JPH06181985A - Pre-filled syringe - Google Patents

Abstract

PURPOSE:To provide a structure ensuring the reduction of the loss of liquid after mixed and the loss (non-administered amount) of a powder medicine housed in the first chamber, the easy check of the through-state of a double-ended needle, and resistance against the a trouble such as the clogging of a needle, regarding a pre-filled syringe of such type as using a double-ended needle. CONSTITUTION:A structure is so made that a recess 8 is formed on the edge of the second gasket 4 movable within a cylindrical vessel 1 at the rear side of the first chamber and such a position as corresponding to the section of the first gasket 1 where a double-ended needle 10 passes.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides a syringe-shaped container containing a drug and a solution or dispersion thereof or another drug solution.
The present invention relates to a so-called prefilled syringe, which is pre-filled in each individual chamber in a container.

[0002]

2. Description of the Related Art Generally, in a prefilled syringe, an injection needle can be attached to the front end and a cylindrical container in which a plunger with a rod is inserted from the rear end is moved forward and backward by a gasket movable in the container. In the side wall of the first chamber on the front end side, when the movable gasket is moved by pressing the plunger with the rod, the liquid such as the dissolving liquid or the dispersion liquid contained in the second chamber on the rear end side is divided into two parts.
It adopts a structure in which an injection groove for transferring to the chamber side is formed.

In such a prefilled syringe, a double-headed needle (double-edged needle) may be used as an injection needle in consideration of performing air removal from the first chamber. In this case, as illustrated in FIG. 9, the first gasket 42 capable of piercing the double-ended needle 40 is attached to the distal end portion of the tubular container 41, and the first gasket 42 and the plunger with rod 43 are connected to each other. A structure in which a movable second gasket 44 is arranged in between is adopted.
In the figure, 45 is a first chamber, 46 is a second chamber, and 47 is an injection groove.

[0004]

By the way, in the case of adopting the structure of FIG. 9 using the double-ended needle, when both the end faces of the first gasket 42 and the second gasket 44 facing each other are flat as shown in the drawing. The first in the use
Of the liquid mixed in the chamber 45, a volume of liquid corresponding to the length of the double-ended needle 40 protruding from the end face of the first gasket 42 remains, resulting in a large amount of liquid loss. There is.

For the purpose of reducing the amount of this loss liquid, FIG.
Although it is conceivable to form a recess 48 on the end face of the first gasket 42 on the rear end side as shown in FIG.
In this case, it is difficult to confirm the penetration of the double-ended needle 40 when the double-ended needle 40 is attached, and the powdered drug is often contained in the first chamber 45.
In some cases, the powdered medicine may accumulate inside 8 and the powdered medicine may be recessed 4
If the double-ended needle 40 is pierced in the state of being accumulated in the needle 8, aggregates of powder may enter the needle and cause clogging.
Further, when the powdered drug is suspended in the first chamber 45 by its solution or the like and then administered, the needle tip is directed downward, so that a part of the powdered drug is settled in the recess 48, so that the powdered drug is suspended. Although the remaining amount of the liquid is reduced, there is a problem that the amount of loss of the powdered drug, which is the active ingredient, is increased.

The present invention has been made in view of the above circumstances, and in a prefilled syringe of a type using a double-ended needle, the loss amount of the liquid after mixing and the loss amount of the powdered drug contained in the first chamber ( It is an object of the present invention to provide a prefilled syringe having a small amount (non-dosage amount), easy confirmation of double-ended needle penetration, and less likely to cause problems such as needle clogging.

[0007]

A structure for achieving the above object will be described with reference to FIG. 1 which is an embodiment drawing, and a prefilled syringe of the present invention is a movable container in a cylindrical container 1. The second gasket 4 is characterized in that a concave portion 8 is formed at a position corresponding to the piercing portion of the double-ended needle 10 of the first gasket 2 on the end surface on the first chamber 5 side.

