JPH0611743U - Blood processing equipment - Google Patents

Abstract

(57) [Summary] [Purpose] A leukocyte-removing filter that removes leukocytes in whole blood or blood products is installed in the conduit that conveys the whole blood or blood products contained in the supply-side container to the part to be supplied. In the blood processing apparatus described above, the whole amount of the whole blood or blood product contained in the supply-side container can be transferred to the supply target portion without leaving the whole blood or blood product in the duct and the leukocyte removal filter. To [Structure] An outside air intake portion T is provided at a position on a side of a conduit 3 which is on the upper side of an interposed portion of a leukocyte removal filter, and the outside air intake portion T allows air to flow therethrough and blocks bacteria from passing therethrough. The filter 5 is provided, and the plug means S is provided to switch between the flow state in which the outside air is allowed to flow through the pipe line 3 and the cut-off state in which the outside air is not allowed to flow through the filter for sterilization 5.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention provides blood in which a leukocyte-removing filter for removing leukocytes in whole blood or blood products is inserted in a conduit for conveying whole blood or blood products contained in a supply-side container to a supply part. Regarding a processing device.

[0002]

[Prior art]

 In such a blood processing device, when transfused, white blood in transfused whole blood or blood products may cause side effects or ineffective transfusion.Therefore, whole blood or blood products are supplied from a container on the supply side through a duct. It removes leukocytes in whole blood or blood products by a leukocyte removal filter inserted in the duct when it is transported to the site.

In such a blood processing apparatus, conventionally, the supply-side container and the supply-receiving part have been connected to each other by a conduit having a leukocyte removal filter interposed therebetween.

[0004]

[Problems to be solved by the device]

 However, in the above-mentioned conventional device, even if the delivery of whole blood or a blood product from the supply-side container to the supply-receiving part is completed, the system from the supply-side container to the supply-receiving part via the duct and leukocyte removal filter Is always kept airtight against the outside air, so whole blood or blood products remain in the duct and leukocyte removal filter, and the residual whole blood or blood products is wasted. was there.

The present invention has been made in view of the above circumstances, and an object of the present invention is to store whole blood or a blood liquid preparation in a supply side container without leaving the whole blood or blood liquid preparation in a duct or a leukocyte removal filter. The point is to provide a blood processing apparatus that can convey the whole amount of whole blood or blood products to the supply destination.

[0006]

A first characteristic configuration of a blood processing apparatus according to the present invention is that an outside air intake portion is provided at a position on the side of the pipe that is higher than an intervening portion of the leukocyte removal filter, and the outside air intake portion is provided. A filter for sterilization that allows the passage of air and blocks the passage of bacteria is provided in the intake part, and the state where the outside air is allowed to pass through the above-mentioned filter for sterilization and the state where it does not flow The point is that a plug means is provided for switching to the flow blocking state.

A second characteristic configuration is a preferable specific configuration for implementing the first characteristic configuration, in which the outside air intake section connects the pipeline and the sterilization filter. A branch pipe, a part of the branch pipe of which is formed of a flexible pipe, and the plug means includes a communication portion that is fitted into the flexible pipe and that has a communication passage extending from both ends thereof. It is composed of a folding rod that includes a lid member that closes one open end of the communicating portion and a fragile portion that can be separated by bending to separate the communicating portion and the lid member. . A third characteristic configuration is that, in the second characteristic configuration, the sterilization filter and the bent rod are fixed to each other.

[0008]

[Action]

 According to the first characteristic configuration, the whole blood or the blood product contained in the supply-side container is conveyed to the supply target part in the state where the plug means is in the flow blocking state, and then the plug means is inserted. When switched to the above-mentioned flow-through state, the air sterilized by the sterilization filter flows into the duct, and the whole blood or blood products remaining in the duct and the leukocyte removal filter are supplied. Flows into the department.

According to the second characteristic configuration, in the state where the communication portion of the bent rod and the lid member are connected without being separated, the lid member blocks the communication between the duct and the sterilization filter. Therefore, the plug means is in the above-mentioned flow blocking state, and in the state where the communication part of the bent rod and the lid member are separated, since the pipe part and the sterilization filter are communicated by the communication part, the plug means is the above-mentioned communication. It is in a flowing state. Therefore, the whole blood or the blood product contained in the supply-side container is transported to the supply destination without bending the bent rod, that is, in the state in which the plug means is in the flow blocking state. When the bent rod is bent from the outside of the flexible pipe to separate the communication part and the lid member at the fragile part, that is, when the plug means is switched to the above-mentioned flow state, the air sterilized by the sterilization filter is used. Flows into the duct, and the whole blood or blood product remaining in the duct and the leukocyte removal filter flows into the supply destination part.

