JPH0587709A - Automatic manufacturing device of specimen sample for inspection - Google Patents

Abstract

PURPOSE:To prevent unmatching between a specimen and its specific information by directly printing the specific information which is read by a reader on a slide glass which completed centrifugal smearing treatment and then automatically recording it. CONSTITUTION:A vertical slide plate 12 and a horizontal slide plate 14 are connected to respective motors and are subjected to reciprocating motion on guide rails 1b and 13. Each motor and a cam motor 19c are electrically connected to a controller, thus enabling drive to be controlled. When a slide glass 4 which completed centrifugal smearing treatment is carried in, each motor is controlled by the controller based on information which is read by a reader, the vertical slide plate 12 is moved in X-axis direction and the horizontal slide plate 14 is moved in Y-axis direction for localization at a proper position. Then, by rotating an eccentric column 18, a pen-holding body 17 is elevated or lowered against a spring 15 and a hard pen 16 records data on the slide glass 4. After staining, the slide glass 4 which is subjected to marking treatment produces a blood sample by drying. The specimen and information match each other since the specimen information is recorded immediately after the centrifugal smearing treatment.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic sample preparation device for testing.

[0002]

2. Description of the Related Art A test sample automatic preparation apparatus for a test carries a test tube (a blood collection tube) containing a sample (blood) by a carrying means and prepares a blood sample for each blood collection tube. For example, after the blood in the selected blood collection tube is stirred by the stirring means, the blood is sampled by the preparative means, centrifugally smeared on the slider glass by the centrifugal smearing means, transferred to the staining step, and dried through the blood sample. To make. On the prepared blood sample (slide glass), as shown in FIG. 7, an identification number or the like for identifying the sample is handwritten on the upper surface of one end side (sample information recording area 41) of the slide glass 4.

[0003]

In the conventional automatic sample preparation device for a test, although a blood sample can be automatically prepared,
The information record identifying the sample is handwritten with an ink pen. That is, the operator manually writes the information specifying the patient of the sample on the slide glass based on the attached list or the like. However, the recording area of the slide glass (15m wide)
Since m) is narrow, it has to be recorded in multiple stages, which is disadvantageous in that it is difficult to record and difficult to recognize. In addition, a recording error may occur due to a simple recording error, or the order of the samples may be out of order due to damage to the slide glass, and the specific information may not match the sample on the slide glass, or the ink recording by the pen may be lost. As a result, there is a risk that the inspection may be hindered.

It is an object of the present invention to solve the above problems, and to provide an automatic sample preparation apparatus for a test which can automatically record the specific information of the sample and does not cause any discrepancy between the sample and the specific information. And

[0005]

In order to achieve this object, the test sample automatic preparation apparatus of the present invention has the following configuration. The automatic sample preparation device for testing uses the agitating means to agitate the selected blood sample, and then dispenses the text by the aliquoting means, centrifuge smears it on a slider glass by the centrifugal smearing means, and then transfers it to the dyeing step for staining. A device for processing, a reader for reading the ID information of the selected blood sample, and a stamp which is arranged in the vicinity of the centrifugal smearing means and directly prints the information read by the reader on a slide glass which has completed the centrifugal smearing process. And means are provided.

In the test sample automatic preparation apparatus having such a structure, a plurality of test tubes (blood collection tubes) containing a sample (blood) are conveyed to the stirring means side by the conveying means. During this transportation, the barcodes of the blood collection tubes are read by the barcode reader in the order of transportation. Then, the blood collection tubes (the blood therein) are agitated in the order of being read by the reader, and then are dispensed by the sorting means. on the other hand,
A slide glass for preparing a specimen sample is conveyed and set to the centrifugal smearing means. Here, the sample is centrifugally smeared on the slider glass by the centrifugal smearing means. After this, the marking means (X-axis /
The sample specifying information read by the reader is printed by a hard pen that can move freely in the Y-axis direction. Then, the slide glass that has been subjected to the engraving process is transferred to the dyeing process to finish the dyeing, and then the blood sample is prepared through the drying process.

Thus, since the sample information is recorded immediately after the centrifugal smearing process is completed, the sample on the slide glass and the ID information do not become inconsistent. In addition, since the method is to engrave on the slide glass, there is no fear that the recording will be lost. Furthermore, since blood is smeared on the slide glass and the data is engraved and then stained, the contrast of the character portion becomes clear and the data recognition efficiency at the time of analysis of the sample is improved.

[0008]

EXAMPLE FIG. 5 is an explanatory view showing a concrete example of the test sample automatic preparation apparatus according to the present invention.

