JP3157935B2 - Test specimen for measurement - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a test piece for measuring components in a body fluid such as urine, which is inexpensive and easy to measure.

[0002]

2. Description of the Related Art Conventionally, component analysis of blood, plasma, serum, urine, and other body fluids or secretions has been used for, for example, diagnosis, determination of disease state and therapeutic effect, and therapeutic guidelines.
Test papers are used for simple tests on components of bodily fluids such as urine and blood because they are easy to handle and portable. In the field of clinical testing, test strips are, for example, urine p
H, blood sugar, urine sugar, urine protein, urinary occult blood, urobilinogen,
It is used in tests for bilirubin, ketone bodies, serum cholinesterase, and the like.

[0003]

The test using a sanitary tool is performed by using a sanitary tool as a liquid to be tested and then measuring the change in color tone due to the color reaction of the measuring reagent holding portion of the sanitary tool with the naked eye or an instrument. Is However, in this sanitary tool, the type of reagent printed, impregnated, or applied to the reagent holding section differs depending on the measurement item, and the permeability and water retention of the test liquid into the reagent holding section of the sanitary tool. Are different,
The amount of the liquid to be inspected is not constant with respect to the amount of the reagent, because the use mode differs depending on the operator.

[0004] For this reason, for example, when the test liquid adheres only in a small amount, the color becomes thinner than it should be, and the amount of the test liquid adhered locally on the test specimen for measurement. If there is a difference, color unevenness occurs in the coloration, making determination difficult.
Furthermore, when a large amount of the test liquid adheres to the test sample, the color on the test sample is diluted by the excessive test liquid and becomes thinner than the actual test solution, thereby causing an erroneous determination. In addition, excess liquid to be inspected is wiped off at the edge of the liquid container to be inspected, or is absorbed by filter paper, etc.
It is difficult to make the amount of the test liquid adhered constant, and the operation is complicated, which is a problem. SUMMARY OF THE INVENTION It is an object of the present invention to solve the problem relating to the amount of liquid to be inspected adhering to a test paper when an inspection is performed using a conventional test paper.

[0005]

SUMMARY OF THE INVENTION The present invention relates to a measuring test which can measure a color reaction without causing outflow of a reagent even when a large amount of a test liquid reacts with a reagent in a test strip for a simple measurement. The purpose is to provide pieces. That is, the present invention
The absorbent material layer to have a capillary gap or hole, one end
Formed into a piece of absorbent material having an immersion end at
End of the immersion material piece and the opposite end to the immersion end.
Lengthwise oil ink absorbent material piece connecting the ends
That has boundaries are formed, the people on both sides of each sandwiching the boundary line, the position of the inner not immersed away from the dipping end, is by that test reagent area printing inks containing reagent for measuring The measurement reagents in the measurement reagent region that are formed and formed on both sides of the boundary line, respectively, are different types of reagents from each other in a measurement test strip for a simple urinalysis. is there.

In the present invention, the test liquid refers to body fluids such as blood and urine of healthy persons and patients, and includes applications to animals. In the present invention, the test piece for measurement is made of an absorbent material, and the absorbent material referred to herein is formed of nonwoven fabric such as paper, fiber, chemical fiber, porous absorbent resin, woven fabric, knitted fabric and paper. However, the material is not particularly limited as long as it has absorptivity. However, the test piece for measurement is preferably made of filter paper. In the present invention, in the test piece, the gap formed between the plurality of fibers and the capillary-shaped hole of the porous body cause a capillary phenomenon, for example, in one area other than the reagent holding portion of the test piece. The test liquid attached to the portion can be moved to the reagent holding portion above, that is, from below to above by capillary action.

In the present invention, the test piece for measurement is formed in a thin film, plate, cylinder, or rod shape. In the present invention, the test piece for measurement can be formed by fixing the first absorbent material layer having the reagent holding portion for measurement to the second absorbent material layer. In this case, the first absorbent material layer and the second
Is formed in a shape corresponding to the shape of the test piece for measurement. The first absorbent material layer and the second absorbent material layer can be bonded and fixed with an adhesive. The adhesive in this case is selected so as not to affect the measurement, and for example, an adhesive based on polyvinyl alcohol can be used.

The first absorbent material layer and the second absorbent material layer can be the same absorbent material layer, but need not necessarily be the same absorbent material layer. However, when the thickness of the absorbent material layer is changed or the properties of the absorbent material are changed, the absorbent material on the side to which the test liquid is attached is more than the absorbent material layer provided with the measurement reagent holding portion. It is preferable that the layer has a larger movement of the test liquid due to the capillary phenomenon.

In the present invention, the measuring reagent printed or coated on the reagent holding portion of the test strip includes, for example, urine pH, blood sugar, urine sugar, urine protein, urinary occult blood, urobilinogen, bilirubin, ketone bodies, serum cholinesterase and the like. The well-known printing ink for printing test papers containing these measuring reagents is used. In the present invention,
Sanitary utensil textiles are textiles used in toilet paper, tissue paper, disposable diapers, excretory bands and incontinence pads. In the present invention, when a plurality of measurement reagents are provided in one measurement absorbent material piece so that a plurality of measurements can be performed at a time, the plurality of measurement reagent holding units may be inspected. An oily boundary can be formed by printing or coating so that the liquids do not mix with each other.

