the research and development and industrialization of biomedical adhesive glue are rapidly developed. The medical adhesive can be tightly embedded with the wound surface, can firmly keep the involution state of the wound, reduces the bleeding and infection probability of the wound, and has the effects of controlling bleeding, closing the wound, inhibiting scar hyperplasia and the like.
CN110960724A discloses a medicinal hydrogel and a preparation method thereof. The medical hydrogel is obtained by uniformly dispersing raw materials comprising methacrylic acid esterified gelatin, polydopamine hyaluronic acid and first nanoparticles and performing a cross-linking reaction; the weight ratio of the methacrylated gelatin to the polydopamine hyaluronic acid is (1-5): 1, and the weight of the first nanoparticles accounts for 0.05-0.2% of the total weight of the methacrylated gelatin and the polydopamine hyaluronic acid; the first nano-particle is obtained by dispersing beta-cyclodextrin modified graphene oxide and N, N '-di-sec-butyl-N, N' -dinitroso-1, 4 phenylenediamine into an organic solvent according to the weight ratio of 1 (1.5-2.5), stirring and reacting for 8-20h in a dark place, and standing. The hydrogel prepared by the technical scheme has the functions of fitting the wound and stopping bleeding along with the change of the shape of the wound, but the preparation process is complex.
CN111420125A discloses a medical hydrogel and a preparation method thereof. The preparation method comprises the following steps: providing an acidic aqueous solution of gelatin; adding a coupling agent into the acidic aqueous solution of the gelatin to carry out a first crosslinking reaction to obtain a gelatin/coupling agent solution, wherein the coupling agent is a silane coupling agent containing amino and/or epoxy bonds; standing the gelatin/coupling agent solution at 1-4 ℃ to obtain gelatin/silicon dioxide hybrid hydrogel; and (2) soaking the gelatin/silicon dioxide hybrid hydrogel in a specific salt solution for 1-2 days, and drying the hydrogel for 2-3 days at room temperature to obtain the gelatin/silicon dioxide toughened hydrogel, wherein the specific salt solution is a salt solution formed by sulfate radical, monohydrogen phosphate, dithiosulfate radical anions, ammonium ions and sodium ions. The hydrogel prepared by the technical scheme has better mechanical property and biocompatibility, but the preparation process is more complex.
In addition, peripheral nerve damage caused by accidental or iatrogenic injury can easily result in loss of local sensation, perception, motor function, and even life-long disability, severely affecting the quality of life of the patient and placing a heavy economic burden on the patient's home. Peripheral nerve injury is one of the most common difficult and problematic diseases in surgical clinic, and clinically selecting an appropriate treatment means to promote the regeneration and repair of nerves is a very challenging problem.
The gel has a naturally formed communication network structure and flexibility close to soft tissue, so that the gel has great advantages when being used for repairing the nerve defect by selecting natural or synthetic high polymer crosslinked into flexible adhesive gel with stable materialization. For example, CN111001036A discloses a single-walled carbon nanotube composite material conductive nerve sleeve, and a preparation method and application thereof. The single-walled carbon nanotube composite material conductive nerve sleeve consists of a tube body and a coating covering the surface of the tube body; the tube body is a single-walled carbon nanotube containing carboxyl; the coating and the pipe body are combined together in a physical adsorption and chemical bond combination mode; the coating is composite hydrogel. The conductive nerve sleeve prepared by the invention has excellent characteristics of good biocompatibility, conductivity and the like, and realizes the effects of repairing large-section nerve defects and promoting the repair of peripheral nerve injury.
In addition, electrical stimulation can promote proliferation of neurons and glial cells and growth of axons, thereby stimulating regeneration of nerve tissue. The conductive material is introduced into the adhesive glue, so that the important research significance is realized on repairing the nerve defect, the conductivity of the conductive material can stimulate the growth and the function exertion of nerve cells, and the conductive material and the nerve cells have biological interaction in various ways, and a new thought is provided for improving the fracture repair of the adhesive glue on peripheral nerve tissues and realizing the treatment.
