JPH06237700A - Vitamin k3 preparation for addition to feed - Google Patents

Abstract

PURPOSE:To obtain a coated vitamin K3 preparation having extremely slight deterioration even by addition and blending with a feed, a feed additive and a feed containing the coated vitamin K3 preparation. CONSTITUTION:Menadione sodium hydrogensulfite or menadione dimethylpyrimidinol hydrogensulfite is coated with a coating agent selected from a hardened oil higher fatty acid, bees wax and wax to give a vitamin K3 preparation, a feed additive and a feed containing the coated vitamin K3 preparation.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a vitamin K ₃ preparation for feed addition for livestock and aquatic animals, and a feed additive containing the same.
It relates to mixed feed.

[0002]

2. Description of the Related Art Physiological actions of vitamin K ₃ include carboxylation of glutamic acid residues of proteins to give Ca-binding ability, synthesis of coagulation factors in blood coagulation reaction, and bone formation. It has been clarified that Ca acts on Ca deposits and the like, and it is known that when insufficient, it causes prolongation of blood coagulation time and bleeding resulting from this, and bone weakness.

Until now, in general, vitamin K ₃ is synthesized in the digestive tract by intestinal bacteria, so it is considered that no deficiency is seen except in birds with a small number of intestinal bacteria, and vitamin K ₃ deficiency. The conditions for the occurrence of bile are as follows: when the content of vitamin K ₃ in the feed is low, when vitamin synthesis by intestinal bacteria is suppressed by the use of antibiotics or sulfa drugs, when the feces are suppressed for some reason, the secretion of bile. It has been considered when the absorption of vitamin K ₃ has been hampered by the lack or gastrointestinal disorders.

However, in recent years, the breeding method of aquaculture and livestock breeding has spurred high density and high efficiency, and so-called breeding is generally performed under a stressed condition.
The required amount of vitamin K ₃ is dramatically increased, and the amount added to the feed as vitamin K ₃ also tends to increase.

However, when the vitamin K ₃ content in a properly mixed feed is measured, there are many cases in which a value far below the blended amount is shown.

[0006]

Stabilization of vitamin K ₃ in feed is essential, and the present inventors have found that vitamin K ₃ is deteriorated in feed.
In order to solve this difficulty, the present invention is to provide a coated vitamin K ₃ which is extremely deteriorated even when added to and mixed with feed.

[0007]

The present invention has been made based on the above findings and relates to stabilization of vitamin K ₃ in feed. That is, the surface of powder or particles of menadione sodium bisulfite or dimethylpyrimidinol menadione bisulfite is coated with a coating agent selected from hydrogenated oil, higher fatty acid, beeswax, wax, etc., and vitamin K ₃ mixed in feed is mixed. It is to sequester and stabilize substances that destroy it, such as choline chloride and various minerals.

As the hardened oil used in the present invention, hardened oil derived from animal fat or vegetable fat may be used, and higher fatty acid,
As for beeswax, wax and the like, any beeswax, wax or the like can be used regardless of its type and raw material as long as it is solid at room temperature. The melting point of these coating materials is arbitrarily selected and used, but a melting point of 35 ° C. or higher is preferable, and a melting point of 60 ° C. or higher is particularly preferable for feed production. These raw materials can be used alone or in combination of two or more.

The method for producing the coated vitamin K ₃ may be any method as long as it can coat the vitamin K ₃ with a raw material such as hydrogenated oil.
For example, a method of spraying and coating molten hydrogenated oil, higher fatty acid, beeswax, wax or the like while flowing or rolling menadione sodium bisulfite or dimethylpyrimidinol bisulfite, or menadione sodium bisulfite or menadione sulfite. It is possible to use a spray granulation method or the like in which hydrogen dimethylpyrimidinol or the like and molten hardened oil or the like are mixed in advance, and the mixture is sprayed and granulated at room temperature or low temperature.

In the method of granulating while flowing or rolling, a method of coating a powdered product of vitamin K ₃ with a part of hardened oil and the like, further adding powder of vitamin K ₃ and coating with hardened oil or the like Repeat coating to obtain a good coated vitamin K ₃ .

Further, in the method of premixing vitamin K ₃ and hardened oil and the like, and spray granulating, by adjusting a spray nozzle or a rotating disk and selecting a spray temperature, a desired size of coated vitamin K ₃ is obtained. be able to.

The content of sodium menadione bisulfite or menadione dimethylpyrimidinol menadione in the coated vitamin K ₃ preparation is preferably about 10 to 90%, and its particle size is preferably about 50 to 1000 μm.

[0013]

[Example 1] 70 parts by weight of extremely hardened soybean oil was dissolved in a hot water bath, 30 parts by weight of sodium menadione sodium bisulfite was added and suspended, and the suspension was spray-granulated at an intake temperature of 15 ° C. A granular coated vitamin K ₃ was obtained.

Next, a feed additive was prepared by blending a coated vitamin K ₃ so as to contain 0.15% of menadione sodium trisulfite as a total vitamin premix containing 20% of choline chloride. For comparison, a feed additive containing the same amount of menadione sodium trisulfite as uncoated was prepared.

The feed additive obtained above was treated at 40 ° C. and 7% relative humidity.
An accelerated test was carried out for 3 weeks in an environment of 5% to measure the residual rate of menadione sodium bisulfite. The results are shown in Table 1.
The coated vitamin K _{3 group} of the present invention maintained the residual rate of 80% or more, while the non-coated sample of Comparative Example 1 had a half rate.

[0016]

[Table 1]

[0017]

Example 2 15 parts by weight of beeswax and 50 of extremely hardened soybean oil
And 35 parts by weight of menadione bisulfite dimethylpyrimidinol were added in advance, and the resulting mixture was well stirred and suspended to carry out spray granulation in the same manner as in Example 1 to obtain granular coated vitamin K. Got ₃ .

Next, Vitamin K coated so that 0.15% of menadione bisulfite dimethylpyrimidinol is added to a multivitamin premix containing 15% of choline chloride.
₃ was blended to produce a feed additive. Further, 0.2% of these feed additives were blended with other conventional feed ingredients to obtain a poultry feed.

[0019]

EFFECTS OF THE INVENTION By coating vitamin K ₃ with hydrogenated oil, higher fatty acid, beeswax, and wax, it is possible to directly add substances such as choline chloride minerals that destroy vitamin K ₃ when added to a feed additive or feed. It is possible to avoid unnecessary contact and maintain stability.

Vitamin K present in the feed according to the invention
It is possible to prevent the influence of the destructive factors of No. ₃ , or the manufacturing process of feed, storage conditions, etc., and to ensure the quality of feed.

Claims (2)

[Claims] 1. A vitamin K ₃ preparation for feed addition, which comprises coating menadione sodium bisulfite or menadione bisulfite dimethylpyrimidinol with a coating agent selected from hydrogenated oil, higher fatty acid, beeswax, wax and the like. . 2. Vitamin K for feed addition according to claim 1.
Feed additives and formulated feeds containing ₃ formulations.