JPH06125977A - Functional medicine for external application - Google Patents

Abstract

PURPOSE:To provide a medicine for external application comprising a support body and an adhesive layer in which stay of exudation at a wounded part by forming the support body of a water-vapor permeable material, and the adhesive layer of a rubber-based adhesive and a composition including a specific water absorbing and/or water swelling polymer. CONSTITUTION:A functional medicine 1 for external application which is effective it is used for a wound such as a chronic skin ulcer which is hard to be cured comprises a support body 2 and an adhesive layer 3, a water-vapor permeable material having a water-vapor permeability of 300-2000g/m<2>.24hr is used for the support body 2, and an adhesive composition comprising a rubber-based adhesive, a water absorbing and/or water swelling polymer, and a metal oxide and/or a metal salt is used for the adhesive layer 3. For the water absorbing and/or water swelling polymer, a functional group having a salt forming property and/or a coordination property is used. Transpiration of water in exudation absorbed and stored in the adhesive layer can thus be accelerated, thereby change of composition of the adhesive layer by absorption of the excudation, etc., can be restricted.

Description

Detailed Description of the Invention

[0001]

The present invention has various medical applications, especially in the fields of wound dressing, incontinence and artificial anus treatment,
Particularly, the present invention relates to a functional external material particularly effective for use in a difficult-to-treat wound such as chronic skin ulcer.

[0002]

Hydrocolloid adhesive compositions have been known for many years. That is, Chen, in U.S. Pat. No. 3,339,549, discloses one or more water-soluble or water-swellable rubber elastomers such as polyisobutylene and one or more water-soluble or water-swellable substances such as powder mixtures of pectin, gelatin and carboxymethylcellulose. A hydrocolloid-type adhesive composition comprising a hydrocolloid is disclosed.

In this hydrocolloid-type adhesive composition, the rubber elastomer provides the adhesive property, and the hydrocolloid powder has a function of absorbing a liquid or a liquid material.

This hydrocolloid type adhesive composition is
It is gaining increasing attention as a dressing for skin ulcers, burns and other exudative wounds.

For example, Japanese Patent Laid-Open No. 58-190446 discloses a hermetically-sealed multilayer bandage in which an adhesive layer is formed on one surface of an external water-impermeable polymer film with an intermediate layer made of semi-open cell polymer foam interposed. Wherein the adhesive layer comprises one or more pressure sensitive adhesive materials and optionally one or more thermoplastic elastomers,
Consisting essentially of a homogeneous blend of one or more water-dispersible hydrocolloids and, optionally, one or more water-swellable cohesive strengtheners and / or one or more hydratable polymers A multi-layered bandage has been proposed which is characterized by

However, this is a hermetically sealed type bandage, and the hydrocolloid type adhesive layer swells due to absorption of wound exudate, body fluid, etc., and each component is separated in due course. The rubber elastomer (rubber-based adhesive) that binds the particles to each other is dispersed and exists in a point state, that is, an independent state.

Therefore, as a result of the relationship between the constituents of the hydrocolloid-type adhesive layer becoming weaker, the shape retention property is lost and a part of the hydrocolloid-type adhesive layer flows out to the outside of the support, and the adhesive force at the fixing peripheral portion is also increased. Deteriorates and the role as an external patch cannot be fulfilled.

In order to solve this problem, it is conceivable to improve the strength of the rubber-based pressure-sensitive adhesive. However, with such a constitution, when it is brought into contact with wound exudate and body fluid, its absorption capacity is lowered and The purpose of the period cannot be achieved.

[0009] Therefore, recently, studies have been made by devising a water-absorbing and / or water-swelling hydrocolloid (polymer) side. For example, JP-A-2-13463
Japanese Patent Laid-Open Publication proposes the use of polycationic hydrocolloid particles and polyanionic hydrocolloid particles as hydrocolloid particles.

Examples of the polycationic hydrocolloid particles include water-soluble chitosan salts such as chitosan maleate and chitosan glutarate. Further, as the polyanionic hydrocolloid particles, pectin,
Carboxymethyl cellulose, alginate and the like are mentioned.

[0011]

By virtue of such a constitution, the binding force between the hydrocolloid particles can be improved to some extent, but the adhesive force still decreases due to the absorption of wound exudate and body fluid, and The hydrocolloid-type adhesive composition is dissolved by the absorption of the liquid, and flows out of the support.

