JPH0449229A - Composition for cutis - Google Patents

Abstract

PURPOSE:To provide a composition substantially not adsorbing a liquid drug, capable of sufficiently exhibiting the activity of the drug, having excellent touch to skin and useful for cutis, by allowing a carrier to absorb the liquid drug containing a sterilizer, the carrier comprising chemical fibers containing polyester fibers. CONSTITUTION:A liquid drug used for cutis and comprising a sterilizer such as benzalkonium chloride or chlorohexidine glyconate as a main ingredient and other ingredient such as naphazoline chloride or dipcain chloride dissolved in water is impregnated into a carrier comprising a chemical fiber article containing polyester fibers, such as a non-woven fabric comprising the polyester fibers or a mixture thereof with other fibers to provide a composition for cutis. The composition substantially not adsorb the liquid drug on the fibers compared with conventional compositions, is useful for cutis and is used for sterilized disinfected cotton, towel, wound-protecting materials such as emergency adhesive tapes or sterilized gauze, analgestic, antipruritic, astringent, and antiphlogistic agents, cataplasm, anhidrotic agent, puppurative diseases, etc.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to dermal compositions.

More specifically, the present invention relates to a skin composition in which a nonwoven fabric made of polyester fibers or a mixture of polyester fibers and other fibers is selected as a carrier, and a skin liquid containing a fungicide is absorbed therein.

[Prior Art] Conventionally, a solution of a skin disinfectant such as chlorhexidine or benzalkonium chloride absorbed into cellulose fibers such as absorbent cotton or gauze has been used to disinfect and disinfect the skin.

However, it has been known that most of the drugs in these sterilizing and disinfecting compositions are adsorbed to cellulose fibers, significantly reducing the effectiveness of the drugs.

As a method for solving this problem, there has been a method of adding a divalent or higher valent metal salt or a higher alcohol sulfate ester salt, as shown in JP-A-50-18616 and JP-A-50-18617.

However, none of these methods are completely satisfactory; for example, when adding divalent or higher valent metal salts, calcium chloride, which has a good adsorption prevention effect, causes strong local irritation, and magnesium chloride has a very bitter taste. Because it is strong,
For example, it had the disadvantage that it could not be used to clean nipples.

On the other hand, when adding higher alcohol sulfate ester salts, there is a problem in that the bactericidal activity of the skin fungicide decreases.
Further, higher alcohol sulfate salts themselves have unfavorable effects on the skin (penetration, irritation).

Furthermore, as a method for preventing these adsorptions, Japanese Patent Application Laid-Open No. 621986
There is a method of adding a monovalent metal salt (for example, sodium chloride) as described in Publication No. 9, which can prevent to some extent the adsorption of skin fungicides such as chlorhexidine gluconate from cellulose and cotton. However, it is not possible to completely prevent adsorption.

[Problem to be solved by the invention] As a result of many years of study on how to elute drugs well without adding the above additives, we have developed a method using chemical fibers, especially polyester fibers, as carriers. The inventors completed the invention by discovering that in some cases, a liquid preparation for the skin containing a bactericide is hardly adsorbed, and the effect of the active ingredient can be fully exerted.

[Structure] The skin composition of the present invention is made of a chemical fiber material containing polyester fibers, which has been absorbed with a liquid agent for skin containing a fungicide.

The above-mentioned "chemical fiber material containing polyester fibers" is a chemical fiber material in which the surface of the fibers is sufficiently covered with polyester fibers that hardly absorb liquid agents for outer skin containing disinfectants. (1) Materials consisting only of polyester fibers, (2) Materials that use other chemical fibers as the fiber core material and polyester as the sheath component, such as heat-fused fibers, (3) Materials that use polyester fibers and other chemical fibers as the sheath component. Examples include materials in which polyester fibers are mixed with other chemical fibers, and therefore, polyester fibers and other chemical fibers can be mixed at a ratio of 0 to 100%, respectively.

Here, "other chemical fibers" include chemical fibers such as polyethylene, rayon, nylon, polypropylene, vinylon, and polyamide.

The chemical fiber material is preferably a non-woven fabric, and it is further preferable that such a non-woven fabric feels good on the skin, has chemical resistance, has a large liquid storage capacity, and has the characteristics that the contents are not adsorbed.

For example, polyester nonwoven fabric has a basis weight of 40 to 44 mg/
It is suitable that the nonwoven fabric having a thickness of II+2 and a thickness of 0.46a+ffl is occluded with 6 to 8 ffl/g of liquid.