The automatic sample preparation device for inspection is provided with a blood collection tube 5
Transporting means 31 for transporting the sample, stirring means 32 for stirring the selected blood sample (blood in the blood collection tube), dispensing means 33 for injecting blood from the stirred blood collection tube 5, and slider glass for the dispensed blood. Centrifugal smearing means 35 for centrifugally smearing onto 4
And a reader 2 for reading the ID information of the selected blood sample, and a marking means 1 provided near the centrifugal smearing means 35 for directly printing the information read by the reader 2 on the centrifugally smeared slide glass 4. , And a dyeing means 36 for dyeing the slide glass 4 for which the marking process has been completed.

FIG. 4 is a flow chart showing a specific processing operation of the automatic sample preparation apparatus for inspection of the embodiment. As shown in FIG. 5, a plurality of blood collection tubes (test tubes filled with a blood sample) 5 are housed in a rack, and the rack is placed on the transport means 31. The blood collection tube 5 is transported to the stirring means 32 side by the rack-by-rack transport means 31 [step (hereinafter, referred to as ST
1). During this transportation, as shown in FIG. 5, the barcode reader 2 reads the barcode (specimen identification information / ID information) attached to the blood collection tube 5 (ST2).
Then, the plurality of blood collection tubes 5 in the rack are taken out in order from the beginning by the taking-out means (not shown). The blood collection tube 5 is stirred by the stirring means 32 (ST3). On the other hand, the slide glass stock 34 is provided with a plurality of slide glasses 4 for preparing a specimen sample, and the slide glasses 4 are transferred by a conveying means (not shown) to the centrifugal smearing means 35.
Each sheet is conveyed to the side and set (ST4). In this state, the blood sample is dispensed from the blood collection tube 5 by the sorting means 33 (ST5). Then, the dispensed blood sample is smeared on the slide glass 4 by the centrifugal smearing means 35 (ST6). Further, thereafter, the slide glass 4 which has been smeared is conveyed to the marking means 1 (ST7). In the marking means 1, the ID information read by the reader 2 with the hard pen 16 is directly printed and recorded on the slide glass 4 (ST8). After this, the slide glass 4 is stained with the dyeing means 36.
And is dyed (ST9).

FIG. 3 is a perspective view of an essential part showing the marking means 1 of the automatic sample preparation apparatus for examination in the embodiment. Marking means 1
Is a vertical slide plate 12 fitted on a guide rail 1b provided on the vertical wall surface 1a of the engraved case body, and the vertical slide plate 12 conveys the slide glass 4 in the conveying direction (X
A flat plate-like substrate 11 that reciprocates in the axial direction, and this substrate 11
A horizontal slide plate 14 that is fitted to the guide rail 13 that is fixed to the slide glass 4 and slides in a direction (Y-axis direction) perpendicular to the transport direction of the slide glass 4, and a spring 15 that moves upward with respect to the horizontal slide plate 14. It is composed of a pen gripping body 17 which is urged and attached and has a hard pen 16, and an eccentric cam 18 which moves the pen gripping body 17 up and down.

The vertical slide plate 12 has a lower end fitted to the guide rail 1b and an upper end fixed to the back surface of the substrate 11. A guide rail 13 is attached to the upper surface of one end of the board 11 in parallel with the end side. A slider 14a below the horizontal slide plate 14 is fitted on the guide rail 13. Also, the horizontal slide plate 1
On the upper surface of 4, the pen gripping body 17 is attached to the front end side via a spring 15 with the pen gripping body 17 biased upward.
A hard pen 16 having a diamond tip is vertically inserted into and fixed to 7. As shown in FIG. 2, this hard pen 16
Is positioned such that the tip end portion thereof corresponds to above the slide glass 4 being conveyed.

The eccentric cam 18 is, as shown in FIG.
A cam mounting plate 19 including a side plate 19a and a top plate 19b is attached to the side plate 19a and is connected to a motor 19c provided on the outer surface of the side plate 19a. The eccentric cam 18 is arranged close to the side surface of the pen gripping body 17 and rotates to press the protruding shaft portion 17a provided on the side surface of the pen gripping body 17,
The pen gripping body 17 is moved up and down. Also,
The lower end of the side plate 19a is fixed to the upper end of the horizontal slide plate 14, and the top plate 19b corresponds to the upper surface of the pen gripping body 17. In the normal state, the upper surface of the pen gripping body 17 biased by the spring 15 is in contact with the back surface of the top plate 19b.

Vertical slide plate 12 and horizontal slide plate 1
4 is connected to a motor (not shown) and is set so as to reciprocate on the guide rails 1b and 13, and each motor of the slide plates 12 and 14 and the cam motor 19c.
Are electrically connected to a control device (not shown) to control the driving. Therefore, in the marking means 1, when the slide glass 4 is conveyed, each motor is driven by the control device based on the data read by the reader 2, the vertical slide plate 12 moves in the X-axis direction, and the horizontal movement occurs. The slide plate 14 moves in the Y-axis direction and is localized at an appropriate position. When the eccentric cam 18 rotates, the pen gripping body 17 moves up and down against the spring 15. As a result, the data is printed on the slide glass 4.

