JPH05295391A - Cleaning fluid for hard contact lens - Google Patents

Abstract

PURPOSE:To obtain the objective fluid which has excellent cleaning power, does not injure the lens surface, can prevent the readhesion of stains during cleaning and can protect the hydrophilicity of the lens by mixing at least one member selected from among SiO2, Al2O3 and TiO2 each of which has a specified particle diameter with a surfactant. CONSTITUTION:At least one member selected from among SiO2, Al2O3 and TiO2 each of which has a mean particle diameter of 20-100nm is mixed with a surfactant to obtain this fluid. This fluid has excellent power of cleaning stains such as lacrimal components or cosmetics, scarcely injures the lens surface, and can keep the hydrophilicity of the lens.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cleaning solution for hard contact lenses.

[0002]

2. Description of the Related Art Up to now, various cleaning solutions for hard contact lenses have been known. However, with the development of a lens having a high oxygen permeability, problems have arisen that the lens is soft and therefore the lens is easily scratched by cleaning, and the cleaning power for dirt is insufficient. In order to improve this, various cleaning liquids for oxygen permeable lenses have been developed (for example, JP-A-56-6215 and JP-A-63-146017). However, these have insufficient dirt cleaning power for contact lenses, particularly oxygen permeable hard contact lenses, and thus have a low oxygen permeability coefficient (Dk).
A contact lens having a value of more than 70 has a drawback of causing fine scratches on its surface.

[0003]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide excellent cleaning power for hard contact lenses, particularly tear components adhering to oxygen-permeable hard contact lenses or stains such as cosmetics, and to prevent scratches on the lens surface. The purpose of the present invention is to provide a cleaning liquid that maintains the hydrophilicity of the lens.

[0004]

Means for Solving the Problems As a result of intensive studies on a cleaning solution for hard contact lenses, the present inventors have found that a cleaning solution containing a specific inorganic fine powder and a surfactant removes stains well, and The present invention was found to prevent the occurrence of scratches on the surface and maintain the water wettability of the lens, and the present invention has been completed based on this finding.

That is, the present invention has an average particle size of 20 to
It is a cleaning liquid containing one or more kinds selected from 100 nm of silicon oxide, aluminum oxide and titanium oxide and a surfactant. The inorganic fine powder of the present invention has an average primary particle diameter of 20 to 100 n measured by an electron microscope.
It is necessary that the average particle size is 20 to 40 nm, because it has a good balance of storage stability of the cleaning liquid, prevention of scratches on the lens surface, and cleaning ability. If the thickness is less than 20 mm, the cleaning ability is small and the hydrophilicity retaining ability of the lens surface is poor. Also, 100 nm
Large particles that exceed the range have poor cleaning ability and are likely to be scratched on the lens surface.

As the inorganic fine powder of the present invention, silicon chloride,
There are silicon oxide, aluminum oxide, titanium oxide, etc. produced by high-temperature hydrolysis of metal chlorides such as aluminum chloride and titanium chloride in oxyhydrogen flame. One or a mixture of two or more selected from these is available. used. Among these, titanium oxide is more preferable because it has less scratches on the lens surface and has excellent cleaning ability.

By using the inorganic fine powder of the present invention, the hydrophilicity of the lens can be maintained. The inorganic fine powder of the present invention is used at about 0.1% by weight to about 10% by weight. The surfactant of the present invention is any one of a nonionic surfactant, an anionic surfactant, a cationic surfactant or an amphoteric surfactant, or a nonionic surfactant and an ionic surfactant. A mixture with any of the above can be used.

As the nonionic surfactant, poly (oxyethylene) -poly (oxypropylene) block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ester, polyoxyethylene. Mixtures of one or more selected from sorbitan alkyl ester, polyoxyethylene hydrogenated castor oil and the like can be used.

Examples of the anionic surfactant include sodium alkylbenzene sulfonate, sodium alkyl sulfate, sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether sulfate, sodium alkyloylmethyl taurine, sodium alkyloylbenzalcosinate, and poly sodium. It is possible to use one kind or a mixture of two or more kinds selected from sodium oxyethylene alkyl ether phosphate, sodium di (polyoxyethylene alkyl ether) phosphate, sodium polyoxyethylene alkylphenyl ether sulfate and the like.

As the cationic surfactant, one kind or a mixture of two or more kinds selected from alkylamine salts, alkylammonium salts and the like can be used. Examples of the amphoteric surfactant include alkyl imidazoline type, alkyl sulfobetaine type, alkyl acetate betaine type, and the like. For example, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N- Sodium carboxymethyl-N-carboxymethyloxyethyl imidazolinium betaine, coconut oil fatty acid amide propyldimethylhydroxysulfopropylammonium betaine, lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amide propyldimethylaminoacetic acid betaine, etc. Or, a mixture of two or more kinds can be used. Of these, glycine-type amphoteric surfactants are preferable because they have a good balance of detergency and bactericidal activity, and examples thereof include N-lauroylaminopropyl-N, N-dimethylglycine and N-cocoylaminopropyl-N,
N-dimethylglycine, N-lauroylaminopropyl-N-carboxymethyl-N-hydroxyethylglycine, N-oleylaminopropyl-N-carboxymethyl-N-hydroxyethylglycine, N-3dodecyloxy-2-hydroxypropyl-N, N-dimethylglycine, N-cocoylaminopropyl-N-hydroxyethyl-3-amino-propionic acid, tree (3- (N-
Cocoylaminoethyl-N-hydroxyethyl-N-carboxymethyl) amino-2-hydroxy-propanol) phosphate, alkyldiaminoethylglycine
Hydrochloride (Alkyl group is mainly composed of those containing 12 and 14 carbon atoms) 1
One kind or a mixture of two or more kinds can be used.

