JPH0528209B2 - - Google Patents

Description

[Detailed description of the invention]

[Field of Application] The present invention relates primarily to a composition used to improve the moisture content of the skin. As is known, the environment, especially the atmosphere, has a variety of effects on the skin of many people by causing sensitization or sensitivity. Hemorrhoids and other diseases often combine with venous drainage to cause unpleasant symptoms. A wide variety of solutions have been described in the literature for the treatment of these conditions, and a review of these would be beyond the scope of a typical patent specification. There are several known solutions, including: 1) a soothing and analgesic effect on sensitized or sensitized skin;
2. Provides a pore-constricting effect in the case of fatty skin, especially sensitized skin. 3. Provides a regenerative, nutritional and epithelializing effect on the skin. 4. Provides a stimulating effect on local circulation. , 5 preservative and bactericidal action,
A solution that simultaneously provides a mild antiperspirant effect would meet societal demands. The compositions of the invention contain from 2 to 50% by weight of active ingredient, based on the total weight of the composition, together with the carriers and/or vehicles normally used in the preparation of the compositions. The active ingredient consists of the following % by weight, based on the total weight of the composition: Namely: 1. Roman Camillera oil 0.05-0.50 2. Lavender resinoid 0.5-5.0 3. Alcoholic extract of oak bark 0.5-5.0 4. Water extract of Potenteira anserina
1.0-10.0 5 Water extract of Dijuglans 0.0-5.0 Optionally 1 Camille oil 0.01-0.25 2 Water extract of Camille 0.5-5.0 3 Water extract of Salvia 0.5-5.0 4 Alcoholic extract of willow bark 0.5-5.0 5 Pot Concrete 0.5-5.0 Compositions of the above composition can be used on any type of skin, including dry and/or sensitized skin, as well as fatty and anhydrous skin, and fatty skin. can be used. The frequency of use and the amount to be used should be determined by a skilled skin care practitioner. The compositions of the invention can be used to reverse the condition of hemorrhoids and small surface veins, especially in combination with other pharmaceutical or surgical treatments for the pre- or post-treatment of these conditions. can do. The compositions of the invention can be prepared by conventional methods for preparing cosmetics, such as creams, emulsions, solutions or drops, baths or compositions for application. A particularly advantageous application is the production of sanitary napkins by soaking conventional carriers, such as fibrous or paper, in so-called base solutions. The total content of active ingredients in the compositions of the invention can vary depending on the form of use. For example, in the case of creams or emulsions, the total content of active ingredients ranges from 2 to
20% is preferred; in the case of bath-like preparations this range is 3-30% and in the case of lubricating substances and base solutions for the manufacture of sanitary napkins 10-15%. The preparation of the compositions according to the invention can be carried out by techniques routinely used in cosmetic engineering, but the active ingredient mixture may be prepared in small amounts before mixing with the carriers and/or media normally used for the preparation of cosmetic compositions. It should be noted that it passes through a pore filter. The active ingredient mixture of the compositions of the invention is a mixture of extracts from various plants with water, alcohol, preferably ethyl alcohol. This mixture is a transparent brown liquid with the aroma characteristic of herbal medicines, and its pH when diluted with an equal volume of water is 4.0~
It is 6.0. This solution can be stored for one year at a temperature of 5 to 25°C if sealed in a light-tight container. Storage for longer periods of time will result in the formation of fine precipitates, so it is useful to strain the mixture before making the final product. The physical properties of each component of the active ingredient mixture are as follows. A Essential Active Ingredient 1 Roman Camille Oil (Anthemis nobilis, Flos) This essential oil has a characteristic aroma and fluid consistency. Immediately after preparation, it is dark green, but during storage it turns greenish-brown, especially under the influence of light. Viscosity is 8±
4mPa.s, and the pH of the aqueous suspension (1+50) is 3.0
~4.5. 2 Lavender Resinoid (Lavendra officinalis, Helva) A jam-like mass with a unique lavender aroma.
It is dark green. The pH of the aqueous suspension (1+50) is 3.0
~4.5. 3. Alcoholic Extract of Oak Bark (Cercus Roble, Cortex) This neutral product has a slight alcohol odor and a dark green color. Immediately after preparation, it has a high viscosity, but if left undisturbed, the consistency changes to a solid and becomes brittle. The dry matter content immediately after preparation is 35-45%,
The preparation becomes thick during storage. Aqueous suspension (1:
