JPH0474114A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity application having suppressed bitter taste and metallic taste, useful as a sweetener and having excellent applicability by compounding hernandulcin with a cyclic ketone selected from l-menthol, menthone, isomenthone and piperitone. CONSTITUTION:The objective composition is produced by compounding hernandulcin with one or more cyclic ketones selected from l-menthol, menthone, isomenthone and piperitone. The amount of hernandulcin is usually 0.005-1 wt.% (especially 0.01-0.5 wt.%) based on the total composition and that of l-menthol is preferably about 0.03-5 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to an oral composition containing hernandurtin, and more specifically, it has excellent taste, good feeling of use, and long-term durability. This invention relates to an oral composition that exhibits little deterioration in flavor even after storage.

[Problems to be solved by conventional techniques and inventions] Conventionally,
It is known to incorporate hernanzurtin into oral compositions as a sweetening agent (Japanese Patent Laid-Open No. 62-500030).

However, this Hernanzurutin toothpaste.

When used as a sweetener for oral compositions such as mouthwashes and mouthwashes, the present inventors have found that when Q-menthol, which is often used as a freshener, is used in combination with oral compositions, O-menthol The bitter taste is emphasized, and a metallic taste may be produced, resulting in a poor usability.

Furthermore, hernanzurtin is easily decomposed by heat and loses its sweet taste (Chem, 5bstr, 103(II):
86674C).

For this reason, there is a problem in that it is difficult to impart a long-term stable flavor to oral compositions.

The present invention has been made in view of the above-mentioned circumstances, and improves the poor feeling of use such as the bitterness and metallic taste of oral compositions that occur when hernanzurtin and Q-menthol are used together. An object of the present invention is to provide an oral composition that can improve the long-term stability of hernandurtin in a product and maintain a good feeling of use over a long period of time.

[Means and effects for solving the problem] The present inventors,
In order to achieve the above purpose, as a result of intensive study on measures to improve the usability and flavor stability of oral compositions containing hernanzurtin and Q-menthol,
By adding one or more selected from menthone, immenthone, and piperitone to the composition, the bitterness and metallic taste caused by the combined use of hernandurtin and Q-menthol can be improved, and the composition can be improved. The present invention was completed based on the idea that it is possible to improve the stability of hernanzultin in a product, suppress the reduction in sweetness over time as much as possible, and maintain a stable flavor over a long period of time. be.

The present invention will be explained in more detail below.

The oral composition of the present invention contains hernanzurtin, Ω-menthol, and one or more cyclic ketones selected from menthone, immentone, and piperitone.

Here, the blending amount of hernanzurtin is not particularly limited, but it is usually 0.005 to 1% (weight %, same hereinafter) of the entire composition, especially 0.01 to 0.5%. is preferred. If the amount is less than 0.005%, the sweetness may not be sufficiently imparted, while if it exceeds 1%, the sweetness may become too strong and the feeling of use of the oral composition may be impaired.

In addition, Q-menthol is blended into the composition as a refreshing agent, and its blending amount can be a normal amount.
Specifically, 0. It is preferable to set it to about 3 to 5%.

Note that if the amount of Q-menthol added is less than 0.03%, a sufficient refreshing feeling may not be imparted, while if it is added to 5%, the irritation may be too strong and the feeling of use may be impaired.

Further, the amount of the cyclic ketone blended is not particularly limited, but is 0.01 to 0.5%, particularly 0.02 to 0.5% of the total composition.
The content is preferably 0.1%; if it is less than 0.01%, the effect of improving the feeling of use and the effect of improving storage stability may not be obtained, while if it exceeds 0.5%, the bitterness of the cyclic ketone itself may occur. The smell may become strong and the feeling of use may be impaired. In addition, the blending ratio of this cyclic ketone and hernanzurtin is 9:1 to 1:9, especially 7:3 by weight.
It is preferable to set the ratio to ~2:8. By using such a blending ratio, the effect of improving the feel of the cyclic ketone in use and the effect of improving the stability over time become particularly remarkable, resulting in an excellent feel in use and good stability over time. Oral compositions can be obtained more reliably.

In addition to the above-mentioned hernandurtin, the oral composition of the present invention may contain other sweeteners, such as saccharin sodium, stevioside, rebaudioside, and neohesberry. Dildihydrochalcone, glycyrrhizin, glycyrrhizin dipotassium.

Examples include perillartine, P-methoxycinnamic aldehyde, and one or more of these can be used.

As other components of the oral composition of the present invention, appropriate components depending on the type, dosage form, etc. of the oral composition may be blended. For example, when manufacturing toothpaste, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, and insoluble sodium metaphosphate.

Abrasives such as amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, resin (compounding amount usually 20 to 60% by weight), sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, alginate.

Binder such as carrageenan, gum arabic, polyvinyl alcohol (usually 0.3 to 5% by weight), polyethylene glycol, sorbitol, glycerin.

