JPH0489051A - Superficial cancer and deep cancer therapeutic tool - Google Patents

Abstract

PURPOSE:To satisfy the comfortableness of a patient by using a chemical pocket heater storing a heating composition material made of iron powder, salt, water and a carbonic material for a heat source. CONSTITUTION:A heating composition material made of iron powder, salt, water and a carbonaceous material is stored in a chemical pocket heater used for a heat source, heat can preferably reach the deeper section of an affected part when one or two or more kinds of materials selected among ceramics, zeolite and zirconium generating far infrared rays are added. This chemical pocket heater is merely required to be stuck or mounted on the affected part for a superficial cancer or at the portion where heat is most easily transferred to an affected part for a deep cancer. Only cancer tissues can be killed while no injury is given to the healthy portion of a cancer patient, and the comfortableness of the patient can be satisfied.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a device for treating superficial cancer and deep cancer.

More specifically, the present invention relates to a device for treating superficial cancer and deep cancer using a chemical iron as a heat source containing a heat generating composition consisting of iron powder, salts, water and carbonaceous material. In addition,
Cancer as used in the present invention also includes malignant sarcoma and lymphoma.

[Conventional technology]

Traditionally, cancer treatment methods include: +1) surgical treatment (removal of the affected area and regional lymph nodes), (2) chemical treatment (administration of anticancer drugs, etc.), and (3) immunotherapy (interferon, interleukin, etc.). (4) radiation therapy, etc. Once cancer is discovered, surgical treatment is performed if it is resectable, followed by administration of anticancer drugs and other treatments.

However, all of the above-mentioned treatments cause considerable damage to the patient's healthy body parts, and they do not satisfy the patient's comfort (quality of life), which has become important in recent years. . For example, breast cancer is common in women, and women who have their breasts removed suffer tremendous psychological pain.

On the other hand, thermotherapy is a cancer treatment method that does not cause any damage to the patient's healthy parts, satisfies the patient's comfort, and can be treated without reducing the quality of life.

Hyperthermia therapy is as follows: ■Cell survival rate decreases rapidly with heating above 42°C, and this tendency is stronger in cancer cells than in normal cells (taking into account the effect on normal cells, 42-45
°C range or preferred for hyperthermia), ■ Cancerous tissues are more easily heated than normal tissues due to their environment (undernutrition, hypoxia, low pH) and special characteristics of blood vessel construction, and therefore cancer is selected. This method takes advantage of properties such as the fact that it is easily susceptible to necrosis. Specifically, (1) local thermotherapy (high frequency therapy, peritoneal perfusion method, etc.), (2) whole body thermotherapy (blood is removed from the artery, heated to 45°C, and then returned to the vein).
It is often used in combination with chemotherapy, which generally includes mitomycin, atreamine, and cisplatin.

However, these conventional hyperthermia treatments require very expensive equipment such as high-frequency generators, cause pain to the patient because hot water is circulated inside the body, and require the patient to be immobilized and anesthetized. However, it was not necessarily a widely accepted treatment. Although development in this field has progressed in recent years with improvements such as heating devices, there is still a strong perception that it is an expensive treatment method.

[Problem to be solved by the invention]

In view of the problems of the prior art described above, the present invention provides a thermal cancer treatment device that kills only cancerous tissue without damaging normal tissue, and that can be used easily and inexpensively without reducing the quality of life of the patient. This was done for the purpose of providing.

[Means and actions to solve the problem]

In order to maintain cancer tissue at 42-45°C, a heat source that constantly heats it is required, but the present inventors have developed a method using iron powder, salts,
As a result of intensive study, we attempted to use a chemical power source containing a heat-generating composition consisting of water and carbonaceous materials as a heat source.
Fever starts easily upon contact with oxygen, has enough calorific value to maintain the affected area at 42-45°C for more than 2 hours, is simple and inexpensive to use, and is The present inventors have discovered that this method satisfies patient comfort more than conventional thermotherapy, and have completed the present invention.

That is, the present invention relates to a treatment device for superficial cancer and deep cancer, characterized in that a chemical iron containing a heat-generating composition consisting of iron powder, salts, water, and carbonaceous material is used as a heat source.