Based on the influence of conductivity on nerve regeneration function, how to provide a medical adhesive with better conductivity and adhesiveness becomes a technical problem to be solved at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a conductive medical adhesive and a preparation method and application thereof. The invention designs the raw material components of the conductive medical adhesive glue and further adopts the conductive agent and the modifier, so that the prepared medical adhesive glue has better conductivity and adhesiveness and better biocompatibility, and is suitable for being used as a wound surface sealing material or a bonding repair material for peripheral nerve injury.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a conductive medical adhesive, which is prepared from the following raw materials in parts by weight: 15-50 parts of gelatin, 0.1-3 parts of conductive agent and 20-50 parts of modifier.
According to the invention, through the design of the raw material components of the conductive medical adhesive glue and further adopting a conductive agent and a modifier, the medical adhesive glue has better conductivity and adhesiveness, and is suitable for being used as a wound surface sealing material or a bonding repair material for peripheral nerve injury.
In the invention, the medical adhesive has better conductivity by using the conductive agent and controlling the content of the conductive agent within a specific range. If the content of the conductive agent is too small, the prepared medical adhesive has poor conductivity; if the content of the conductive agent is too much, the prepared medical adhesive can generate a powder falling phenomenon, and the production cost of the medical adhesive can be increased.
In the present invention, the gelatin may be 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 27 parts, 30 parts, 33 parts, 36 parts, 38 parts, 40 parts, 42 parts, 46 parts, 50 parts, or the like by weight.
The conductive agent may be present in an amount of 0.1 part, 0.2 part, 0.5 part, 0.7 part, 1 part, 1.3 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3 parts, or the like, by weight.
The modifier may be in the amount of 20, 22, 25, 27, 30, 33, 36, 38, 40, 42, 46, or 50 parts by weight, etc.
The following is a preferred embodiment of the present invention, but not a limitation to the embodiment provided by the present invention, and the object and advantageous effects of the present invention can be more preferably achieved by the following preferred embodiment.
As a preferred embodiment of the present invention, the conductive agent is selected from any one of silver nanowires, carbon nanotubes, graphene, and MXene, or a combination of at least two of the foregoing.
MXene is a two-dimensional inorganic compound in material science, and is composed of several atomic layer thick transition metal carbides, nitrides, or carbonitrides. In the present invention, the process for preparing the conductive medical adhesiveThe silver nanowire and the carbon nanotube used in the present invention are commercially available silver nanowire solution and carbon nanotube solution, respectively, and the MXene used in the present invention is MXene nanosheet colloidal solution, illustratively including but not limited to Ti 3 C 2 -MXene nanoplatelet colloidal solution.
Preferably, the diameter of the silver nanowires is 20-60nm, such as 20nm, 22nm, 25nm, 27nm, 30nm, 33nm, 36nm, 40nm, 42nm, 46nm, 50nm, 52nm, 55nm, 57nm, or 60nm, etc.
Preferably, the carbon nanotubes have a length of 10 to 30 μm, and may be, for example, 10 μm, 12 μm, 14 μm, 16 μm, 18 μm, 20 μm, 22 μm, 24 μm, 26 μm, 28 μm, 30 μm, or the like.
Preferably, the carbon nanotubes have a diameter of 5 to 15nm, and may be, for example, 5nm, 6nm, 7nm, 8nm, 9nm, 10nm, 11nm, 12nm, 13nm, 14nm, 15nm, or the like.
Preferably, the number of layers of the graphene is 1-5, and may be 1, 2, 3, 4 or 5, for example.
In a preferred embodiment of the present invention, the mass percentage of the modifier in the modifier solution is 10% to 40%, and may be, for example, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 27%, 30%, 33%, 35%, 38%, 40%, or the like.