[0010]

According to the present invention, the test liquid is adhered to a part of the area other than the measurement reagent holding section of the measurement test piece, and the attached test liquid is moved to the measurement reagent holding section of the test piece. Then, a color reaction with the reagent in the measurement reagent holding section is performed,
The test liquid heading toward the measurement reagent holding unit is caused by capillary action, and therefore can be constant regardless of the amount of the test liquid adhering. Therefore, according to the present invention, the test liquid adhering to the measurement test piece is moved by the capillary phenomenon through the absorbent material piece or the second absorbent material layer having no measurement reagent holding portion, and the test liquid is measured. Since the liquid under test comes into contact with the reagent for measurement held in the reagent holding unit, the moving liquid under test becomes saturated due to capillary action, and the amount of the liquid to be tested coming into contact with the reagent for measurement can be made substantially constant. Therefore, the amount of the test liquid that comes into contact with the measurement reagent is constant regardless of the fluctuation factor of the test liquid amount such as a difference in the manner of use by the measurer, and the variation in coloration due to the fluctuation in the test liquid amount. Alternatively, color unevenness can be eliminated, stable measurement can be performed, and handling of the test specimen for measurement can be facilitated.

[0011]

Embodiments of the present invention will be described below with reference to the drawings. However, the present invention is not limited by the following description and the illustrated embodiments.
FIG. 1 is a schematic side sectional view illustrating a measurement test piece according to an embodiment of the present invention, and FIG. 2 is a schematic plan view illustrating the measurement test piece according to the embodiment illustrated in FIG. FIG. 3 is a schematic plan view illustrating a measurement test piece according to still another embodiment of the present invention.

In the embodiment shown in FIGS. 1 and 2, the test piece 1 for measurement is attached to the surface 3 of the absorbent material piece 2 made of filter paper.
The measurement reagent-containing ink 4 containing the measurement reagent is printed. Since the present example is configured as described above, the end 5 of the test piece for measurement 1 is immersed in urine (not shown) of the test liquid. Urine rises in the absorbent material piece 2 made of filter paper by capillary action, and comes into contact with a reagent (not shown) in the measurement reagent-containing ink 4 held in the absorbent material piece 2, for example, to remove urine. Color changes according to the pH value. The pH value of urine can be measured based on the degree of coloration of the measurement reagent.

In the embodiment shown in FIG. 3, FIG. 3 shows a plan view of one surface side 8 of the absorbent material piece 7 of the test piece 6 for measurement. In this example, a boundary line 9 is printed with an oil-based ink in the length direction of the absorbent material piece 7, and two kinds of measurement reagent-containing inks 10 and 11 are provided on both sides of the boundary line 9. Printed.

Since the present embodiment is configured as described above,
The end 12 of the measurement test piece 6 is immersed in urine (not shown) of the test liquid. The urine rises on both sides of the boundary line 9 of the piece of absorbent material 6 made of filter paper by capillary action and comes into contact with the reagents in the measurement reagent-containing inks 10 and 11 held on the piece of absorbent material 7, for example. The measurement reagents in the measurement reagent-containing inks 10 and 11 are colored according to urine sugar and urine protein.

Urine sugar and urine protein can be measured based on the degree of coloration of the measurement reagent-containing inks 10 and 11. In the above example, the measurement reagent is provided on the test piece by printing the ink containing the measurement reagent, but may be provided by coating.

[0016]

According to the present invention, the test liquid is adhered to a part of the area other than the measurement reagent holding part of the test specimen, and the adhered liquid is attached to the measurement reagent holding part of the test specimen. By moving it, a color reaction with the reagent in the reagent holding part for measurement is performed, so that there is no variation in color and uneven color as compared with the conventional measurement method and the test piece for measurement, and the measurement is stable. And easy handling

Further, according to the present invention, the test liquid adhering to the test piece for measurement moves through the absorbent material piece or the second absorbent material layer having no measuring reagent holding portion by capillary action. Since the portion above the reagent holding portion for measurement that is in contact with the reagent holding portion for measurement is not a colored portion and is not contaminated with the liquid to be tested, the conventional measuring method and test piece can be used. In comparison, even if the test is carried by holding the test piece, it can be detected before the hands become dirty, so that it is very clean.

Although the reagent is expensive, in the present invention,
Since only the colored portion is printed and applied, only the necessary amount is used, and the cost can be greatly reduced as compared with the conventional measurement method and test piece.

Since the reagent holding portion is not provided in the lower second absorbent material layer, the liquid to be inspected is not stained, and a correct inspection can always be performed. After the saturation due to the capillary action, the reagent in the upper first absorbent material layer does not flow to the lower layer. In the present invention, toilet paper and tissue paper can be used, but since the toilet paper and tissue paper are thin, the reaction value can be sufficiently confirmed.

[Brief description of the drawings]

FIG. 1 is a schematic side sectional view illustrating a test piece for measurement according to an embodiment of the present invention.

FIG. 2 is a schematic plan view illustrating a measurement test piece of the embodiment shown in FIG.

FIG. 3 is a schematic plan view illustrating a measurement test piece according to yet another embodiment of the present invention.

[Explanation of symbols]

 1, 6 Measurement material piece 2, 7 Absorbing material piece 3 Surface 4, 10, 11 Ink containing measurement reagent 5, 12 End 8 One surface side 9 Boundary line

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int. Cl. ⁷ , DB name) G01N 33/52 G01N 31/22

Claims (1)

(57) [Claims] 1. A absorbent material have a capillary-like gaps or holes
The layer forms a piece of absorbent material with a dipping end at one end.
Dipping end of said piece of absorbent material and said dipping end
Ink I that border oily in the length direction of the absorbent material piece connecting the opposite end are formed on both sides of the respective To sandwiching the boundary line, away from the dipping end to inside of a portion not immersed, the measuring reagent and the measurement reagent zone <br/> Ru good in printing ink containing is formed of the measurement reagent of the measurement reagent regions which are respectively formed on both sides of the boundary line, A test strip for a simple urinalysis , characterized by different types of reagents.