The chemical iron used in the present invention contains a heat-generating composition consisting of iron powder, salts, water and carbonaceous materials as described above. A chemical heat treatment to which one or more selected substances are further added is preferable because it allows heat to reach deeper parts of the affected area.

Further, the heat-generating composition may optionally contain a water retaining agent such as wood flour or perlite, a polymeric water absorbing agent, or a hydrogen generation inhibitor such as sodium metasilicate.

In order to store the heat-generating composition, a bag with air permeability is usually used.This heat-generating composition storage bag can be made of, for example, a film made of paper or non-woven fabric laminated with a heat-fusible synthetic resin. Bags are made from films made of polyethylene, polypropylene, polyurethanes, or plastics modified to make them flexible, and which have micropores or continuous micropores on the surface and inside.

Further, the fine continuous pore film may be used alone, or may be used as a storage bag for reinforcement by laminating a thin non-woven fabric or the like to an extent that does not impair flexibility. The shape of the exothermic composition storage bag made of these films is arbitrary, and may be, for example, plate-like or tubular so that it can be easily inserted into the rectum. Further, the thickness is appropriately selected in consideration of its physical properties, that is, air permeability, tear strength, workability, feel, etc., and is usually used in the order of 01 to 3.0.

The cancer treatment device of the present invention is characterized in that the above-mentioned chemical iron is used as a heat source, and is composed of the chemical iron and a patch for applying it to the affected area or a holding material for indwelling it. As an attachment material for the device, double-sided tape with an adhesive layer may be pasted on one or both sides of the chemical iron, or a separate piece of tape can be attached to the chemical iron during use. You may also do so.

Here, it is also possible to adjust the temperature of the affected area by appropriately sandwiching cloth, sorting material, etc. between the chemical dye and the tape. In addition, when inserting a tubular chemical electrolyte into the rectum, a tubular retaining material may be further placed on the outside of the chemical electrolyte to form a two-layer structure, so that it can be easily placed in the affected area.

The cancer treatment device of the present invention is usually stored in an airtight film and opened when used. When applying the cancer treatment device of the present invention, it may be applied or placed in the affected area in the case of superficial cancer, or at the site where heat is most easily transmitted to the affected area in the case of deep cancer. For example, for breast cancer, which is a superficial cancer, the cancer treatment device of the present invention is preferably worn inside a bra, and the temperature of the tumor is reduced to 43°C.
It lasts for 2 to 3 hours and can be used easily without worrying about getting burned. Further, in cases such as rectal cancer and esophageal cancer, the cancer treatment device of the present invention, which has a two-layered tubular structure consisting of a chemical iron and a retaining material placed on the outside thereof, can be suitably used. Furthermore, even for deep-seated cancers such as colon cancer, it is possible to apply the cancer treatment device of the present invention to an appropriate site by selecting a chemical formula that allows heat to reach deeper areas.

By using the cancer treatment device of the present invention, it is expected that the proliferation of cancer cells will be suppressed and the tumor will shrink, and a multidisciplinary treatment effect will also be achieved when used in combination with anti-inflammatory drugs, other chemotherapy, and radiotherapy. It is possible.

〔Example〕

Next, test examples and examples of the present invention will be shown, but these are for illustrating the present invention and are not intended to limit it.

Test Example 1 The superficial cancer and deep cancer treatment devices of the present invention were prepared by attaching a double-sided tape to the chemically heated surface of the exothermic composition shown in Table 1 below, and subjected to the following tests.

Table 2 (The unit of the numerical value shown under the elapsed time in the table is °C) The above-mentioned cancer treatment device of the present invention was attached to a Wistar rat, and the epidermal temperature and large intestine temperature of the attached part were measured. The results are shown in Table 2. In addition, all chemical forces comply with 341 of the Japanese Industrial Standards.
According to No. 00, the maximum temperature of 55 to 56°C was maintained for more than 4 hours.

As a result of the test, when using Chemical Power Iro■, the epidermal temperature was 4.
I was able to keep it at 3℃, but the colon temperature was 36℃.
It was a low C. On the other hand, in the case of the cancer treatment device of the present invention using Chemical Power Iro■ and Chemical Power Iro■ containing far-infrared generating components, the colon temperature can be maintained at 42 to 43°C, and the epidermal temperature and colon It was observed that the difference in temperature was small, and that the heat reached deeper parts of the body.

