JPH061278B2 - Dispenser for automatic analyzer - Google Patents
Dispenser for automatic analyzerInfo
- Publication number
- JPH061278B2 JPH061278B2 JP1104045A JP10404589A JPH061278B2 JP H061278 B2 JPH061278 B2 JP H061278B2 JP 1104045 A JP1104045 A JP 1104045A JP 10404589 A JP10404589 A JP 10404589A JP H061278 B2 JPH061278 B2 JP H061278B2
- Authority
- JP
- Japan
- Prior art keywords
- probe
- reagent
- liquid
- container
- dispenser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【発明の詳細な説明】 本発明は少なくとも1台の分注器を具え、この分注器に
よってそのプローブ内に複数の試薬,試料などの液体の
1種以上を各別の容器から吸引し、かつ、その吸引され
た液体をプローブより反応容器内に分注する装置に関す
るものである。DETAILED DESCRIPTION OF THE INVENTION The present invention comprises at least one dispenser, which dispenses one or more liquids such as a plurality of reagents, samples, etc. into its probe from separate containers, It also relates to a device for dispensing the sucked liquid from the probe into the reaction container.
上述した形式の分注装置は多量の試料(検体)を対象と
する自動化学分析装置などにおいて使用されるものであ
り、個々の試料や検体情報(分析項目)に対応した試薬
を反応容器内に分注することを目的としている。この種
の分注装置においては、分析精度の低下を防止するた
め、試料または試薬間のコンタミネーションを可能なか
ぎり排除しなくてはならない。The dispenser of the above-mentioned type is used in automatic chemical analyzers that target a large amount of samples (samples), and reagents corresponding to individual samples and sample information (analysis items) are placed in the reaction container. The purpose is to dispense. In this type of dispensing device, contamination between samples or reagents must be eliminated as much as possible in order to prevent deterioration of analysis accuracy.
そのための解決策の1つとして、各試薬に対応して複数
の分注装置を設けることが考えられるが、かかる構成は
スペース的および価格的に著しく不都合である。他の解
決策として、複数の試薬に対して1つの分注流体系統を
設け、この流体系統の一端を任意の試薬を収めた容器
と、また他端を試料容器とそれぞれ接続可能とし、更に
流体系統に1つのポンプを切替弁を介して接続し、切替
弁の操作によって試薬の吸引、試料の吸引、ならびに反
応容器に対する試料および試薬の同時分注を行なう構成
のものも公知である。しかし、この公知の装置において
は流体系統が試薬によって完全に満たされるため、吸引
はされたが分注されない試薬が無駄となるのみならず、
試薬の種類を変える都度流路全体を洗浄する必要があ
り、しかも弁の切替機構および切替操作が複雑で作動の
信頼性を十分に高めることが困難である。As one of the solutions for that, it is conceivable to provide a plurality of dispensing devices corresponding to each reagent, but such a configuration is extremely inconvenient in terms of space and cost. As another solution, one dispensing fluid system is provided for a plurality of reagents, one end of the fluid system can be connected to a container containing an arbitrary reagent, and the other end can be connected to a sample container. A configuration is also known in which one pump is connected to a system via a switching valve and a reagent is sucked, a sample is sucked, and a sample and a reagent are simultaneously dispensed to a reaction container by operating the switching valve. However, in this known device, since the fluid system is completely filled with the reagent, not only the reagent that has been aspirated but not dispensed is wasted,
It is necessary to wash the entire flow path every time the type of reagent is changed, and the valve switching mechanism and switching operation are complicated, and it is difficult to sufficiently enhance the reliability of operation.
