JPH06154304A - Functional material for external use - Google Patents
Functional material for external useInfo
- Publication number
- JPH06154304A JPH06154304A JP4223389A JP22338992A JPH06154304A JP H06154304 A JPH06154304 A JP H06154304A JP 4223389 A JP4223389 A JP 4223389A JP 22338992 A JP22338992 A JP 22338992A JP H06154304 A JPH06154304 A JP H06154304A
- Authority
- JP
- Japan
- Prior art keywords
- adhesive
- water
- irradiation
- adhesive layer
- radiations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、各種の医療用途、特に
傷用包帯、失禁及び人工肛門治療の分野に用途があり、
特に切傷、擦過傷、手術創、熱傷、潰瘍等の創傷の治療
に特に有効な機能性外用材に関する。INDUSTRIAL APPLICABILITY The present invention has various medical applications, particularly in the fields of wound dressing, incontinence and colostomy.
In particular, the present invention relates to a functional external use material that is particularly effective in treating wounds such as cuts, abrasions, surgical wounds, burns, and ulcers.
【０００２】[0002]
【従来の技術】ハイドロコロイド型接着剤組成物は、多
年にわたり公知である。即ち、チェン(Ｃhen)は、米国
特許第３,３３９,５４９号公報にポリイソブチレンのよ
うなゴムエラストマー及びペクチン、ゼラチン更にカル
ボキシメチルセルロースの粉末混合物のような１種以上
の水溶性又は水膨潤性のハイドロコロイド型接着剤組成
物を開示している。Hydrocolloid adhesive compositions have been known for many years. That is, Chen, in U.S. Pat. No. 3,339,549, discloses one or more water-soluble or water-swellable rubber elastomers such as polyisobutylene and one or more water-soluble or water-swellable materials such as powder mixtures of pectin, gelatin and carboxymethylcellulose. A hydrocolloid adhesive composition is disclosed.
【０００３】このハイドロコロイド型接着剤組成物にお
いては、ゴムエラストマーが接着性を提供し、又、ハイ
ドロコロイド粉末が液体や液状体等の生体液を吸収する
機能を有する。In this hydrocolloid-type adhesive composition, the rubber elastomer provides adhesiveness, and the hydrocolloid powder has a function of absorbing a biological fluid such as a liquid or a liquid.
【０００４】このハイドロコロイド型接着剤組成物は、
皮膚の潰瘍、火傷（熱傷）及び他の滲出性傷用の包帯と
して次第に注目されている。このハイドロコロイド型接
着剤組成物は、傷滲出液及び体液等の吸収に伴って膨潤
し、ハイドロコロイド粒子どうしがくっつき、連続相を
形成してなり、一方、体液等吸収前まで連続相を形成し
ていたゴムエラストマー部分が、傷滲出液及び体液等の
吸収に伴って分散して点状態、いわゆる相転移を生ずる
機構となっている。This hydrocolloid type adhesive composition is
It is gaining increasing attention as a dressing for skin ulcers, burns (burns) and other exudative wounds. This hydrocolloid adhesive composition swells with the absorption of wound exudates and body fluids, and the hydrocolloid particles stick to each other to form a continuous phase. The rubber elastomer portion is dispersed by absorption of wound exudate, body fluid, and the like to form a point state, so-called phase transition.
【０００５】[0005]
【発明が解決しようとする課題】しかしながら、このハ
イドロコロイド型接着剤組成物は、以下に示すような問
題点を有する。即ち、この接着剤組成物は、創傷面に貼
付するものであり、事前に減菌処理をしておく必要があ
る。減菌方法としては、ＥＯＧ減菌、湿熱、乾熱、放射
線減菌(γ線、電子線等)等があるが、ＥＯＧ減菌では、
厚み１〜２mm厚の分厚い材料では、充分に内部まで効力
を示さず、湿熱、乾熱では、それぞれ、水蒸気の影響、
材料の耐熱性等に問題点を有している。従って、減菌方
法としては、放射線減菌、特にγ線減菌に頼らざるをえ
ないところがある。However, this hydrocolloid type adhesive composition has the following problems. That is, this adhesive composition is to be applied to the wound surface and needs to be sterilized in advance. Examples of sterilization methods include EOG sterilization, wet heat, dry heat, radiation sterilization (γ ray, electron beam, etc.), but with EOG sterilization,
Thick materials with a thickness of 1 to 2 mm do not show sufficient effect to the inside, and wet heat and dry heat have the effect of water vapor, respectively.
There is a problem in the heat resistance of the material. Therefore, as a sterilization method, there is a case where it is necessary to rely on radiation sterilization, particularly γ-ray sterilization.