The present invention has been completed in view of the above technical problems, and the adhesive layer has a rubber-based adhesive and water-absorbing and / or
Or an adhesive composition comprising a water-swellable polymer and metal oxide and / or metal salt particles, and
By using the water-absorbing and / or water-swelling polymer having a functional group having a salt-forming ability and / or a coordinating ability, this adhesive layer is adhered to an application site of a human body such as a wound site, Upon absorption of wound exudate and body fluid, the metal ion generated from the metal oxide and / or metal salt and the water-absorbing and / or water-swelling polymer form an ionic bond or a coordinate bond, whereby the adhesive layer To improve the binding strength of the adhesive layer to maintain the shape retention of the adhesive layer and prevent its dissolution and outflow,
Moreover, by forming the support with a moisture-permeable film or sheet, the moisture in the wound exudate that is absorbed and stored in the adhesive layer is evaporated to the outside, so that the adhesive layer is absorbed by the wound exudate and the like. It suppresses the compositional change and maintains the adhesion to the application site of the human body, and the exudate is always retained on the surface of the application site such as the wound site by effectively absorbing the wound exudate with the adhesive layer. It is an object of the present invention to provide a safe and functional external use material that is preventive and hygienic, and that does not destroy the application site such as a wound when peeling.

[0013]

In order to achieve the above object, the functional external material of the present invention is an external material comprising a support and an adhesive layer, wherein the support is moisture permeable and the adhesive layer is Is formed of an adhesive composition comprising a rubber-based adhesive, a water-absorbing and / or water-swelling polymer, a metal oxide and / or a metal salt, and the water-absorbing and / or water-swelling polymer thereof. Has a functional group having a salt-forming ability and / or a coordinating ability.

The support used in the present invention is not particularly limited as long as it is formed of a moisture permeable film or sheet, and examples thereof include those formed of natural materials and synthetic materials. Among them, in particular, a film or sheet formed of a synthetic resin is formed into a porous film, whereby a support that secures moisture permeability of the film or sheet is easy to secure strength, price and excellent stretchability. desirable.

The thickness of the moisture-permeable support is 10
It is desirable to make a film having a thickness of up to 100 μm, particularly 20 to 80 μm. If the thickness is less than 10 μm, it is not preferable because it causes problems in strength and handleability. It is not preferable because the adhesiveness to the application site of the human body is deteriorated, the handling property is deteriorated, and the moisture permeability is deteriorated. On the other hand, when a foamed sheet is used for this support, it is preferably of continuous porosity in order to have moisture permeability and bacterial barrier properties, and the thickness may be as thick as 100 to 5000 μm, preferably 300. ~ 2000 μm is preferable.

The above-mentioned synthetic resin porous support includes
A film or sheet formed of a synthetic resin is perforated with an ultrafine needle, directly formed into a porous body by uniaxial stretching or biaxial stretching, or formed into a porous body by stretching, and then further formed with an acid, an alkali or It may be a porous support formed by eluting the filler with water or the like. However, it is also possible to impart a bacterial barrier property by laminating a thin highly moisture-permeable film on the surface of the porous body.

The porous support made of synthetic resin is not particularly limited, but for example, polyethylene resin, polypropylene resin, polyester resin, polyurethane resin, polyamide polyether urethane resin, polyvinyl chloride resin, polyvinylidene chloride. A porous film or sheet made of at least one resin selected from the group consisting of resins, polyamide resins, etc., that is, a porous layer formed of these resins in a single layer, two layers or three or more layers. It may be either a film or a sheet.

In the above porous support made of synthetic resin,
A polyethylene resin, especially one using a linear low-density polyethylene resin is excellent in the production and processability of the support, and the production cost is low, and the obtained porous support has a large stretchability. Most preferred is high strength.

The linear low-density polyethylene resin is a copolymer of ethylene and α-olefin, and examples of the α-olefin include butene, hexene, octene and the like.

The above-mentioned synthetic resin porous support includes, if desired, those mixed with a filler. Examples of the filler include calcium carbonate, talc, clay, kaolin, silica, barium sulfate and sulfuric acid. Kaolin, aluminum hydroxide, zinc oxide, calcium oxide, titanium oxide,
Examples thereof include alumina and mica.

The average particle size of this filler is 30 μm or less, and preferably 0.1 to 10 μm. From the standpoint that the bacterial barrier property is a necessary characteristic, 0.5 μm or less is necessary.

