JPH06181718A - Enteral nutrient - Google Patents

Abstract

PURPOSE:To provide an enteral nutrient containing a purified protein of kacang hijiau (Phaseolus radiatus L.) in a prescribed amount, not giving side effects, capable of be applied also to the case of lactose intolerance, excellent in its nutritive value and digestive absorption property, and suitable for the control of nutrients in hospitals, etc. CONSTITUTION:The objective enteral nutrient comprises the purified protein of the kacang hijiau in an amount of 1-20wt.% based on its dry weight, preferably 40-95wt.% of a carbohydrate such as glucose 0-20wt.% of a fat or oil such as corn oil, and 5-40wt.% of the total proteins including the purified protein of the kacang hijiau, all of the amounts being based on their dry weights. The nutrient is administered preferably at a dose of 20-35ml/kg. a day for an adult in the liquid form of 25%(W/V%).

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an enteral nutritional supplement utilizing a novel purified protein.

[0002]

[Prior art and its problems] Kacang Hijia
u, Scientific name: Phaseolus Radius
atus L.) is a green bean produced mainly in Indonesia (Green
gram or Mungbeans), and locally, the bean powder is dissolved in water to be used as a drink or sprinkled on other foods for consumption. On the other hand, in hospitals, liquid nutrition is the main source of nutritional management for patients, and for enteral nutrition, nasal and oral nutritional products, milk casein-based products are only partially used. It is in the present condition that management is not done. Moreover, in Indonesia, there are generally few opportunities for children to eat milk, and there are many cases of lactose intolerance.

In view of the current situation, the supply of proteins commensurate with nutritional management of Indonesian children can be cited as one of the most noticeable issues at present.

The present inventors focused their attention on the above-mentioned Kachanghija produced in Indonesia in the course of earnest research from the viewpoint of solving the above-mentioned problems, and as a result of purifying the protein, the excellent nutrition that the protein meets the above-mentioned purpose. It has valency and other properties, and is suitable as a protein source for enteral nutritional products (including nasal and oral nutritional products), and its use can be advantageously applied to cases of lactose intolerance, It has been found that an enteral nutritional supplement for the purpose of providing a nutritional improvement effect that is satisfactory for nutritional management in a hospital is provided.

The present invention has been completed based on the above findings.

[0006]

That is, according to the present invention,
Enteral nutritional supplement containing 1 to 20% by weight of Kachanhija purified protein on a dry weight basis, more specifically 40 to 95% by weight of carbohydrate, 0 to 20% by weight of fat on a dry weight basis and total protein 5 containing the Kachanhija purified protein. -40% by weight of Kachan Hija purified protein-containing enteral nutrition and Kachan Hija purified protein content of 3 of total protein
An enteral nutritional supplement is provided which is 0 to 100% by weight.

Kachanhija purified protein used in the enteral nutrition of the present invention has an excellent nutritional value comparable to soybean protein, and its amino acid composition is also preferable as a protein source for nutritional supplementation.

The enteral nutritional supplement of the present invention can replenish a patient with a sufficient protein source based on the use of the above-mentioned purified protein of Kachanhija, and is particularly characterized in that it can be used with peace of mind even in patients with lactose intolerance. There is no particular inconvenience in terms of texture (taste, odor, etc.), and nasal administration and oral administration are also sufficiently possible. In particular, the use of the enteral nutritional product of the present invention makes it possible to improve the unbalanced diet and to appropriately supply energy and nutrients (calories) necessary for the activity of the living body.

The production of the purified protein of Kachanhija used in the present invention will be described in detail below. The purified protein is obtained by, for example, dipping Kachanhija (raw beans) in water, grinding and filtering, and centrifuging raw soymilk. Obtained by spray drying the supernatant.

Kachanhija, which is used as a raw material bean here, is also called as Indonesian mung bean, and according to the analysis according to the food analysis method conducted by the present inventors, 25% protein is contained.
(Wt%, the same below), fat 1.3%, carbohydrate 56.
It contains 6%, water content 13.6%, and ash content 3.5%, and minerals such as phosphorus 498 mg, iron 593 mg, calcium 115 mg, sodium 1.94 mg, magnesium 180 mg, chlorine 26 mg in 100 g (additionally zinc 3
Carotene 0.16m together with 6.3ppm)
g, retinol 90 IU, vitamin B ₁ 0.58 mg,
Vitamin B ₂ 0.16 mg, Vitamin B ₆ 0.38 m
g, vitamin C 12 mg, vitamin D 190 IU, vitamin E 10.8 mg, nicotinic acid 2.12 mg, folic acid 0.22 mg, etc., and the calorific value is about 341 kc.
It is al / 100g. Its protein content is about twice as high as that of chicken egg, which is suitable as a protein material.

The above-mentioned raw material beans are ground by, for example, dipping the raw material beans in water (the raw material beans soaked in about twice the amount of the beans for about 30 minutes) with a colloid mill (for example, a special machine). Chemical Industry Co., Ltd.) and the like.