The pH of 1) is 4.0 to 5.0. 4. Aqueous extract of Potenteira anserina (Potenteira anserina, Helva) This preparation has an aroma similar to boiled oxalis, is dark brown in color, has a dense jam-like consistency, and is dried immediately after preparation. Substance content is 40-55%
It is. The pH of the water dilution (1:1) is 4.0-5.0. 5 Water extract of Diuglans leaves (Dyuglans regia, folium) This lumpy substance has a mild aroma, is black in color,
The consistency is pitch-like and the dry matter content immediately after preparation is 40-50%. Water diluted solution (1:
The pH of 1) is 4.0 to 6.0. B Optional Active Ingredients 1 Camille Oil (Matricaria Chamomilla, Floss) This fluid oil has a mild aroma characteristic of Camille or sunflower stumps and is dark blue in color immediately after preparation, but after storage: Especially under the influence of light, it turns green, then rust brown. Its viscosity is 5±3mPa.s
and the pH of the aqueous dispersion (1+50) is 4.5 to 5.5. 2. Water Extract of Camille (Matricaria chamomilla, floss) This preparation has a mild aroma, is dark brown in color, and is thick fluid in consistency, with a dry matter content of 40-50% immediately after preparation. . Water diluted solution (1:
The pH of 1) is 4.0 to 5.5. 3 Salvia aqueous extract (Salvia oficinalis, folium) It has a characteristic aroma resembling wild rose jam or fruit juice, is dark brown in color, jam-like in consistency, and has a dry matter content of 40 to 40% immediately after preparation. It is 50%. The PH for aqueous suspensions is 4.5-5.5. 4. Alcoholic extract of willow bark (Salix alba, Cortex) A thick fluid with a mild alcoholic odor, neutral and dark brown in color, with a dry matter content of about 70-80%. The pH of the water suspension (1:1) is
It is between 3.5 and 5.5. 5 Hop Concrete (Humulus lupulus, Stropulus) It has a mild aroma, is dark brown in color, and has a rough resinous consistency, but is processable and soluble, with a water content of 1 to 2%, at most
It is 15%. The pH of water suspension (1+50) is 3.5 to 5.5
It is. The above active ingredient is prepared as follows. 1 Roman Camillera Oil An essential oil separated by steam distillation from the flower stalks of Antomys nobilis L. This flowering plant is not a wild Hungarian plant, but many improved varieties are cultivated. This essential oil does not contain detectable amounts of plant protection components by gas chromatography. This plant is steam-distilled at a pressure of 300 to 400 kPa in a stainless steel distiller equipped with a steam pipe and a cooling coil. The distillation rate is 80 to 100/h, and the distillate is stored in a glass receiver. 2. Lavender Resinoid Lavender resinoid is extracted from the flower stalks of the annual Lavendra veera L by distilling a volatile solvent and drying. The dried plant, preferably after being ground, is first extracted with dichloromethane, then the solvent is evaporated from the extract and, after cooling, the residue is dissolved in ethyl alcohol. This alcohol should have a purity of 90%, and it is preferable to use 10 times the volume. 3 Alcoholic extract of oak bark Quercus ropul L, Quercus boudonculata Ehrh, Quercus petri L or Quercus
Prepared by extracting the bark of Ceciliflore sarisbus with 50% ethyl alcohol. After crushing the bark, 50%
soaked in ethyl alcohol, the soaking time is preferably 12 hours, then the alcohol solution is taken out and filtered,
Evaporate to a dry matter content of approximately 50%. The bark used as a raw material is collected only from trees that do not have cork bark and are less than 10 cm in thickness. 4 Alcohol extract of willow resin Extract the bark of Salix caprea L with 50% ethyl alcohol. After the bark is ground, it is soaked in 50% ethyl alcohol, the soaking time being preferably 12 hours, and then the alcohol solution is filtered and evaporated to a dry matter content of about 50%. Since this extract has a relatively high sugar content and coagulates, it is preferred to prepare the extract immediately before use. 5. Hop Concrete Prepared from the peduncles of a plant called "hop cone" in substantially the same manner as in the preparation of lavender resinoid above. 6 Potenteira anserina water extract The stems, leaves and flowers of Potenteira anserina L are dried and crushed as above and soaked in 10 times the volume of water. Preferably, the water is heated to 55°C. The temperature is kept constant for 4 hours and the aqueous extract obtained is filtered and distilled. At this time, the pressure is preferably 6 kPa.
For economical reasons, the dipping is repeated three times. 7. Water extract of Diuglans leaves Dry the leaves of Diuglans regia L and soak in 10 times the volume of water. The water is preferably heated to 55° and, after being kept at this temperature for at least 4 hours, the aqueous extract obtained is filtered and distilled. At this time, the pressure is preferably 6 kPa. For economic reasons, the dipping is repeated three times. 8 Camille water extract and Camille oil To extract this ingredient, Avisabole content 20%