【０００６】ところが、γ線減菌においても、以下に述
べる問題点がある。即ち、γ線照射によるハイドロコロ
イド型接着剤組成物の劣化の問題である。特にこの接着
剤組成物に関しては、ゴムエラストマー部分の劣化に関
して顕著である。例えば、γ線照射後のハイドロコロイ
ド型接着剤組成物を人体に貼付し、数日経過後、貼付状
態を観察すると、明らかに、γ線未照射の接着剤組成物
品に比べると、γ線照射品の方に製剤からのはみ出しが
認められる。However, the γ-ray sterilization also has the following problems. That is, it is a problem of deterioration of the hydrocolloid adhesive composition by γ-ray irradiation. Particularly, regarding this adhesive composition, the deterioration of the rubber elastomer portion is remarkable. For example, a hydrocolloid adhesive composition after γ-ray irradiation was applied to a human body, and after a few days, when the application state was observed, it was clear that the γ-ray-irradiated product was On one side, protrusion from the formulation is observed.
【０００７】これはハイドロコロイド型接着剤組成物に
γ線を照射することにより、ポリイソブチレンが、分子
切断され、実際の創傷面に適用した際、体液等により接
着剤組成物が溶解、流出する傾向が大となり、保形性が
低下する為である。This is because when a hydrocolloid adhesive composition is irradiated with γ-rays, polyisobutylene is molecularly cleaved, and when applied to the actual wound surface, the adhesive composition tends to dissolve and flow out due to body fluids and the like. Is large and the shape retention property is deteriorated.
【０００８】本発明は、ポリイソブチレンに架橋型物質
を配合することにより、放射線減菌が可能になり、しか
も放射線照射によって特性が低下しないばかりか、むし
ろ特性が向上するのであり、しかも圧迫による糊はみ出
しがなく、人の皮膚に貼付した際、糊残りがない上、滲
出液を吸った際もある程度のゲル強度を有し、接着剤組
成物が溶解、流出しない機能性外用材を提供することを
目的とする。In the present invention, by adding a cross-linking substance to polyisobutylene, it becomes possible to sterilize radiation, and not only the characteristics are not deteriorated by irradiation with radiation, but also the characteristics are improved. To provide a functional external material which does not squeeze out, has no adhesive residue when applied to human skin, has a certain gel strength even when absorbing exudate, and does not dissolve or flow out an adhesive composition. With the goal.
【０００９】[0009]
【課題を解決するための手段】上記目的を達成するため
に、本発明の機能性外用材においては、支持体及び接着
層よりなる外用材であって、この接着層が、ゴム系接着
剤と少なくとも吸水性及び／又は水膨潤性のポリマー粒
子の混合組成物よりなり、上記ゴム系接着剤が、ポリイ
ソブチレンと、放射線照射によって架橋する架橋型物質
よりなり、且つ上記接着層には放射線照射処理が施され
ている事を特徴とするものである。In order to achieve the above object, the functional external-use material of the present invention is an external-use material comprising a support and an adhesive layer, the adhesive layer being a rubber-based adhesive. A mixture composition of at least water-absorbing and / or water-swelling polymer particles, wherein the rubber-based adhesive comprises a polyisobutylene and a crosslinkable substance that crosslinks upon irradiation with radiation, and the adhesive layer is subjected to irradiation treatment. It is characterized by being applied.
【００１０】以下、本発明を詳細に説明する。本発明の
機能性外用材においては、支持体及び接着層よりなる基
本的な構造を有する。そして、この接着層が、ゴム系接
着剤と少なくとも吸水性及び／又は水膨潤性のポリマー
粒子の混合組成物よりなり、上記ゴム系接着剤が特定の
ゴム系接着剤の混合物からなり、且つ上記接着層には放
射線照射処理が施されている事を特徴とするものであ
る。The present invention will be described in detail below. The functional external material of the present invention has a basic structure including a support and an adhesive layer. The adhesive layer is composed of a mixed composition of a rubber-based adhesive and at least water-absorbing and / or water-swellable polymer particles, the rubber-based adhesive is a mixture of a specific rubber-based adhesive, and The adhesive layer is characterized by being irradiated with radiation.
【００１１】本発明で用いられる支持体としては、特に
限定はないが、透湿性のフィルムが好都合である。これ
らのフィルムは、多孔質にし、透湿性を上げる事もでき
る。これらのフィルムの材質としては、透湿性に優れ、
伸縮性も有するポリウレタンが、好都合である。なお、
この支持体層の厚みとしては、使用感や取扱性等の観点
より、１０〜１００μm厚、特に２０〜８０μm厚のフィ
ルム状とするのが望ましい。The support used in the present invention is not particularly limited, but a moisture permeable film is convenient. These films can also be made porous to increase moisture permeability. As the material of these films, excellent moisture permeability,
Polyurethanes that are also stretchable are convenient. In addition,
The thickness of the support layer is preferably a film having a thickness of 10 to 100 [mu] m, particularly 20 to 80 [mu] m from the viewpoint of usability and handleability.
【００１２】ゴム系接着剤のポリイソブチレンは、粘度
平均分子量が３〜１０万程度、特に３．５〜６万程度の
ものが好都合であるが、強度を上げる為、粘度平均分子
量が７５〜２００万程度の高分子ポリイソブチレンを添
加する事も可能である。The rubber-based adhesive polyisobutylene preferably has a viscosity average molecular weight of about 3 to 100,000, particularly about 3.5 to 60,000, but in order to increase the strength, it has a viscosity average molecular weight of 75 to 200. It is also possible to add high molecular weight polyisobutylene.