Separation of raw soymilk from the ground product can be carried out, for example, by using a filter press or the like under a condition of about 2 kg / cm ² .

The raw soybean milk obtained above is used, for example, in 3000r.
The starch fraction and supernatant can be separated by centrifugation at pm for about 5 minutes, and the supernatant thus obtained is used as a desired protein-containing solution and dried by, for example, spray drying to obtain the purpose. The purified protein of the present invention can be obtained. The above drying operation can also be carried out under a temperature condition of about 40 ° C. by using a vacuum dryer, a drum dryer or the like.

The Kachanhija purified protein of the present invention thus obtained has a specific amino acid composition described below. The amino acid composition was obtained by analyzing the above purified product with an amino acid automatic analyzer (Amino Acid Analyzer manufactured by NEC Corporation, JLC-20).
It is the value measured by high-performance liquid chromatography analysis.
In addition, this amino acid composition is based on the same measurement method throughout this specification.

The enteral nutritional product of the present invention requires the use of the above-mentioned purified protein of Kachanhija as all or a part of the protein source, and is otherwise adjusted in the same manner as this type of enteral nutritional product. You can Its preferable composition is, for example, 40 to 95% by weight of carbohydrate, 0 to 20% by weight of fat, and 5 to 40% by weight of total protein, more preferably 60 to 90% by weight of carbohydrate, based on the dry matter weight.
Examples include those containing 5 to 15% by weight of fat and 10 to 25% by weight of total protein. In particular, it is preferable that the enteral nutritional supplement of the present invention uses 30 to 100% by weight of the above-mentioned purified protein of Kachanhija based on the total protein.

In the above-mentioned enteral nutritional product of the present invention, as the carbohydrates, fats and protein sources other than the above-mentioned Kachanhija purified protein, any of various types conventionally used in this type of enteral nutritional product can be used. it can. Examples thereof include carbohydrates such as glucose, maltose, sucrose, isomaltose, maltotetraose, maltotriose, maltopentaose, maltohexaose, lactose, glycogen, dextrin, monosaccharides such as starch, oligosaccharides, and polysaccharides. Sugars and the like, in fat, for example, rice fat, cottonseed oil, corn oil, soybean oil, olive oil, sunflower oil, cocoa butter, sesame oil, safflower oil, peanut oil, butter, lard, palm oil, nut oil, palm oil, rapeseed oil. , Medium chain triglyceride (MCT), and other proteins, such as casein, sodium caseinate, calcium caseinate, enzymatically-degraded gelatin (water-soluble gelatin), enzymatically-degraded casein, soybean protein, wheat protein, corn gluten meal, etc. The enzymatic decomposition products and the like can be exemplified. Of the above, for carbohydrates, for example rice dextrin, for fats, for example corn oil, and for other proteins, for example sodium caseinate are particularly preferred.

In addition to the above-mentioned three essential components, the enteral nutritional product of the present invention may further contain various conventional additives in the same manner as a general enteral nutritional product, if necessary. . As the additive, various vitamins (vitamin A,
Vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin D, vitamin E, niacin, folic acid, pantothenic acid, etc.), minerals (calcium, iron, potassium, sodium, magnesium, phosphorus,
Examples thereof include salts such as chlor, etc.), synthetic and natural flavors, natural sweeteners (thaumatin, stevia, etc.) and synthetic sweeteners (saccharin, cyclamate, etc.), colorants, emulsifiers, stabilizers, preservatives and the like.

The method of preparing the enteral nutritional supplement of the present invention may be the same as the usual enteral nutritional supplement of this kind and is not particularly limited. For example, a method of mixing and emulsifying each of the above components may be used. More specifically, water-soluble components such as carbohydrates and proteins are dissolved in water or hot water, and then heated, and oil-soluble components such as fat are added to the mixture, and lecithin, sugar ester and the like are generally used as needed. As a preferable method, a method of emulsifying with an appropriate emulsifying machine using an emulsifier can be exemplified.

The enteral nutritional product of the present invention thus prepared is
After aseptically filling an appropriate container or filling a can, a retort pouch, etc., heat sterilization (for example, 1
The product can be obtained by subjecting it to 20 ° C. for about 20 minutes), which can be directly or appropriately diluted and put to practical use as a nutritional supplement.

The dose is about 25% per adult per day.
It is appropriate that the amount selected from the range of about 10 to 50 ml / kg, preferably about 20 to 35 ml / kg in the liquid form (w / v%) is used as a guide, and this is the patient to whom this is applied. It can be increased or decreased depending on the situation.

[0021]

INDUSTRIAL APPLICABILITY The enteral nutritional supplement of the present invention has a high protein content, a high calorie content and an excellent nutritional balance, is well decomposed (digested) and absorbed in the intestinal tract, and has side effects such as diarrhea, vomiting and nausea. There is hardly any, and the desired nutritional state improving effect can be always exerted stably and sufficiently. In addition, this does not require intravenous administration such as infusion, and compared to this, more physiological oral and enteral administration such as nasal administration is possible, and by this enteral administration, it can be applied to various patients and healthy individuals. Applicable as a nutritional supplement.

