JPH0515581A - Eggshell membrane sheet and production thereof - Google Patents
Eggshell membrane sheet and production thereofInfo
- Publication number
- JPH0515581A JPH0515581A JP3175552A JP17555291A JPH0515581A JP H0515581 A JPH0515581 A JP H0515581A JP 3175552 A JP3175552 A JP 3175552A JP 17555291 A JP17555291 A JP 17555291A JP H0515581 A JPH0515581 A JP H0515581A
- Authority
- JP
- Japan
- Prior art keywords
- eggshell membrane
- eggshell
- sheet
- pieces
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- Materials For Medical Uses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、新規な卵殻膜シートお
よびその製造法に関する。TECHNICAL FIELD The present invention relates to a novel eggshell membrane sheet and a method for producing the same.
【０００２】[0002]
【従来の技術】卵殻膜には消炎作用や上皮形成（促進）
作用があるため、例えば熱傷などの創傷部に卵殻膜をそ
のまま直接貼るなど、卵殻膜は従来から皮膚代用物とし
て用いられている。しかし生の卵殻膜は大きさが限られ
ていることから、使用上使い易い大きさとするため、卵
殻膜から卵殻膜シートをつくろうとする考えがあり、具
体的には、糊料などを用いて卵殻膜どうしを接着させて
シート状化する方法や繊維、例えば不織布に卵殻膜を貼
着させてシート状化する方法などが提案されている。2. Description of the Related Art Anti-inflammatory action and epithelial formation (promotion) on eggshell membranes
Because of its action, the eggshell membrane has been used as a skin substitute from the past, for example, by directly attaching the eggshell membrane directly to a wound such as a burn. However, since the raw eggshell membrane is limited in size, there is an idea to make an eggshell membrane sheet from the eggshell membrane in order to make it easy to use in use. Specifically, using glue etc. A method of adhering eggshell membranes to each other to form a sheet and a method of adhering eggshell membranes to a fiber such as a nonwoven fabric to form a sheet have been proposed.
【０００３】[0003]
【発明が解決しようとする課題】ところが卵殻膜は、上
記のように皮膚代用物のとして用いられることから、糊
料や繊維などを使用することは必ずしも好ましいとは言
い難い。よって、本発明は、糊料などの接着剤や繊維な
どの支持物を使用することなく卵殻膜片を一体化させて
なる新規な卵殻膜シートおよび該卵殻膜シートの製造法
を提供することを目的とする。However, since the eggshell membrane is used as a skin substitute as described above, it is not always preferable to use a paste or fiber. Therefore, the present invention provides a novel eggshell membrane sheet obtained by integrating eggshell membrane pieces without using an adhesive such as glue or a support such as fiber, and a method for producing the eggshell membrane sheet. To aim.
【０００４】[0004]
【課題を解決するための手段】本発明者は鋭意研究の結
果、上記の目的は、高圧処理手段を利用することにより
達成されることを見出し、本発明を完成するに至った。
本発明は、第一に、卵殻膜片が重なり合い部分を有して
シート状に一体化されていることを特徴とする卵殻膜シ
ートを提供するものである。また、本発明は、第二に、
卵殻膜片どうしを密着させ、次いで高圧をかけて一体化
させてシート状化することを特徴とする卵殻膜シートの
製造法を提供するものである。As a result of earnest research, the present inventor has found that the above object can be achieved by utilizing a high-pressure processing means, and has completed the present invention.
The present invention firstly provides an eggshell membrane sheet characterized in that the eggshell membrane pieces have an overlapping portion and are integrated into a sheet shape. In addition, the present invention, secondly,
The present invention provides a method for producing an eggshell membrane sheet, which comprises bringing the eggshell membrane pieces into close contact with each other and then applying a high pressure to integrate them into a sheet.
【０００５】以下、本発明を順次詳しく説明する。本発
明における卵殻膜は当分野において従来用いられている
卵殻膜と何ら異なるものではなく、鶏、あひる、がちょ
う、うずら等の卵殻の内側から得られる膜をいう。原料
入手の容易さから鶏卵の卵殻から得られる膜が好まし
い。卵殻から卵殻膜を得る方法も特に限定されるもので
はなく、通常、割卵して卵液を除去した卵殻を、好まし
くは予めある程度の大きさに破砕したのち流水中で機械
的手段あるいは人手でもって攪拌しながら卵殻から卵殻
膜を分離して収集するのが一般的である。The present invention will be described in detail below. The eggshell membrane in the present invention is not different from the eggshell membranes conventionally used in this field, and refers to a membrane obtained from the inside of eggshell such as chicken, duck, ginkgo, and quail. Membranes obtained from eggshells of chicken eggs are preferred because of easy availability of raw materials. The method for obtaining the eggshell membrane from the eggshell is not particularly limited, and usually the eggshell obtained by breaking eggs to remove the egg liquid is preferably crushed to a certain size in advance and then mechanically or manually in running water. It is common to separate and collect the eggshell membrane from the eggshell with stirring.