【００１３】この場合、この高分子ポリイソブチレンの
配合割合は、糊流れ、剥離時の糊残り、滲出液の吸収性
等の観点より、ポリイソブチレン全体の５〜２０重量
％、特に７〜１５重量％の範囲とするのが望ましい。In this case, the blending ratio of the high molecular weight polyisobutylene is 5 to 20% by weight, especially 7 to 15% by weight of the whole polyisobutylene from the viewpoints of adhesive flow, adhesive residue during peeling, absorbability of exudate and the like. It is desirable to set it in the range of%.
【００１４】本発明においては、ゴム系接着剤が、上記
ポリイソブチレンと、放射線照射によって架橋する架橋
型物質よりなる。In the present invention, the rubber adhesive is composed of the above polyisobutylene and a crosslinkable substance which is crosslinked by irradiation with radiation.
【００１５】この架橋型物質としては放射線によって架
橋するものであれば特に限定されるものではないが、特
に天然ゴム、ポリイソプレン、ポリブタジエン、ポリエ
チレン又はエチレン−プロピレン共重合体から選ばれた
少なくとも１種からなるものが、接着特性や体液吸収性
更に保形性等の観点より、望ましい。The crosslinkable substance is not particularly limited as long as it is crosslinkable by radiation, but at least one selected from natural rubber, polyisoprene, polybutadiene, polyethylene or ethylene-propylene copolymer. From the viewpoints of adhesive properties, body fluid absorbability, shape retention, and the like, those consisting of are preferable.
【００１６】そして、本発明で用いられる接着層には放
射線照射処理によって減菌が施されている。この放射線
処理の条件は、一般に医療用具の減菌に使用される範囲
であれば特に限定されるものではないが、一般に、例え
ばコバルト６０を線源としたガンマ線（γ線）、減菌線
量として２５ｋＧｙで行われる。The adhesive layer used in the present invention is sterilized by irradiation treatment. The condition of this radiation treatment is not particularly limited as long as it is a range generally used for sterilization of medical devices, but in general, for example, gamma rays (γ-rays) using cobalt 60 as a radiation source, sterilization dose It is performed at 25 kGy.
【００１７】ところで、ポリイソブチレンは、(劣化が)
放射線照射に対し崩壊型であり、γ線照射により、極度
にゴム強度が低下し、柔らかくなる。一方、天然ゴム、
ハイシスポリイソプレン、ポリエチレン等は(劣化が)架
橋型であり、硬くなり脆くなる方向に劣化が進行する。
筆者等は、このポリイソブチレンと架橋型物質をブレン
ドする事により、γ線照射後の物性が、低下しないばか
りか、むしろ向上する事を見い出した。By the way, polyisobutylene is (deteriorated)
It is a collapsible type against radiation irradiation, and the rubber strength is extremely reduced and becomes soft by γ-ray irradiation. On the other hand, natural rubber,
High-cis polyisoprene, polyethylene and the like are (deteriorated) cross-linking type, and deterioration progresses in the direction of becoming hard and brittle.
The authors have found that blending this polyisobutylene with a crosslinkable substance not only reduces the physical properties after γ-irradiation but rather improves it.
【００１８】これらの架橋型物質としては、天然ゴム、
ポリイソプレン、ポリブタジエン、ポリエチレン、エチ
レン−プロピレン共重合体がある。これらのうち、ポリ
イソプレンは、粘度平均分子量が、５０万〜１５０万程
度、特にハイシスポリイソプレンが望ましい。また、ポ
リブタジエンは、ハイシス−１,４−ポリブタジエンが
望ましい。ポリエチレンは、低密度ポリエチレンで、メ
ルトフローインデックス(ＡＳＴＭ Ｄ−１２３８)が２
０〜８０のものが望ましい。As these cross-linking substances, natural rubber,
There are polyisoprene, polybutadiene, polyethylene, and ethylene-propylene copolymer. Among these, polyisoprene has a viscosity average molecular weight of about 500,000 to 1,500,000, and high cis polyisoprene is particularly desirable. The polybutadiene is preferably high cis-1,4-polybutadiene. Polyethylene is low density polyethylene with a melt flow index (ASTM D-1238) of 2.
Those of 0 to 80 are desirable.
【００１９】この架橋型物質のゴム系接着剤全体（ハイ
ドロコロイド粒子含まず）に対する割合は、糊流れ、剥
離時の糊残り、滲出液の吸収性等の観点より、５〜３０
重量％、特に７〜２０重量％の範囲とするのが望まし
い。The ratio of the cross-linking substance to the whole rubber-based adhesive (not including hydrocolloid particles) is 5 to 30 from the viewpoints of adhesive flow, adhesive residue during peeling, exudate absorbability and the like.
It is desirable that the amount is in the range of 7% by weight, particularly 7 to 20% by weight.