特開昭54-5790号公報に記載された他の既知の装置にお
いては、複数種類の試薬を個別に収容する試薬容器をタ
ーンテーブル上に並べ、ターンテーブルをスリップ機構
を介してモータにより一定方向に回転させ、所望の試薬
を収めた容器が吸引位置に到達したときにターンテーブ
ルを電磁的に停止させて当該試薬を吸引している。試薬
容器は、ターンテーブル上に載置可能とするために、小
型のものが望ましく、そのためには試薬として通常のも
のと対比して数十倍程度濃縮したものを使用する。した
がって試薬はプローブによって吸引してから反応容器内
に分注するまでの間に希釈液(例えば水)によって希釈
しなければならず、そのための手段および工程が必然的
に付加されることになる。さらに1種類の試薬しか分注
しない場合でも常に全ての試薬容器をターンテーブルご
と回転・停止させる必要があるから作動に無駄があると
共に、駆動および停止機構も必然的に大がかりなものと
なる。In another known device described in JP-A-54-5790, reagent containers that individually store a plurality of types of reagents are arranged on a turntable, and the turntable is driven in a fixed direction by a motor through a slip mechanism. When the container containing the desired reagent reaches the suction position, the turntable is electromagnetically stopped to suck the reagent. The reagent container is preferably small in size so that it can be placed on the turntable, and for that purpose, a reagent which is concentrated several tens of times as compared with a normal reagent is used. Therefore, the reagent must be diluted with a diluting liquid (for example, water) between the time when the reagent is sucked by the probe and the time when the reagent is dispensed into the reaction container, and means and steps therefor are inevitably added. Further, even when only one kind of reagent is dispensed, it is necessary to rotate and stop all the reagent containers together with the turntable at all times, which is wasteful in operation, and the driving and stopping mechanism is inevitably large.
本発明の目的は、従来装置における上述の欠点を解決す
るために、試料または試薬の容器群を移動させることな
く所望の試料または試薬を反応容器内に分注することが
でき、しかも構成が簡単で作動効率が高い自動分析装置
の分注装置を提供するにある。The object of the present invention is, in order to solve the above-mentioned drawbacks in the conventional apparatus, it is possible to dispense a desired sample or reagent into the reaction container without moving the container group of the sample or reagent, and the structure is simple. To provide a dispensing device for an automatic analyzer having high operating efficiency.
すなわち本発明は、試薬または試料などの液体を収容す
る複数の液体容器から液体を吸引して反応容器内に吐出
するためのプローブを有する自動分析装置の分注器にお
いて、円形状の少なくとも一部の移動経路に沿って回動
可能なプローブと、前記プローブの移動経路に沿って該
移動経路の一部を除いて固定配置された複数の液体容器
と、前記液体容器が配置されない前記プローブの移動経
路を横切るように順次移送される複数の反応容器と、前
記プローブを所望の液体容器と前記反応容器が横切る所
定位置とに位置決めする手段を備えたものである。That is, the present invention is a dispenser of an automatic analyzer having a probe for sucking a liquid from a plurality of liquid containers containing a liquid such as a reagent or a sample and discharging the liquid into a reaction container. Of the probe that is rotatable along the movement path of the probe, a plurality of liquid containers that are fixedly arranged along the movement path of the probe except a part of the movement path, and movement of the probe in which the liquid container is not arranged. It is provided with a plurality of reaction vessels sequentially transferred across the path, and means for positioning the probe at a predetermined position where the desired liquid vessel and the reaction vessel cross.
本発明の一実施例を示す第1図および第2図において、
1はポンプボックスで、回転アーム2と結合されてい
る。アーム2は歯車軸3と結合し、ポンプボックス1を
その円形移動経路に沿って配置された試薬容器9および
洗浄水容器8の各吸引開口、ならびに反応容器11上に移
動させる。歯車軸3は軸受6により支承し、歯車4を介
してモータ5により回転させる。ポンプボックス1には
プローブ7を取りつける。10は反応レーンで、図示しな
い駆動手段により分注工程と同期して間欠的に駆動す
る。反応レーン10を円形とし、プローブ7の円形移動径
路と外接させる。円形に配列した試薬容器9は反応レー
ン10の近傍には位置させない。1 and 2 showing an embodiment of the present invention,
Reference numeral 1 is a pump box, which is connected to the rotary arm 2. The arm 2 is connected to the gear shaft 3 and moves the pump box 1 onto the respective suction openings of the reagent container 9 and the wash water container 8 and the reaction container 11 arranged along the circular movement path thereof. The gear shaft 3 is supported by a bearing 6 and is rotated by a motor 5 via a gear 4. The probe 7 is attached to the pump box 1. 10 is a reaction lane, which is intermittently driven by a driving means (not shown) in synchronization with the dispensing step. The reaction lane 10 is circular and is circumscribed with the circular movement path of the probe 7. The reagent containers 9 arranged in a circle are not located near the reaction lane 10.