Here, it is preferable to form a recess 2a on the end surface of the first gasket 2 on the tip side to facilitate the penetration of the double-ended needle 10. In addition, for the purpose of facilitating the operation of removing air bubbles in the liquid after the injection liquid is generated by mixing at least two components in the first chamber 5, the first chamber 5 excluding the concave portion 8 of the second gasket 4. The end surface on the side of the first gasket 2 may have a convex curved surface shape, and the end surface of the first gasket 2 on the side of the first chamber 5 may have a concave curved surface shape (see FIG. 3).

Further, as illustrated in FIG. 4, the structure of the second gasket 4 has a plurality of circular ribs 4 along its outer circumference.
00, and a plurality of vertical ribs 401 are formed between the circular ribs 400, which have the same height as those of the circular ribs 400 and partition the annular recesses formed between the circular ribs 400. It is desirable to set the amount because it is possible to reduce the amount of liquid that gets into the annular recess between the circular ribs 400 when the second chamber 4 passes through the discontinuous portion 7 of the cylindrical container 1 during administration. . Here, the substantially equal height means the vertical ribs 40.
In addition to the case where 1 is lower than the circular rib 400 by a predetermined dimension and the case where it is higher, the case where these both have exactly the same height is also included. The structure in which the circular rib 400 and the vertical rib 401 are combined can be similarly applied to the seal member 3 a of the plunger 3. In addition, each of these ribs,
In order to improve the slidability with respect to the cylindrical container 1, the sliding surface may be curved in the axial direction. Also, each circular rib 4
The depth of the recess between 00 is preferably as shallow as possible so as not to impair the slidability.

Furthermore, the pressing of the plunger 3 causes the tip of the second gasket 4 to reach the front of the tip of the discontinuous portion 7, and the rear end surface of the second gasket 4 contacts the tip surface of the plunger 3. Further, at least the latter half of the seal member of the plunger 3 does not enter the discontinuous portion 7 and keeps sliding with respect to the inner wall of the tubular container 1, so that the plunger 3 is temporarily stopped. It is preferable to provide a locking mechanism and a releasing mechanism between the plunger and the plunger 3.

[0011]

Operation: The first chamber 5 is penetrated through the first gasket 2.
The double-ended needle 10 protruding to the side enters into the recess 8 on the second gasket 4 side, and the amount of liquid loss is only the volume of the recess 8. Since it is not necessary to provide a recess on the first chamber 5 side of the first gasket 2, it does not hinder the confirmation of penetration of the double-ended needle 10, and when the double-ended needle 10 is pierced, the second gasket 4 is Since it is located away from the gasket 2 of No. 1, the powder in the concave portion 8 does not enter the needle when the needle is inserted. In addition, since the concave portion 8 is located above the first chamber 5 during administration, suspended particles do not settle inside thereof.

Further, the first chamber 5 of the second gasket 4
If the end surface on the side (excluding the portion where the concave portion 8 is formed) has a convex curved surface shape, and the end surface on the first chamber 5 side of the first gasket 2 that faces the end surface has a concave curved surface shape along this, the When removing air bubbles in the injection solution mixed in the chamber 5, the air bubbles are concentrated in the upper central portion in the first chamber 5 with the needle facing upward, facilitating the air bleeding operation. .

When a structure in which the circular ribs 400 and the vertical ribs 401 are combined is adopted as the second gasket 4 or the seal member 3a of the plunger 3 in addition to the second gasket 4, a structure in which a plurality of circular ribs 400 are simply provided is compared with the structure. Then, when the second gasket 4 or the seal member 3a of the plunger 3 passes through the discontinuous portion 7 during administration, the amount of the liquid that enters the recesses between the circular ribs 300 is the vertical rib 40.
The presence of 0 reduces it to a fraction.