【００２０】また、このゴム系接着剤には、接着特性の
改善の為、ロジン系、石油樹脂系等の粘着付与剤、鉱油
等の軟化剤を一般の感圧接着剤組成物と同様に、添加す
ることができる。In order to improve the adhesive properties, this rubber-based adhesive contains a tackifier such as rosin or petroleum resin, or a softening agent such as mineral oil, as in a general pressure-sensitive adhesive composition. It can be added.
【００２１】本発明で用いられる吸水性及び／又は水膨
潤性のポリマー粒子（ハイドロコロイド粒子）としては
特に限定されないが、特に生理食塩水に浸した場合、浸
透性が速く、且つ吸液力の大きいポリマーが望ましい。The water-absorbing and / or water-swelling polymer particles (hydrocolloid particles) used in the present invention are not particularly limited, but particularly when immersed in physiological saline, the penetrating speed is fast and the liquid absorbing power is large. Polymers are desirable.
【００２２】この吸水性及び／又は水膨潤性のポリマー
粒子としては、特に限定されるものではなく、例えば多
糖類としてはカルボキシメチルセルロース(ナトリウム
塩やカルシウム塩を含む)、カラヤゴム、ペクチン、ゼ
ラチン、グアーゴム、ローカストビーンガム、コラーゲ
ン、カラギーナン、アルギン酸ナトリウム、キサンタン
ガム、また、合成ポリマーとしてはポリビニルアルコー
ル、ポリビニルピロリドン、ポリエチレングリコール、
ポリアクリルアミド等から選ばれた少なくとも１種が挙
げられる。The water-absorbing and / or water-swelling polymer particles are not particularly limited, and examples of the polysaccharide include carboxymethyl cellulose (including sodium salt and calcium salt), karaya gum, pectin, gelatin, guar gum. , Locust bean gum, collagen, carrageenan, sodium alginate, xanthan gum, and synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol,
At least one selected from polyacrylamide and the like can be mentioned.
【００２３】この吸水性及び／又は水膨潤性のポリマー
粒子の配合割合は、接着特性や体液の吸収性更に保形性
等の観点より、ハイドロコロイド型接着剤組成物の全体
(ゴム系接着剤と吸水性及び／又は水膨潤性のポリマー
粒子総重量)に対して２０〜７５重量％が望ましい。The mixing ratio of the water-absorbent and / or water-swellable polymer particles is such that the hydrocolloid adhesive composition as a whole may be selected from the viewpoints of adhesive properties, body fluid absorbability and shape retention.
It is preferably 20 to 75% by weight based on the total weight of the rubber adhesive and the water-absorbent and / or water-swellable polymer particles.
【００２４】また、滲出液を吸った際、生ずるハイドロ
コロイドゲルを補強する架橋剤として、金属酸化物及び
／又は金属塩を配合する事が望ましい。このような金属
酸化物及び／又は金属塩としては特に限定されるもので
はないが、例えば酸化亜鉛、酸化カルシウム、酸化アル
ミニウム、水酸化アルミニウム、シュウ酸カルシウム、
クエン酸カルシウム、カリウムミョウバン、塩化カルシ
ウム、水酸化カルシウム、炭酸カルシウム等が挙げられ
る。Further, it is desirable to add a metal oxide and / or a metal salt as a cross-linking agent for reinforcing the hydrocolloid gel produced when the exudate is absorbed. Such metal oxides and / or metal salts are not particularly limited, but for example, zinc oxide, calcium oxide, aluminum oxide, aluminum hydroxide, calcium oxalate,
Examples include calcium citrate, potassium alum, calcium chloride, calcium hydroxide, calcium carbonate and the like.
【００２５】これらの金属酸化物及び／又は金属塩の含
有量は、保形性や体液の吸収性更に接着特性等の観点よ
り、ハイドロコロイド型接着剤組成物全体の１〜５％と
する事が望ましい。The content of these metal oxides and / or metal salts may be 1 to 5% of the total amount of the hydrocolloid adhesive composition from the viewpoints of shape retention, body fluid absorbability and adhesive properties. desirable.
【００２６】この場合において、カチオン系ポリマーと
してキトサンマレエート等キトサンの塩とアニオン系ポ
リマーとの混合物を添加し、ポリイオンコンプレックス
を形成させ得るようにすることも出来る。In this case, a mixture of a salt of chitosan such as chitosan maleate and an anionic polymer may be added as a cationic polymer so that a polyion complex can be formed.
【００２７】これらのハイドロコロイド型接着剤の厚さ
としては、一般に５０〜３０００μｍ、特に１０００〜
２０００μｍとするのが望ましいが、５０〜３００μｍ
の、比較的薄い厚みの範囲では、透明性を有し、症状を
直接、外より観察出来る利点を有する為、場合により使
い分けする事も可能である。The thickness of these hydrocolloid adhesives is generally 50 to 3000 μm, and particularly 1000 to
It is preferable that the thickness is 2000 μm, but 50 to 300 μm
In the range of comparatively thin thickness, it is transparent and has the advantage of being able to observe the symptoms directly and from the outside, so it is possible to use it properly depending on the case.