In the automatic sample preparation apparatus for a test having such a structure, the plurality of blood collection tubes 5 containing the sample (blood) are conveyed to the stirring means 32 by the conveying means 31. During this transportation, the barcode of the blood collection tube 5 is read by the barcode reader 2 in the order of transportation.
Then, the blood collection tubes (the blood therein) 5 are agitated in the order read by the reader 5, and then the blood is collected by the sorting means 33. On the other hand, the slide glass 4 for preparing the sample specimen is conveyed and set from the stock 34 to the centrifugal smearing means 35.
Here, the sample is centrifugally smeared on the slider glass 4 by the centrifugal smearing means 35. Then, the slide glass 4 after the centrifugal smearing process is conveyed to the marking means 1. In the marking means 1, based on the sample specifying information read by the reader 2,
By sliding the vertical slide plate 12 in the X-axis direction (slide glass transport direction) and the horizontal slide plate 14 in the Y-axis direction (direction perpendicular to the slide glass transport direction), a rigid pen (pen gripping body 17) is obtained. The ID information is directly printed on the slide glass by moving the 16 in the X-axis and Y-axis directions. Then, the slide glass 4 that has undergone the marking process is transferred to the dyeing process 36, and a blood sample is prepared through a drying process.

Thus, as shown in FIG. 6, the ID information can be directly marked on the upper surface of the slide glass 4, that is, the upper surface that has been smeared (the upper surface that will be dyed later), and many character data can be recorded in a line. obtain. Moreover, since the sample information is recorded immediately after the centrifugal smearing process is completed, the sample on the slide glass 4 and the ID information do not become inconsistent. Further, since the system is such that the slide glass 4 is directly engraved, there is no fear that the recording will be lost. Blood is smeared on the slide glass 4 and the data is imprinted and then stained, so that the contrast of the character portion becomes clear,
The data recognition efficiency at the time of sample analysis is improved.

[0017]

According to the present invention, the ID of the selected blood sample
Immediately after completing the centrifugal smearing step, a reader for reading information and a marking means arranged near the centrifugal smearing means for directly printing the information read by the reader on the centrifugally smeared slide glass are provided. In addition, since the sample information is recorded, the sample on the slide glass and the ID information do not become inconsistent. In addition, since the method is to engrave on the slide glass, there is no fear that the recording will be lost. Furthermore, since the slide glass is smeared with blood and stained after the data is engraved, the contrast of the character part becomes clear and the data recognition efficiency at the time of analysis of the sample is improved. Have.

[Brief description of drawings]

FIG. 1 is a side view showing a marking means of an automatic sample specimen preparation apparatus according to an embodiment.

FIG. 2 is a front view showing a marking means of the sample specimen automatic preparation apparatus according to the embodiment.

FIG. 3 is a main part perspective view showing a marking means of the sample specimen automatic preparation apparatus according to the embodiment.

FIG. 4 is a flowchart showing a processing operation of the sample specimen automatic preparation apparatus according to the embodiment.

FIG. 5 is an explanatory diagram showing an automatic sample specimen preparation device of Example.

FIG. 6 is an explanatory diagram showing a sample specimen manufactured by the sample specimen automatic preparation apparatus according to the embodiment.

FIG. 7 is an explanatory diagram showing a sample specimen manufactured by a conventional automatic sample specimen manufacturing apparatus.

[Explanation of symbols]

 1 marking means 2 reader 4 slide glass 5 blood collection tube (specimen) 32 stirring means 33 preparative means 35 centrifugal smearing means 36 staining means

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Michihiko Mizutani, 370 Omron Matsusaka Co., Ltd., 1855 Kubo-cho, Matsusaka City, Mie Prefecture (72) Inventor Ryuichi 370 Omron Matsusaka, 1855, Kubo-cho, Matsusaka City, Mie Prefecture Within the corporation

Claims (1)

[Claims] 1. An inspection sample in which a selected blood sample is agitated by an agitating means, then is dispensed by a preparative means, centrifugally smeared on a slider glass by a centrifugal smearing means, and then transferred to a dyeing step for dyeing treatment. In the automatic sample preparation device, a reader for reading ID information of the selected blood sample,
An automatic sample preparation apparatus for testing, comprising: a marking means for directly printing the information read by the reader on a slide glass, which has been placed in the vicinity of the centrifugal smearing means and has been subjected to the centrifugal smearing process.