The surfactant of the present invention comprises about 0.01% by weight.
Used at about 10% by weight. The type of these surfactants is selected according to the type of gas permeable hard contact lens, but in general, poly (oxyethylene)
One or more selected from poly (oxypropylene) block copolymers, polyoxyethylene alkyl ethers, polyoxyethylene alkyl esters, polyoxyethylene alkylphenyl ethers, sodium alkylbenzenesulfonate, sodium alkylsulfate, One or two or more selected from sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether sulfate, sodium polyoxyethylene alkylphenyl ether sulfate and the like have excellent detergency when combined with the above inorganic fine powder, It is preferable because dirt is prevented from being redeposited when the lens is washed, the dimension of the lens is not changed, and the hydrophilicity of the lens is maintained to improve the wearing feeling.

If desired, the cleaning solution of the present invention contains isotonic solution components such as sodium chloride, potassium chloride, sodium bicarbonate, sodium phosphate, sodium borate and boric acid in an amount of 0 to about 10% by weight, EDTA.2Na, 0 to about 0.7% by weight of a chelating agent such as trihydroxymethylaminomethane and 0 to about 2% by weight of a thickening agent such as polyethylene glycol, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone or polyvinyl alcohol are used together. it can.

[0013]

EXAMPLES The present invention will be described in more detail with reference to Examples and Comparative Examples. The characteristic evaluation in the examples was carried out by the following methods. <Dirt detergency test> 1. Lipid and protein stain test Mix 8 g of egg white with 0.1 g of sodium chloride, add 2 g of beef tallow heated to about 40 ° C, mix well, apply to a lens, and leave in a thermostat at 37 ° C for 8 hours. The lens was washed with a test liquid (cleaning liquid), and the degree of stain remaining on the lens surface was evaluated by observing with a polarizing microscope.

Rank 1 ... No stain is recognized. Rank 2 ... Slightly stains remain. Rank 3: Dirty remains on more than half of the lens surface. The cleaning was performed by the three-finger method (thumb, index finger, middle finger). 2. Cosmetic stain test: Apply half of the front surface of the lens with a liquid black eyeliner (Selfit manufactured by Shiseido Co., Ltd.) and air dry.
Repeated times to create a model soil sample.

This lens was washed with a test liquid (washing liquid) and the degree of stain remaining on the lens surface was observed. Rank 1 ... No stain is observed. Rank 2 ... Slightly stains remain. Rank 3 ... Almost all of the painted eyeliner remains.

The cleaning was performed by the three-finger method (thumb, index finger, middle finger). <Lens hydrophilicity test> After immersing the lens in a lens preservation solution for 2 weeks to make the lens surface hydrophilic, it is washed with a test solution (washing solution) for 30 seconds, the lens is washed with purified water, and then physiological saline is added. The lens was held vertically by rinsing with water and the state of water adhesion on the surface was observed.

Rank 1 ... The entire surface of the lens is wet. Rank 2: More than half of the lens surface is wet. Rank 3 ...- Wet only locally. <Dimensional Stability of Lens> The lens was immersed in the test solution, and the base curve of the lens was measured after 1 week and 1 month, and compared with that before immersion.

Rank 1 ... The base curve does not change. Rank 2 ... Change is within 0.05 mm. Rank 3 ... Change exceeds 0.05 mm. <Average particle size> Dispersing the sample in methanol by 1% by weight,
The adhesive surface of the adhesive tape was evenly sprayed and dried. An electron microscope [S-53 manufactured by Hitachi, Ltd.]
[0] was fixed to the sample holder and the photograph was taken at a magnification of 100,000 times or more, and the diameter of each particle in two directions was measured. Randomly measured values of 30 particles were averaged to obtain an average particle diameter.

[0019]

Example 1 5.0 g of titanium oxide (Titanium Dioxide P25 manufactured by Degussa, Germany, average particle size of primary particles measured by an electron microscope is about 21 nm) 5.0 g, sodium polyoxyethylene stearyl sulfate 8.0 g, lauryl Dissolve 0.25 g of sodium sulfate in 100 ml of purified water,
A washing solution was prepared by further adding 3.0 g of sodium chloride and uniformly dissolving it.

As a result of carrying out a washing test of this washing liquid, fat and protein stains were almost completely washed and no stain was found on the lens in the cosmetic stain test. As a result of observing the lens surface after this washing with a polarizing microscope, no scratch was recognized on the surface. Also, the performance was excellent in both the hydrophilicity test and the dimensional stability test. The results are shown in Table 1. There was also no aggregation during storage.