According to the third characteristic configuration, since the sterilization filter and the folding rod are integrally formed in a fixed state, the sterilization filter and the folding rod can be easily formed into a flexible pipe. Can be attached to.

[0011]

[Effect of device]

 Therefore, according to the present invention, the whole amount of the whole blood or blood product contained in the supply-side container is conveyed to the supply target portion without leaving the whole blood or blood product in the duct and the leukocyte removal filter. be able to.

Furthermore, according to the third characteristic configuration, the assembly configuration for implementing the present invention is simplified, and as a result, the cost for implementing the present invention can be made as low as possible.

[0013]

【Example】

 [First Embodiment] An embodiment in which the present invention is applied to a blood processing apparatus for removing leukocytes from whole blood or blood products will be described with reference to FIGS. 1 and 2. First, the overall configuration of the blood processing apparatus will be described with reference to FIG.

In the figure, 1 is a supply-side container that contains whole blood or blood products, and 2 is a supply-side container that serves as a supply target portion. The supply-side container 1 and the supply-side container 2 are connected by a tube 3 as a conduit so that the supply-side container 2 is conveyed.

A leukocyte removal filter 4 that removes leukocytes in whole blood or blood products is interposed in the middle of the tube 3. The leukocyte removal filter 4 is filled with polyester ultrafine fibers, and is configured to remove leukocytes by adhering to the ultrafine fibers while whole blood or a blood product flows through the leukocyte removal filter 4. I am doing it.

An outside air intake portion T is provided at a position on the tube 3 that is on the upper side of the interposed portion of the leukocyte removal filter 4. The outside air intake portion T allows air to flow therethrough and allows bacteria to pass therethrough. A sterilizing filter 5 for blocking is provided, and a stopper means S for switching between a flowing state in which the outside air flows through the tube 3 and a blocking state in which the outside air does not flow through the sterilizing filter 5 is provided. There is.

Next, based on FIG. 1, each of the outside air intake portion T, the sterilization filter 5, and the stopper means S will be described.

The outside air intake portion T is configured by a branch pipe 6 including a branch portion 6a interposed in the middle of the tube 3 and a flexible pipe 6b connected to the opening portion of the branch portion 6a, and the branch pipe 6a. The tube 3 is connected to the sterilization filter 5 by the tube 6. The branch portion 6a is made of a hard synthetic resin, and the flexible pipe 6b is made of a soft synthetic resin so as to have flexibility.

The sterilizing filter 5 is composed of a casing portion 5a having openings in the upper portion and the lower portion, and a filter member 5b housed in the casing portion 5a. The casing portion 5a is made of hard synthetic resin. The filter member 5b is, for example, a porous membrane made of polyethylene, polypropylene, nylon or the like, and has a pore diameter of 0. By appropriately setting the range of 02 μm to 15 μm, the passage of bacteria and the passage of liquid are blocked while allowing the passage of air.

The stopper means S includes a communication part 7a having communication paths extending to both ends, a lid member 7b closing one opening end of the communication part 7a, and a separation of the communication part 7a and the lid member 7b. Therefore, the bent rod 7 is made of a hard synthetic resin and is provided with a thin fragile portion 7c that can be separated by bending. The outer diameter of the communication portion 7a is substantially equal to the inner diameter of the flexible pipe 6b, and the communication portion 7a is fitted into the flexible pipe 6b with the lid member 7b positioned on the branch portion 6a side. I am allowed to do it. Further, the maximum outer diameter of the lid member 7b is smaller than the inner diameter of the flexible pipe 6b and larger than the inner diameter of the opening of the branch portion 6a, and the bending rod 7 is bent to connect the communication portion 7a and the lid. Even if the member 7b is separated, the lid member 7b is stopped at the opening of the branch portion 6a so that it does not fall into the tube 3. Further, the outer periphery of the lid member 7b is made uneven so that the opening of the branch portion 6a is not closed by the foot member 7b.

The opening on the lower side of the casing portion 5a of the sterilization filter 5 and the other opening end of the communication portion 7a of the folding rod 7 are fixed to each other, so that the sterilization filter 5 and the fold filter 7 are folded. The rod 7 is integrally formed. That is, by fitting the communication portion 7a of the bent rod 7 into the flexible pipe 6b from the opening end side of the flexible pipe 6b, the sterilization filter 5 and the bent rod 7 are connected to the flexible pipe 6b. It is configured so that it can be installed.