Preferably, the modifier comprises a combination of modifier a and modifier B.
Preferably, the modifier a is sodium citrate.
Preferably, the modifier B is selected from any one of aluminum chloride, ammonium chloride or ammonium sulfate or a combination of at least two thereof.
Preferably, the mass ratio of modifier a to modifier B is (1.8-2.2) 1, and can be, for example, 1.8.
In a preferred embodiment of the present invention, the raw material for preparing the conductive medical adhesive further comprises 50 to 85 parts of water, for example, 50 parts, 52 parts, 55 parts, 57 parts, 60 parts, 63 parts, 65 parts, 68 parts, 70 parts, 72 parts, 75 parts, 78 parts, 80 parts, 83 parts or 85 parts.
In a second aspect, the present invention provides a method for preparing the conductive medical adhesive glue according to the first aspect, wherein the method comprises the following steps:
(1) Mixing gelatin, a conductive agent and water, and solidifying to obtain hydrogel;
(2) And (2) modifying the hydrogel obtained in the step (1) and a modifier to obtain the conductive medical adhesive.
According to the invention, firstly, the hydrogel is prepared from gelatin, a conductive agent and water, then the surface of the hydrogel is modified by the modifier, the medical adhesive with better conductivity and adhesiveness is prepared, and the prepared conductive medical adhesive has better biocompatibility.
Specifically, the modifier in the invention selects the combination of the modifier A and the modifier B, generates an aluminum citrate complex or an ammonium citrate complex through the reaction between the sodium citrate of the modifier A and the aluminum ions or ammonium ions in the modifier B, and then modifies the surface of the hydrogel through the generated complex to obtain the conductive medical adhesive with better adhesion.
As a preferred embodiment of the present invention, the mixing temperature in the step (1) is 60 to 100 ℃ and may be, for example, 60 ℃, 65 ℃, 70 ℃, 75 ℃, 80 ℃, 85 ℃, 90 ℃, 95 ℃ or 100 ℃.
Preferably, the mixing time in step (1) is 0.5-1.5h, such as 0.5h, 0.6h, 0.7h, 0.8h, 0.9h, 1h, 1.1h, 1.2h, 1.3h, 1.4h or 1.5h, etc.
Preferably, the solidification method in step (1) is low-temperature standing.
Preferably, the low temperature stationary temperature is 4-10 degrees C, such as 4 degrees C, 5 degrees C, 6 degrees C, 7 degrees C, 8 degrees C, 9 degrees C or 10 degrees C.
Preferably, the low temperature standing time is 0.5-1h, such as 0.5h, 0.6h, 0.7h, 0.8h, 0.9h or 1h.
As a preferable technical scheme of the invention, the method also comprises a post-treatment step after the mixing in the step (1) is finished.
Preferably, the post-treatment is carried out at 60-100 deg.C, such as 60 deg.C, 65 deg.C, 70 deg.C, 75 deg.C, 80 deg.C, 85 deg.C, 90 deg.C, 95 deg.C or 100 deg.C.
It should be noted that the method of defoaming is not limited in the present invention, and includes, but is not limited to, standing at 60-100 deg.C for defoaming. If the defoaming treatment is not carried out, the hydrogel prepared in the step (1) contains bubbles, so that the finally prepared conductive medical adhesive has defects and has adverse effects on the conductivity and the adhesiveness of the adhesive.
In a preferred embodiment of the present invention, the modification method in step (2) is to immerse the hydrogel in a modifier for modification.
Preferably, the time of the modification is 0.5 to 1h, and may be, for example, 0.5h, 0.6h, 0.7h, 0.8h, 0.9h, 1h, or the like.
As a preferred technical scheme of the invention, the preparation method specifically comprises the following steps:
(1) Mixing gelatin, conductive agent and water at 60-100 deg.C for 0.5-1.5 hr, standing for defoaming, cooling to 4-10 deg.C, standing for solidifying for 0.5-1 hr to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 0.5-1h for modification to obtain the conductive medical adhesive.
