JPH0559780B2 - - Google Patents
Info
- Publication number
- JPH0559780B2 JPH0559780B2 JP703986A JP703986A JPH0559780B2 JP H0559780 B2 JPH0559780 B2 JP H0559780B2 JP 703986 A JP703986 A JP 703986A JP 703986 A JP703986 A JP 703986A JP H0559780 B2 JPH0559780 B2 JP H0559780B2
- Authority
- JP
- Japan
- Prior art keywords
- solute
- container
- solvent
- bottle
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002904 solvent Substances 0.000 claims description 28
- 229920002457 flexible plastic Polymers 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 description 10
- 238000011109 contamination Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Description
【発明の詳細な説明】
〔発明の利用分野〕
本発明は、例えば体外診断用医薬品等に於て、
夫々別々の容器に入つている凍結乾燥品等被溶解
質（溶質）と例えば緩衝液の如き溶解剤（溶媒）
とを用時混合して、該溶質を該溶媒に溶解若しく
は懸濁せしめんとする際の効果的な混合方法に関
する。[Detailed Description of the Invention] [Field of Application of the Invention] The present invention is applicable to, for example, in vitro diagnostic drugs, etc.
A lyophilized substance (solute) and a solubilizing agent (solvent) such as a buffer solution, each in a separate container.
It relates to an effective mixing method for dissolving or suspending the solute in the solvent by mixing the solute before use.
例えば体外診断用医薬品等の商品にあつては、
多くの場合酵素等の凍結乾燥品やその他の粉末等
被溶解質（溶質）と、これを溶解する例えば緩衝
液の如き溶解剤（溶媒）とが、別々の容器、多く
の場合びんに別々に容れられてセツトされてお
り、用時に両者を混合して使用すべく指定されて
いる。このような場合、溶質がびんから全量とり
出し難いとか、汚染を防止する目的からとかの理
由で、上記別々のびんを第４図に示す通りコネク
ターでつないで、両方のびんを一見一体となし、
振り混ぜる方法がとられることが多い。
For example, for products such as in vitro diagnostic drugs,
In many cases, the solute (solute), such as a freeze-dried product such as an enzyme or other powder, and the solubilizing agent (solvent), such as a buffer solution, are kept in separate containers, often bottles. It is specified that the two should be mixed together at the time of use. In such cases, because it is difficult to remove the entire amount of solute from the bottle, or for the purpose of preventing contamination, the separate bottles may be connected with a connector as shown in Figure 4, making both bottles appear to be one. ,
A method of shaking is often used.
その場合、コネクターは当然容器のびんと同様
に清浄に保持されねばならず、１組のびんに対し
ては常に１個を用意して汚染を防止せねばならぬ
等、幾多の不便不都合がつきまとつていた。 In that case, the connector must be kept clean just like the bottles in the container, and there are many inconveniences such as having to always prepare one connector for each set of bottles to prevent contamination. It was a mess.
本発明は、上記した如き状況に鑑みなさたもの
で、夫々別々の容器に入つている溶質と溶媒とを
コネクターを使用せず、しかも液漏れや汚染の心
配をすることなく、極めて効果的に混合し得る方
法を提供することを目的とする。
The present invention was developed in view of the above-mentioned circumstances, and it is possible to extremely effectively transfer solute and solvent contained in separate containers without using a connector and without worrying about liquid leakage or contamination. The purpose is to provide a method that allows mixing.
本発明は、夫々別々の容器に入つている溶質と
溶媒とを用時に混合して該溶質を該溶媒に溶解若
しくは懸濁せしめんとするに当り、溶質容器とし
てバイアルびん等のガラスびん或は硬質プラスチ
ツク製のびんを用い、溶媒容器として溶質容器の
びん口に僅かな力をもつて嵌合できるようびん口
の内径を溶質容器のびん口の外径より微少に小さ
くした可撓性プラスチツク製のびんを用いて、溶
質容器のびん口と溶媒容器のびん口とを嵌合さ
せ、振とうすることにより該溶質と該溶媒とを混
合させることを特徴とする、別々の容器に入つて
いる溶質と溶媒との混合方法である。
In the present invention, when a solute and a solvent contained in separate containers are mixed at the time of use and the solute is dissolved or suspended in the solvent, a glass bottle such as a vial or a glass bottle such as a vial is used as the solute container. A flexible plastic bottle that uses a hard plastic bottle and has an inner diameter slightly smaller than the outer diameter of the solute container so that it can be fitted into the solute container with little force as a solvent container. The solute and the solvent are mixed by fitting the bottle opening of the solute container and the bottle opening of the solvent container using a plastic bottle and shaking the bottle, which are contained in separate containers. This is a method of mixing solute and solvent.
