JPH05115543A - Medical equipment - Google Patents
Medical equipmentInfo
- Publication number
- JPH05115543A JPH05115543A JP3307072A JP30707291A JPH05115543A JP H05115543 A JPH05115543 A JP H05115543A JP 3307072 A JP3307072 A JP 3307072A JP 30707291 A JP30707291 A JP 30707291A JP H05115543 A JPH05115543 A JP H05115543A
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- fluorine
- ring structure
- contained
- base material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、医療用機器に関するも
のである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to medical equipment.
【０００２】[0002]
【従来の技術】従来より、人体または血液循環に使用さ
れるチューブおよび機器は、ナイロン、ポリ塩化ビニ
ル、ウレタン、ポリエチレン、シリコーン等の樹脂、あ
るいはステンレス等の金属が使用されているが、抗血栓
性、高い摺動性、低い穿刺抵抗性を備えた、パーフルオ
ロエチレンプロピレン樹脂、エチレン−テトラフルオロ
エチレン共重合体樹脂等のフッ素樹脂もよく用いられて
いる。それらのフッ素樹脂は、優れた特徴を持つ一方
で、加工する上において接着性が悪い、あるいは成形に
特殊な成形機を必要とするなどの難点があり、また、柔
軟性の要求されるカテーテルの場合には、フッ素樹脂の
もつ硬さという点から、製造は困難であった。また、樹
脂のチューブにフッ素樹脂を被覆しようとしても、フッ
素樹脂の被覆加工温度が高いために被覆を施すことはで
きなかった。2. Description of the Related Art Conventionally, tubes and devices used for the human body or blood circulation use resins such as nylon, polyvinyl chloride, urethane, polyethylene, silicone, etc., or metals such as stainless steel. Fluorine resins, such as perfluoroethylene propylene resin and ethylene-tetrafluoroethylene copolymer resin, which have excellent properties, high slidability, and low puncture resistance are often used. While these fluororesins have excellent characteristics, they have drawbacks such as poor adhesiveness during processing, or require a special molding machine for molding, and catheters that require flexibility. In this case, the production was difficult because of the hardness of the fluororesin. Further, even if an attempt is made to coat the resin tube with the fluororesin, the coating cannot be performed because the fluororesin coating processing temperature is high.
【０００３】[0003]
【発明の解決しようとする課題】本発明は、前述のよう
な人体および血液用のチューブおよび機器に認められる
材料選択上の問題点を解消し、かつ、前述のようなフッ
素樹脂のもつ優れた特徴を備えたチューブおよび機器を
新規に提供することを目的とするものである。DISCLOSURE OF THE INVENTION The present invention solves the above-mentioned problems in material selection recognized in the tubes and devices for human body and blood, and is excellent in the above-mentioned fluororesin. It is an object of the present invention to newly provide a tube and a device having features.
【０００４】[0004]
【課題を解決するための手段】本発明者は、上記問題点
の認識に基づいて、鋭意検討を重ねた結果、人体および
血液用のチューブの内面と外面、または機器の内面に含
フッ素脂肪族環構造を有する重合体を被覆することによ
り、抗血栓性、摺動性、低穿刺抵抗性を備えることがで
き、また、被覆後にもチューブ材料の持つ柔軟性を維持
しており、また、基材を侵さずに被覆ができることを新
規に見いだすに至った。Means for Solving the Problems The present inventor has conducted extensive studies based on the recognition of the above-mentioned problems, and as a result, has found that fluorine-containing aliphatic compounds are formed on the inner and outer surfaces of human body and blood tubes, or on the inner surface of equipment. By coating with a polymer having a ring structure, antithrombogenicity, slidability, and low puncture resistance can be provided, and the flexibility of the tube material is maintained even after coating. We have newly found that coating can be done without attacking the material.
【０００５】すなわち、本発明は含フッ素脂肪族環構造
を有する重合体による被覆層が形成された医療用機器を
提供するものである。That is, the present invention provides a medical device in which a coating layer made of a polymer having a fluorine-containing alicyclic structure is formed.
【０００６】含フッ素脂肪族環構造を有する重合体とし
ては、含フッ素環構造を有するモノマーを重合して得ら
れるものや、少なくとも２つの重合性二重結合を有する
含フッ素モノマーを環化重合して得られる主鎖に環構造
を有する重合体が好適である。The polymer having a fluorinated alicyclic structure is obtained by polymerizing a monomer having a fluorinated cyclic structure, or a fluorinated monomer having at least two polymerizable double bonds is cyclopolymerized. A polymer having a ring structure in the main chain obtained as described above is suitable.
【０００７】含フッ素環構造を有するモノマーを重合し
て得られる主鎖に環構造を有する重合体は、特公昭６３
−１８９６４等により知られている。即ち、パーフルオ
ロ（２，２−ジメチル−１，３−ジオキソール）等の含
フッ素環構造を有するモノマーを単独重合ないし、テト
ラフルオロエチレンなどのラジカル重合性モノマーと共
重合することにより得られる。A polymer having a ring structure in its main chain obtained by polymerizing a monomer having a fluorine-containing ring structure is disclosed in Japanese Examined Patent Publication No. 63-63.