上記実施例の装置の動作を次に説明する。初期状態にお
いてポンプ1およびプローブ7は洗浄水容器8上に位置
し、プローブ7は上昇位置にある。最初にポンプ1で水
の吸引を行ないプローブ7は先端まで水が満たされてい
る。まずモータ5で歯車4、軸3、アーム2を介してプ
ローブ7を所要の試薬が収められた試薬容器9の上方ま
で移動させる。次にプローブ7を下降させ、試薬中に浸
漬させて所要量の試薬を吸引する。次にプローブ7を上
昇させ、モータ5により反応容器11上に移動させる。こ
の位置で試薬を反応容器11内に分注した後、プローブ7
を洗浄水容器8上に移動させる。さらにプローブ7を下
降させ、洗浄水に浸漬してプローブ7外壁を洗浄し、ま
たプローブ7より水を排出することによりプローブ7内
壁も洗浄する。最後にプローブ7を上昇させることによ
り1分注工程を完了する。反応レーン10は分注工程に同
期して1ステップずつ送られる。The operation of the apparatus of the above embodiment will be described below. In the initial state, the pump 1 and the probe 7 are located on the wash water container 8, and the probe 7 is in the raised position. First, the pump 1 sucks water, and the probe 7 is filled with water up to the tip. First, the motor 5 moves the probe 7 via the gear 4, the shaft 3 and the arm 2 to a position above the reagent container 9 containing a required reagent. Next, the probe 7 is lowered and immersed in the reagent to suck a required amount of the reagent. Next, the probe 7 is raised and moved onto the reaction container 11 by the motor 5. After dispensing the reagent into the reaction vessel 11 at this position, the probe 7
Are moved onto the wash water container 8. Further, the probe 7 is lowered and immersed in washing water to wash the outer wall of the probe 7, and the inner wall of the probe 7 is also washed by discharging water from the probe 7. Finally, the probe 7 is raised to complete the 1-dispensing process. The reaction lane 10 is sent step by step in synchronization with the dispensing process.
上述の実施例によれば次のような利点を有する(1)1台
の分注器で、1種以上の複数の試薬または試料などの液
体を収容する容器を移動させることなく選択的に分注さ
せることができる。すなわち、プローブの円形移動経路
上の所定位置に、吸引すべき液体を収容する容器が固定
配置されているので、試薬ターンテーブル方式の欠点で
ある試薬等容器全体の大掛かり且つ無駄の多い駆動機構
が不要であり、分注プローブのみを移動させればよいか
ら、高速制御が可能で経済的な装置が得られる。(2)プ
ローブの円形状移動経路上の所定位置に、反応レーン上
の複数の反応容器が送られて来るので、該所定位置を常
に分注位置として大量の分注処理ができる。(3)試薬ご
とにポンプを設ける従来の方式と比べてポンプが1台で
足り、経済性および信頼性を高めることができる。(4)
1台の試薬ポンプを有し、試薬吸引系の4流路を切り替
える従来の装置に比べて、複雑な流路切り替え機構およ
びポンプの洗浄機構が不要であり、しかも流路を試薬で
満たす必要がないので試薬の無駄を排除することができ
る。なお、本発明の分注器は上述の実施例には限定され
ない。例えば、実施例においては本発明による分注器を
試薬分注器として例示したが、試薬容器の代わりに試料
容器を、または試薬および試料の容器を同時にプローブ
の移動経路に沿って固定配置しても、本発明の分注器が
得られることはもちろんである。According to the above-described embodiment, the following advantages are obtained. (1) One dispenser selectively dispenses a liquid containing one or more reagents or samples without moving a container. Can be poured. That is, since the container for containing the liquid to be aspirated is fixedly arranged at a predetermined position on the circular movement path of the probe, a large and wasteful drive mechanism of the entire container such as the reagent, which is a drawback of the reagent turntable system, is provided. Since it is unnecessary and only the dispensing probe needs to be moved, a high-speed control and economical device can be obtained. (2) Since a plurality of reaction vessels on the reaction lane are sent to a predetermined position on the circular movement path of the probe, a large amount of dispensing can be performed with the predetermined position always being the dispensing position. (3) Compared with the conventional system in which a pump is provided for each reagent, only one pump is required, and the economical efficiency and reliability can be improved. (Four)
Compared with the conventional device that has one reagent pump and switches four channels of the reagent suction system, a complicated channel switching mechanism and a pump cleaning mechanism are unnecessary, and moreover, the channels need to be filled with the reagent. Since it does not exist, waste of reagents can be eliminated. The dispenser of the present invention is not limited to the above embodiment. For example, in the embodiments, the dispenser according to the present invention is illustrated as a reagent dispenser, but instead of the reagent container, a sample container or a reagent and sample container is simultaneously fixedly arranged along the movement path of the probe. However, it goes without saying that the dispenser of the present invention can be obtained.