即ち、本発明者らは、夫々別々の容器に入つて
いる溶質と溶媒とをコネクターを使用せずに、効
果的に、液漏れや汚染の心配をすることなく混合
し得る方法を求めて鋭意研究を重ねた結果、バイ
アルびん等のガラスびん或は硬質プラスチツク製
のびん等の溶質容器に対し、溶媒容器として溶質
容器のびん口に僅かな力をもつて嵌合できるよう
びん口の内径を溶質容器のびん口の外径より微少
に小さくした可撓性プラスチツク製のびんを用
い、溶質容器のびん口と溶媒容器のびん口とを嵌
合させ、振とうすることにより該目的を達成し得
ることを見出し本発明を完成するに到つた。 That is, the present inventors have worked diligently to find a method that can effectively mix solute and solvent, which are contained in separate containers, without using a connector and without worrying about liquid leakage or contamination. As a result of repeated research, we have determined that the inner diameter of the bottle opening can be adjusted to fit solute containers such as glass bottles such as vials or hard plastic bottles as a solvent container into the bottle opening of the solute container with a slight force. This purpose is achieved by using a flexible plastic bottle whose outer diameter is slightly smaller than the outer diameter of the solute container's bottle spout, fitting the solute container's bottle spout with the solvent container's bottle spout, and shaking the bottle. The present invention was completed based on the discovery that the present invention can be obtained.
本発明に用いられる可撓性プラスチツクとして
は、殆ど凡ゆる液状内容物に適用できる軟質ポリ
エチレンが最も代表的なものとして挙げられる
が、勿論これに限定されるものではない。 The most typical flexible plastic used in the present invention is soft polyethylene, which can be used for almost any liquid content, but is not limited thereto.
本発明は、溶質容器をバイアルびんなどのガラ
スびんとか硬質のプラスチツクびんに選び、溶媒
容器として上記可撓性プラスチツク製のびんを用
い、且つびん口の内径を、溶質容器のびん口の外
径より微少に小さく、即ち、溶質容器のびん口を
溶媒容器のびん口に、僅かな力を以て嵌合できる
寸法にし、第１図の如く溶質容器のびん口を溶媒
容器のびん口に嵌合させて振りまぜることにより
実施される。 In the present invention, the solute container is selected from a glass bottle such as a vial or a hard plastic bottle, and the above flexible plastic bottle is used as the solvent container, and the inner diameter of the bottle opening is set to the outer diameter of the bottle opening of the solute container. The size is slightly smaller, that is, the size is such that the solute container's bottle spout can be fitted into the solvent container's bottle spout with a slight force, and the solute container's bottle spout is fitted into the solvent container's bottle spout as shown in Figure 1. This is done by shaking the mixture.
本発明のより効果的な実施態様としては、可撓
性プラスチツク製のびんのびん口内面に第２図に
示す如き段差を設け、これを溶媒容器として用い
る方法が挙げられる。この場合には、溶質容器の
びん口の挿入を本段差を以て停止させることがで
きるので、挿入の程度を加減する必要がなく、標
準化でき、また、溶質容器のびん口と本段差との
接合によつて、振りまぜるときの液漏れがより防
止できる。その嵌合の状態は第３図に示す通りで
ある。 A more effective embodiment of the present invention is to provide a step as shown in FIG. 2 on the inner surface of the mouth of a flexible plastic bottle and use this step as a solvent container. In this case, the insertion of the solute container bottle opening can be stopped at this level difference, so there is no need to adjust the degree of insertion and standardization can be achieved. Therefore, liquid leakage during shaking can be further prevented. The fitted state is as shown in FIG.
本発明の方法によれば、液漏れや汚染の恐れが
極めて少なく、またコネクターという無駄なもの
の介在が不要となり、操作も極めて簡易であり、
コネクター使用の欠点は一挙に解消された。 According to the method of the present invention, there is extremely little risk of liquid leakage or contamination, and there is no need for a useless connector, and the operation is extremely simple.
The disadvantages of using connectors were eliminated at once.