By configuring the blood processing apparatus as described above, the whole blood or the blood product contained in the supply-side container 1 is transported to the supply-side container 2, and then shown in FIG. As shown in FIG. 1B, when the bent rod 7 is bent from the outside of the flexible pipe 6b and the communication portion 7a and the lid member 7b are separated by the fragile portion 7c, the sterilizing filter 5 is obtained. The air thus sterilized flows through the tube 3, and the whole blood or the blood product remaining in the tube 3 and the leukocyte removal filter 4 flows into the supply-side container 2.

Second Embodiment Based on FIG. 3, a blood processing apparatus for separating whole blood collected from a blood sampler into blood components and removing leukocytes from the whole blood or each blood component is provided. An example of applying the invention will be described. First, the overall configuration of the blood processing apparatus will be described.

A blood collection tube 12 having a blood collection needle 11 for collecting blood from a blood sampler at its tip is connected to a parent bag 13. A transfer tube 15 having a branch pipe 14 connected to the tip thereof is connected to the parent bag 13, and a first child bag 17 and a second connection tube 18 are connected to the branch pipe 14 via a first connection tube 16. The second child bags 19 are connected to each other via. Further, the parent bag 13 contains an anticoagulant solution (for example, ACD-A) for preventing blood coagulation.

Then, this blood processing apparatus performs a blood component fractionation operation as follows.

Whole blood collected from a blood collector is passed through the blood collection tube 12 and stored in the parent bag 13. Subsequently, the whole blood contained in the parent bag 13 is separated into an upper platelet-rich plasma layer and a lower red blood cell layer by a centrifugation operation. Subsequently, by pressurizing the parent bag 13, the upper platelet-rich plasma layer is caused to flow through the transfer tube 15 and the first connecting tube 16 and is accommodated in the first child bag 17. Then, the parent tube 13 is separated from the first child bag 17 and the second child bag 19 by sealing and cutting the middle of the transfer tube 15. Subsequently, the platelet-rich plasma layer contained in the first child bag 17 is separated into an upper plasma layer and a lower platelet layer by a centrifugation operation. Subsequently, by pressing the first child bag 17, the upper plasma layer is caused to flow through the first connecting tube 16 and the second connecting tube 18, and is housed in the second child bag 19.

In the blood processing apparatus configured as described above, the white blood cell removal tube 4, the first connection tube 16, and the second connection tube 18 are appropriately provided with the leukocyte removal filter 4, and A branch pipe 6 equipped with a sterilizing filter 5 and a folding rod 7 is interposed at a position on the side on the side better than the insertion position, as in the above-described first embodiment. Although FIG. 3 illustrates the case where the blood collection tube 12 and the first connecting tube 16 are provided with the leukocyte removal filter 4, the sterilization filter 5 and the branch pipe 6 equipped with the folding rod 7, respectively. The blood collection tube 12, the first connection tube 16, and the second connection tube 18 may be provided in any one or in any two or all of them.

For example, the function when the blood sampling tube 12 is interposed will be described. Whole blood collected from a blood sampler is passed through the blood collection tube 12 and stored in the parent bag 13. At that time, leukocytes are removed from the whole blood flowing through the blood collection tube 12 by the leukocyte removal filter 4. When the folding rod 7 is bent after the blood collection is completed, the air sterilized by the sterilization filter 5 flows into the blood collection tube 12 and remains in the blood collection tube 12 and the white blood cell removal filter 4. Blood flows into the parent bag 13. Some white blood cell removal filters 4 remove not only white blood cells but also platelets. In this case, it is preferable to remove only white blood cells.

Next, the function when the first connecting tube 16 is interposed will be described. The platelet-rich plasma layer above the parent bag 13 is accommodated in the first child bag 17 through the transfer tube 15 and the first connecting tube 16. At that time, leukocytes are removed by the leukocyte removal filter 4 from the platelet-rich plasma flowing through the first connecting tube 16. When the folding rod 7 is bent, the air sterilized by the sterilization filter 5 flows into the first connecting tube 16 and remains in the leukocyte removal filter 4 and the first connecting tube 16. The platelet-rich plasma flows into the first child bag 17. Also in this case, it is preferable that the leukocyte removal filter 4 removes only leukocytes.