In addition, it is also possible to apply these body warmers to superficial cancer by sandwiching a cloth or the like between the chemical force Iro (1) or the chemical force Iro (2) and the affected area.

Test Example 2 The effects on methylcholanthrene-induced skin cancer were investigated using Chemical Power Iro (■) and Chemical Power Iro (■) of Test Example 1. Methylcholanthrene 10 on the back of Wistar rats
(2) was applied three times to induce skin cancer. After confirming the occurrence of cancer, the cancer treatment device of the present invention was applied to the cancerous site for two hours a day, and the therapeutic effect of the treatment device on skin cancer was examined.

The results are shown in Table 3.

Table 3 The carcinoma shrank or disappeared. The high frequency generator was also effective, but it was extremely disadvantageous in terms of economy and simplicity, and the usefulness of the cancer treatment device of the present invention was confirmed.

Test Example 3 Using Kanmoto rats, which have a high incidence of primary colorectal cancer, the cancer treatment effects of Chemical Power Iro (■) and Chemical Power Iro (2) in Test Example] were investigated. The results are shown in Table 4.

Table 4 (n=6) As a result of the test, the results of all the tests showed that the therapeutic effect of Chemikyoku Iro■ on colorectal cancer is Although the results were low, a significant decrease in the tumor-bearing rate was observed in Chemiyuki Iro■, confirming the therapeutic effect.

Therefore, it can be seen that the chemical agent containing a far-infrared ray generating component is more effective as a deep cancer treatment device.

Example 1 When the cancer treatment device using the chemical force Iro (■) shown in Test Example 1 was applied to subcutaneously transplanted cancer of the colon cancer in government rats,
] Significant shrinkage of the subcutaneous mass was observed macroscopically.

Example 2 A device for treating superficial cancer and deep cancer of the present invention was prepared by attaching the Chekkiyoku Iro ■ used in Test Example 1 to the inside of a bra, and was used to treat the underarm area of an elderly breast cancer patient who refused surgical treatment. Applied to the mammary gland area.

After changing the heating pad every day and continuing the treatment for two hours a day to avoid low-temperature burns for 30 days, the breast cancer mass significantly shrunk.

Example 3 The superficial cancer and deep cancer treatment device of the present invention prepared using the chemical method of Test Example 1 was used for the treatment of colon cancer in Kanmoto rats, and the anticancer agent atreamynon, Mitomynon or nsplatin was administered intraperitoneally. When the treatment was continued for one month, shrinkage of the carcinoma was observed, and there were no side effects, confirming the usefulness of the cancer treatment device of the present invention.

Example 4 When the chemical agent used in Test Example 1 was pasted on the perineum of a patient with rectal cancer recurrence and used for 6 hours a day for 2 weeks, the tumor size decreased and pain was not felt. reduced or disappeared.

〔Effect of the invention〕

As explained in detail so far, the superficial cancer and deep cancer treatment device of the present invention uses a heat generating composition consisting of iron powder, salts, water and carbonaceous material, or a heat generating composition consisting of iron powder, salts, water and carbonaceous material, or generates far infrared rays together with this as a heat source for thermotherapy. It uses a chemical ceramic containing one or more substances selected from ceramic, zeolite, luconium, etc. The cancer treatment device of the present invention is capable of killing only cancerous tissue without causing damage to healthy areas of cancer patients, satisfies patient comfort, and can be used anytime, anywhere at low cost and easily. It can be used for

Patent applicant Dainippon Pyrethrum Co., Ltd.

Claims (2)

[Claims] (1) A treatment device for superficial cancer and deep cancer, characterized in that a chemical iron containing a heat generating composition consisting of iron powder, salts, water and carbonaceous material is used as a heat source. (2) As a heat source, a chemical body warmer containing one or more substances selected from heat-generating compositions consisting of iron powder, salts, water, and carbonaceous substances, and ceramics that generate far infrared rays, zeolites, zirconium, etc. A treatment device for superficial cancer and deep cancer, characterized in that it is used for the treatment of superficial cancer and deep cancer.