尚、本発明の適用範囲は、例えば酵素類と緩衝
液との組合せの如き体外診断用医薬品の分野のみ
に限定されるものではない。 The scope of application of the present invention is not limited to the field of in vitro diagnostic drugs, such as combinations of enzymes and buffer solutions.
以上述べた如く、本発明は、夫々別々の容器に
入つている溶質と溶媒とをより効果的に混合し得
る方法を提供するものであり、本発明の方法によ
れば、操作が簡便で、液漏れや汚染の恐れが絶無
に近く、また、コネクターという無駄なものの介
在が不要となつた点等に顕著な効果を奏するもの
である。
As described above, the present invention provides a method for more effectively mixing a solute and a solvent contained in separate containers.According to the method of the present invention, the operation is simple, This has a remarkable effect in that there is almost no risk of liquid leakage or contamination, and there is no need for a useless connector.
第１図は本発明の方法による混合溶解操作を示
し、第２図は本発明の実施態様の一つに係る段差
を設けた可撓性プラスチツク製びんのびん口の断
面図を示し、第３図は第２図の如きびん口を有す
る溶媒容器を用いた場合の本発明の方法に係る嵌
合の状態を断面図で示し、第４図は従来のコネク
ター使用の状態を断面図で示す。図中の符号は、
１は溶質容器、２は溶媒容器、３は従来のコネク
ターを示す。
FIG. 1 shows the mixing and dissolving operation according to the method of the present invention, FIG. The figure shows a sectional view of a fitting state according to the method of the present invention when a solvent container having a bottle opening as shown in FIG. 2 is used, and FIG. 4 shows a sectional view of a state in which a conventional connector is used. The symbols in the diagram are
1 is a solute container, 2 is a solvent container, and 3 is a conventional connector.
Claims (1)
用時に混合して該溶質を該溶媒に溶解若しくは懸
濁せしめんとするに当り、溶質容器としてバイア
ルびん等のガラスびん或は硬質プラスチツク製の
びんを用い、溶媒容器として溶質容器のびん口に
僅かな力をもつて嵌合できるようびん口の内径を
溶質容器のびん口の外径より微少に小さくした可
撓性プラスチツク製のびんを用いて、溶質容器の
びん口と溶媒容器のびん口とを嵌合させ、振とう
することにより該溶質と該溶媒とを混合させるこ
とを特徴とする、別々の容器に入つている溶質と
溶媒との混合方法。1. When mixing a solute and a solvent that are contained in separate containers at the time of use and dissolving or suspending the solute in the solvent, the solute container may be a glass bottle such as a vial or a hard plastic bottle. A flexible plastic bottle with an inner diameter slightly smaller than the outer diameter of the solute container spout is used as a solvent container so that it can be fitted into the solute container spout with a slight force. A solute and a solvent contained in separate containers, characterized in that the solute and the solvent are mixed by fitting the bottle opening of the solute container and the bottle opening of the solvent container and shaking. How to mix with.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP703986A JPS62163734A (en) | 1986-01-16 | 1986-01-16 | Mixing method |
| US07/000,173 US4779991A (en) | 1986-01-16 | 1987-01-02 | Bottle for mixing and method for mixing with the said bottle |
| ES198787100455T ES2027232T3 (en) | 1986-01-16 | 1987-01-15 | BOTTLE TO MIX AND METHOD TO MIX WITH SUCH BOTTLE. |
| EP87100455A EP0230273B1 (en) | 1986-01-16 | 1987-01-15 | Bottle for mixing and method of mixing with the said bottle |
| AT87100455T ATE70245T1 (en) | 1986-01-16 | 1987-01-15 | MIXING BOTTLE AND MIXING PROCEDURE USING THIS BOTTLE. |
| DE8787100455T DE3775071D1 (en) | 1986-01-16 | 1987-01-15 | MIXING BOTTLE AND MIXING METHOD WITH THIS BOTTLE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP703986A JPS62163734A (en) | 1986-01-16 | 1986-01-16 | Mixing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62163734A JPS62163734A (en) | 1987-07-20 |
| JPH0559780B2 true JPH0559780B2 (en) | 1993-08-31 |
Family
ID=11654902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP703986A Granted JPS62163734A (en) | 1986-01-16 | 1986-01-16 | Mixing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62163734A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002028220A (en) * | 2000-05-09 | 2002-01-29 | Kanto Chem Co Inc | Housing bag for medical liquid agent |
-
1986
- 1986-01-16 JP JP703986A patent/JPS62163734A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62163734A (en) | 1987-07-20 |
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