【０００６】本発明において卵殻膜片とは、卵殻膜の小
片状のものをいい、具体的には上記のようにして得られ
た卵殻膜そのままかまたはこれをある程度の大きさに小
片化したものを意味する。卵殻膜片の大きさは限定的で
はないが、最終製品の卵殻膜シートの厚みのバラツキを
少なくするためには小さ目の方が好ましい。具体的には
０．０１〜１０mm大程度にしたものが好ましい。本発明
の高圧処理に際しては卵殻膜片は乾燥状あるいは非乾燥
状のいずれの状態にあってもよいが、卵殻から採取した
卵殻膜を上記のような大きさの卵殻膜片とするには、ま
ず乾燥状とし、次いで例えばハンマーミル、スパイラル
ミル等を用いて適宜粉砕するとよい。尚、乾燥は常温乾
燥、凍結乾燥、加熱乾燥、送風乾燥、天日乾燥などいず
れの方法であってもよいが、比較的短時間で乾燥させう
ることから凍結乾燥あるいは加熱乾燥が好ましい。乾燥
の程度は、乾燥後のものが上記したような粉砕手段で所
望の大きさに粉砕されうるようになるまででよい。乾燥
を加熱乾燥法で行なう場合は、卵殻膜はケラチンを主成
分とする蛋白質であることから高温による変性を避ける
ために、例えば１００℃で６０分間程度とすればよい。
また、卵殻膜が卵殻から採取したばかりの生のもの、あ
るいはそれに近い状態にある場合は、直接凍結乾燥をし
て粉砕できるようにしてもよい。In the present invention, the piece of eggshell membrane means a piece of eggshell membrane, and specifically, the eggshell membrane obtained as described above as it is or is cut into pieces to a certain size. Means something. The size of the eggshell membrane piece is not limited, but a smaller size is preferable in order to reduce variations in the thickness of the eggshell membrane sheet of the final product. Specifically, it is preferable that the size is about 0.01 to 10 mm. In the high-pressure treatment of the present invention, the eggshell membrane pieces may be in a dry or non-dried state, but in order to make the eggshell membrane pieces collected from the eggshell into the eggshell membrane pieces of the above size, First, it may be dried and then appropriately crushed using, for example, a hammer mill or a spiral mill. The drying may be any method such as room temperature drying, freeze drying, heat drying, blast drying, and sun drying, but freeze drying or heat drying is preferable because it can be dried in a relatively short time. The degree of drying may be such that the dried material can be crushed to a desired size by the crushing means as described above. When the drying is carried out by a heat-drying method, the eggshell membrane is a protein containing keratin as a main component, and therefore it may be performed at 100 ° C. for about 60 minutes in order to avoid denaturation at high temperature.
Further, when the eggshell membrane is a fresh one just collected from the eggshell or in a state close to that, it may be lyophilized directly so as to be crushed.
【０００７】本発明の卵殻膜シートは、上記したような
卵殻膜片が重なり合い部分を有してシート状に一体化さ
れているものである。重なり合い部分の有無は、肉眼で
は判別しにくくても、光学顕微鏡（倍率１００倍程度）
で観察した場合に、重なり合い部分と重なり合いのない
部分とにおける光の透過光量の差による濃淡の模様の有
無で判別することができる。濃淡模様があれば重なり合
い部分があることを示す。重なり合い部分の面積の大小
は問わない。In the eggshell membrane sheet of the present invention, the eggshell membrane pieces described above are integrated into a sheet shape having overlapping portions. Even if it is difficult to determine with the naked eye whether or not there is an overlapping portion, an optical microscope (magnification of about 100)
In the case of (1), it can be determined by the presence or absence of a shade pattern due to the difference in the amount of transmitted light between the overlapping portion and the non-overlapping portion. If there is a shade pattern, it means that there is an overlapping part. The overlapping area does not matter.
