JPH05249107A - Measuring method for component of liquid specimen, and test piece and sanitary tool therefor - Google Patents

Abstract

PURPOSE:To obtain a method, test piece, and sanitary tool for measuring the component of a liquid specimen which are easily handled and from which a uniform color reaction can be obtained. CONSTITUTION:After part of the title test piece for measurement is dipped in a liquid specimen except its reagent retaining section for measurement, the liquid is moved to the reagent retaining section so that the liquid can be brought into contact with a reagent retained in the reagent retaining section. Then the presence/absence of a color reaction is discriminated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a component measuring method and a test strip for measuring components in body fluids such as blood and urine inexpensively and easily. Toilet paper, tissue paper,
The present invention relates to a sanitary instrument for measurement such as disposable diapers, excretory zones and incontinence pads.

[0002]

2. Description of the Related Art Conventionally, component analysis of blood, plasma, serum, urine and other body fluids or secretory fluids has been used, for example, for diagnosis, determination of disease state and therapeutic effect, therapeutic guideline, etc.
Since it is easy to handle and can be carried around, test papers are used for simple tests for components of body fluids such as urine and blood. In the field of clinical examination, test papers are used for urine p
H, blood glucose, urine sugar, urine protein, occult blood, urobilinogen,
It is used for testing for bilirubin, ketone bodies, and serum cholinesterase.

[0003]

[Problems to be Solved by the Invention]
After immersing the test paper in the liquid to be inspected, take it out,
It is performed by measuring the change in color tone due to the color reaction with the naked eye or with an instrument. However, in this test paper, depending on the measurement item, the type of reagent to be printed, impregnated or applied to the reagent holding part is different, and the permeability and water retention of the test liquid to the test paper are different, Since the usage pattern differs depending on the worker, the amount of test liquid is not constant relative to the amount of reagent.

For this reason, for example, when a small amount of the test liquid adheres, the coloration becomes lighter than it should be, and the amount of the test liquid locally adheres to the measurement test body. If there is a difference, color unevenness will occur, making determination difficult.
Furthermore, if a large amount of the test liquid adheres to the measurement test body, the coloration on the measurement test body will be diluted by an excess of the test liquid and will be thinner than it actually is, which may cause misjudgment. In addition, excess test liquid is wiped off with the edge of the test liquid container, or is absorbed by filter paper, etc.
It is difficult to make the amount of the test liquid adhered to be constant, and the operation is complicated, which has been a problem. An object of the present invention is to solve the problem relating to the amount of the liquid to be inspected attached to the test paper when performing the inspection with the conventional test paper.

[0005]

DISCLOSURE OF THE INVENTION The present invention provides a test piece for measurement in which the amount of test liquid that reacts with the reagent of the test piece can be easily made uniform, easy to handle, and has a uniform color reaction. The purpose is to provide sanitary equipment. That is, the present invention, in a part of the region other than the measurement reagent holding portion of the measurement test piece, the test liquid is attached, and the attached test liquid is moved to the measurement reagent holding portion of the test piece. The present invention provides a method for measuring a component of a test liquid, which comprises contacting a reagent in the measurement reagent holding part to measure the presence or absence of coloration of the measurement reagent holding part. The material piece has a measurement reagent region formed on a part of the inner side thereof, and a region to be immersed in the test liquid at an end portion thereof is formed. Further, the present invention is characterized in that the first absorbent material layer holding the measuring reagent is adhered onto the second absorbent material layer to form the absorbent material piece. The first absorbent material layer, which is on the test piece for measuring the component of the liquid to be inspected and further holds the measurement reagent, Absorbent material layer absorbent material is formed is fixed to the piece, in sanitary tool comprising a component measuring function of the test liquid, characterized in that it is supported on the textile hygiene tool.

In the present invention, the test liquid means a body fluid such as blood, urine and the like of healthy persons and patients, and includes application to animals. In the present invention, the test piece for measurement is made of an absorptive material, and the absorptive material referred to here is formed by a nonwoven fabric such as paper, fiber, chemical fiber, porous absorbent resin, woven fabric, knitted fabric and paper. The material is not particularly limited as long as it has absorbency. However, the test piece for measurement is preferably made of filter paper. In the present invention, in the test piece, the gaps formed between the plurality of fibers and the pores formed in the capillaries of the porous body cause a capillary phenomenon, for example, in a region other than the reagent holding portion of the test piece. The test liquid adhering to the part can be moved to the upper reagent holding part, that is, from the bottom to the top by the capillarity.

In the present invention, the test piece for measurement is formed in the shape of a thin film, plate, cylinder or rod. In the present invention, the measurement test piece can be formed by fixing the first absorbent material layer having the measurement reagent holding portion to the second absorbent material layer. In this case, the first absorbent material layer and the second absorbent material layer
The absorbent material layer is formed in a shape corresponding to the shape of the measurement test piece. The first absorbent material layer and the second absorbent material layer can be adhesively fixed with an adhesive. The adhesive in this case is selected so as not to affect the measurement, and for example, a polyvinyl alcohol-based adhesive can be used.

