JPH0614996A - Adsorption module - Google Patents

Adsorption module

Info

Publication number
JPH0614996A
JPH0614996A JP5125421A JP12542193A JPH0614996A JP H0614996 A JPH0614996 A JP H0614996A JP 5125421 A JP5125421 A JP 5125421A JP 12542193 A JP12542193 A JP 12542193A JP H0614996 A JPH0614996 A JP H0614996A
Authority
JP
Japan
Prior art keywords
housing
inorganic hollow
adsorption
hollow fibers
adsorption module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5125421A
Other languages
Japanese (ja)
Inventor
Saburo Ikeda
田 三 郎 池
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SB Kawasumi Laboratories Inc
Original Assignee
Kawasumi Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawasumi Laboratories Inc filed Critical Kawasumi Laboratories Inc
Priority to JP5125421A priority Critical patent/JPH0614996A/en
Publication of JPH0614996A publication Critical patent/JPH0614996A/en
Pending legal-status Critical Current

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Abstract

PURPOSE:To improve the adsorption efficiency of a material to be removed by fitting inorganic hollow fibers in a housing in particular in improving an adsorption module used for the treatment of an autoimmune disease patient. CONSTITUTION:Hollow fibers 3 made of an inorganic material and coated with ligand (inorganic hollow fibers 3) are fitted in a housing 2, and a cap 9 having an outlet 7 of a body fluid and a cap 5 having an inlet 6 of the body fluid are provided at end sections of the housing 2 via stoppers having many holes to form an adsorption module. The number and inner diameter of the inorganic hollow fibers 3 can be properly selected according to the disease of a patient, thus various adsorption modules can be provided. The flow of blood is made smooth, and the adsorption efficiency is improved.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、自己免疫疾患患者の治
療用に使用される吸着モジュ−ルの改良に関するもの
で、特に無機質中空糸をハウジング内に装填し、除去物
質の吸着効率を向上させた吸着モジュ−ルを提供するも
のである。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement of an adsorption module used for treating patients with autoimmune diseases, and in particular, an inorganic hollow fiber is loaded in a housing to improve the adsorption efficiency of a substance to be removed. And an adsorption module for the same.

【0002】[0002]

【従来技術及び発明が解決しようとする課題】現在、吸
着モジュ−ルは、ビ−ズ表面に担体をコ−ティングしこ
れらをカラムに充填したものや、合成(または天然)繊
維からなる中空糸と担体をコ−ティングしたビ−ズを一
つのハウジング内に充填したものが使用されている。
2. Description of the Related Art At present, an adsorption module is a hollow fiber composed of synthetic (or natural) fibers obtained by coating a carrier on the bead surface and packing them in a column. A single housing is filled with beads coated with a carrier.

【0003】しかしながら前者では、血液、血漿等の体
液の流れが阻害されやすく、ビ−ズの表面積は大きいに
もかかわらず十分に機能を発揮できなかった。このため
後者のように体液の流れを確保するために中空糸を装填
し、ビ−ズで除去物質の吸着効果を高めるようにしてい
るが、ビ−ズ状の吸着剤では、吸着モジュ−ルとして組
み立てた後、製品として運搬する途中でおたがいの摩擦
により、微小塊が発生するので、これを捕捉するための
フィルタ−を新たに装着しなければならずコスト高にな
っていた。そこで本発明は、以上の課題を解決するため
に鋭意検討を重ねた結果次の発明に到達した。
However, in the former case, the flow of body fluids such as blood and plasma is liable to be impeded, and although the beads have a large surface area, they cannot sufficiently exhibit their functions. For this reason, as in the latter case, hollow fibers are loaded in order to secure the flow of body fluid, and the bead-like adsorbent is used to enhance the adsorbing effect of the substance to be removed. After assembling as described above, minute lumps are generated due to friction of each other in the course of transportation as a product, and a filter for capturing this is required to be newly attached, resulting in high cost. Therefore, the present invention has reached the following invention as a result of intensive studies to solve the above problems.

【0004】[0004]

【課題を解決するための手段】本発明は、リガンドをコ
−ティングした無機材料よりなる中空糸3(以下「無機
質中空糸3」)がハウジング2内に装填され、該ハウジ
ング2の端部に体液の出口7を有するキャップ9と体液
の入口6を有するキャップ5を多数の孔8を有するスト
ッパ−4を介在させて装着した吸着モジュ−ル1を提供
するものである。
According to the present invention, a hollow fiber 3 made of an inorganic material coated with a ligand (hereinafter referred to as "inorganic hollow fiber 3") is loaded into a housing 2, and the end portion of the housing 2 is filled with the hollow fiber 3. The adsorption module 1 is provided in which a cap 9 having a body fluid outlet 7 and a cap 5 having a body fluid inlet 6 are mounted via a stopper 4 having a large number of holes 8.