The above-mentioned "liquid for skin containing a bactericide" refers to a liquid for skin that contains a bactericide as a main ingredient, and such "bactericide" includes, for example, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, Mention may be made of ionic fungicides such as povidone-iodine, acrinol, dequalinium chloride, cetonomide.

The "liquid for skin containing a bactericide" may also contain other drugs commonly used for skin, such as ethyl aminobenzoate, dibucaine (or its hydrochloride), probiotics, etc. Local anesthetics, analgesics and anti-inflammatories such as Licoin (or its hydrochloride), lidocaine (or its hydrochloride), glycyrrhizic acid (or its salts), clycyrrhetinic acid, indomethacin, corticosteroids, tetrazoline hydrochloride, naphazoline hydrochloride , phenylephrine hydrochloride, dff-methylephedrine hydrochloride, vasoconstrictors such as epinephrine hydrochloride, chlorpheniramine maleate, diphenhydramine (or its salts), antihistamines such as isothipendyl hydrochloride, zinc oxide, calamine, potassium aluminum sulfate, allantoin, astringents such as derivatives of allantoin such as aluminum chlorhydroxyallantoinate, antipruritics such as crotamiton, menthol, camphor, methyl salicylate;
and vitamins, as well as benzoic acid and its sodium salt, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, isobutyl paraoxybenzoate, sorbic acid and its potassium salt, Mention may be made of preservatives such as dehydroacetic acid and its sodium salt, calcium propionate, sodium propionate.

Furthermore, the concentration of the drug added to the "liquid for skin containing a bactericide" may be the amount commonly used in pharmaceuticals, quasi-drugs, and cosmetics.

As the solvent for the liquid preparation for the skin, those that dissolve the above and are less irritating to the skin can be used, such as water, aqueous solvents such as hydrated ethanol, macrogol, glycerin, and propylene glycol, miglyol, corn oil, peanut oil, Mention may be made of oily solvents such as olive oil, rapeseed oil, sesame oil, liquid paraffin.

[Effects] As shown in the test examples below, the composition of the present invention, which is polyester alone or fibers made of polyester fibers and rayon, exhibits almost no adsorption compared to conventional cotton made only of cellulose fibers. Excellent feel to the skin.

[Test example] The survival rate in the test example was determined by the following method.

l) Add an internal standard solution (diphenhydramine hydrochloride 0.1% solution) to 311 ml of each of the benzalkonium chloride impregnating solution and squeezing solution, and dilute to exactly 10 ml with purified water.
+nl, and a test was conducted by liquid chromatography for each 30 μm, and the peak area ratios Qt (squeezing solution) and Qs (impregnating solution) of benzalkonium chloride to the peak area of the internal standard substance were determined and calculated.

Residual rate (%) -〇t Qs
Add 1ml, make exactly 25a+1 with purified water, and make 25a+1 each.
A test was conducted using liquid chromatography at 0 μm, and the beak volume ratios qt (squeezing solution) and (ls (impregnating solution)) of each drug to the peak area of the internal standard were determined, and the residual rate was calculated using the following formula.

Residual rate (%) -〇t Qsxloo 3) 200L11 of each of the chlorhexidine gluconate impregnating liquid and squeezing liquid was diluted with water to make 20ml.

Absorbance E at wavelength 197nffl with water as a control
t (squeezed liquid) and Es (standard solution) were measured, and the residual rate was calculated.

4) 3 ml of an internal standard solution (0.1% solution of hydrochloric acid propylene) was added to each of the hydrochloric acid propylene impregnating solution and the squeezing solution, and the total volume was made up to 20 ml with the mobile phase. Test the sample solution and standard solution with a liquid chromatography method of 20 μm, determine the ratio of the peak area of pro-hydrochloric acid to the peak area of the internal standard substance, Qt (squeezing solution) and Qs (impregnating solution), and calculate the residual rate. did.

5) Allantoin The allantoin quantitative method prescribed by the local government was applied.

[Test Example 1] Prepare a 0.1% solution of benzalkonium chloride, Part 1
ml was impregnated into 0.15 g of nonwoven fabric made of various chemical fibers, sealed in an aluminum laminate bag, and left at room temperature for up to 72 hours. Changes in the residual rate of benzalkonium chloride in the squeezing solution over time were observed.

As is clear from Table 1, looking at the changes in the residual rate of benzalkonium chloride from nonwoven fabrics made of various chemical fibers over time, the adsorption reached an equilibrium state in 4 hours, and the nonwoven fabric made of chemical fibers There was a clear difference in the residual rate compared to cotton wool.