As described above, it is preferable to select and use chamomile having a chamomile content of 3% or more in the essential oil. The raw Camille substance must be free of impurities and harmful plants. It may contain up to 10% weed as long as it is harmless and does not contain essential oils. The essential oil must not contain plant protection components, even at levels detectable only by gas chromatography. The preparation of Camille essential oil is substantially similar to that of Roman Camille oil. Parallel to the steam distillation, the boiling water condensed at the bottom of the still is collected, mechanical impurities are separated, and the liquid is evaporated to a dry matter content of approximately 50%. At this time, the evaporation pressure is preferably 6 kPa. The jam-like substance produced is
After dissolving in 96% ethyl alcohol, this solution
Refrigerate for 24 hours. Proteins and polysaccharides are separated and separated to obtain a Camille water extract. 9 Salvia water extract Decoct the petiole and flower stalk of Salvia oficinalis L for 4 hours, filter the resulting liquid to remove coagulated polysaccharides and proteins, and vacuum distillate at 60°C. The above active ingredients are mixed as follows. That is, the active ingredients, water extract, alcohol extract, essential oil and lavender resinoid, are mixed separately with the hop concrete used, and the mixtures are combined into a single mixture. Preferably, the active ingredient mixture has an ethyl alcohol content of 40% by volume. This mixture is then preferably filtered under reduced pressure. After storage and cooling for 6 days,
to obtain a “mirror-like” solution. Products for sale are prepared by further processing the active ingredient mixture prepared as described above with carriers and/or media. This will depend on the type of application for a given composition. The most important points in selecting the carrier and/or medium to be used at this time are that substances that sensitize the skin or mixtures made by other manufacturing methods must not be used, and the pH must be between 5.0 and 6.0. be. This PH value is within the most preferable range for the skin. Among the many products, we must first mention sanitary napkins and novel solutions used for treating hemorrhoids, for example during work or travel. For the manufacture of napkins, a suitable fibrous or paper-like carrier is saturated with a base solution containing 10 to 25% of the active ingredient mixture according to the invention. Additionally, the base solution preferably contains glycerin in aqueous ethyl alcohol, thereby promoting adhesion and film-forming properties of the product. Compositions of solutions or drop products for application or other topical treatments are prepared in a similar manner to the base solutions described above. Creams are versatile products and are primarily used to increase the moisture content of the skin. It is prepared by adding 2 to 20% of the active ingredient to the carrier and/or medium. The quality and quantity of the latter are selected depending on the type of skin to be treated. The most useful creams are hydrating, semi-oily (approximately 30%), high water content (55-60%), and low alcohol content (2-4%), with a pH of 4.5-6.5, and active ingredients. Contains a solubilizer that promotes the adsorption of The emulsions are of similar composition but are characterized by a lower dry matter content. In the preparation of creams and emulsions, the active ingredient mixture is first mixed with suitable solubilizers and then the fragrant essence is added. The mixture thus prepared is added to the gelatinized emulsion at a predetermined temperature. Rejuvenating bubble baths and sitz baths, primarily used for the treatment of hemorrhoids and veins, are also advantageous forms of the product. To adjust this, a surfactant is added to 3 to 30% of the active ingredient of the invention. The surfactants are selected in such a way that, on the one hand, they mildly sensitize the skin and, on the other hand, provide an optimal cleansing effect. Appropriate additives are used to provide greasy and preservative properties. The main advantages of the compositions of the present invention are the biologically complex effect, the simple method of preparation and the utilization of natural products as the basic active ingredients. The invention will be explained in further detail by the following examples. Example 1-4 Preparation of cream for skin regeneration This cream consists of three phases A, B, and C, and the composition of each phase is indicated. The components of phase A, the oil phase, are melted at 70-75°C in a water bath. In the preparation of phase B, ie the aqueous phase, after dissolving the solubilizing additive in the mixture of water and other solvents used, the temperature is adjusted to 72-77°C. The components of Phase C, ie fresh active ingredient, perfume composition, and solubilizer, are mixed separately. Phase A at 70-75°C is added with stirring to phase B at 72-75°C in a double-walled container and the resulting mixture is stirred for 5 minutes without cooling. The mixture is slowly cooled while stirring. When the temperature reached approximately 50°C, phase C was added while stirring the system, and finally 25°C was added.
Continue stirring until cooled to ~30°C.