In a third aspect, the present invention provides an application of the electrically conductive medical adhesive glue according to the first aspect in preparing a wound sealing material or a bonding repair material for peripheral nerve injury.
Compared with the prior art, the invention has the following beneficial effects:
the invention adopts the conductive agent and the modifier through the design of the raw material components of the conductive medical adhesive, and the content of the conductive agent is further controlled within a specific range by using the modifier A and the modifier B in a matching way, so that the medical adhesive has better conductivity and adhesiveness, the resistivity is 0.3-790 omega.m, and the adhesive strength is 356-800N/m; is suitable for being used as wound surface sealing material or adhesive repairing material for peripheral nerve injury.
Drawings
Fig. 1 is a real object diagram of the conductive medical adhesive provided in embodiment 1 of the present invention.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Some of the feed component sources in the following examples and comparative examples are as follows:
gelatin: sigma-Aldrich;
silver nanowires: beijing Germany island gold technologies, inc.;
carbon nanotube: nanjing Xiancheng nanomaterial science and technology Co., ltd;
graphene: nanjing Xiancheng nanomaterial science and technology Co., ltd;
Ti 3 C 2 -MXene nanoplatelet colloidal solution: prepared according to the method described in CN 110098326A.
Example 1
The embodiment provides a conductive medical adhesive and a preparation method thereof, the physical diagram of which is shown in fig. 1, and the preparation raw materials of the conductive medical adhesive comprise the following components in parts by weight: 40 parts of gelatin, 1 part of graphene, 40 parts of modifier solution and 59 parts of water;
the modifier solution comprises 30% of a modifier by mass, wherein the modifier consists of sodium citrate and aluminum chloride according to a mass ratio of 2.
The preparation method of the conductive medical adhesive comprises the following steps:
(1) Mixing gelatin, graphene and water at 70 ℃ for 1h, standing for defoaming, cooling to 4 ℃, standing for solidification for 1h to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 30min for modification to obtain the conductive medical adhesive.
Example 2
The embodiment provides a conductive medical adhesive and a preparation method and application thereof, and the raw materials for preparing the conductive medical adhesive comprise the following components in parts by weight: 30 parts of gelatin, 0.2 part of carbon nano tube, 30 parts of modifier solution and 70 parts of water;
the modifier solution comprises 10% of a modifier by mass, and the modifier consists of sodium citrate and ammonium chloride according to a mass ratio of 15.
The preparation method of the conductive medical adhesive comprises the following steps:
(1) Mixing gelatin, carbon nanotubes and water at 60 ℃ for 1.5h, standing for defoaming, cooling to 10 ℃, standing for solidification for 1h to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 40min for modification to obtain the conductive medical adhesive.
Example 3
The embodiment provides a conductive medical adhesive and a preparation method and application thereof, and the preparation raw materials of the conductive medical adhesive comprise the following components in parts by weight: 15 parts of gelatin, 3 parts of silver nanowires, 20 parts of modifier solution and 85 parts of water;
the mass percentage of the modifier in the modifier solution is 20%, and the modifier consists of sodium citrate and ammonium sulfate according to the mass ratio of 1.8.
The preparation method of the conductive medical adhesive comprises the following steps:
(1) Mixing gelatin, silver nanowires and water at 100 ℃ for 0.5h, standing for defoaming, cooling to 6 ℃, standing for solidification for 40min to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 50min for modification to obtain the conductive medical adhesive.
Example 4
The embodiment provides a conductive medical adhesive and a preparation method and application thereof, and the preparation raw materials of the conductive medical adhesive comprise the following components in parts by weight: 50 parts of gelatin and Ti 3 C 2 0.1 part of MXene nanosheet colloidal solution, 50 parts of modifier solution and 50 parts of water;
the mass percentage of the modifier in the modifier solution is 40%, and the modifier consists of sodium citrate and aluminum chloride according to the mass ratio of 2.2.