The locking mechanism between the cylindrical container 1 and the plunger 3 and the releasing mechanism thereof have the function of facilitating the operation for ensuring the mixing or dispersion of the two components before administration. That is, in the actual administration of the injection liquid, the liquid in the second chamber 6 is almost in the first chamber 5 so that the drug in the first chamber 5 and the liquid in the second chamber are uniformly dispersed or mixed. It is necessary to shake the syringe well when it is completely infused. The liquid in the second chamber 6 is almost liquid when the rear surface of the second gasket 4 and the front surface of the plunger 3 come into contact with each other in a state in which the front end surface of the second gasket 4 has stopped before the front end portion of the discontinuous portion 7. It is completely injected into the chamber 5. Therefore, the front surface of the plunger 3 contacts the rear surface of the second gasket 4 by the pressing of the plunger 3, at least the tip of the second gasket 4 reaches the front of the tip of the discontinuous portion 7, and at least the plunger 3 If a locking mechanism that temporarily stops the plunger 3 is provided at a position where the latter half portion does not enter the discontinuous portion 7 and is kept in sliding contact with the inner wall of the cylindrical container 1, the second gasket 4 is prevented from overshooting. In addition to being able to prevent it, it is possible to ensure the above-mentioned operations such as mixing before administration without the liquid flowing out, and when mixing is completed, the lock can be released by the release mechanism, allowing administration to the living body. Becomes

[0015]

FIG. 1 is a sectional view showing the structure of an embodiment of the present invention.
It is a figure shown in the state where the double-ended needle 10 was attached.

A first gasket 2 is attached to the opening of the end of the cylindrical container 1 while being inserted into the inner surface of the container 1, and a needle sleeve is attached to the outer peripheral surface of the end of the container 1. A needle holding member 9 for holding a double-ended needle 10 integrally provided with 11 on its needle sleeve 11 is fixed.

A plunger 3 with a rod composed of a seal member 3a and a rod 3b is inserted into the rear end opening of the tubular container 1, and the tip of the plunger 3 with the rod and the first gasket 2 are connected together. In between, a second gasket 4 is slidable in the axial direction along the inner wall surface of the tubular container 1.
Is inserted, and the inside of the cylindrical container 1 is partitioned by the second gasket 4 into a first chamber 5 and a second chamber 6. In the first chamber 5 on the tip side, for example, a liquid,
Drugs such as tablets, granules, powders, and microcapsules are dissolved or dispersed in the second chamber 6 on the rear end side,
Alternatively, other types of liquid medicines are stored respectively. An injection groove 7 is formed on the side wall of the first chamber 5 of the cylindrical container 1 so as to project outward with a predetermined width, and the length of the injection groove 7 is larger than the thickness of the second gasket 4. long.

The first and second gaskets 2 and 4 are each made of synthetic resin or rubber, and the end surface of the first gasket 2 on the first chamber 5 side is flat, while the second gasket 4 is A recess 8 is formed in the central portion of the end surface on the side of the first chamber 5. The depth of the recess 8 is slightly larger than the length of the double-ended needle 10 protruding from the first gasket 2 into the first chamber 5 in the mounted state of the double-ended needle 10 described later. Also, the first
A recess 2a for facilitating the insertion of the double-ended needle 10 is formed on the end surface of the gasket 2 on the front end side.

In the above embodiment of the present invention, the double-ended needle 10 and its needle sleeve 11 are not attached when not in use,
In use, first, the needle sleeve 1 is placed in the needle holding member 9.
1 and push the rear end of the double-ended needle 10 into the first gasket 2
Pierce into.

At this time, since the end surface of the first gasket 2 on the first chamber 5 side is flat, the double-ended needle 10
It is easy to confirm the penetration, and at the same time, it is less likely that the powder in the first chamber 5 will enter the double-ended needle 10 when the needle is pierced.