【0005】[0005]

【作用】体液の入口6から無機質中空糸3内に導入され
た体液は流路を妨げられることなくスム−ズに無機質中
空糸3内を流れ体液の出口7より排出される。体液中の
除去物質は無機質中空糸3内を流れる途中でリガンドに
吸着除去される。
The body fluid introduced from the body fluid inlet 6 into the inorganic hollow fiber 3 smoothly flows through the inorganic hollow fiber 3 without being obstructed in the flow path and is discharged from the body fluid outlet 7. The removed substance in the body fluid is adsorbed and removed by the ligand while flowing through the inorganic hollow fiber 3.

【0006】[0006]

【実施例】図1は本発明の吸着モジュ−ル1の概略図で
ある。吸着モジュ−ル1は、図2に示すようなリガンド
を内面と外面にコ−ティングした複数の無機質中空糸3
をハウジング2内に装填している。
1 is a schematic view of an adsorption module 1 of the present invention. The adsorption module 1 comprises a plurality of inorganic hollow fibers 3 coated with ligands on the inner and outer surfaces as shown in FIG.
Are loaded in the housing 2.

【0007】ハウジング2の端部には図3に示すように
らせん状の凸部10を形成した大径の接続部11が形成
され、これに図4に示すような多数の孔8を有する網目
状のストッパ−4を介在させて、図5に示すような体液
の入口6(出口7)を有し前記らせん状の凸部10に対
応するらせん状の凹部12が形成されたキャップ5
(9)が装着される。
As shown in FIG. 3, a large-diameter connecting portion 11 having a spiral convex portion 10 is formed at the end of the housing 2, and a mesh having a large number of holes 8 as shown in FIG. A cap 5 having a body fluid inlet 6 (outlet 7) as shown in FIG. 5 and a spiral concave portion 12 corresponding to the spiral convex portion 10 formed with a stopper 4 interposed therebetween.
(9) is attached.

【0008】本発明に使用されるリガンドは、生物学的
吸着剤として、例えばプロテインA(IgG、抗血小板
抗体)、第9因子(抗第9因子抗体)、オリゴ糖(抗
A、B抗体)、シビレエイ/α183−200(抗Ac
hR抗体)、シビレエイ/α128−142(抗Ach
R抗体)、抹消性ミエリン/P2 蛋白の66−78残基
(抗ミエリン抗体)、抗LDL抗体(LDLコレステロ
−ル)、抗ビリルビンMAb(ビリルビン)等が使用で
きる(( )内は除去物質)。また物理学的吸着剤とし
て、デキストラン硫酸(LDLコレステロ−ル、抗DN
A抗体、抗カルジオリピン抗体)、フェニルアラニン
(免疫複合体、抗DNA抗体)、4級アンモニウムクロ
ライド(ビリルビン、胆汁酸)、トリプトファン(抗A
chR抗体)、ポリエステル不織布(リンパ球)、スル
ファチゾ−ル(抗AchR抗体、βリンパ球)、MMA
−DVB(β2 ミクログロブリン)、organic
compound(β2 ミクログロブリン)、HMDI
(β2 ミクログロブリン)、TP、RCA(CD4、C
D8細胞)等が使用できる(( )内は除去物質)。
The ligand used in the present invention is a biological adsorbent, for example, protein A (IgG, anti-platelet antibody), factor 9 (anti-factor 9 antibody), oligosaccharide (anti-A, B antibody). , Torpedo / α183-200 (anti-Ac
hR antibody), Torpedo / α128-142 (anti-Ach
R antibody), 66-78 residues of peripheral myelin / P 2 protein - in (anti myelin antibody), an anti-LDL antibody (LDL cholesterol Le), anti-bilirubin MAb (bilirubin), and the like can be used (() is removing material ). As a physical adsorbent, dextran sulfate (LDL cholesterol, anti-DN
A antibody, anti-cardiolipin antibody), phenylalanine (immune complex, anti-DNA antibody), quaternary ammonium chloride (bilirubin, bile acid), tryptophan (anti-A)
chR antibody), polyester non-woven fabric (lymphocyte), sulfatizole (anti-AchR antibody, β lymphocyte), MMA
-DVB (β 2 microglobulin), organic
compound (β 2 microglobulin), HMDI
2 microglobulin), TP, RCA (CD4, C
D8 cells) and the like can be used (removed substances in ()).