【００２８】[0028]
【作用】本発明は、上記構成を有し、ポリイソブチレン
は、放射線照射に対し崩壊型であり、γ線照射により、
分子切断され、実際の創傷面に適用した際、体液等によ
り接着剤組成物が溶解、流出する傾向が大となり、保形
性が低下するが、このポリイソブチレンに、放射線照射
により架橋する架橋型物質をブレンドする事により、放
射線照射後の物性が、低下しないばかりか、むしろ向上
し、至極優れた保形性を発現する作用を有するのであ
る。The present invention has the above-mentioned constitution, and polyisobutylene is a disintegrating type upon irradiation with radiation, and by irradiation with γ-ray,
When it is molecularly cut and applied to the actual wound surface, the adhesive composition tends to dissolve and flow out due to body fluids, etc., and the shape retention decreases, but this polyisobutylene is crosslinked by irradiation. By blending the substances, not only the physical properties after irradiation of the radiation are not lowered, but the properties are improved rather, and an extremely excellent shape retention property is exerted.
【００２９】[0029]
【実施例】以下、本発明を実施例に基づき詳細に説明す
るが、本発明はこれに限定されるものではない。 実施例１ 予め、カルボキシメチルセルロースのナトリウム塩１７
g、ペクチン１７g、ゼラチン１７g、水酸化アルミニウ
ム２gの粉末をよく混合して、吸水性及び／又は水膨潤
性のポリマー粒子（ハイドロコロイド）を得た。EXAMPLES The present invention will now be described in detail based on examples, but the present invention is not limited thereto. Example 1 Sodium salt of carboxymethyl cellulose 17 in advance
Powders of 17 g of pectin, 17 g of gelatin, 17 g of gelatin and 2 g of aluminum hydroxide were well mixed to obtain water-absorbing and / or water-swelling polymer particles (hydrocolloid).
【００３０】続いて、ポリイソブチレン(粘度平均分子
量５万)３８gとハイシスポリイソプレン(粘度平均分子
量９０万)４gをニーダーにてよく混練する。これに上述
のハイドロコロイド混合物を添加し、さらに混練する事
により、吸水性及び／又は水膨潤性の接着剤組成物を得
た。Then, 38 g of polyisobutylene (viscosity average molecular weight 50,000) and 4 g of high cis polyisoprene (viscosity average molecular weight 900,000) are well kneaded with a kneader. The above-mentioned hydrocolloid mixture was added thereto and further kneaded to obtain a water-absorbing and / or water-swelling adhesive composition.
【００３１】このものを、ヒートプレスにて、１．５mm
厚のシートにし、これを支持体(ポリエーテル系ポリウ
レタンフィルム３０μm)上に積層し、更に、この接着層
の露出面にセパレーター層(シリコーン処理剥離紙)を積
層して三層シートを形成し、次いで、この接着層にはγ
線照射を２５ｋＧｙ量行って放射線処理を行い、本発明
の機能性外用材を得た。This product was heat-pressed to 1.5 mm
A thick sheet, which is laminated on a support (polyether-based polyurethane film 30 μm), and a separator layer (silicone-treated release paper) is laminated on the exposed surface of the adhesive layer to form a three-layer sheet, The adhesive layer is then γ
Radiation treatment was carried out by irradiating with radiation of 25 kGy to obtain a functional external material of the present invention.
【００３２】比較例１ 実施例１において、γ線照射を行わない以外は、実施例
１と同様にして得たものを用いた。Comparative Example 1 A sample obtained in the same manner as in Example 1 except that the γ-ray irradiation was not carried out was used.
【００３３】比較例２ 実施例１と同様に、予め、実施例１と同量のハイドロコ
ロイド粉末をよく混合し、吸水性及び／又は水膨潤性の
ハイドロコロイドを得た。Comparative Example 2 In the same manner as in Example 1, the same amount of hydrocolloid powder as in Example 1 was thoroughly mixed beforehand to obtain a water-absorbent and / or water-swellable hydrocolloid.
【００３４】続いて、ポリイソブチレン(粘度平均分子
量５万)３８gと崩壊型ポリマーである高分子量ポリイソ
ブチレン(粘度平均分子量９９万)４gをニーダーにてよ
く混練する。これに上述のハイドロコロイドを添加し、
さらに混練する事により、吸水性及び／又は水膨潤性の
接着剤組成物を得た。Subsequently, 38 g of polyisobutylene (viscosity average molecular weight of 50,000) and 4 g of high molecular weight polyisobutylene (viscosity average molecular weight of 990,000) which is a disintegrating polymer are well kneaded with a kneader. Add the above hydrocolloid to this,
By further kneading, a water-absorbent and / or water-swellable adhesive composition was obtained.