-18964 and the like. That is, it can be obtained by homopolymerizing a monomer having a fluorine-containing ring structure such as perfluoro (2,2-dimethyl-1,3-dioxole) or copolymerizing with a radical polymerizable monomer such as tetrafluoroethylene.
【０００８】また、少なくとも２つの重合性二重結合を
有する含フッ素モノマーを環化重合して得られる主鎖に
環構造を有する重合体は、特開昭６３−２３８１１１号
や特開昭６３−２３８１１５等により知られている。即
ち、パーフルオロ（アリルビニルエーテル）やパーフル
オロ（ブテニルビニルエーテル）等のモノマーの環化重
合、またはテトラフルオロエチレンなどのラジカル重合
性モノマーと共重合することにより得られる。Further, polymers having a ring structure in the main chain obtained by cyclopolymerization of a fluorine-containing monomer having at least two polymerizable double bonds are disclosed in JP-A-63-238111 and JP-A-63-63. It is known by 238115 etc. That is, it can be obtained by cyclopolymerization of a monomer such as perfluoro (allyl vinyl ether) or perfluoro (butenyl vinyl ether), or copolymerization with a radical polymerizable monomer such as tetrafluoroethylene.
【０００９】また、パーフルオロ（２，２−ジメチル−
１，３−ジオキソール）等の含フッ素環構造を有するモ
ノマーとパーフルオロ（アリルビニルエーテル）やパー
フルオロ（ブテニルビニルエーテル）等の少なくとも２
つの重合性二重結合を有する含フッ素モノマーを共重合
して得られる重合体でもよい。Further, perfluoro (2,2-dimethyl-
A monomer having a fluorine-containing ring structure such as 1,3-dioxole) and at least 2 such as perfluoro (allyl vinyl ether) or perfluoro (butenyl vinyl ether)
It may be a polymer obtained by copolymerizing a fluorine-containing monomer having one polymerizable double bond.
【００１０】含フッ素脂肪族環構造を有する重合体は、
主鎖に環構造を有する重合体が好適であるが、環構造を
２０％以上含有するものが透明性、機械的特性等の面か
ら好ましい。The polymer having a fluorinated alicyclic structure is
A polymer having a ring structure in the main chain is preferable, but a polymer containing 20% or more of the ring structure is preferable in terms of transparency, mechanical properties and the like.
【００１１】本発明において、医療用機器とは、人体へ
挿入あるいは接触する機器または人体より取り出した媒
体（例えば血液）の接触する機器をいう。また被覆層は
人体または上記媒体の接触する面に形成される。In the present invention, the medical device means a device which is inserted into or in contact with a human body or a device which is contacted with a medium (eg blood) taken out from the human body. In addition, the coating layer is formed on the surface of the human body or the surface of the medium which comes into contact.
【００１２】医療用機器の具体例としては、人工肺、人
工心臓、心臓人工弁、人工血管などの人工臓器、血管内
視鏡カテーテル、バルーンカテーテル、血管造影カテー
テル、膀胱留置カテーテルなどのカテーテル、体外循環
用カニューレ、血液用ポンプ、成分輸血用機器、血液循
環用チューブ、血液バッグ、注射器などが例示される。Specific examples of medical devices include artificial lungs, artificial hearts, artificial heart valves, artificial blood vessels and other artificial organs, angioscopic catheters, balloon catheters, angiographic catheters, catheters such as bladder indwelling catheters, and extracorporeal bodies. Examples include a circulation cannula, a blood pump, a component transfusion device, a blood circulation tube, a blood bag, and a syringe.
【００１３】中でも、血液が接触するものに特に効果が
大きく、また形状としてはチューブ状または袋状のもの
が好ましい。例えばカテーテル、血液用ポンプ、血液バ
ッグ、血液循環用チューブなどである。形状がチューブ
状または袋状のものでないと、前記重合体被覆層の形成
が容易でなくなる。Of these, the effect is particularly great for those in contact with blood, and the shape is preferably tube-like or bag-like. Examples include catheters, blood pumps, blood bags, blood circulation tubes, and the like. If the shape is not tube-like or bag-like, it becomes difficult to form the polymer coating layer.
【００１４】また、本発明において被覆される基材材料
としては、適度な柔軟性および機械的強度を有するもの
であれば特に限定されない。中でも成形性の面から合成
樹脂、例えば、ナイロン、ポリ塩化ビニル、ウレタン、
ポリエチレン、シリコーン等が例示される。The base material coated in the present invention is not particularly limited as long as it has appropriate flexibility and mechanical strength. Among them, from the viewpoint of moldability, synthetic resins such as nylon, polyvinyl chloride, urethane,
Examples are polyethylene and silicone.