The preparation method of the conductive medical adhesive comprises the following steps:
(1) Mixing gelatin and Ti at 80 deg.C 3 C 2 Mixing the-MXene nanosheet colloidal solution with water for 35min, standing for defoaming, cooling to 7 ℃, standing for solidifying for 40min to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 1h for modification to obtain the conductive medical adhesive.
Example 5
The embodiment provides a conductive medical adhesive and a preparation method thereof, and the difference from the embodiment 1 is only that the weight part of graphene is 0.1 part, and other conditions are the same as the embodiment 1.
Example 6
The embodiment provides a conductive medical adhesive and a preparation method thereof, and the difference from the embodiment 1 is only that the weight part of graphene is 3 parts, and other conditions are the same as those of the embodiment 1.
Example 7
The embodiment provides a conductive medical adhesive and a preparation method thereof, and the difference from the embodiment 1 is only that the modifier is sodium citrate, and other conditions are the same as the embodiment 1.
Comparative example 8
The present embodiment provides a conductive medical adhesive and a preparation method thereof, which are different from those of embodiment 1 only in that the modifier is aluminum chloride, and other conditions are the same as those of embodiment 1.
Comparative example 1
The comparison example provides a conductive medical adhesive and a preparation method thereof, and the difference from the example 1 is only that the weight part of the graphene is 0.05 part, and other conditions are the same as the example 1.
Comparative example 2
The comparison example provides a conductive medical adhesive and a preparation method thereof, and the difference from the example 1 is only that the weight part of the graphene is 5 parts, and other conditions are the same as the example 1.
The conductive medical adhesive provided by the above examples and comparative examples were tested for their performance according to the following test criteria:
resistivity: testing the resistivity of the conductive medical adhesive provided by the above examples and comparative examples by an RTS-9 type double electric test four-probe tester, wherein the thickness of the conductive medical adhesive is 1mm;
adhesive strength: the conductive medical adhesive provided in the above examples and comparative examples were peeled from glass according to the T-peel test (ASTM D903) to test the adhesive strength.
The above examples and comparative examples provide test results of the properties of the conductive medical adhesive glue as shown in table 1:
TABLE 1
As can be seen from the data in the table 1, the invention adopts the conductive agent and the modifier through the design of the raw material components of the conductive medical adhesive, and the content of the conductive agent is further controlled within a specific range through the matching use of the modifier A and the modifier B, so that the medical adhesive has better conductivity and adhesiveness, the resistivity is 0.3-790 omega.m, and the adhesive strength is 356-800N/m; is suitable for being used as wound surface sealing material or adhesive repairing material for peripheral nerve injury.
Compared with example 1, if only sodium citrate is used as the modifier in the raw materials for preparing the medical adhesive glue (example 7) or only aluminum chloride is used as the modifier in the raw materials for preparing the medical adhesive glue (example 8), the prepared conductive medical adhesive glue has poor adhesion. Therefore, the conductive medical adhesive prepared by using the modifier A and the modifier B has better adhesion.
Compared with example 1, if the content of the conductive agent in the raw materials for preparing the conductive medical adhesive glue is too small (comparative example 1), the conductivity of the prepared conductive medical adhesive glue is poor, and the resistivity of the conductive medical adhesive glue is 2900 Ω · m; if the content of the conductive agent in the raw materials for preparing the medical adhesive glue is too large (comparative example 2), the prepared medical adhesive glue has better conductivity, but the powder falling phenomenon can be generated, and the production cost of the medical adhesive glue can be increased. Therefore, the content of the conductive agent is controlled within a specific range, so that the prepared conductive medical adhesive has better conductivity and can not generate powder falling.