After mounting the double-ended needle 10, the plunger 3 with a rod is pushed in. As a result, the second gasket 4 advances through the liquid in the second chamber 6, but after the second gasket 4 reaches the position where the injection groove 7 is formed, the injection groove 7 causes the first chamber 5 to move. Since the second chamber 6 and the second chamber 6 communicate with each other, the liquid in the second chamber 4 flows into the first chamber 2 through the injection groove 7 by pressing the plunger 3 with the rod, and both are mixed to form a suspension. To be done.

After the inflow of the liquid into the second chamber 6 is completed and the tip of the plunger 3 comes into contact with the rear end surface of the second gasket 4, the plunger 3 directly presses the second gasket 4. However, in this state, the plunger 3 is further pressed to evacuate the air in the first chamber 5 and then administered to the human body or the like.

When the plunger 3 with the rod is advanced during this administration, as shown in the sectional view of the main part in FIG.
Since the portion penetrating the first gasket 2 and projecting into the first chamber 5 is accommodated in the recess 8 of the second gasket 4, the tip surface of the second gasket 4 and the first It is possible to advance the gasket 2 until it comes into contact with the rear end surface of the gasket 2, and the amount of liquid remaining in the container 1 is reduced. Further, at the time of this administration, since the tip of the double-ended needle 10 is directed downward, the concave portion 8 is located above in the first chamber 5 containing the suspension, and the suspended particles are settled therein. And the remaining amount of the powder, which is the active ingredient, is reduced.

Here, the smaller the diameter of the recess 8 is, the better. However, it is naturally limited by the centering accuracy of the puncture needle and the needle diameter. Further, the shape of the concave portion 8 is not limited to a cylindrical shape, a conical shape, or a cylindrical shape having a rounded bottom portion as long as it can accommodate the rear end portion of the double-ended needle 10. Of course.

Further, the surfaces of the first and second gaskets 2 and 4 that face each other with the first chamber 5 interposed therebetween may be formed into a concave curved surface shape and a convex curved surface shape, respectively, as shown in the sectional view of FIG. desirable. That is, the rear end surface of the first gasket 2 (end surface on the side of the first chamber 5) has a concave curved surface shape facing the side of the first chamber 5, and the front end surface of the second gasket 4 excluding the portion where the recess 8 is formed. (The end surface on the first chamber 5 side) has a convex curved surface shape that faces the first chamber 5 side in accordance with this. With such a shape, after the two components are mixed or dispersed in the first chamber 5 to produce an injection solution, the tip of the cylindrical container 1 is moved upward so as to remove bubbles in the injection solution prior to administration. When it is directed to, the air bubbles in the injection solution are concentrated in the central portion of the concave curved surface of the first gasket 2, so that the air bubbles can be easily removed via the double-ended needle 10, contributing to the improvement of the convenience of use. It becomes big where you do

By the way, in this type of syringe, the second gasket 4 and the seal member 3a of the rod-equipped plunger 3 usually have a plurality of circumferentially protruding ribs, that is, a plurality of circular ribs. As a structure
It is considered that the liquid tightness between the first chamber 5 and the second chamber 6 or the liquid tightness between the second chamber 6 and the outside of the container 1 is maintained and the slidability in the container 1 is good. It
In such a structure, when the second gasket 4 or the seal member 3a of the plunger 3 itself passes through the injection groove 7 by the pressing of the plunger 3 with a rod, the liquid accumulated in the injection groove 7 becomes a second liquid. The injection solution enters the annular recess formed between the circular ribs of the gasket 4 or the seal member 3a of the plunger 3, and the injection liquid is not administered by that amount, resulting in a loss. In order to solve this, it is conceivable to make the recess shallow so as not to impede the slidability of the second gasket 4 or the seal member 3a, but in order to further reduce the loss, You should take measures such as.

FIG. 4 is an external view of the second gasket 4 provided with the countermeasure, in which a plurality of circular ribs 400 are formed on the outer periphery of the second gasket 4 respectively, and between the circular ribs 400, these circular ribs 400 and these are substantially omitted. A plurality of vertical ribs 40 having the same height
The vertical ribs 401 divide the voids formed between the circular ribs 400 into a plurality of small voids G. In this example, four vertical ribs 401 are formed in each gap at positions where the outer circumference of the second gasket 4 is divided into four portions, whereby the gap between the circular ribs 400 is divided into four equal parts. There is.