【００３５】このものを、ヒートプレスにて、１．５mm
厚のシートにし、これを支持体(ポリエーテル系ポリウ
レタンフィルム３０μm)上に積層し、更に、この接着層
の露出面にセパレーター層(シリコーン処理剥離紙)を積
層して三層シートを形成し、次いで、この接着層にはγ
線照射を２５ｋＧｙ量行って放射線処理を行い、比較例
とした。This product was heat-pressed to 1.5 mm
A thick sheet, which is laminated on a support (polyether-based polyurethane film 30 μm), and a separator layer (silicone-treated release paper) is laminated on the exposed surface of the adhesive layer to form a three-layer sheet, The adhesive layer is then γ
Radiation treatment was carried out by performing linear irradiation at a dose of 25 kGy and used as a comparative example.
【００３６】このようにして得られた実施例及び各比較
例の応力−歪曲線を以下の方法で測定した結果を図１に
示す。応力−歪曲線の測定方法は以下の通りである。 応力−歪曲線測定方法 インストロン型引張試験機を用い、サンプルサイズ４０
ｍｍ（長さ）×１０ｍｍ（幅）×１．５ｍｍ（厚さ）の
サンプルを、チャック間距離１０ｍｍ、引張速度３００
ｍｍ／分にて応力を測定、応力−歪曲線を作製した。FIG. 1 shows the results of measuring the stress-strain curves of the examples and comparative examples thus obtained by the following method. The method for measuring the stress-strain curve is as follows. Stress-strain curve measurement method Using an Instron type tensile tester, sample size 40
mm (length) × 10 mm (width) × 1.5 mm (thickness) sample, chuck distance 10 mm, pulling speed 300
The stress was measured at mm / min to prepare a stress-strain curve.
【００３７】又、このようにして得られた各実施例及び
比較例１のサンプルを人体背中に貼り、就寝時、圧迫が
加わるようにし、２日後、評価したところ、比較例のも
のは、γ線照射によってポリイソブチレンの分子切断が
生じて流れ出しがひどく衣服を汚す等の問題が生じた。
一方、各実施例については、このような問題が発生しな
いことが認められた。Further, the samples of Examples and Comparative Example 1 thus obtained were attached to the back of a human body so that pressure was applied at bedtime, and after 2 days, evaluation was made. The irradiation of rays caused molecular breakage of polyisobutylene, resulting in problems such as excessive outflow and soiling of clothes.
On the other hand, it was confirmed that such a problem did not occur in each example.
【００３８】又、図１に示す結果より、ポリイソブチレ
ンに、ポリイソプレン等の架橋型物質を配合する事によ
り、γ線を照射しても強度低下等の劣化をきたさない事
が認められた。From the results shown in FIG. 1, it was confirmed that by blending polyisobutylene with a cross-linking substance such as polyisoprene, deterioration such as strength reduction did not occur even when irradiated with γ-rays.
【００３９】更に、ポリイソブチレンに架橋型物質を配
合しないものは、γ線照射によって、滲出液を多量に吸
って、溶解、流出するのに対し、ポリイソブチレンに、
ポリイソプレン等の架橋型物質を配合する事により、γ
線を照射しても、ある程度のゲル強度を有し、保形性を
保つことができる上、また人の皮膚に貼付した場合で
も、ゴム強度がある為、のり残りしない等、種々の面で
好結果が得られることが認められた。Further, polyisobutylene containing no cross-linking substance absorbs a large amount of exudate by γ-ray irradiation, and dissolves and flows out.
By incorporating a cross-linking substance such as polyisoprene, γ
Even if it is irradiated with rays, it has a certain degree of gel strength and can retain its shape-retaining property, and even when it is attached to human skin, it has rubber strength, so it does not leave adhesive residue and so on. It was confirmed that good results were obtained.
【００４０】[0040]
【発明の効果】本発明は、上記構成を有し、これによっ
て、放射線減菌が可能になり、しかも放射線照射によっ
て特性が低下しないばかりか、むしろ特性が向上するの
である。そして、圧迫による糊はみ出しがない事、人の
皮膚に貼付した際、糊残りがない事、また、滲出液を吸
った際もある程度のゲル強度を有し、接着剤組成物が溶
解、流出しない等、至極優れた効果を有するのである。EFFECTS OF THE INVENTION The present invention has the above-mentioned constitution, which makes it possible to sterilize radiation, and not only the characteristics are not deteriorated by irradiation of radiation, but also the characteristics are improved. The adhesive does not squeeze out due to pressure, there is no adhesive residue when applied to human skin, and it has some gel strength even when absorbing exudate, and the adhesive composition does not dissolve or flow out. And so on, it has an extremely excellent effect.
【００４１】[0041]
【図１】図１は実施例及び各比較例の応力−歪曲線を示
す特性図である。FIG. 1 is a characteristic diagram showing stress-strain curves of examples and comparative examples.