If the particle size exceeds 30 μm, the particle size becomes too large and the through-holes become large, so that the water vapor transmission rate becomes too large, and conversely, if it is less than 0.1 μm, aggregation occurs and the dispersibility deteriorates. Absent.

Further, in the present invention, when polyethylene resin or polypropylene resin is used, the kneading property and dispersibility of the filler are improved, the shaping and processability are improved, or the functional strength of the film is improved. To let
The olefin terpolymer and the softening agent may be blended.

The olefin terpolymer is not particularly limited as long as it is a rubber-like substance having a number average molecular weight of 5,000 to 200,000, and specific representative examples thereof include ethylene, α-olefin and non-conjugated diolefin. A cyclic or acyclic copolymer having a heavy bond (hereinafter referred to as E
PDM) is used.

The EPDM is a terpolymer consisting of ethylene, propylene or butene-1 and the polyene monomers listed below. Examples of the polyene monomer include dicyclopentadiene, 1,5-cyclooctadiene and 1,1- Cyclooctadiene, 1,6-cyclododecadiene, 1,7-cyclododecadiene, 1,5
9-cyclododecatriene, 1,4-cycloheptadiene, 1,4-cyclohexadiene, 1,6-heptadiene, norbornadiene, methylenenorbornene, 2-methylpentadiene-1,4,1,5-hexadiene, methyl-tetrahydro Examples include indene and 1,4-hexadiene. The copolymerization ratio of each monomer is preferably 30 to 80 mol% of ethylene and 0.1 to 2 of polyene.
A terpolymer having 0 mol% of the remainder being α-olefin and having a Mooney viscosity ML ₁₄ (100 ° C.) of 1 to 60 is preferable.

The softening agent is not particularly limited as long as it has a number average molecular weight of 1,000 to 30,000, and specific representative examples thereof include a petroleum process oil as a low viscosity softening agent, Liquid paraffin, aliphatic oils, and low molecular weight plasticizers are available, and softeners such as polybutene, low molecular weight polyisobutylene, and liquid rubber are preferably used as a relatively high-viscosity softening agent.

The thermoplastic porous film contains
It may be the one formed by adding an antioxidant, an ultraviolet stabilizer, an antistatic agent, a pigment, a lubricant, a fluorescent agent and the like which are usually used.

The moisture-permeable support used in the present invention has a moisture permeability of 300 to 2000 g / m ² · 24 hr, especially 5
It is desirable that it is from 00 to 1500 g / m ² · 24 hr,
If the water vapor transmission rate is less than 300 g / m ² · 24 hr, the water vapor transmission rate will be too small and the evaporation of water in the wound exudate, etc. will deteriorate, causing a change in the composition of the adhesive layer and causing the phenomenon that the adhesive layer flows out. On the other hand, it is not preferable because the moisture permeability exceeds 2000 g / m ² · 24 hr, the moisture permeability is too large, the components in the adhesive layer evaporate and the wound surface is dried, resulting in healing. It is not preferable because it will be delayed.

In the present invention, the water vapor permeability is a value measured by the Paynes cup method.

The adhesive layer used in the present invention is formed of a water-absorbing and / or water-swelling adhesive composition, and the adhesive layer is made of a rubber-based adhesive and a water-absorbing and / or water-swelling agent. The water-absorbing and / or water-swelling polymer formed of an adhesive composition comprising a polymer and a metal oxide and / or a metal salt has a functional group having a salt-forming ability and / or a coordinating ability. I have.

In this case, the thickness of the adhesive layer is generally 200 to 3000 μm, especially 1000 to 2000.
If the thickness is less than 200 μm, the adhesive strength will be reduced, causing a problem in the adhesion to the application site of the human body and the liquid absorption amount being too small, which is not preferable. If it exceeds 3,000 μm, the thickness becomes too thick, which causes a problem in adhesion to a human body, and the thickness makes it easy to come off, and causes a problem such as local stress.

The rubber adhesive used in the present invention is not particularly limited as long as it provides adhesiveness when dried, and a natural or synthetic viscous rubber-like substance,
For example, at least one selected from natural rubber, polyisobutylene rubber, polyurethane rubber, silicone rubber, acrylonitrile rubber and the like can be mentioned. Among these, low molecular weight polyisobutylene having a viscosity average molecular weight of about 36,000 to 120,000 is pressure-sensitive adhesive. Is desirable.

Further, the water-absorbing and / or water-swelling polymer used in the present invention is not particularly limited, but a polymer having a high penetrability and a high liquid absorbing ability is particularly preferable when immersed in physiological saline. .