The first absorbent material layer and the second absorbent material layer can be the same absorbent material layer, but they do not necessarily have to be the same absorbent material layer. However, when changing the thickness of the absorptive material layer or changing the properties of the absorptive material, the absorptive material on the side to which the test liquid is attached is more absorbent than the absorptive material layer provided with the measurement reagent holding part It is preferable that the layer has a larger movement of the test liquid due to the capillarity.

In the present invention, the measuring reagent printed or applied on the reagent holding portion of the test piece is, for example, urine pH, blood sugar, urine sugar, urine protein, occult blood, urobilinogen, bilirubin, ketone bodies and serum cholinesterase. The well-known printing ink for printing test paper containing these measuring reagents is used. In the present invention,
Textile products for sanitary equipment are textile products used for toilet paper, tissue paper, disposable diapers, excretory zones and incontinence pads. In the present invention, when a plurality of measurement reagents are provided on one piece of the absorbent material for measurement so that a plurality of measurements can be performed at one time, the plurality of measurement reagent holding sections are inspected. Oily boundaries can be formed by printing or painting so that the liquids do not mix with each other.

[0010]

According to the present invention, the test liquid is attached to a part of the area other than the measurement reagent holding portion of the measurement test piece, and the attached test liquid is moved to the measurement reagent holding portion of the test piece. The color reaction with the reagent in the measuring reagent holding section,
Since the liquid to be inspected toward the measuring reagent holding portion is caused by the capillary phenomenon, it can be kept constant regardless of the amount of the liquid to be inspected attached. Therefore, according to the present invention, the test liquid adhering to the test piece for measurement moves through the absorbent material piece or the second absorbent material layer having no reagent holding portion for measurement by the capillarity phenomenon to be used for measurement. Since the measuring liquid held in the reagent holding portion comes into contact with the measuring liquid, the moving liquid to be inspected becomes saturated due to the capillary phenomenon, and the amount of the liquid to be in contact with the measuring reagent can be made substantially constant. Therefore, the amount of the test liquid that comes into contact with the measurement reagent becomes constant regardless of the factors that change the amount of the test liquid, such as the difference in the usage mode by the measurer, and the variation in color due to the variation in the test liquid amount. Or, even color unevenness can be eliminated, stable measurement can be performed, and the test piece for measurement can be easily handled.

[0011]

Embodiments of the present invention will be described below with reference to the drawings, but the present invention is not limited to the following description and illustrated embodiments.
FIG. 1 is a schematic side sectional view for explaining a measuring test piece of one embodiment of the present invention, and FIG. 2 is a schematic plan view for explaining a measuring test piece of the embodiment shown in FIG. FIG. 3 is a schematic side sectional view for explaining a measurement test piece of another embodiment of the present invention, and FIG.
It is a schematic plan view explaining the measurement test piece shown in FIG. 5 is a schematic partial side sectional view for explaining a toilet paper having a measuring function according to an embodiment of the present invention other than the embodiment shown in FIGS. 1 and 3, and FIG. It is a schematic plan view explaining the test piece for a measurement of further another Example of invention.

In the embodiment shown in FIGS. 1 and 2, a test piece 1 for measurement is provided on a surface 3 of an absorbent material piece 2 made of filter paper.
The measurement reagent-containing ink 4 containing the measurement reagent is printed. Since this example is configured as described above, the end portion 5 of the measurement test piece 1 is immersed in urine (not shown) of the test liquid. The urine rises up the absorbent material piece 2 made of filter paper by a capillary phenomenon and comes into contact with a reagent (not shown) in the measurement reagent-containing ink 4 held by the absorbent material piece 2, and Color develops depending on the pH value. The pH value of urine can be measured by the degree of coloration of the measuring reagent.

In the embodiment shown in FIGS. 3 and 4,
The test piece for measurement 6 has an absorbent support material layer 7 made of filter paper and an absorbent reagent holding layer 9 made of filter paper, in which the ink 8 containing the measurement reagent is printed, by an adhesive, for example, a polyvinyl alcohol-based adhesive. Adhered and held. Since this example is configured as described above, the end portion 10 of the absorbent support material layer 7 of the measurement test piece 6 is placed in the urine of the test liquid (not shown).
Soak in. Urine rises in the absorbent support material layer 7 made of filter paper due to capillarity and comes into contact with the reagent in the measuring reagent-containing ink 8 held in the absorbent reagent holding layer 9, for example, the pH of urine.
Color according to the value. Depending on the degree of color development of this reagent 4,
The pH value of urine can be measured.

In the embodiment shown in FIG. 5, the toilet paper 11 is an upper layer portion 1 made of toilet paper.
2, the intermediate layer portion 13 and the lower layer portion 14 are formed of three layers, and the measurement reagent-containing ink (not shown) is printed on the lower layer portion 14 on the side that is not normally used. Since this example is configured as described above, the upper layer portion 12 of the piece 15 of the toilet paper 11 is used. Therefore,
In this example, urine (not shown) of the test liquid adheres to the upper layer portion 12, moves to the lower layer portion 14 made of the filter paper through the middle layer portion 13 made of the filter paper by the capillarity, and reaches the lower layer portion 14. Upon contact with the retained reagent, it develops color, for example depending on the pH value of the urine. The pH value of urine can be measured by the degree of color development of the reagent 4.