【０００８】本発明は、また、このような卵殻膜シート
の製造法に係るが、その方法によれば、まず卵殻膜片ど
うしを密着させる。具体的には卵殻膜片どうしをぴった
りとつけることを意味する。尚、この際通常、重合せた
状態でぴったりとつけるのが一般的である。実際には、
例えば卵殻膜片を、高圧処理に耐えうる可撓性の袋（例
えば、ポリエチレン、ポリプロピレン製の袋）に収容
し、卵殻膜片の移動が困難とならない程度に空気を抜
き、卵殻膜片を、例えば１００cm2 当り０．５〜２ｇ位
となるように薄く均一に平らにして所定の厚さにし、次
いでバキウムシールして卵殻膜片を固定すればよい。あ
るいは別法として、板状物上に卵殻膜片を、例えば篩な
どを用いて均一に散布した上に更に板状物を重ねて卵殻
膜片を固定してもよい。いずれの場合も卵殻膜片の厚さ
は特に限定的ではなく、所望する最終製品に基づいて決
定すればよい。０．１〜０．３mm程度が一般的である。
あまり薄いとシート状化したものが破れ易く、また、あ
まり厚いとシール状化したものが取扱いにくくなる傾向
がある。The present invention also relates to a method for producing such an eggshell membrane sheet. According to the method, the eggshell membrane pieces are first brought into close contact with each other. Specifically, it means that the eggshell membrane pieces are attached tightly together. In addition, at this time, it is general to attach the resin in a polymerized state. actually,
For example, the eggshell membrane piece is housed in a flexible bag that can withstand high-pressure treatment (for example, a bag made of polyethylene or polypropylene), air is evacuated to the extent that the movement of the eggshell membrane piece is not difficult, and the eggshell membrane piece is For example, the eggshell membrane piece may be fixed by thinly and uniformly flattening it to a thickness of about 0.5 to 2 g per 100 cm 2 to a predetermined thickness, and then sealing with vaccum. Alternatively, the eggshell membrane pieces may be fixed on the eggshell membrane pieces by spraying the eggshell membrane pieces evenly on a plate-like material, for example, using a sieve or the like, and then further stacking the plates. In any case, the thickness of the eggshell membrane piece is not particularly limited and may be determined based on the desired final product. Generally, it is about 0.1 to 0.3 mm.
If it is too thin, the sheet-shaped product tends to tear, and if it is too thick, the sealed product tends to be difficult to handle.
【０００９】本発明の方法によれば、上記のようにして
密着させた卵殻膜片どうしに次いで高圧をかけて卵殻膜
片どうしを一体化させてシート状化する。ここにおいて
高圧とは、一般的に大気圧の１００〜数千倍程度の圧力
をいい、特に本発明においては卵殻膜片を相互に接着さ
せて一体化させうる圧力をいう。実用的には５００〜８
０００気圧（１気圧は約１kg／cm2 ）程度が好ましい。
密着状態にある卵殻膜片を、具体的には例えば上記した
ような、可撓性の袋に収容後所定の厚さにして固定状態
にした卵殻膜片を、上記のような気圧下に、１〜数十分
間、通常１〜１０分間保持すると、卵殻膜片が相互に接
着され一体化し、シール状となる。保持時間があまり短
いと接着が不充分となり、また保持時間があまり長くて
も接着効果はほとんど変らないことから、上記範囲内で
保持するのが一般的である。具体的には１０００気圧の
場合は５〜１０分間、５０００気圧の場合は２〜５分間
程度を目安とすればよい。なお、高圧処理にはレシプロ
式ポンプを用いた加工装置が一般的に用いられる。例え
ば三菱重工業（株）製の高圧加工装置（ＭＦＰ−７００
０型）などを挙げることができる。According to the method of the present invention, the eggshell membrane pieces adhered as described above are then subjected to a high pressure to integrate the eggshell membrane pieces into a sheet. Here, the high pressure generally means a pressure of about 100 to several thousand times the atmospheric pressure, and in particular, in the present invention, it means a pressure at which eggshell membrane pieces can be adhered to each other and integrated. Practically 500-8
It is preferably about 000 atm (1 atm is about 1 kg / cm 2 ).
The eggshell membrane piece in a close contact state, specifically, for example, as described above, the eggshell membrane piece fixed in a predetermined thickness after being housed in a flexible bag, under the atmospheric pressure as described above, When the eggshell membrane pieces are held for 1 to several tens of minutes, usually 1 to 10 minutes, the eggshell membrane pieces are adhered to each other and integrated to form a seal. If the holding time is too short, the adhesion will be insufficient, and even if the holding time is too long, the adhesive effect will hardly change. Therefore, it is generally held within the above range. Specifically, it may be about 5 to 10 minutes in the case of 1000 atm and about 2 to 5 minutes in the case of 5000 atm. A processing device using a reciprocating pump is generally used for high-pressure processing. For example, a high pressure processing device (MFP-700 manufactured by Mitsubishi Heavy Industries, Ltd.)