As the metal oxide and / or metal salt used in the present invention, when the adhesive layer absorbs wound exudate or body fluid, the produced metal ion is a water-absorbing and / or water-swelling polymer described later. It is not particularly limited as long as it forms an ionic bond or a coordinate bond with, but specifically, for example, zinc oxide, calcium oxide, aluminum oxide, aluminum hydroxide, calcium oxalate,
Examples include calcium citrate, aluminum alum, potassium alum, calcium chloride, calcium hydroxide and calcium carbonate.

The water-absorbing and / or water-swelling polymer used in the present invention exhibits adhesiveness when wet and has a functional group having salt-forming ability and / or coordinating ability. It is not particularly limited as long as it is, but specifically, for example, polyacrylic acid and / or a salt thereof, acrylic acid / vinyl alcohol copolymer, crosslinked carboxymethylmethyl cellulose (including sodium salt and calcium salt), Long chain polymer of methyl vinyl ether / maleic acid, carboxymethyl cellulose (including sodium salt and calcium salt), starch-acrylate graft polymer, carboxycellulose-acrylate graft polymer, acrylic acid-acrylamide copolymer, alginic acid and / or Its soda salt, methyl vinyl ether / anhydrous Ynoic acid copolymer, gelatin, pectin, carrageenan, but polyvinyl pyrrolidone, at least one selected from these are used.

Further, in the present invention, if desired, other water-absorbing and / or water-swelling polymer may be contained in the adhesive layer. In this case, the shape retention of the adhesive layer is maintained. In order to ensure that the content is 50% by weight of the total adhesive layer
The following adjustments are desirable.

This example is not particularly limited as long as it exhibits adhesiveness when wet, and is selected from, for example, karaya gum, guar gum, locust bean gum, polyvinyl alcohol, polyethylene glycol, polyacrylamide and the like. And at least one kind.

Further, in the present invention, if desired, a so-called superabsorbent polymer may be contained in the adhesive layer in addition to the above polymer. In this case, in order to maintain the shape retention of the adhesive layer. In addition, it is desirable to adjust the content to 50% by weight or less of the entire adhesive layer. When the content of the superabsorbent polymer is 50% by weight or more, the shape retention property may be deteriorated and a part of the polymer may flow out. As an example of this super absorbent polymer, it has a water absorption capacity of 20 times or more its own weight, especially 50 times or more its own weight even when immersed in physiological saline. For example, water-insoluble starch-acrylonitrile graft polymer, At least one selected from water-insoluble cross-linked dextrin and the like can be mentioned.

The rubber adhesive (A) in the adhesive layer used in the present invention and the water-absorbing and / or water-swelling polymer (B) having a functional group having a salt-forming ability and / or a coordinating ability.
And the compounding ratio of the metal oxide and / or the metal salt (C),
From the viewpoint of the adhesiveness to the application site of the human body, the speed and amount of water absorption or water swelling, and the shape retention of the adhesive layer, the above (A) is in the range of 15 to 70% by weight, particularly 35 to 50% by weight. The range (B) is 30 to 75% by weight, especially 50 to 65
% By weight, 0.5-20% by weight of (C) above, especially 2-1
It is preferably 0% by weight.

In the present invention, if desired, other rubber elastomers may be added to the above adhesive layers in order to improve the adhesiveness and stretchability of these adhesive layers.

Specific examples of the rubber elastomer include high molecular weight polyisobutylene having a viscosity average molecular weight of about 1,000,000 to 1.6,000,000, a copolymer of isobutylene and a small amount of isoprene, and a viscosity average molecular weight of about 50,000,000 to 100,000,000.
Butyl rubber having an amount of 10,000, and styrene copolymers such as styrene-butadiene-styrene (S-B-S) and styrene-isoprene-styrene (S-I-S) and styrene-ethylene / butylene-styrene (S-EB-S) The preferred examples include styrene-isoprene-styrene block polymers.

In this case, in the above adhesive layer, the compounding ratio of the added rubber elastomer is 0.5 to 20 of the whole adhesive layer.
It is desirable to set the content in the range of 2% by weight, particularly 2 to 8% by weight. If the mixing ratio of the thermoplastic elastomer is less than 0.5% by weight, it is meaningless to add the compound. The concentration of a water-absorbing and / or water-swelling polymer having a functional group having a salting agent and / or a coordinating ability is relatively reduced, resulting in a decrease in adhesive strength and a decrease in exudate absorption characteristics. It is not desirable because it may occur.