In conclusion, the invention adopts the conductive agent and the modifier through the design of the raw material components of the conductive medical adhesive glue, and further controls the content of the conductive agent in a specific range through the matching use of the modifier A and the modifier B, so that the medical adhesive glue has better conductivity and adhesiveness, and is suitable for being used as a wound surface sealing material or a bonding repair material for peripheral nerve injury.
The applicant states that the present invention is illustrated by the detailed process flow of the present invention through the above examples, but the present invention is not limited to the above detailed process flow, that is, it does not mean that the present invention must rely on the above detailed process flow to be implemented. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The conductive medical adhesive is characterized by comprising the following raw materials in parts by weight: 15-50 parts of gelatin, 0.1-3 parts of conductive agent and 20-50 parts of modifier.
2. The conductive medical adhesive according to claim 1, wherein the conductive agent is selected from any one of or a combination of at least two of silver nanowires, carbon nanotubes, graphene and MXene;
preferably, the diameter of the silver nanowire is 20-60nm;
preferably, the length of the carbon nanotube is 10-30 μm;
preferably, the diameter of the carbon nano tube is 5-15nm;
preferably, the number of layers of the graphene is 1-5.
3. The electrically conductive medical adhesive according to claim 1 or 2, wherein the modifier is a modifier solution;
preferably, the mass percentage of the modifier in the modifier solution is 10-40%;
preferably, the modifier comprises a combination of modifier a and modifier B;
preferably, the modifier A is sodium citrate;
preferably, the modifier B is selected from any one of aluminum chloride, ammonium chloride or ammonium sulfate or a combination of at least two of the aluminum chloride, the ammonium chloride and the ammonium sulfate;
preferably, the mass ratio of the modifier A to the modifier B is (1.8-2.2): 1.
4. The conductive medical adhesive glue according to any one of claims 1 to 3, wherein the raw materials for preparing the conductive medical adhesive glue further comprise 50 to 85 parts of water.
5. The preparation method of the conductive medical adhesive glue according to any one of claims 1 to 4, characterized in that the preparation method comprises the following steps:
(1) Mixing gelatin, a conductive agent and water, and solidifying to obtain hydrogel;
(2) And (2) modifying the hydrogel obtained in the step (1) and a modifier to obtain the conductive medical adhesive.
6. The method according to claim 5, wherein the temperature of the mixing in the step (1) is 60 to 100 ℃;
preferably, the mixing time of the step (1) is 0.5-1.5h;
preferably, the solidification method in the step (1) is low-temperature standing;
preferably, the temperature of the low-temperature standing is 4-10 ℃;
preferably, the low-temperature standing time is 0.5-1h.
7. The method according to claim 5 or 6, wherein the step (1) further comprises a post-treatment step after the mixing;
preferably, the post-treatment method is defoaming at 60-100 ℃.
8. The method according to any one of claims 5 to 7, wherein the modification in step (2) is carried out by immersing the hydrogel in a modifying agent;
preferably, the time for the modification is 0.5 to 1h.
9. The method according to any one of claims 5 to 8, comprising in particular the steps of:
(1) Mixing gelatin, conductive agent and water at 60-100 deg.C for 0.5-1.5 hr, removing bubbles, cooling to 4-10 deg.C, standing for 0.5-1 hr, and coagulating to obtain hydrogel;
(2) And (2) soaking the hydrogel obtained in the step (1) in a modifier solution for 0.5-1h for modification to obtain the conductive medical adhesive.
10. Use of the electrically conductive medical adhesive of any one of claims 1-4 in the preparation of wound sealing materials or adhesive repair materials for peripheral nerve injury.
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2021
- 2021-05-27 CN CN202110584793.6A patent/CN115400231A/en active Pending
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| JPH06254150A (en) * | 1993-03-10 | 1994-09-13 | Sekisui Chem Co Ltd | Medical adhesive agent |
| US20090270709A1 (en) * | 2007-11-02 | 2009-10-29 | Tyco Healthcare Group Lp | Novel Electrodes |
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