Furthermore, after performing a cleaning test for two years, the performance of the lens was inspected, and it was found that there was no dimensional change, change in optical performance, scratches on the surface, etc., and no influence was given to the lens. I understood.

[0022]

Example 2 2.5 g of aluminum oxide fine powder (manufactured by Degussa of Germany, aluminum oxide C, average particle size of primary particles measured by an electron microscope is about 20 nm) 2.5 g, poly (oxyethylene) -poly (oxypropylene) ) 10 g of block copolymer (Pluronic, L-64) was dissolved in 100 ml of purified water, 0.9 g of sodium chloride, EDT
A. Disodium 0.1 g, boric acid 0.12 g, and borax 0.03 g were further added and uniformly dissolved to prepare a cleaning liquid.

As a result of carrying out a washing test of this washing solution, fat and protein stains were almost completely washed, and no stain was found on the lens in the cosmetic stain test. Also, the performance was excellent in both the hydrophilicity test and the dimensional stability test. The results are shown in Table 1. There was also no aggregation during storage. As a result of inspecting the performance of the lens after performing a cleaning test for two years, the center thickness of the lens was reduced by 1 μm, and there was no dimensional change, change in optical performance, or surface damage. ..

[0024]

Comparative Example 1 2.5 g of silicon oxide (average particle size of primary particles measured by an electron microscope is about 3 μm) and 2.25 g of polyoxyethylene (20) sorbitan monooleate were dissolved in 100 ml of purified water and chlorinated. A washing solution was prepared by further adding 9.0 g of sodium and dissolving it uniformly. As a result of carrying out the washing test of this washing solution, a slight amount of fat and protein stains remained, and stains were found on the lens in the cosmetic stain test.
Also, many scratches were observed on the lens surface. The results are shown in Table 1.

[0025]

[Example 3] Silicon oxide (AERO manufactured by Degussa of Germany)
SIL OX50, the average particle diameter of primary particles measured by an electron microscope is 40 nm) 2.5 g, polyoxyethylene (20) sorbitan monooleate 2.25 g is dissolved in purified water 100 ml, and sodium chloride 9.0 g is further added. In addition, it was dissolved uniformly to prepare a cleaning solution.

As a result of carrying out the washing test of this washing solution, the fat and protein stains were washed almost completely, and the cosmetic stain test showed no stains on the lens and no scratches. The lens was immersed in this cleaning solution for 1 week to measure the dimensional change of the lens. The power was -15.00 and -9.0.
There was no change in the lenses of 0 and -6.00, and the base curve was stable. The results are shown in Table 1. There was also no aggregation during storage.

[0027]

[Comparative Example 2] Silicon oxide (made by Degussa of Germany, AERO
SIL130, 2.5 g of primary particles having an average particle size of about 16 nm measured by an electron microscope, polyoxyethylene (2
0) 2.25 g of sorbitan monooleate was added to purified water 10
It was dissolved in 0 ml and 9.0 g of sodium chloride was further added to uniformly dissolve it to prepare a washing solution. As a result of carrying out the washing test of this washing solution, a slight amount of fat and protein stains remained, and stains were found on the lens in the cosmetic stain test. The results of the cleaning test are shown in Table 1.

[0028]

Example 4 Titanium oxide (manufactured by Degussa of Germany, titanium dioxide P25, average value of primary particles measured by an electron microscope is about 21 nm) 1.2 g, silicon oxide (manufactured by Degussa of Germany, AEROSIL OX- 50, average particle size of primary particles measured by electron microscope is about 40 nm)
1.3 g, sodium polyoxyethylene stearyl sulphate 2 g, sodium lauryl sulphate 0.25 g, polyethylene glycols having an average degree of polymerization of 400 and 1000, 1.0 g and 4.5 g, respectively, and 1.0 g of hydroxyethyl cellulose were dissolved in 100 ml of purified water. , 9.0 g of sodium chloride were further added and uniformly dissolved to prepare a cleaning liquid.

As a result of carrying out a washing test of this washing solution, fat and protein stains were almost completely washed, and no stain was found on the lens in the cosmetic stain test. As a result of observing the lens surface after this washing with a polarizing microscope, no scratch was recognized on the surface. Also, the performance was excellent in both the hydrophilicity test and the dimensional stability test. There was also no aggregation during storage.

[0030]

[Table 1]

[0031]

EFFECTS OF THE INVENTION The present invention is directed to stains (lipids,
It provides an excellent cleaning solution having excellent cleaning power for proteins, cosmetics, etc., preventing redeposition of stains during cleaning, scratching the lens surface, maintaining the hydrophilicity of the lens, and not causing dimensional change of the lens.

Claims (1)

[Claims] 1. A 1 selected from silicon oxide, aluminum oxide and titanium oxide having an average particle diameter of 20 to 100 nm.
A cleaning liquid for hard contact lenses, which contains one or more kinds and a surfactant.