Such a structure of the outer circumference can be applied to the seal member 3a of the plunger 3 in exactly the same manner, and is essential for a syringe which employs the structure of FIG. 4 for both the second gasket 4 and the seal member 3a of the plunger 3. A partial cross-sectional view is shown in FIG.

By adopting such a structure, when the second gasket 4 and the seal member 3a pass through the injection groove 7 by the pressing of the plunger 3 with a rod, the injection groove 7
The injection solution enters between any of the circular ribs 400 through the small ribs G divided by the vertical ribs 401, but cannot enter the adjacent small gaps due to the presence of the vertical ribs 401, and In this example, as compared with the case where only the circular rib 400 is provided, the injection liquid remaining in the gap between the second gasket 4 and the seal member 3a is reduced to about 1/4.

The number of vertical ribs 401 provided in each space between the circular ribs 400 is not limited to four, and may be any number of two or more. Although it can be reduced, the slidability of the second gasket 4 or the seal member 3a is reduced accordingly, so it is desirable to use a proper number in consideration of these factors. The vertical ribs 401 may be formed only on the second gasket 4.

In the two-component prefilled syringe, prior to the actual administration, the plunger 3 with the rod is pressed to press the second chamber 6 so that the two components are uniformly dissolved, dispersed or mixed in the first chamber 5. The liquid inside is first
It is necessary to stop the plunger 3 once with almost complete inflow into the chamber 5 and still not flow out from the tip of the container 1, and shake the syringe well in this state. The liquid that has moved into the chamber 5
In order to prevent the reverse flow of the injection groove 7 and the flow out of the original second chamber 6 side, that is, beyond the seal member 3a of the plunger 3 to the rear part of the cylindrical container 1, the plunger 3 with the rod is temporarily set at an optimum position. The operation for stopping is not easy unless skilled, and the seal member 3a of the plunger 3 may be accidentally moved too far.

6 to 7 show an embodiment in which such an operation is facilitated. In the example shown in FIG. 6, a convex portion 101 is formed on the inner peripheral surface of the finger grip 100 attached to the rear end of the cylindrical container 1 so as to project circumferentially inward from the inner peripheral surface of the cylindrical container 1. In addition, the rod 3b of the plunger 3 with a rod is formed with a plurality of protrusions 301 on the same circumference at a predetermined position in the axial direction. The position where each projection 301 is formed in the axial direction of the rod 3b is such that the tip surface of the second gasket 4 reaches the front of the tip portion of the injection groove 7 by the pressing of the plunger 3, and In a state where the end surface is in contact with the tip end surface of the plunger 3 and further at least the latter half of the seal member 3a of the plunger 3 does not enter the injection groove 7 and keeps sliding with the inner wall of the cylindrical container 1, The position is such that it is in contact with the convex portion 101 of the finger grip 100, and the distance between the center axis of the rod 3b and the tip of each protrusion 301 is slightly larger than the inner diameter dimension of the convex portion 101 of the finger grip 100. . Further, the material of the finger grip 100 is flexible such as synthetic resin.

According to the above construction, when the plunger with rod 3 is pushed in from the unused state of FIG. 6 (A),
While the liquid is moving, the second gasket 4 remains near the tip of the injection groove 7 as shown in (B), but when further pushed in, the projection 301 contacts the convex portion 101 as shown in (C). The plunger 3 temporarily stops due to the resistance caused by the contact.
In that state, the liquid in the second chamber 6 is
Completely, and the tip of the second gasket 4 reaches the front of the tip of the injection groove 7, and the latter half of the seal member 3a of the plunger 3 does not enter the injection groove 7 and the container 1 The sliding state with the inner wall surface is maintained, and both the front end and the rear end of the injection groove 7 are closed. In that state, the syringe is shaken to uniformly dissolve, disperse or mix the two components. After that, when the plunger with rod 3 is strongly pushed, the finger grip 100 bends and the projection 30
1 passes through the convex portion 101, and the injection solution after dissolution, dispersion or mixing can be administered to the living body.