In the present invention, if desired, a plasticizer or solvent such as a mineral oil or petrolatum, a mineral oil or a tackifier such as a terpene resin may be added to the adhesive layer.

The compounding ratio of the plasticizer or solvent or the tackifier is 1 to 20% by weight, especially 3% by weight of the whole adhesive layer.
It is desirable to set it in the range of 10 to 10 parts by weight, and if this blending ratio is less than 1% by weight, there is no point in blending, while 20
If the content exceeds 50% by weight, the concentration of the rubber-based adhesive or the water-absorbing and / or water-swelling polymer having a functional group having a salt-forming ability and / or a coordinating ability is relatively lowered, and the exudate-absorbing property is improved. It is not desirable because it may decrease.

In the present invention, the adhesive layer contains an antibacterial substance,
For example, one of ibitine substances such as Hibitene, benzalkonium chloride, benzethonium chloride, povidone iodine, silver sulfadiazin, sulfa drugs and antibiotics such as fradiomycin sulfate, gentamicin sulfate, etc.
They can be added in combination with one another or in combination, and the addition amount is in the range of 0.01 to 20%, preferably 0.05 to 5%, to disinfect and sterilize the application site of the human body and prevent the growth of bacteria. Is desirable.

[0046]

In the functional external use material of the present invention, having the above-mentioned constitution, the adhesive layer has a rubber-based adhesive and water-absorbing and / or water-swelling having a functional group having a salt-forming ability and / or a coordinating ability. Formed of an adhesive composition composed of a water-soluble polymer and metal oxide and / or metal salt particles, and this adhesive layer is adhered to a human body application site such as a wound site to absorb wound exudates and body fluids. Then, the metal ion generated from the metal oxide and / or the metal salt and the water-absorbing and / or water-swelling polymer form an ionic bond or a coordinate bond, thereby improving the binding force of the adhesive layer. It has the function of maintaining the shape retention of the adhesive layer and preventing its dissolution and outflow.

[0047]

EXAMPLES The present invention will now be described in detail based on examples, but the present invention is not limited thereto.

Structural Example of Functional External Material of the Present Invention In FIGS. 1 and 2, the functional external material 1 of the present invention comprises a support 2 having an adhesive layer 3 formed on one surface thereof, and the support 2 is transparent. The adhesive layer 3 is wet and has a rubber-based adhesive, a water-absorbing and / or water-swelling polymer, a metal oxide, and / or
Alternatively, the water-absorbing and / or water-swelling polymer is formed of an adhesive composition composed of a metal salt and has a functional group having a salt-forming ability and / or a coordinating ability. In addition, 4 is a separator, and the adhesive layer 3 is formed by the separator 4.
The exposed surface of is covered.

Example 1 Powders of 12 g of starch-acrylic acid graft polymer and 12 g of pectin, 12 g of sodium salt of carboxymethyl cellulose and 8 g of aluminum hydroxide were mixed well in advance, and this was mixed in advance with a small kneader to obtain polyisobutylene (viscosity). Add 40 g of average molecular weight of 50,000) and 4 g of high molecular weight polyisobutylene (viscosity average molecular weight of 1 million) to a well kneaded product and knead well. Press this kneaded product
A 1.5 mm thick sheet is used as the adhesive layer 3.

A polyurethane film (30 μm) was used as the support 2, and the adhesive layer 3 was laminated on one side thereof to obtain a functional external material 1 of the present invention.

Example 2 12 g of starch-acrylic acid graft polymer, 12 g of pectin, 12 g of gelatin, 12 g of sodium salt of carboxymethyl cellulose and 8 g of zinc oxide were mixed well in advance, and this was mixed in advance with a small kneader to give polyisobutylene. Add 40 g of (viscosity average molecular weight 50,000) and 4 g of high molecular weight polyisobutylene (viscosity average molecular weight 1,000,000) to a well kneaded product and knead well. The kneaded product is pressed into a sheet having a thickness of 1.5 mm to form the adhesive layer 3. A polyurethane film (30 μm) was used as the support 2, and the adhesive layer 3 was laminated on one side of the support to obtain a functional external material 1 of the present invention.

Comparative Example 1 As Comparative Example 1, 12 g of starch-acrylic acid graft polymer, 12 g of pectin, 12 g of gelatin, and 12 g of sodium salt of carboxymethyl cellulose were thoroughly mixed in advance, and further polyisobutylene 4 was added to this mixture.
4 g was added and kneaded in the same manner as in the example, and this kneaded product was laminated on the same film as that used in the example.