0 type) etc. can be mentioned.
【００１０】上記したような本発明の方法により製造さ
れた卵殻膜シートは、卵殻膜片が相互に接着されて一体
的な相互結合の状態にあることから、卵殻膜シートの通
常の取扱い過程において一枚のシートとして取扱うこと
かできる。In the eggshell membrane sheet produced by the method of the present invention as described above, the eggshell membrane pieces are bonded to each other and are in a state of being integrally interconnected. Therefore, in the normal handling process of the eggshell membrane sheet. It can be handled as a single sheet.
【００１１】[0011]
【実施例】以下、本発明を実施例でもって更に詳しく説
明する。実施例
鶏の殻付卵を割卵して卵液を除去した卵殻を、２〜５mm
大に破砕したのち、流水中で人手でもって攪拌しながら
卵殻から卵殻膜を分離収集し、次いでこのものを送風乾
燥して乾燥状卵殻膜を得た。この乾燥状卵殻膜をハンマ
ーミルを用いて平均して０．５〜２mm大程度となるまで
粉砕し、次いで２ｇをポリエチレン製の袋（たて：１５
cm，よこ：１０cm）に収容し、卵殻膜片の移動が困難と
ならない程度に空気を抜き、卵殻膜片を薄く均一に平ら
にして０．２mm程度の厚さにし、バキウムシールして卵
殻膜片を固定した。こうして固定したものを次いで三菱
重工業（株）製の高圧加工装置ＭＦＰ−７０００型内に
配置して２０００気圧で８分間高圧をかけて卵殻膜片ど
うしを一体化させてシール状化し、本発明の卵殻膜シー
トを製造した。このシートは、倍率１００倍の光学顕微
鏡で観察してみたところ、重なり合い部分の存在による
濃淡模様が認められた。EXAMPLES The present invention will be described in more detail below with reference to examples. Example An egg shell obtained by splitting a chicken shell egg to remove the egg liquid is 2 to 5 mm.
After crushing into large pieces, the eggshell membranes were separated and collected from the eggshells by stirring manually in running water, and then dried by blast drying to obtain dry eggshell membranes. The dried eggshell membranes were crushed with a hammer mill until the average size became 0.5 to 2 mm, and 2 g of polyethylene bags (vertical: 15
cm, width: 10 cm), remove air so that the movement of the eggshell membrane pieces does not become difficult, flatten the eggshell membrane pieces evenly to a thickness of about 0.2 mm, and seal the eggshell membrane pieces with a vaccum. Fixed. The thus-fixed product is then placed in a high-pressure processing device model MFP-7000 manufactured by Mitsubishi Heavy Industries, Ltd., and high pressure is applied at 2000 atm for 8 minutes to integrate the eggshell membrane pieces into a seal-like state. An egg shell membrane sheet was produced. When this sheet was observed with an optical microscope at a magnification of 100 times, a light and shade pattern due to the presence of overlapping portions was recognized.
【００１２】[0012]
【発明の効果】本発明の方法により、糊料などの接着剤
や繊維などの支持物を全く用いない卵殻膜片のみからな
る新規な卵殻膜シートが提供される。The method of the present invention provides a novel eggshell membrane sheet consisting only of eggshell membrane pieces that does not use an adhesive such as a glue or a support such as fibers.
Claims (2)
状に一体化されていることを特徴とする卵殻膜シート。1. An eggshell membrane sheet, characterized in that the eggshell membrane pieces are integrated into a sheet having overlapping portions.
かけて一体化させてシート状化することを特徴とする卵
殻膜シートの製造法。2. A method for producing an eggshell membrane sheet, which comprises bringing the eggshell membrane pieces into close contact with each other and then applying a high pressure to integrate them into a sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3175552A JPH0515581A (en) | 1991-07-16 | 1991-07-16 | Eggshell membrane sheet and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3175552A JPH0515581A (en) | 1991-07-16 | 1991-07-16 | Eggshell membrane sheet and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0515581A true JPH0515581A (en) | 1993-01-26 |
Family
ID=15998079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3175552A Pending JPH0515581A (en) | 1991-07-16 | 1991-07-16 | Eggshell membrane sheet and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0515581A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11992508B2 (en) | 2014-10-28 | 2024-05-28 | Biovotec As | Micronized eggshell membrane particles and the use thereof to promote the healing of wounds |
-
1991
- 1991-07-16 JP JP3175552A patent/JPH0515581A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11992508B2 (en) | 2014-10-28 | 2024-05-28 | Biovotec As | Micronized eggshell membrane particles and the use thereof to promote the healing of wounds |
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