On the other hand, in the example shown in FIG. 7, the convex portion 101 is similarly formed on the inner peripheral surface of the finger grip 100 attached to the rear end portion of the cylindrical container 1, and the convex portion 101 is formed.
In addition, as shown in the figure viewed from the axial direction in FIG. 1B, a plurality of notched grooves 102 are formed, and the same number of blades 302 are formed on the rod 3b of the rod-equipped plunger 3. Each blade 302 from the center of the rod 2b
Is larger than the inner diameter of the convex portion 101 of the finger grip 100 and shorter than the distance between the center of the finger grip 100 and the bottom surface of each cutout groove 102. In addition, at the end face position on the tip side of each blade 302, the second gasket 4 reaches the front face of the tip end of the injection groove 7 by the pressing of the plunger 3,
In addition, the rear end surface of the second gasket 4 and the front end surface of the plunger 3 come into contact with each other, and the latter half of the seal member 3a of the plunger 3 does not enter the injection groove 7 and slides against the inner wall of the container 1. The position is such that the blade 302 contacts the rear end surface of the finger grip 100 in the state of being kept.

In the above configuration, in the state before use shown in (A), each blade 302 of the rod 3b does not coincide with the formation position of the notch groove 102 of the finger grip 100, as shown in (C). It is inserted in the cylindrical container 1 in such a state. In use, the plunger with rod 3 is first pushed in in the state of (C). As a result, the liquid starts to move. While the liquid is moving, the tip of the second gasket 4 is stopped near the tip of the injection groove 7 as shown in (D). In this state, the tip of the blade 302 is the finger grip 100.
Not touching. From this state, plunger with rod 3
Is further pushed, as shown in (E), the blade 30
The plunger 3 stops when 2 comes into contact with the rear end surface of the finger grip 100. In that state, the second chamber 6
The liquid therein is completely injected into the first chamber 5, and
Since the front end and the rear end of the injection groove 7 are closed, the syringe is shaken in this state to uniformly dissolve, disperse or mix the two components. After that, when the rod-equipped plunger 3 is rotated so that the blades 302 coincide with the formation positions of the respective cutout grooves 102, the rod-equipped plunger 3 can be pushed in as shown in (F). The injection solution after mixing can be injected into the living body.

It should be noted that, without adopting the structure shown in FIG. 6 or FIG. 7 as described above, a tubular shape at a predetermined position in front of the tip of the injection groove 7, for example, at a position about 2 mm in front of the injection groove 7. It is also effective to provide a line-shaped mark along the circumferential direction on the outer or inner peripheral surface of the container 1. That is, when the plunger 3 is pressed so that the tip surface of the second gasket 4 does not exceed the mark, the liquid in the second chamber 6 is almost completely injected into the first chamber 5, Shake the syringe in this state.

As shown in FIG. 8, the second gasket 4 is divided into a front side 4a and a rear side 4b, and the rear side 4b is mounted inside the second chamber 6. After the liquid is filled and steam heating sterilization is performed in that state, the inner surface of the syringe of the first chamber 5 is dried, and then the second gasket 4a on the front side is inserted from the front end opening of the tubular container 1, and Each technique of the present invention can be applied to a device that can adopt the manufacturing method of mounting the first gasket 2 after inserting the powder drug.
In this case, it goes without saying that the recess 8 is formed in the front side 4a.