Next, the function when the second connecting tube 18 is interposed will be described. The upper plasma layer of the first child bag 17 is accommodated in the second child bag 19 through the first connecting tube 16 and the second connecting tube 18. At that time, leukocytes are removed from the plasma flowing through the second connecting tube 18 by the leukocyte removal filter 4. When the folding rod 7 is bent, the air sterilized by the sterilization filter 5 flows into the second connecting tube 18 and remains in the leukocyte removal filter 4 and the second connecting tube 18. Plasma flows into the second child bag 19. In this case, the leukocyte removal filter 4 may be one that removes leukocytes and platelets.

[Other Examples] Next, other examples will be listed.

In each of the above-described embodiments, the case where the outside air intake portion T is configured by the branch pipe 6 has been illustrated, but the configuration of the outside air intake portion T can be variously changed, and for example, the outside air intake portion T can be opened on the pipe wall of the pipe line 3. You may comprise by forming a mouth part. In this case, the sterilization filter 5 is provided by directly connecting to the opening.

In each of the above embodiments, the case where the stopper means S is configured by the bent rod 7 has been illustrated, but the configuration of the stopper means S can be variously changed. For example, the opening of the sterilization filter 5 that faces the outside air. It may be configured by a lid provided in a state where the portion is opened or closed, or a cap or the like.

In each of the above-described embodiments, the case where the sterilization filter 5 and the folding rod 7 are integrally formed is illustrated, but instead of this, the sterilization filter 5 and the folding rod 7 are separately formed. You can do it. In this case, the bent rod 7 is provided in the flexible pipe 6b of the branch pipe 6, and the sterilization filter 5 is connected to the open end of the flexible pipe 6b.

In the second embodiment, the case where two child bags are provided has been exemplified, but the number of child bags to be provided may be one or three depending on the type of blood component to be separated. The above is also acceptable.

The present invention is applicable to various blood processing apparatuses other than the blood processing apparatuses shown in the above-described embodiments, that is, when whole blood or blood products are transported from the supply-side container 1 to the supply destination through the conduit 3. Any blood processing apparatus can be applied as long as it is configured to remove white blood cells in whole blood or blood products by the leukocyte removal filter 4 interposed in the duct 3. For example, the whole blood or the blood product contained in the supply-side container 1 can be applied to a blood processing apparatus configured to transfuse the transfusion person through the conduit 3.

It should be noted that reference numerals are added to the claims of the utility model for convenience of comparison with the drawings, but the invention is not limited to the configurations of the accompanying drawings by the entry.

[Brief description of drawings]

FIG. 1 is an enlarged vertical cross-sectional view of the vicinity of an installation location of an outside air intake section in a blood processing apparatus according to a first embodiment of the present invention.

FIG. 2 is an overall configuration diagram of the blood processing apparatus according to the first embodiment of the present invention.

FIG. 3 is an overall configuration diagram of a blood processing apparatus according to a second embodiment of the present invention.

[Explanation of symbols]

 1 Supply side container 3 Pipe line 4 Leukocyte removal filter 5 Sterilization filter 6 Branch pipe 6b Flexible pipe 7 Bend rod 7a Communication part 7b Lid member 7c Fragile part S Plug means T Outside air intake part

Claims (3)

[Scope of utility model registration request] 1. A leukocyte-removing filter for removing leukocytes in whole blood or blood products in a conduit (3) for transporting the whole blood or blood products contained in a supply side container (1) to a supplied part. 4) The blood processing apparatus in which the leukocyte removal filter (4) in the conduit (3) is provided.
The outside air intake part (T) is provided at a position on the side better than the intervening part, and the outside air intake part (T) is provided with a sterilization filter (5) that allows air flow and blocks the passage of bacteria. A stopper means (S) is provided which switches between a flow state in which outside air is allowed to flow through the pipe line (3) and a cut-off state in which the outside air is not allowed to flow through the sterilizing filter (5). Blood processing equipment. 2. The outside air intake part (T) is composed of a branch pipe (6) connecting the pipe line (3) and the sterilization filter (5), and the branch pipe (6) A part formed of a flexible pipe (6b), the plug means (S) being fitted in the flexible pipe (6b), and having a communication part (7a) having communication paths extending to both ends; A lid member (7b) that closes one open end of the communication portion (7a), and a fragile portion (7c) that is separable by bending the communication portion (7a) and the lid member (7b) for separation. The blood processing apparatus according to claim 1, wherein the blood processing apparatus is composed of a bent rod (7) having a. 3. The blood processing apparatus according to claim 2, wherein the sterilization filter (5) and the bent rod (7) are fixed to each other.