JPH0581569B2 - - Google Patents

Info

Publication number
JPH0581569B2
JPH0581569B2 JP63500179A JP50017988A JPH0581569B2 JP H0581569 B2 JPH0581569 B2 JP H0581569B2 JP 63500179 A JP63500179 A JP 63500179A JP 50017988 A JP50017988 A JP 50017988A JP H0581569 B2 JPH0581569 B2 JP H0581569B2
Authority
JP
Japan
Prior art keywords
pdgf
igf
purified
bone
alone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63500179A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01500199A (ja
Inventor
Harorudo Shii Antoniadesu
Rei Shii Uiriamuzu
Samyueru Ii Riinchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of JPH01500199A publication Critical patent/JPH01500199A/ja
Publication of JPH0581569B2 publication Critical patent/JPH0581569B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63500179A 1986-11-14 1987-11-13 創傷の治癒および骨の再生 Granted JPH01500199A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US930,762 1978-08-03
US93076286A 1986-11-14 1986-11-14

Publications (2)

Publication Number Publication Date
JPH01500199A JPH01500199A (ja) 1989-01-26
JPH0581569B2 true JPH0581569B2 (enExample) 1993-11-15

Family

ID=25459724

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63500179A Granted JPH01500199A (ja) 1986-11-14 1987-11-13 創傷の治癒および骨の再生

Country Status (15)

Country Link
EP (1) EP0289584B1 (enExample)
JP (1) JPH01500199A (enExample)
KR (1) KR960005708B1 (enExample)
CN (1) CN1027346C (enExample)
AT (1) ATE88899T1 (enExample)
AU (1) AU600069B2 (enExample)
DE (1) DE3785758T2 (enExample)
DK (1) DK175889B1 (enExample)
IE (1) IE60517B1 (enExample)
MX (1) MX170454B (enExample)
NO (1) NO883127L (enExample)
NZ (1) NZ222551A (enExample)
OA (1) OA09159A (enExample)
WO (1) WO1988003409A1 (enExample)
ZA (1) ZA878566B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849407A (en) * 1986-08-13 1989-07-18 Zymogenetics, Inc. Biologically active mosaic proteins
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
IL95641A0 (en) * 1989-09-15 1991-06-30 Curative Tech Inc Preparation of a platelet releasate product
ZA9010332B (en) * 1989-12-22 1991-08-28 Ciba Geigy Method of reducing or preventing adverse effect of steroid therapy and compositions therefor
CA2060208C (en) * 1990-04-10 2001-02-20 Harry N. Antoniades Wound healing
DE69133087T2 (de) * 1990-05-30 2003-04-03 Institute Of Molecular Biology Inc., Boston Kombination aus IGF-I und TGF-beta zur Knochenregenerierung
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7208179B1 (en) 1990-11-27 2007-04-24 The American National Red Cross Methods for treating disease and forming a supplemented fibrin matrix
WO1993008825A1 (en) * 1991-11-04 1993-05-13 Zymogenetics, Inc. Pdgf gel formulation
FR2691911B1 (fr) * 1992-06-05 1994-11-25 Delmas Olivier Dispositif permettant l'obtention d'un surnageant de thrombocytes activés, procédé mettant en Óoeuvre le dispositif et surnageant obtenu.
JPH06510065A (ja) * 1992-06-08 1994-11-10 カイロン　コーポレーション 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法
FR2696095B1 (fr) * 1992-09-30 1994-11-25 Inoteb Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application.
CN1055023C (zh) * 1993-01-03 2000-08-02 周至譓 伤口护理剂
ATE180674T1 (de) * 1993-03-29 1999-06-15 Zymogenetics Inc Osteoblastswachstumfordernde zusammensetzungen die pdgf und vitamin-d enthalten
US7026299B2 (en) 1994-07-12 2006-04-11 Human Genome Sciences, Inc. Connective tissue growth factor-2
JPH10502534A (ja) 1994-07-12 1998-03-10 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド 結合組織増殖因子−２
US5728676A (en) * 1994-09-08 1998-03-17 Ciba-Geigy Corporation Use of insulin-like growth factors I and II for inhibition of inflammatory response
EP1486565B1 (en) * 1995-10-11 2007-11-21 Novartis Vaccines and Diagnostics, Inc. Combination of PDGF, KGF, IGF, and IGFBP for wound healing
EP0948538B1 (en) 1996-12-13 2008-06-11 Novartis Vaccines and Diagnostics, Inc. Analysis and separation of platelet-derived growth factor proteins
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
GB2369572A (en) 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7241874B2 (en) 2002-06-26 2007-07-10 Zimmer Ortho Biologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
BRPI0618794A2 (pt) 2005-11-17 2011-09-13 Biomimetic Therapeutics Inc uso de uma matriz biocompatìvel, kit e composição para aumento ósseo, especialmente para aumento do osso maxilofacial
EP2311505B1 (en) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
ES2664229T3 (es) 2006-06-30 2018-04-18 Biomimetic Therapeutics, Llc Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador
WO2008073628A2 (en) 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
ES2422259T3 (es) 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
MX2011002555A (es) 2008-09-09 2011-08-03 Biomimetic Therapeutics Inc Composiciones de factor de crecimiento derivadas de plaquetas y metodo para el tratamiento de lesiones de tendon y ligamentos.
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
CN102397534B (zh) * 2010-09-07 2013-10-23 中国人民解放军总医院 胰岛素在制备促进颌骨组织愈合的药物中的用途
WO2013077641A1 (ko) * 2011-11-22 2013-05-30 (주)아모레퍼시픽 성장 인자를 포함하는 피부 재생 촉진제
CN107106492B (zh) 2014-10-14 2022-07-05 塞缪尔·林奇 用于治疗伤口的组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor

Also Published As

Publication number Publication date
DE3785758T2 (de) 1993-08-05
IE873075L (en) 1988-05-14
WO1988003409A1 (en) 1988-05-19
EP0289584B1 (en) 1993-05-05
ATE88899T1 (de) 1993-05-15
IE60517B1 (en) 1994-07-27
KR890700033A (ko) 1989-03-02
AU600069B2 (en) 1990-08-02
NZ222551A (en) 1989-11-28
ZA878566B (en) 1989-07-26
CN1027346C (zh) 1995-01-11
EP0289584A4 (en) 1990-01-08
CN87101250A (zh) 1988-06-08
AU8328987A (en) 1988-06-01
JPH01500199A (ja) 1989-01-26
DK175889B1 (da) 2005-05-30
DK393288D0 (da) 1988-07-14
KR960005708B1 (ko) 1996-05-01
EP0289584A1 (en) 1988-11-09
NO883127L (no) 1988-09-12
OA09159A (en) 1992-03-31
DK393288A (da) 1988-09-13
NO883127D0 (no) 1988-07-13
DE3785758D1 (de) 1993-06-09
MX170454B (es) 1993-08-24

Similar Documents

Publication Publication Date Title
JPH0581569B2 (enExample)
US4861757A (en) Wound healing and bone regeneration using PDGF and IGF-I
US5019559A (en) Wound healing using PDGF and IGF-II
CA2040410C (en) Wound healing compositions containing il-1 and a growth factor
EP0394349B1 (en) Wound healing
EP0382841B1 (en) Wound healing
EP0479799B1 (en) Wound healing
US5256644A (en) Wound healing using IGF-II and TGF
EP0531425A1 (en) Wound healing
AU613776B2 (en) Wound healing

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