以上詳述した如く、本発明の自動分析装置における分注
器は、試薬、試料などの液体を収容する複数の液体容器
を移動させることなくプローブの移動のみで反応容器に
対して分注できるから、液体容器のための大掛かりで且
つ無駄の多い駆動装置が不要となり、経済的で作動効率
が高い分注ができる。As described above in detail, the dispenser in the automatic analyzer of the present invention can dispense to the reaction container only by moving the probe without moving a plurality of liquid containers containing liquids such as reagents and samples. Therefore, a large-scale and wasteful drive unit for the liquid container is not required, and dispensing can be performed economically and with high operating efficiency.
第1図は本発明の一実施例を示す斜視図,第2図はその
平面図である。 1………ポンプボックス 7………プローブ 8………洗浄水容器 9………試薬容器 11………反応容器FIG. 1 is a perspective view showing an embodiment of the present invention, and FIG. 2 is a plan view thereof. 1 ... Pump box 7 ... Probe 8 ... Wash water container 9 ... Reagent container 11 ... Reaction container
Claims (1)
の液体容器から液体を吸引して反応容器内に吐出するた
めのプローブを有する自動分析装置の分注器において、
円形状の少なくとも一部の移動経路に沿って回動可能な
プローブと、前記プローブの移動経路に沿つて該移動経
路の一部を除いて固定配置された複数の液体容器と、前
記液体容器が配置されない前記プローブの移動経路を横
切るように順次移送される複数の反応容器と、前記プロ
ーブを所望の液体容器と前記反応容器が横切る所定位置
とに位置決めする手段を備えたことを特徴とする自動分
析装置の分注器。1. A dispenser of an automatic analyzer having a probe for sucking a liquid from a plurality of liquid containers containing a liquid such as a reagent or a sample and discharging the liquid into a reaction container,
A probe that is rotatable along at least a part of a circular movement path, a plurality of liquid containers fixedly arranged along the movement path of the probe except a part of the movement path, and the liquid container. A plurality of reaction vessels that are sequentially transferred so as to traverse the movement path of the probe that is not arranged, and means for positioning the probe at a predetermined position where the desired liquid vessel and the reaction vessel traverse are provided. Analytical instrument dispenser.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1104045A JPH061278B2 (en) | 1989-04-24 | 1989-04-24 | Dispenser for automatic analyzer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1104045A JPH061278B2 (en) | 1989-04-24 | 1989-04-24 | Dispenser for automatic analyzer |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4819779A Division JPS55140155A (en) | 1979-04-19 | 1979-04-19 | Distribution device |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0249166A JPH0249166A (en) | 1990-02-19 |
JPH061278B2 true JPH061278B2 (en) | 1994-01-05 |
Family
ID=14370248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1104045A Expired - Lifetime JPH061278B2 (en) | 1989-04-24 | 1989-04-24 | Dispenser for automatic analyzer |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH061278B2 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5016631U (en) * | 1973-06-08 | 1975-02-21 | ||
JPS5016631A (en) * | 1973-06-15 | 1975-02-21 | ||
JPS5611109B2 (en) * | 1975-02-20 | 1981-03-12 |
-
1989
- 1989-04-24 JP JP1104045A patent/JPH061278B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0249166A (en) | 1990-02-19 |
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