Binder such as propylene glycol (usually 10 to 70% by weight), sodium lauryl sulfate, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N- Contains foaming agents such as acyl glutamates and sucrose fatty acid esters (usually 0.1 to 5% by weight), other fragrance ingredients such as carvone, eugenol, and anethole, preservatives such as essential oils, and various active ingredients. It can be produced by mixing these components with water and following a conventional method. Also,
In mouthwashes and other mouthwashes, ingredients are appropriately blended depending on the properties of the product.

〔Effect of the invention〕

The oral composition of the present invention is produced by adding one or more cyclic ketones selected from menthone, isothantone, and piperitone to an oral composition containing hernanzultin and Ω-menthol in combination. Zulchin and Q
- It effectively suppresses the bitterness and metallic taste that occur when used in combination with menthol, and also improves the stability of hernandurtin over time, providing an excellent feeling of use and maintaining this feeling of use for a long period of time. It can be maintained for a long time.

Next, the effects of the present invention will be specifically illustrated by experimental examples.

[Experimental Example 1] Toothpaste compositions N011 to 11 having the following compositions containing the fragrance components shown in Table 1 were prepared, and the presence or absence of improvement in bitterness and metallic taste was sensory evaluated by the following method. The results are also listed in Table 1.

Living Book 1L■ Calcium phosphate dihydrate dihydrate 48.0% glycerin (85%) 19.5 carboxymethyl cellulose 1.8 Sodium lauryl sulfate 1.4 Q-menthol 0.5 Hernandurtin
0.1 Fragrances shown in Table 1 No. 1
1 Purified water meter shown in the table 100.0 ■ A professional panel of 10 people brushed their teeth with the test toothpaste and scored them according to the following rating scale for the degree of improvement in bitterness and metallic taste.
The average score of the participants was taken as the evaluation result based on the following criteria.

■--Bitterness and metallic taste are clearly improved compared to the stand control (toothpaste with the same composition as above except that it does not contain the flavorings shown in Table 1) = 5 points improvement Yes Slightly improved by 4 points
3 points have not improved or have worsened.

Evaluation criteria ◎: 4 points or more 0: 3 points or more, less than 4 points △: 2 points or more, less than 3 points X: 1 point or more, less than 2 points Table 1 2 points 1 point From the results shown in Table 1, It has been found that the bitterness and metallic taste of oral compositions containing hernanzurtin and Ω-menthol can be improved by blending menthone, isothantone, or piperitone.

[Experimental Example 2] Toothpaste compositions Nos. 12 to 16 were prepared having the same composition as Experimental Example 1 except that hernanzurtin and menthone as a fragrance ingredient were used in combination in the amounts shown in Table 2. The presence or absence of improvement in bitterness and metallic taste and the intensity of sweetness after storage at 50'C for one month were sensory evaluated using the following method. The results are also listed in Table 2.

2 A panel of 10 experts brushed their teeth with the tested toothpaste, and scored the degree of improvement in bitterness and metallic taste, as well as the sweetness after storage at 50°C for 1 month, according to the following ratings, and the average score of the 10 people was calculated. The evaluation results were based on the following criteria.

Bitterness and metallic taste are clearly improved compared to the control (toothpaste with the same composition except that no menthone is added): 5 points improved, 4 points slightly improved. There is ・
3 points not improved, 2 points actually worsened: 1 point rating Compared to the control (toothpaste with the same composition stored at -5℃ for 1 month) at 50℃ for 1 month. It has the same sweetness 5 points Slightly less sweetness 4 points Slightly less sweetness
3 points: Weak sweetness 2 points: No taste at all 1 point: Kawara i base! O: 4 points or more O: 3 points or more, less than 4 points Δ: 2 points or more, less than 3 points , an oral composition containing hernandurtin and Q-menthol has improved bitterness and metallic taste, provides a good feeling of use, and retains good sweetness even after being stored at 50°C for one month. It was confirmed that the product had excellent storage stability.

Examples will be shown below, but the present invention is not limited to the following examples. The fragrance composition used on each side is shown below.

[Fragrance B]