【００１５】本発明において、含フッ素脂肪族環構造を
有する重合体を被覆せしめる方法としては特に限定はな
いが、該重合体をパーフルオロ（トリブチルアミン）等
のフッ素系溶剤に溶解した溶液に、基材を浸漬して引き
上げるディップコート法などが好適な被覆方法である。In the present invention, the method for coating the polymer having a fluorine-containing alicyclic structure is not particularly limited, but a solution prepared by dissolving the polymer in a fluorine-based solvent such as perfluoro (tributylamine) is used. A suitable coating method is a dip coating method in which the substrate is immersed and pulled up.
【００１６】また、基材と含フッ素脂肪族環構造を有す
る重合体との接着強さが必要な場合には、基材をプライ
マー処理したり、あるいは、活性エネルギー線処理を施
したのちに含フッ素脂肪族環構造を有する重合体を被覆
する方法をとるのがよい。When adhesive strength between the base material and the polymer having a fluorinated alicyclic structure is required, the base material is treated with a primer or after being treated with active energy rays. A method of coating a polymer having a fluoroaliphatic ring structure is preferred.
【００１７】[0017]
【実施例】次に、本発明の実施例について更に具体的に
説明するが、この説明が本発明を限定するものでないこ
とは勿論である。EXAMPLES Next, examples of the present invention will be described more specifically, but it goes without saying that the description does not limit the present invention.
【００１８】パーフルオロ（ブテニルビニルエーテル）
を重合して得られた主鎖に含フッ素脂肪族環構造を有す
る重合体（重合体Ａ）を、溶剤パーフルオロ（２−ブチ
ル−テトラヒドロフラン）に５重量％に溶解した溶液
に、ナイロン製カテーテルを浸漬後引き上げたのち、８
０℃で溶剤を乾燥して、重合体Ａが被覆されたナイロン
製カテーテルを得た。このカテーテルの抗血栓性は、パ
ーフルオロアルコキシ樹脂（ＰＦＡ）と同等であった。
また、患者の血管に挿入する際の穿刺抵抗は、挿入時の
痛みの大小から判断して、やはりＰＦＡと同等であり、
ナイロンのカテーテル自体と比較して、性能の向上が認
められた。また、このカテーテルはナイロン製カテーテ
ルと同様の柔軟性を有していた。Perfluoro (butenyl vinyl ether)
The polymer having a fluorine-containing alicyclic structure in the main chain (polymer A) obtained by polymerizing the above was dissolved in a solvent of perfluoro (2-butyl-tetrahydrofuran) in an amount of 5% by weight, and a nylon catheter was added. After immersing and pulling up, 8
The solvent was dried at 0 ° C. to obtain a nylon catheter coated with the polymer A. The antithrombogenicity of this catheter was equivalent to that of perfluoroalkoxy resin (PFA).
In addition, the puncture resistance when inserting into a blood vessel of a patient is also equivalent to PFA, judging from the magnitude of pain during insertion.
An improvement in performance was observed as compared to the nylon catheter itself. Further, this catheter had the same flexibility as the nylon catheter.
【００１９】[0019]
【発明の効果】本発明の医療用機器は、従来のフッ素樹
脂製カテーテルと同様の抗血栓性を有し、かつ、柔軟性
に優れたものである。The medical device of the present invention has the same antithrombogenicity as conventional fluororesin catheters and is excellent in flexibility.
Claims (1)
る被覆層が形成された医療用機器。1. A medical device having a coating layer formed of a polymer having a fluorinated alicyclic structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3307072A JPH05115543A (en) | 1991-10-25 | 1991-10-25 | Medical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3307072A JPH05115543A (en) | 1991-10-25 | 1991-10-25 | Medical equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05115543A true JPH05115543A (en) | 1993-05-14 |
Family
ID=17964708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3307072A Pending JPH05115543A (en) | 1991-10-25 | 1991-10-25 | Medical equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH05115543A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020246813A1 (en) * | 2019-06-05 | 2020-12-10 | 주식회사 오아이디 | Surface coating structure of surgical prosthesis, and method for modifying surface of surgical prosthesis by using same |
| US11987054B2 (en) | 2020-03-18 | 2024-05-21 | Toshiba Tec Kabushiki Kaisha | Ink tube and inkjet printer |
-
1991
- 1991-10-25 JP JP3307072A patent/JPH05115543A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020246813A1 (en) * | 2019-06-05 | 2020-12-10 | 주식회사 오아이디 | Surface coating structure of surgical prosthesis, and method for modifying surface of surgical prosthesis by using same |
| CN114173836A (en) * | 2019-06-05 | 2022-03-11 | 株式会社Oid | Surface coating structure for surgical prosthesis and method for modifying surface of surgical prosthesis using the same |
| US11987054B2 (en) | 2020-03-18 | 2024-05-21 | Toshiba Tec Kabushiki Kaisha | Ink tube and inkjet printer |
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