[0038]

As described above, according to the present invention,
To accommodate the rear end portion of the double-ended needle that is pierced by the first gasket and protrudes toward the first chamber on the end surface of the movable second gasket that separates the first chamber and the second chamber from the first chamber side Since it has a structure in which the concave portion of is formed,
Only the liquid remaining in this recess becomes the loss amount (non-dose amount),
The amount of liquid loss can be reduced as compared with the case where both the end faces of the first and second gaskets are flat. Moreover, since the end surface of the first gasket through which the double-ended needle is pierced can be made flat, it is easy to confirm the penetration of the double-ended needle and the powder in the first chamber enters the recess. However, since the second gasket is located away from the needle when the double-ended needle is pierced, the powder does not enter the needle when the needle is pierced to cause clogging. Further, since the recess is located above the first chamber even during administration after the liquid in the second chamber has flowed into the first chamber to be suspended, the suspended particles are accumulated in the recess. There is no administration loss.

By providing the second gasket and the seal member of the plunger in addition to this with a plurality of vertical ribs for partitioning the gap between the circular ribs, the seal member of the second gasket or the plunger has a discontinuous portion. The amount of the injection solution entering the voids between the circular ribs when passing through is reduced, and the amount of injection solution loss can be further reduced.

Further, by forming a recess on the tip side of the first gasket corresponding to the piercing portion of the double-ended needle, the piercing can be facilitated. Furthermore, by making the front end surface of the second gasket a convex curved surface facing the first chamber side and the rear end surface of the first gasket a concave curved surface facing the first chamber side corresponding thereto, an injection prior to administration is performed. The work of removing bubbles from the liquid is facilitated.

Furthermore, due to the pressing of the plunger, the tip of the second gasket reaches the front of the discontinuous portion of the tubular container, and the rear end surface of the second gasket and the tip end surface of the plunger come into contact with each other. In addition, at the position where the latter half of the plunger seal member does not discontinue and keeps sliding condition with the inner wall of the container, a rod and a cylindrical container for pressing the plunger so that the plunger once stops. By providing a locking mechanism between the two and providing a releasing mechanism, the work of uniformly dissolving, dispersing or mixing the two components prior to administration can be facilitated, and at the same time, backflow of the liquid can be prevented. Combined with the ease of the bubble removal work described above, it becomes possible to greatly improve the ease of use.

[Brief description of drawings]

FIG. 1 is a sectional view showing a configuration of an embodiment of the present invention.

FIG. 2 is a cross-sectional view of the main part at the time of administration

FIG. 3 is a cross-sectional view showing end face shapes of first and second gaskets according to another embodiment of the present invention.

FIG. 4 is an external view showing a structure of an outer peripheral surface of a second gasket according to still another embodiment of the present invention.

5 is a cross-sectional view of a main part when the structure of FIG. 4 is also applied to a seal member of a plunger.

FIG. 6 is an explanatory view of still another embodiment of the present invention, showing an example of a locking mechanism between a plunger with a rod and a cylindrical container and a releasing mechanism thereof.

FIG. 7 is an explanatory view of still another embodiment of the present invention, similarly showing another example of the locking mechanism between the plunger with rod and the cylindrical container and the releasing mechanism thereof.

FIG. 8 is a sectional view showing the configuration of still another embodiment of the present invention.

FIG. 9 is a sectional view showing a configuration example of a conventional two-component prefilled syringe.

FIG. 10 is a cross-sectional view of essential parts showing a comparative example of measures for reducing the remaining amount of an injection solution.