[0022]

EXAMPLES Examples will be given below to explain the present invention in more detail.

[0023]

Example 1 Preparation of Protein Purified Product of the Present Invention Kachan Hija (Scientific Name: Phaseolus Ra
diatus L.) 3.3 kg was added to an equal amount of water and immersed for 30 minutes, then ground (20,000 rpm) with a colloid mill (manufactured by Tokushu Kika Kogyo Co., Ltd.), separated by filter filtration, and separated into raw soymilk. 115 kg and 3.116 kg of Okara were obtained.

[0024] The raw soy milk was centrifuged (3000 rpm,
After 5 minutes, 10.997 kg of the supernatant and the starch fraction were separated, and 9.790 kg of the supernatant was spray-dried (pump pressure: 5 kg / cm ² , intake: 190 ° C., exhaust: 100).
℃), and then the Kachanhija purified protein powder 58 of the present invention
1 g (water content 3.1%) was obtained.

The starch fraction was dried at 50 ° C. to recover 368 g of Kachanhija purified starch powder (water content 10.8%).

The amino acid analysis results of the purified protein powder were as follows.

Arginine 4.72% (wt%, same below) Phenylalanine 4.19% Isoleucine 2.82% Alanine 2.82% Glutamic acid 11.8% Aspartic acid 7.80% Lysine 4.73% Tyrosine 2.02 % Methionine 0.88% Glycine 2.38% Serine 3.46% Tryptophan 0.71% Histidine 1.94% Leucine 5.28% Valine 3.61% Proline 2.81% Threonine 2.12% Cystin 0.34 %

[0028]

Example 2 Preparation of Enteral Nutritional Supplement of the Present Invention Using the purified protein of Kachanhija obtained in Example 1 as an essential protein source, an enteral nutritional supplement of the present invention having the following formulation was prepared.
However, the amount of each component is g when the total composition weight is 100 g.
Display as a number.

Rice dextrin 70.1 g Corn oil 9.3 g Sodium casein 8.5 g Kachanhija purified protein 7.0 g Sodium chloride 1.0 g Potassium chloride 0.61 g Magnesium sulfide 0.62 g Calcium glycerophosphate 0.85 g Sodium iron citrate citrate 0.025g Sugar ester 0.2g Various vitamins Note 1) Moisture and other amounts of 100g as a whole The various vitamins Note 1) are as follows.

Vitamin A 466 IU Vitamin B ₁ 0.23 mg Vitamin B ₂ 0.26 mg Vitamin B ₆ 0.47 mg Vitamin B ₁₂ 1.17 μg Nicotinamide 3.5 mg Folic acid 0.12 mg Vitamin C 11.66 mg Vitamin D 46.6 IU Vitamin E 9.32 IU Pantothenic acid 2.33 mg That is, the above-mentioned predetermined amount of water-soluble components such as carbohydrates and proteins were dissolved in hot water (50 ° C), and then the above-mentioned predetermined amount of fat and oil-soluble The components and sugar ester as an emulsifier were added, and the mixture was emulsified (3000 ps) using an emulsifying machine (manufactured by Gaulin) to prepare the enteral nutritional supplement of the present invention.

The thus-obtained enteral nutritional product of the present invention contained the following electrolyte ions and had the weight ratio of carbohydrates, fats and proteins and the calorific ratio.

Na 590 mg (25.6 mEq) K 319 mg (8.2 mEq) Ca 164 mg (8.2 mEq) Mg 62 mg (5.1 mEq) Cl 902 mg (25.4 mEq) P 221 mg Cu 0.03 mg (0.001 mEq) Zn 0.85 mg (0.026 mEq) I 0.03 mg (0.0002 mEq) Fe 2.73 mg (0.1 mEq) Mn 0.03 mg (0.001 mEq) S 82 mg Carbohydrate 70.1 g 280 kcal Fat 9.3 g 84 kcal Protein 14. 0g 56kcal Total 420kcal / 100g The above-mentioned enteral nutritional supplement is 200 ml, 500 ml or 1
For example, 000 ml is filled in a retort container and sterilized by heating to obtain a product form, which is 1000 to 250 per adult per day for a patient who needs nutritional support as an oral / enteral nutritional supplement.
It can be administered enterally in the range of 0 ml, and can exert a sufficient nutritional supplementation effect.

Claims (3)

[Claims] 1. An enteral nutritional product characterized by containing 1 to 20% by weight of a purified protein of Cachanhija (Phaseolus radiatas) on a dry weight basis. 2. The enteral preparation containing the purified protein of Kachan Hija according to claim 1, which contains 40 to 95 wt% of carbohydrate, 0 to 20 wt% of fat and 5 to 40 wt% of total protein including Kachan hija purified protein on a dry weight basis. Nutritional supplement. 3. The enteral nutritional supplement according to claim 1 or 2, wherein the amount of purified protein of Kachanhija is 30 to 100% by weight of the total protein.