cineole eugenol Cassia oil Anethole peppermint oil strawberry flavor ethanol Total [Fragrance C] Methyl salicylate peppermint oil SO, O 40.0 (parts by weight) 5.0 Cassia oil cineole benzaldehyde Anethole ethanol Total [Fragrance D] Methyl salicylate eugenol cineole sage oil orange oil clove oil cardamom oil ethanol 73,0 Total [Fragrance E] peppermint oil lemon oil orange oil 100, 0 10.0 (parts by weight) 10, 0 6.8 cineole Anethole Spilanthol citral ethanol Total [Example 1] Toothpaste Dibasic calcium phosphate・ dihydrate carboxymethylcellulose sodium Propylene glycol Sorbitol liquid (60%) sodium lauryl sulfate tranexamic acid Q-menthol Mentone Fragrance A hernanzurcin 50, 0 43, O 1,2 % Total 100, 0 [Example 2] Toothpaste Silicic anhydride Sodium polyacrylate polyethylene glycol Sorbitol liquid (60%) Glycerin (85%) sodium lauryl sulfate Fatty acid jetanolamide Sodium monofluorophosphate Q-menthol Mentone Isothantone Fragrance A hernanzurcin 30, 0% 1.0 3.7 19,5 20, 0 1, 2 0.4 0.7 0.5 0, 03 0, 02 0.8 0,06 Total [Example 3] Toothpaste Zirconium-bonded silicate carboxymethylcellulose sodium Propylene glycol 100, 0 21.5% 1.2 1, 8 Sorbitol liquid (60%) sodium lauryl sulfate tranexamic acid Q-menthol Mentone piperitone Fragrance B hernanzurcin saccharin sodium Essence water Total [Example 4] Toothpaste aluminum hydroxide carrageenan polyethylene glycol Sorbitol liquid (60%) sodium lauryl sulfate Sucrose fatty acid ester dextranase Ω-menthol 100, 0 Mentone Fragrance B hernanzurcin purified water Total [Example 5] Toothpaste calcium carbonate Glycerin (85%) carrageenan carboxymethyl cellulose sodium sodium lauryl sulfate tranexamic acid Q-menthol piperitone Fragrance A hernanzurcin saccharin sodium 0, 02 0,55 0, 08 100, 0 50° 20° 0° 0° Total [Example 6] Moisturizing toothpaste 100, 0 calcium carbonate Sorbitol liquid (60%) Glycerin (85%) sodium lauryl sulfate tranexamic acid Q-menthol Isothantone Fragrance B hernanzurcin Stevioside 0% Total [Example 6] Liquid toothpaste Glycerin (85%) Propylene glycol Sodium polyacrylate sodium lauryl sulfate ethanol tranexamic acid Q-menthol 100, 0 Mentone Fragrance A hernanzurcin purified water Total [Example 8] Powdered toothpaste Dibasic calcium phosphate・ dihydrate calcium carbonate Glycerin (85%) α-olefin sulfonate Dextran Sodium monofluorophosphate Q-menthol Mentone Fragrance A hernanzurcin Total [Example 9] Mouthwash Disodium phosphate 0.02 1,　○ 0, 08 100, 0 50, 0% 30, 0 10.0 1.0 0.5 0.1 0, 15 0,02 0.8 0.06 Residue 100, 0 0.3 % Citric acid O.

Glycerin (85%) 19゜isopropyl alcohol 18゜sorbitan monooleate
5゜Sodium lauryl sulfate 1゜Chlorhexidine gluconate 0゜0-menthol
O.

Mentone ○・Fragrance A
1゜Hernanzurtin O.

Saccharin sodium 0゜total
100.0 [Example 10] Mouthwash ethanol (90%) 20° Polyoxyethylene hydrogenated castor oil 0° Tranexamic acid
0°Q-Menthol O.

Menthone 0゜isothanthone
0.0% Piperitone fragrance C Hernanzurtin meter [Example 11] Lozenge Gum arabic Glucose gelatin Dextranase Gluconate Chlorhexidine Q-menthol Isothantone Piperitone fragrance B Hernanzurtin meter [Example 12] Pasta polyoxy for oral cavity Ethylene monostearate 0, 01 1.0 0.2 100, 0 5% 100.0 2.0 Sorbitan monooleacetyl alcohol palmityl alcohol propylene glycol carboxymethyl cellulose sodium gelatin lysozyme chloride 5° Chlorhexidine hydrochloride Q-menthol Menthone Fragrance D Hernanzurcintos 1, ○ OoO units/g O,01 0,08 0,05 1,0 0,05 Remaining 100,0 Total [Example 13] Gargling Tablet Sodium Bicarbonate Dibasic Sodium Phosphate Polyethylene glycol Sodium oleate monofluorophosphate 2.0 2.0 3.0 15,0 5.0 54゜10゜3゜0゜O8 Chlorhexidine hydrochloride allanto ink Citric acid Q-Menthol menthone fragrance A Hernanzurtin essential water 100゜Total [Example 14] Mouth freshener (liquid) Ethanol polyoxyethylene hydrogenated castor oil glycerin (95%) Q-menthol menthone fragrance E Hernanzurtin total 100.0 [Example 15]
Solid mouth freshener Milk Sugar Starch Licorice Powder Gum Arabic Liquid Tranexamic Acid Q - Menthol Menthone Flavor B Hernanzurutin Meter [Example 16] Chewing Gum Gum Base Calcium Carbonate Starch syrup Sugar Dextranase Q - Menthol Menthone Flavor B Health Nanzurutin 10, 0% 41, 55 5.0 40, 0 1.0 1, 0 0, 02 1, 4 0, O3 100° 40, 0 15, 0 4o, 0 0.1 0, 2 0, 02 0.3 0.03 Total 100.0 Above Example 1~
The oral composition No. 16 had a good feeling when used without bitterness or metallic taste, and also showed little change in the feeling when used over time.

Claims (1)

[Claims] 1. One or two selected from hernanzurtin, l-menthol, menthone, isothantone, and piperitone
An oral composition characterized in that it contains at least one cyclic ketone.