JPH061723A - Renal function improving medicine - Google Patents

Abstract

PURPOSE:To provide a medicine capable of quickly improving/curing, without side effects, nephropathy (esp. oliguric nephropathy) of mammals including humans through its taking. CONSTITUTION:The medicine (diuretic) containing, as active ingredient, an extract of Asparasus linealis. For the extraction, the leaves or stems of the above plant are extracted with water and/or an organic solvent and the extraction solvent is distilled off the resultant extract; or, such leaves or stems may be ground; or extraction may be carried out in a similar way as with conventional Japanese tea, Chinese tea, or black tea.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a renal function-improving treatment and a diuretic agent containing an active ingredient of Aspalathus linealis belonging to the legume family.

[0002]

2. Description of the Related Art Conventionally, for oliguric kidney disease,
Aldosterone antagonists such as Aldacton (Dainippon Pharmaceutical Co., Ltd.), loop diuretics such as Lasix (Hoechst),
Alternatively, diuretics such as carbonic anhydrase inhibitors such as Diamox (Takeda Pharmaceutical Company) are known.

[0003]

However, the diuretic is N
It is effective as a temporary drug because it has side effects because it uses an artificial synthetic compound that blocks a, K transport carriers, inhibits carbonic anhydrase, or antagonizes aldosterone. It cannot be used for a period of time.

[0004] For renal diseases, a diet therapy that restricts sodium intake has been conventionally performed. However, due to a change in taste in patients' diets, a diet therapy that restricts sodium intake is less effective or long-term. Therefore, it is difficult to obtain a sufficient effect.

The present invention solves the above-mentioned problems and improves kidney disease,
In particular, it is an object of the present invention to provide a therapeutic agent for improving symptoms which is effective for oliguric renal diseases such as acute nephritis.

[0006] Therefore, as a result of intensive studies for achieving the above-mentioned object, the present inventors have found that Asparasus linealis extract belonging to the legume family was excellent against oliguric kidney diseases such as acute nephritis. The present invention has been completed based on the finding that it has effects and can safely improve various skin diseases without side effects.

The active ingredient of this component consists of an extract of Aspalathus linealis. As the extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.

In the case of extraction with water, 50 to 1000 times as much water as Aspalathus linealis is added, and 90 to 100 is added.
It is preferable to extract for about 5 to 30 minutes. Moreover, when making it the same as normal tea, 50 to 1000 times as much water as dry leaves of Aspalathus linealis is added, and the extract is boiled at 90 to 100 degrees for about 5 to 30 minutes to obtain an extract.

Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.

A conventional means such as freeze-drying can be used for distilling off the extraction solvent. In addition, Aspalathus linealis itself can be crushed, and can be used after being miniaturized and powdered.

The composition is prepared by mixing the active ingredient with physiologically acceptable carriers, excipients, binders and diluents, for example granules, powders, hard capsules, soft capsules, coatings and syrups. , Suppositories, orally or parenterally as injections, or as a mixture as it is, solutions, powder granules, tablets,
It can be administered alone in any form such as an emulsion or jelly, can be used as a concentrated solution, or can be mixed with other foods and drinks.

The dose varies depending on the kind and degree of the target disease, but in the case where humans regularly use it as a drink, the dose is 1
It is preferable to eat and drink ~ 5 g dry leaf / 1 solution at 100 ml-2000 ml / day. When given to animals such as pets, it is preferable to give 2 ml / kg body weight to 30 ml / kg body weight. In the case of freeze-dried granule powder, it is preferable to give 1 g to 10 g / day, respectively.

[0013] Aspalathus linealis showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.

[0014]

[Effect] The present invention can treat renal diseases of mammals including humans, in particular, oliguric renal diseases, which can be rapidly improved by eating or drinking without side effects.

[0015]

【Example】

Production example Collected Aspalathus linealis leaves (with stem)
After cutting to a length of 5 mm, dried leaves are subjected to the steps of rolling, enzyme fermentation, and sun drying. 4 g of dried leaves were boiled with 1.5 liters of water for 15 minutes to obtain an extract.

Example 1 cup of the Aspalathus linealis extract obtained in the production example per day for 5 panelists with reduced renal function and edema on the face
~ 5 cups were given and examined for improvement in renal function. As a result, in 4 persons, the amount of urine increased due to a diuretic effect immediately after starting drinking, and facial edema did not appear in 1 to 2 weeks, and the body became tired.

Claims (2)

[Claims] 1. A therapeutic agent for improving renal function, comprising an Aspalathus linealis extract as an active ingredient. 2. A diuretic containing an Aspalathus linealis extract as an active ingredient.