[Test Example 2] Squeezed liquid after 4 hours of impregnation of the compositions of each example, etc. As shown in Table 2, when the residual rate of each drug was compared between the skin composition of the present invention and the control, it was found that the composition of the present invention The adsorption rate of substances is extremely low;
Therefore, it is clear that the effect is excellent.

[Test Example 3] As shown in Table 3, the squeezed liquid after 4 hours of impregnation with the compositions of each example, etc., shows that when the residual rate of each drug is compared with the skin composition of the present invention and the control, it is found that It is clear that the composition has a significantly lower adsorption rate and therefore its effectiveness is excellent.

As described above, the composition for outer skin of the present invention has almost no adsorption to fibers than conventional compositions, and is a useful composition for outer skin.

Therefore, the composition of the present invention can be used as sterilizing cotton, towelettes, wound protectants (emergency bandages, sterile gauze), analgesic, antipruritic, astringent, and antiinflammatory agents (anti-itching agents, etc.), poultices, parasitic skin disease agents ( It can be used as a decubitus ulcer treatment agent, a hemorrhoid agent, an antiperspirant/deodorant, an agent for purulent diseases, and a transdermal absorption agent.

[Production Examples] Next, the present invention will be explained in more detail with reference to Production Examples, but the present invention is not limited thereto.

Control example 1 Benzalkonium chloride o, Ig, naphazoline hydrochloride 0
．． 1 g of dibucaine hydrochloride and 0.1 g of dibucaine hydrochloride were dissolved in distilled water to make a total volume of 100 ml. Dispense 1+nl of this solution onto a pharmacologically absorbent cotton pad.
After impregnating 0.15 g, it was sealed in an aluminum laminate bag.

Example 1 Benzalkonium chloride 0.1 g, naphazoline hydrochloride 0,
1 g of dibucaine hydrochloride Q and Ig were dissolved in distilled water, and the total amount was adjusted to 100 m+1. After impregnating 0.15 g of a nonwoven fabric made of 100% polyester with 1+nl of this liquid,
Sealed in an aluminum laminated bag.

Example 2 0.1 g of benzalkonium chloride, 0.1 g of naphazoline hydrochloride.
1 g of dibucaine hydrochloride O, Ig was dissolved in distilled water, and the total volume was adjusted to 100 ml. Add 1 ml of this solution to polyester 70
After impregnating 0.15 g of a nonwoven fabric consisting of 30% and 30% rayon, it was sealed in an aluminum laminate bag.

Example 3 0.1 g of benzalkonium chloride, 0.1 g of naphazoline hydrochloride.
0.1 g of dibucaine hydrochloride was dissolved in distilled water, and the total amount was adjusted to 100 ffl. 1+nl of this solution was applied to a nonwoven fabric made of 50% polyester and 50% polyethylene.
．． After impregnating 15 g, it was sealed in an aluminum laminate bag.

Control Example 2 0.1 g of chlorhexidine gluconate, 1 g of prolactin hydrochloride, and 0.1 g of allantoin were dissolved in distilled water to make a total volume of 100 ml. Add this solution 1a+1 to 0% cotton
．． After impregnating 15 g, it was sealed in an aluminum laminate bag.

Example 4 0.1 g of chlorhexidine gluconate, 1 g of propyroin hydrochloride, and 0.1 g of allantoin were dissolved in distilled water to make a total volume of 100 ml. After impregnating 0.15 g of a nonwoven fabric made of 100% polyester with this liquid 1a+1, it was sealed in an aluminum laminate bag.

Example 5 0.1 g of chlorhexidine gluconate, 1 g of propylene hydrochloride, and allantoin O and Ig were dissolved in distilled water to make a total volume of 100 ml. 0.15g of this liquid Lo11 was added to a nonwoven fabric made of 70% polyester and 30% rayon.
After impregnating it with water, it was sealed in an aluminum laminated bag.

Example 6 1 g of chlorhexidine gluconate O, 1 g of propyroin hydrochloride, and 0.1 g of allantoin were dissolved in distilled water to make a total volume of 100 ml. Add 1 ml of this solution to polyester 5
0% and 50% polyethylene non-woven fabric 0.15
After impregnating it with g, it was sealed in an aluminum laminate bag.

Applicant: Wakodo Co., Ltd. Agent: Patent Attorney Akio Ohno

Claims (1)

[Claims] A composition for skins made by absorbing a liquid agent for skins containing a fungicide into a chemical fiber material containing polyester fibers.