[Explanation of symbols]

 1 Cylindrical Container 2 1st Gasket 2a Dimple 3 Plunger with Rod 3a Sealing Member 3b Rod 4 Second Gasket 5 1st Chamber 6 2nd Chamber 7 Injection Groove 8 Recess 9 Needle Holding Member 10 Double-ended Needle 11 Needle Sleeve 100 Finger Grip 101 Protrusion 102 Notch 301 Convex portion 302 Blade 400 Circular rib 401 Vertical rib

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[Procedure amendment]

[Submission date] September 21, 1993

[Procedure Amendment 1]

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[Name of item to be corrected] Figure 3

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[Correction method] Change

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[Figure 4]

[Procedure 3]

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[Name of item to be corrected] Figure 5

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[Figure 5]

[Procedure amendment 4]

[Document name to be corrected] Drawing

[Name of item to be corrected] Figure 6

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[Figure 6]

[Procedure Amendment 5]

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[Name of item to be corrected] Figure 7

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[Figure 7]

Claims (8)

[Claims] 1. A front end portion of a tubular container into which a plunger is inserted from a rear end portion is sealed with a first gasket capable of piercing a double-ended needle, and the space between the first gasket and the plunger is the above-mentioned. A movable second gasket is inserted in the tubular container, and the interior of the tubular container is divided into a first chamber on the front end side and a second chamber on the rear end side by the second gasket, and A discontinuity for allowing the liquid in the second chamber to flow into the first chamber when the second gasket is moved by pressing the plunger is formed on the side wall of the container on the first chamber side. A prefilled syringe in which a concave portion is formed at a position corresponding to the double-headed needle piercing portion into the first gasket on the end surface on the first chamber side. 2. The prefilled syringe according to claim 1, wherein a recess is formed at a position corresponding to the double-ended needle piercing portion on the end surface of the first gasket on the distal end side. 3. The end surface of the second gasket on the side of the first chamber excluding the recess is formed in a convex curved surface shape facing the side of the first chamber, and the end surface of the first gasket on the side of the first chamber is formed. The prefilled syringe according to claim 1 or 2, wherein the second gasket is formed into a concave curved surface shape that faces the first chamber side along the convex curved surface shape of the second gasket. 4. The second gasket has a plurality of circular ribs formed along the outer periphery thereof, and the height between the circular ribs is substantially equal to that of the circular ribs.
2. A plurality of vertical ribs for partitioning an annular recess formed between the circular ribs are formed.
The prefilled syringe according to 2 or 3. 5. The seal member of the plunger has a plurality of circular ribs formed along the outer periphery thereof, and the height between the circular ribs is substantially equal to that of the circular ribs. 2. A plurality of vertical ribs for partitioning an annular recess formed between the ribs are formed.
The prefilled syringe according to 2, 3, or 4. 6. The second member is pressed by pressing the plunger.
The front end of the gasket reaches the front of the front end of the continuous portion of the tubular container, the rear end surface of the second gasket contacts the front end surface of the plunger, and at least the latter half of the seal member of the plunger is A locking mechanism is provided between the rod of the plunger and the cylindrical container so that the plunger temporarily stops at a position where it does not enter the discontinuous portion and maintains a sliding state with respect to the inner wall of the cylindrical container. The prefilled syringe according to claim 1, wherein the prefilled syringe is provided with a releasing mechanism. 7. A finger grip is mounted in the vicinity of the rear end of the cylindrical container, and the finger grip is formed with a convex portion projecting inward from the inner peripheral surface of the cylindrical container. , The plunger rod above
A protrusion is formed at a predetermined position in the axial direction, and the protrusion of this rod and the above-mentioned convex portion are engaged with each other by pushing in the rod, the plunger is once stopped, and the rod is further pushed in to engage the protrusion. The prefilled syringe according to claim 6, wherein the prefilled syringe is configured to be released. 8. A finger grip is mounted in the vicinity of the rear end of the cylindrical container, and the finger grip is formed with a protrusion protruding inward from the inner peripheral surface of the cylindrical container, At least one notch extending in the radial direction is formed in the convex portion, while at least one blade extending in the radial direction corresponding to the notch is formed in the rod of the plunger. ,
A state in which the blade and the convex portion are engaged with each other by pushing in the rod to temporarily stop the plunger, and the rod is rotated with respect to the cylindrical container so that the positions of the blade and the notch match. 7. The prefilled syringe according to claim 6, wherein the blade is configured to pass through the notch and release the engagement.