Claims (2)
て、この接着層が、ゴム系接着剤と少なくとも吸水性及
び／又は水膨潤性のポリマー粒子の混合組成物よりな
り、上記ゴム系接着剤が、ポリイソブチレンと、放射線
照射によって架橋する架橋型物質よりなり、且つ上記接
着層には放射線照射処理が施されている事を特徴とする
機能性外用材。1. An external material comprising a support and an adhesive layer, the adhesive layer comprising a mixed composition of a rubber adhesive and at least water-absorbing and / or water-swelling polymer particles. A functional external material, wherein the adhesive is composed of polyisobutylene and a cross-linking substance that cross-links upon irradiation with radiation, and the adhesive layer is subjected to irradiation treatment.
ポリブタジエン、ポリエチレン又はエチレン−プロピレ
ン共重合体から選ばれた少なくとも１種である請求項１
に記載の機能性外用材。2. The crosslinkable substance is natural rubber, polyisoprene,
2. At least one selected from polybutadiene, polyethylene or ethylene-propylene copolymer.
Functional external material described in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4223389A JPH06154304A (en) | 1992-07-29 | 1992-07-29 | Functional material for external use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4223389A JPH06154304A (en) | 1992-07-29 | 1992-07-29 | Functional material for external use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06154304A true JPH06154304A (en) | 1994-06-03 |
Family
ID=16797386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4223389A Pending JPH06154304A (en) | 1992-07-29 | 1992-07-29 | Functional material for external use |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06154304A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0657262A2 (en) * | 1993-12-13 | 1995-06-14 | Hoechst Aktiengesellschaft | Method for reducing the number of bacterial germs in plastic dispersions, trough microwave radiation |
| EP0879597A1 (en) * | 1996-02-07 | 1998-11-25 | TSUMURA & CO. | Transparent aqueous solution of diclofenac sodium and medicinal compositions with the use of the same |
| JP2001345200A (en) * | 2000-05-31 | 2001-12-14 | Ebara Corp | Method of manufacturing charged particle accelerating tube |
| WO2002022182A1 (en) * | 2000-09-14 | 2002-03-21 | Ssp Co., Ltd. | Preparations for coating wound |
| JP2004174266A (en) * | 2002-11-27 | 2004-06-24 | Bristol Myers Squibb Co | Ostomy pouch attachment adhesive resistant to stomal effluent |
| JP2006045381A (en) * | 2004-08-05 | 2006-02-16 | Hayakawa Rubber Co Ltd | Radiation-resisting pressure-sensitive adhesive composition |
| WO2007018210A1 (en) * | 2005-08-10 | 2007-02-15 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch less irritative to skin |
| JP2014532732A (en) * | 2011-11-08 | 2014-12-08 | スリーエム イノベイティブ プロパティズ カンパニー | Hydrocolloid composition and articles containing the same |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5216895A (en) * | 1975-07-28 | 1977-02-08 | Squibb & Sons Inc | Surgical bandage |
| JPS577414A (en) * | 1980-06-14 | 1982-01-14 | Nitto Electric Ind Co Ltd | Preparation of plaster |
| JPS57182375A (en) * | 1981-04-23 | 1982-11-10 | Squibb & Sons Inc | Microporous adhesive tape |
| JPS58190446A (en) * | 1982-04-22 | 1983-11-07 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | Bandage, granul agent and use thereof for wound treatment |
| JPS6020976A (en) * | 1983-06-27 | 1985-02-02 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | Adhesive composition resistant to biological body fluid |
| JPS6263512A (en) * | 1985-09-13 | 1987-03-20 | Nitto Electric Ind Co Ltd | Base for hydrous gel patch |
| JPS62292160A (en) * | 1986-06-11 | 1987-12-18 | ホリスタ−・インコ−ポレ−テッド | Closable bandage for remedy of skin wound |
| JPH0199564A (en) * | 1987-09-08 | 1989-04-18 | E R Squibb & Sons Inc | Adhesive bandage containing pharmaceutical active gradient |
| JPH0213463A (en) * | 1988-05-03 | 1990-01-17 | Minnesota Mining & Mfg Co <3M> | Pressure sensitive adhesive composition |
| JPH0223966A (en) * | 1988-05-27 | 1990-01-26 | Smith & Nephew United Inc | Absorption adhesive dressing having controlled hydration speed |
| JPH05331055A (en) * | 1992-05-28 | 1993-12-14 | Nitto Denko Corp | Hydro-colloidal dressing material and functional external preparation prepared by using the material |
-
1992
- 1992-07-29 JP JP4223389A patent/JPH06154304A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5216895A (en) * | 1975-07-28 | 1977-02-08 | Squibb & Sons Inc | Surgical bandage |
| JPS577414A (en) * | 1980-06-14 | 1982-01-14 | Nitto Electric Ind Co Ltd | Preparation of plaster |
| JPS57182375A (en) * | 1981-04-23 | 1982-11-10 | Squibb & Sons Inc | Microporous adhesive tape |
| JPS58190446A (en) * | 1982-04-22 | 1983-11-07 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | Bandage, granul agent and use thereof for wound treatment |