【0009】また無機質中空糸3は、ガラス、セラミッ
ク等から構成され、内径が200μ〜540μのものを
使用するのが好ましい。内径が200μ以下では径が小
さすぎて体液の流量が充分に確保できないので好ましく
ない。また、内径が540μ以上では、径が大きすぎて
ハウジングの単位容積内に充填できる無機質中空糸3の
本数が少なくなりひいては無機質中空糸3の表面にコ−
ティングした吸着性能を有するリガンドの表面積が小さ
くなり吸着効率を充分に発揮できないので好ましくな
い。無機質中空糸3は、多孔質のもののほうが表面積が
より大となり吸着性能が向上するのでより好ましい。
The inorganic hollow fiber 3 is preferably made of glass, ceramics or the like and has an inner diameter of 200 to 540 μ. If the inner diameter is 200 μm or less, the diameter is too small to ensure a sufficient flow rate of body fluid, which is not preferable. Further, when the inner diameter is 540 μm or more, the diameter is too large and the number of the inorganic hollow fibers 3 that can be filled in the unit volume of the housing is small, and as a result, the surface of the inorganic hollow fibers 3 is coated.
It is not preferable because the surface area of the ligand having the adsorbed adsorption property becomes small and the adsorption efficiency cannot be sufficiently exhibited. The inorganic hollow fiber 3 is more preferably porous because the surface area is larger and the adsorption performance is improved.

【0010】リガンドを無機質中空糸3に結合させる手
段としては、公知の手段によりスペ−サ−を介して行う
ことができる。例えばアミノアルキル基を有する無機質
中空糸3に結合試薬として、水溶性カルボジイミド類
(例えば、1−エチル−3−(3−ジメチルアミノプロ
ピル)カルボジイミド・塩酸、1−シクロヘキシル−3
−(2−モルホリンエチル)カルボジイミドメト−p−
トルエン−スルホン酸塩等)を用いて、前記アミノアル
キル基にリガンドを反応させて結合する方法などが挙げ
られる(この場合はアミノアルキル基と結合試薬がスペ
−サ−の役割を果たす)。反応温度、反応時間は特に限
定されない。
As a means for binding the ligand to the inorganic hollow fiber 3, a known means can be used via a spacer. For example, as a binding reagent for the inorganic hollow fiber 3 having an aminoalkyl group, water-soluble carbodiimides (for example, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide / hydrochloric acid, 1-cyclohexyl-3
-(2-morpholineethyl) carbodiimidemetho-p-
(Toluene-sulfonate, etc.) and the like, a method of reacting a ligand with the above-mentioned aminoalkyl group and binding the same (in this case, the aminoalkyl group and the binding reagent function as a spacer). The reaction temperature and reaction time are not particularly limited.

【0011】ハウジング2内に充填される無機質中空糸
3の本数、内径の大きさは、ストッパ−4の孔8の数、
大きさを適宜変更することにより調整することができ
る。ストッパ−4の孔8は、無機質中空糸3の外径より
も細孔にすることにより無機質中空糸3の端部をより確
実に固定することができる。
The number of the inorganic hollow fibers 3 filled in the housing 2 and the size of the inner diameter are the number of the holes 8 of the stopper-4,
It can be adjusted by appropriately changing the size. The hole 8 of the stopper-4 can be more reliably fixed to the end portion of the inorganic hollow fiber 3 by making the hole smaller than the outer diameter of the inorganic hollow fiber 3.

【0012】本発明の吸着モジュ−ル1は、無機質中空
糸3をハウジング2内に装填した後、これらの両端部に
ストッパ−4を介在させてキャップ5(9)を装着する
ことにより組み立てられる。
The adsorption module 1 of the present invention is assembled by loading the inorganic hollow fibers 3 in the housing 2 and then attaching the caps 5 (9) with stoppers 4 interposed at both ends thereof. .

【0013】表面にリガンドとしてオリゴ糖をコ−ティ
ングした内径200μ、長さ280mmのガラス製の無
機質中空糸3を10,000本ハウジング2内に装填し
た吸着モジュ−ルを作成し、これに血液を通して除去物
質の吸着効率等を確認したところ従来のビ−ズを用いた
吸着モジュ−ルよりも抗A、B抗体の吸着効率が20%
以上向上し良好な結果が得られた。
An adsorption module was prepared by loading 10,000 glass-made inorganic hollow fibers 3 having an inner diameter of 200 μm and a length of 280 mm coated on the surface with oligosaccharides as a ligand into a housing 2, and blood was applied to the adsorption module. The adsorption efficiency of the removed substance was confirmed through 20%, and the adsorption efficiency of the anti-A and B antibodies was 20% as compared with the conventional adsorption module using beads.
The above results were improved and good results were obtained.