【table】

[Table] Laurate Fragrance composition 0.3 0.3 0.3 0.3
1) Contains all 10 possible active ingredients.
2) Contains 5 essential active ingredients.
Experiments Demonstrating the Effects of the Present Invention Purpose Generally, it is necessary for the skin surface to contain moisture and appropriate oil in order to maintain the condition and elasticity of the skin. Therefore, manufacturers of cosmetics and external medicines place importance on the water retention effect of their products. Usually, the stratum corneum (stratum corneum) of the skin
corneum) contains 10-20% water. This water content varies depending on the climate and solid state, but if 10
%, water must be added.
The hydration effect can be measured by an increase in skin conductivity, ie a decrease in skin resistance. However, this measurement not only irritates the nerves in the skin, but is also inappropriate in extremely dry conditions. On the other hand, some of the many topical medicines and cosmetics have the effect of changing the temperature of the skin to which they are applied. The increase in temperature of the skin corresponds to increased local blood circulation, which increases the transport of vitamins and other active substances. In other words, it is effective in stimulating and activating the skin. If the skin temperature increases by 0.5° immediately after application, this effect is significant. Methods and Results 1 Sample Composition A Cream of Example 2 Containing 5 Active Ingredients of the Invention 1 Roman Camille Oil 0.1% by weight 2 Lavender Resinoid 2.0% by weight 3 Alcoholic Extract of Oak Bark 4.0% by weight 4 Potenteira water extract of anserina
6.0% by weight 5 Aqueous extract of Dijugrance 4.0% by weight B Cream of Example 2 containing the following three active ingredients of the invention 1 Roman Camille oil 0.1% by weight 2 Lavender resinoid 2.0% by weight 3 Oak bark Alcohol extract 4.0% by weight C Cream 2 of Example 2 which does not contain the active ingredient of the present invention and contains only the substrate Subjects 25 people (5 men, 20 women) 3 Reduction of skin resistance 4 to 4 on hands and feet An 8 cm ² surface was cleaned and samples A, B, and C were applied three times each day. Changes in the electrical resistance of the skin surface were measured using a commercially available measuring device from Medicor Co., Budapest, Hungary. As mentioned above, the decrease in the electrical resistance of the skin surface is due to the increase in the moisture content of the skin. Composition A, which contains 5 active ingredients, shows a significant decrease in skin resistance, Composition B, which contains 3 active ingredients, shows the next highest decrease, while Composition C, which does not contain any active ingredients, shows almost no change. (See Figure 1). 4 Increase in skin temperature Clean the surface of 6 to 10 cm ² of hands and feet, apply samples A, C, B, and C respectively, and measure the temperature change on the applied skin surface for 3 minutes after application. did. Measurements were taken in Vienna, Austria.
A skin thermometer commercially available from Termini Co. was used. The increase in skin temperature is similar to the decrease in skin resistance in sample A.
is the largest, followed by sample B, and sample C, which does not contain the active ingredient, shows almost no change. (Figure 2
reference). Conclusion Both the decrease in the electrical resistance of the skin surface and the increase in temperature were observed in sample A containing the five active ingredients of the present invention.
However, this is remarkable compared to other samples. This is the fifth aspect of the present invention.
The present invention shows that compositions containing active ingredients of seeds have a significant effect on improving the moisture content of the skin. Example 5-8 Preparation of bubble bath and sitz bath The bath consists of A phase and B phase. Each phase is mixed with the ingredients separately, then phase B is added to phase A with stirring, and finally to the resulting mixture is added distilled water and the fresh active ingredient mixture with stirring over a period of several minutes. The finished solution is filtered, eg under pressure.

[Table] Example 9-12: Preparation of coating composition Prepared by mixing the components. Although its primary use is for topical treatment, it can be absorbed into paper cloth and used in the manufacture of sanitary napkins.

【table】 [Brief explanation of the drawing]

FIG. 1 is a graph showing the decrease in electrical resistance of the skin surface coated with the composition for improving skin moisture content of the present invention. FIG. 2 is a graph showing the rise in skin surface temperature immediately after applying the composition for improving skin moisture content of the present invention.

Claims (1)

[Scope of Claims] 1. A cosmetic composition mainly used for increasing the moisture content of the skin, comprising 2 to 50% by weight of total active ingredients, based on the total weight, and a carrier and/or commonly used in the preparation of cosmetics. 1. A cosmetic composition comprising a medium and each active ingredient in the following weight % based on the total weight. 1 Roman Camille oil 0.05-0.5 2 Lavender resinoid 0.5-5.0 3 Alcohol extract of oak bark 0.5-5.0 4 Water extract of Potenteira anserina
0.1-10.05 Water extract of Dijuglans 0.5-5.02 The composition according to claim 1, further comprising the following components by weight based on the total weight. 1 Camille oil 0.01-0.25 2 Water extract of Camille 0.5-5.0 3 Water extract of Salvia 0.5-5.0 4 Alcoholic extract of willow bark 0.5-5.0 5 Pot concrete 0.5-5.0 3 Total active ingredients based on total weight 2 3. A composition according to claim 1 or claim 2, comprising ~20% by weight. 4. A composition according to claim 1 or claim 2, comprising from 3 to 30% by weight of total active ingredients, based on the total weight. 5. A composition according to claim 1 or 2, containing from 10 to 50% by weight of total active ingredients, based on the total weight, in the form of a topical composition or other topical treatment solution.