In the embodiment shown in FIG. 6, FIG. 6 shows a plan view of the measuring test piece 15 on one side 17 of the absorbent material piece 16. In this example, the absorbent material piece 16
A boundary line 17 is printed with an oil-based ink in the lengthwise direction, and two types of measurement reagent-containing inks 19 and 20 are printed on both sides of the boundary line 18. Since this example is configured as described above, the end portion 21 of the measurement test piece 15 is immersed in urine (not shown) of the test liquid.
Urine rises by capillarity on both sides of the boundary line 18 of the absorbent material piece 16 made of filter paper and comes into contact with the reagents in the measuring reagent-containing inks 19 and 20 held by the absorbent material piece 16, for example, The measuring reagents in the measuring reagent-containing inks 19 and 20 are colored in accordance with urine sugar and urinary protein. Urine sugar and urine protein can be measured by the degree of coloration of the measuring reagent-containing inks 19 and 20. In the above example, the measuring reagent is provided on the test piece by printing the ink containing the measuring reagent, but it may be provided by coating.

[0016]

According to the present invention, the test liquid is adhered to a part of the region other than the measurement reagent holding part of the measurement test piece, and the adhered test liquid is applied to the measurement reagent holding part of the test piece. Since it is moved to cause a color reaction with the reagent in the measurement reagent holding section, variations in coloration and color unevenness are eliminated compared to conventional measurement methods and measurement test pieces, and measurement is stable. And easy to handle

Further, according to the present invention, the test liquid adhering to the measuring test piece moves by the capillarity in the second absorbing material layer which does not have the absorbing material piece or the measuring reagent holding portion. , Contacting the measuring reagent held in the measuring reagent holding portion, the portion above the measuring reagent holding portion is not a colored portion and is not contaminated by the liquid to be inspected. On the other hand, even if a test piece is held and inspected, it can be detected before the hands are soiled, so it is very clean. Although the reagent is expensive, in the present invention, only the colored portion is printed and applied, so that only the necessary amount is used, and the cost can be greatly reduced as compared with the conventional measuring method and test piece.

Since the reagent holding portion is not provided in the lower second absorbent material layer, the liquid to be inspected is not contaminated and the correct inspection can always be performed. Further, after the saturated state due to the capillary phenomenon, the reagent of the upper first absorbent material layer does not flow out to the lower layer portion. With toilet paper and tissue paper, there is no possibility of trouble if the reagent holder does not come into direct contact with the skin. Also, since the toilet paper and tissue paper are thin, the reaction value can be confirmed sufficiently. For paper diapers, excretory belts, and incontinence pads, there is no possibility of trouble if the reagent holder does not come into direct contact with the skin. In addition, since the part which is in direct contact with the skin is usually in the form of a mesh of rayon-based non-woven fabric so that the base can be easily seen, it is easy to confirm the color reaction even when printed and applied to the intermediate layer sheet.

[Brief description of drawings]

FIG. 1 is a schematic side sectional view illustrating a test piece for measurement according to an example of the present invention.

FIG. 2 is a schematic plan view illustrating a measurement test piece of the example shown in FIG.

FIG. 3 is a schematic side sectional view for explaining a measurement test piece of another example of the present invention.

FIG. 4 is a schematic plan view illustrating the measurement test piece shown in FIG.

5 is a schematic partial side sectional view illustrating a toilet paper having a measuring function according to an embodiment of the present invention other than the embodiments shown in FIGS. 1 and 3. FIG.

FIG. 6 is a schematic plan view illustrating a measurement test piece according to still another embodiment of the present invention.

[Explanation of symbols]

 1,6,15 Measurement material piece 2,16 Absorbent material piece 3 Surface 4,8,19,20 Measurement reagent-containing ink 5,10 Edge 7 Absorbing support material piece 9 Absorbing reagent holding layer 11 Toilet paper 12 Upper layer 13 Middle layer 14 Lower layer 17 One side 18 Boundary line

Claims (4)

[Claims] 1. A test liquid is attached to a part of a region other than the measurement reagent holding part of the measurement test piece, and the attached test liquid is moved to the measurement reagent holding part of the test piece, A method for measuring a component of a liquid to be inspected, which comprises contacting a reagent in the measurement reagent holding part to measure the presence or absence of coloration of the measurement reagent holding part. 2. The test liquid, wherein the absorbent material piece has a measuring reagent region formed in a part of the inner side thereof and a region immersed in the test liquid at an end thereof. A test piece for measuring the components of. 3. A test liquid, wherein a first absorbent material layer holding a measuring reagent is adhered onto a second absorbent material layer to form an absorbent material piece. A test piece for measuring the components of. 4. A piece of absorbent material formed by fixing a first absorbent material layer holding a measuring reagent to a second absorbent material layer is supported by a textile product for sanitary goods. A sanitary tool having a function of measuring the components of the liquid to be inspected.