【0014】[0014]

【発明の効果】 無機質中空糸3は、患者の疾患等に応じてハウジング
内に装填する本数、内径等を適宜選択することができる
ので種々の吸着モジュ−ルを提供することができる。 血液の流れがスム−ズになるので吸着効率が向上す
る。 従来のビ−ズを使用する場合のように、微小塊が生じ
ないので、血液流路の途中に特殊フィルタ−を設ける必
要がなくコストダウンが図れる。 無機質中空糸3は、ハウジング2から容易に取りはず
して洗浄、回収でき再使用可能である。
EFFECTS OF THE INVENTION Since the number of the inorganic hollow fibers 3 to be loaded into the housing, the inner diameter, etc. can be appropriately selected according to the patient's disease or the like, various adsorption modules can be provided. Since the blood flow becomes smooth, the adsorption efficiency is improved. As in the case of using a conventional bead, since no minute mass is generated, it is not necessary to provide a special filter in the middle of the blood flow path, and the cost can be reduced. The inorganic hollow fiber 3 can be easily removed from the housing 2, washed, collected, and reused.

【図面の簡単な説明】[Brief description of drawings]

【図1】本発明の吸着モジュ−ルの概略図FIG. 1 is a schematic view of an adsorption module of the present invention.

【図2】本発明に使用される無機質中空糸の概略図FIG. 2 is a schematic view of an inorganic hollow fiber used in the present invention.

【図3】吸着モジュ−ルを構成するハウジングの概略図FIG. 3 is a schematic view of a housing that constitutes an adsorption module.

【図4】無機質中空糸の端部を固定するストッパ−の概
略図
FIG. 4 is a schematic view of a stopper that fixes the end of the inorganic hollow fiber.

【図5】図3のハウジングの両端部に装着されるキャッ
プの概略図
5 is a schematic view of caps attached to both ends of the housing of FIG.

【符合の説明】[Explanation of sign]

1 吸着モジュ−ル 6 血
液入口 2 ハウジング 7 血
液出口 3 無機質中空糸 8 孔 4 ストッパ− 5 キャップ
1 Adsorption Module 6 Blood Inlet 2 Housing 7 Blood Outlet 3 Inorganic Hollow Fiber 8 Hole 4 Stopper 5 Cap

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】 リガンドをコ−ティングした無機材料よ
りなる中空糸3(以下「無機質中空糸3」)がハウジン
グ2内に装填され、該ハウジング2の端部に体液の出口
7を有するキャップ9と体液の入口6を有するキャップ
5を多数の孔8を有するストッパ−4を介在させて装着
したことを特徴とする吸着モジュ−ル1。
1. A cap 9 having a hollow fiber 3 made of an inorganic material coated with a ligand (hereinafter referred to as "inorganic hollow fiber 3") loaded in a housing 2 and having a body fluid outlet 7 at an end of the housing 2. An adsorption module 1 characterized in that a cap 5 having an inlet 6 for body fluid and a stopper 4 having a large number of holes 8 are attached thereto.
JP5125421A 1992-05-01 1993-04-28 Adsorption module Pending JPH0614996A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5125421A JPH0614996A (en) 1992-05-01 1993-04-28 Adsorption module

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4-140047 1992-05-01
JP14004792 1992-05-01
JP5125421A JPH0614996A (en) 1992-05-01 1993-04-28 Adsorption module

Publications (1)

Publication Number Publication Date
JPH0614996A true JPH0614996A (en) 1994-01-25

Family

ID=26461863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5125421A Pending JPH0614996A (en) 1992-05-01 1993-04-28 Adsorption module

Country Status (1)

Country Link
JP (1) JPH0614996A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010158394A (en) * 2009-01-08 2010-07-22 Kaneka Corp Immunoglobulin adsorbent excellent in blood compatibility, and adsorption apparatus
WO2013047549A1 (en) * 2011-09-30 2013-04-04 東レ株式会社 Purification column and method for manufacturing purification column
WO2013129384A1 (en) * 2012-03-02 2013-09-06 東レ株式会社 Adsorption column
JP2014210174A (en) * 2013-04-04 2014-11-13 東レ株式会社 Purification column and method of manufacturing the same
JP2017080400A (en) * 2007-08-31 2017-05-18 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Selective cellular adsorption removal device and the related method

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017080400A (en) * 2007-08-31 2017-05-18 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Selective cellular adsorption removal device and the related method
JP2010158394A (en) * 2009-01-08 2010-07-22 Kaneka Corp Immunoglobulin adsorbent excellent in blood compatibility, and adsorption apparatus
WO2013047549A1 (en) * 2011-09-30 2013-04-04 東レ株式会社 Purification column and method for manufacturing purification column
JPWO2013047549A1 (en) * 2011-09-30 2015-03-26 東レ株式会社 Purification column and purification column manufacturing method
EP2762180A4 (en) * 2011-09-30 2015-05-13 Toray Industries Purification column and method for manufacturing purification column
WO2013129384A1 (en) * 2012-03-02 2013-09-06 東レ株式会社 Adsorption column
JP2014210174A (en) * 2013-04-04 2014-11-13 東レ株式会社 Purification column and method of manufacturing the same

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