Comparative Example 2 Powders of 20 g of sodium salt of carboxymethyl cellulose, 18 g of gelatin and 18 g of pectin were thoroughly mixed,
Further, 44 g of polyisobutylene was added to this mixture and kneaded in the same manner as in the example, and this kneaded product was laminated on the same film as that used in the example.

Next, using each example and each comparative example, immersion evaluation in physiological saline solution was carried out in order to check the water absorption and the shape retention (fluidization). First, the water absorption rate was evaluated by the following method. 2.5cm × 2.5cm × weighed in advance
A 0.1 cm test piece W ₁ (g) is immersed in 50 ml of a physiological saline solution, taken out at regular intervals, excess water is removed with gauze, and then weighed. The weight at that time is W ₂
As (g), the water absorption rate was measured by the following method.

[0055]

[Formula 1]

Next, regarding the shape-retaining property (liquefaction), the slope of the water absorption curve (FIG. 3) (the downward slope shows the liquefaction tendency).
And the state was visually observed.

From the above results, FIG. 3 shows the results of measuring the changes with time in the absorption amount of physiological saline in Examples 1 and 2 and Comparative Examples 1 and 2.

Comparative Examples 1 and 2 fluidized within 6 hours after the immersion, but those of the Examples showed a considerable absorption amount after 24 hours, but showed a considerable amount of absorption and did not fluidize. It was When these three types were applied to a skin defect wound surface by an animal experiment (rat), the exudates of Comparative Examples 1 and 2 fluidized after 1 day and could not serve as an external material. Was recognized. On the other hand, it was confirmed that each of the examples had a shape-retaining property even after 2 days and had a function as an external material.

[0059]

INDUSTRIAL APPLICABILITY In the functional external material of the present invention, the water-absorbing and / or water-absorbing and / or adhesive layer having the above-mentioned constitution and the adhesive layer having a rubber-based adhesive and a functional group having a salt-forming ability and / or a coordinating ability are provided. It is formed of an adhesive composition comprising water-swellable polymer and metal oxide and / or metal salt particles, and this adhesive layer is adhered to an application site of a human body such as a wound part, and wound exudate and body fluid When the water is absorbed, the metal ion generated from the metal oxide and / or the metal salt and the water-absorbing and / or water-swelling polymer form an ionic bond or a coordinate bond.
Improves the adhesive strength of the adhesive layer and maintains the shape retention of the adhesive layer to prevent its dissolution and outflow, resulting in hygiene as a result of the child and destroying the applied site such as a wound when peeling. It is extremely safe and useful.

Further, since the adhesiveness between the adhesive layer and the application site of the human body can be maintained as described above, the wound exudate or the like can be effectively absorbed by the adhesive layer and the surface of the application site such as the wound site can be effectively absorbed. As a result of preventing the exudate from staying, it is extremely hygienic, and by forming an adhesive layer with such a water-absorbing and / or water-swelling adhesive composition, it can be applied to an application site such as a wound. The adhesiveness is moderate and does not develop an excessive adhesive force, so that it does not destroy the application site such as a wound when peeling, and from this viewpoint, the safety is extremely high.

[0061]

[Brief description of drawings]

FIG. 1 is a perspective view showing an embodiment of the functional external material of the present invention.

[0062]

FIG. 2 is a sectional view thereof.

[0063]

FIG. 3 is an absorption characteristic diagram of physiological saline solutions of Examples 1 and 2 and Comparative Examples 1 and 2.

[0064]

[Explanation of symbols]

 1 Functional External Material 2 Moisture Permeable Support 3 Adhesive Layer 4 Separator

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[Procedure amendment]

[Submission date] October 29, 1992

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be amended] Title of invention

[Correction method] Change

[Correction content]

[Title of Invention] Functional external material

Claims (2)

[Claims] 1. An external material comprising a support and an adhesive layer, wherein the support is permeable to moisture, and the adhesive layer is a rubber-based adhesive, a water-absorbing and / or water-swelling polymer, and a metal oxide. And / or a metal salt formed of an adhesive composition, and the water-absorbing and / or water-swelling polymer has a functional group having a salt-forming ability and / or a coordinating ability. Functional external material to be used. 2. The moisture permeability of the support is 300 to 2000 g /
The functional external material according to claim 1, having a m ² · 24 hr.