| JPS6020976A (en) * | 1983-06-27 | 1985-02-02 | イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド | Adhesive composition resistant to biological body fluid |
| JPS6263512A (en) * | 1985-09-13 | 1987-03-20 | Nitto Electric Ind Co Ltd | Base for hydrous gel patch |
| JPS62292160A (en) * | 1986-06-11 | 1987-12-18 | ホリスタ−・インコ−ポレ−テッド | Closable bandage for remedy of skin wound |
| JPH0199564A (en) * | 1987-09-08 | 1989-04-18 | E R Squibb & Sons Inc | Adhesive bandage containing pharmaceutical active gradient |
| JPH0213463A (en) * | 1988-05-03 | 1990-01-17 | Minnesota Mining & Mfg Co <3M> | Pressure sensitive adhesive composition |
| JPH0223966A (en) * | 1988-05-27 | 1990-01-26 | Smith & Nephew United Inc | Absorption adhesive dressing having controlled hydration speed |
| JPH05331055A (en) * | 1992-05-28 | 1993-12-14 | Nitto Denko Corp | Hydro-colloidal dressing material and functional external preparation prepared by using the material |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0657262A3 (en) * | 1993-12-13 | 1995-10-11 | Hoechst Ag | Method for reducing the number of bacterial germs in plastic dispersions, trough microwave radiation. |
| EP0657262A2 (en) * | 1993-12-13 | 1995-06-14 | Hoechst Aktiengesellschaft | Method for reducing the number of bacterial germs in plastic dispersions, trough microwave radiation |
| EP0879597A1 (en) * | 1996-02-07 | 1998-11-25 | TSUMURA & CO. | Transparent aqueous solution of diclofenac sodium and medicinal compositions with the use of the same |
| EP0879597A4 (en) * | 1996-02-07 | 2001-01-31 | Tsumura & Co | Transparent aqueous solution of diclofenac sodium and medicinal compositions with the use of the same |
| JP2001345200A (en) * | 2000-05-31 | 2001-12-14 | Ebara Corp | Method of manufacturing charged particle accelerating tube |
| KR100909233B1 (en) * | 2000-09-14 | 2009-07-23 | 히사미쓰 세이야꾸 가부시키가이샤 | Wound coating preparations |
| WO2002022182A1 (en) * | 2000-09-14 | 2002-03-21 | Ssp Co., Ltd. | Preparations for coating wound |
| JP4971578B2 (en) * | 2000-09-14 | 2012-07-11 | 久光製薬株式会社 | Wound dressing preparation |
| JP2004174266A (en) * | 2002-11-27 | 2004-06-24 | Bristol Myers Squibb Co | Ostomy pouch attachment adhesive resistant to stomal effluent |
| JP2006045381A (en) * | 2004-08-05 | 2006-02-16 | Hayakawa Rubber Co Ltd | Radiation-resisting pressure-sensitive adhesive composition |
| JP2007045738A (en) * | 2005-08-10 | 2007-02-22 | Hisamitsu Pharmaceut Co Inc | Plaster with reduced skin irritation |
| WO2007018210A1 (en) * | 2005-08-10 | 2007-02-15 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch less irritative to skin |
| JP2014532732A (en) * | 2011-11-08 | 2014-12-08 | スリーエム イノベイティブ プロパティズ カンパニー | Hydrocolloid composition and articles containing the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3574159B2 (en) | Adhesive, wound dressing and method for producing the same | |
| JP3616145B2 (en) | Cuttable wound dressing | |
| US4306551A (en) | Sterile improved bandage and sealant | |
| CN111629700B (en) | Buffered adhesive compositions for skin-adhesive medical products | |
| US5429591A (en) | Absorbent dressing having backing and continuous adhesive layer | |
| CA1312396C (en) | Hydrocolloid/adhesive composition | |
| US6583220B1 (en) | Biological fluid absorbing pressure sensitive adhesives | |
| US8110208B1 (en) | Hemostatic compositions for arresting blood flow from an open wound or surgical site | |
| US7456331B2 (en) | Composition for cushions, wounds dressings and other skin-contacting products | |
| JPS6329649A (en) | Adhesive polyethylene oxide hydrogel sheet and its production | |
| JPH0588613B2 (en) | ||
| EP0279118B1 (en) | Adhesive products | |
| CN113088220A (en) | Buffered adhesive compositions for skin-adherent medical products | |
| JP2007327053A (en) | Method for producing highly absorbent hydrocolloid | |
| EP0528191A1 (en) | Dressing | |
| DE60001980T2 (en) | LIQUID-ABSORBING, ADHESIVE HYDROCOLLOID COMPOSITIONS | |
| JPH06154304A (en) | Functional material for external use | |
| JPH06201A (en) | Functional exterior material and its manufacture | |
| KR100459494B1 (en) | Method for the preparation of hydrogels for wound dressings | |
| GB2259464A (en) | Hydrocolloid dressing | |
| JPS6357046A (en) | Bandage for wound and its production | |
| US20230158202A1 (en) | Method for producing local hemostasis material, and local hemostasis material | |
| JPH06125977A (en) | Functional medicine for external application | |
| WO1990010465A1 (en) | Adhesive dressing |