JP2002145762A - Wet tissue-type liniment, packaged wet tissue-type liniment and method for applying - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a wet tissue-type liniment capable of sanitarily and pleasantly treating without directly touching the affected part with a finger and moreover excellently applying a medicine to the affected part, an easy-to-use and sanitary packaged wet tissue-type liniment and a method for applying the same. SOLUTION: There are disclosed a wet tissue-type liniment comprising a base fabric retaining the medicine in the state of moisture retension and a packaged wet tissue-type liniment receiving the base fabric retaining the medicine in the state of moisture retension in a packaging bag. The medicine is preferably retained in the base fabric in the state of liquid. The medicine is an antipruritic and anti-inflammatory drug and preferably contains an antihistamic agent, a bactericide and a moistening agent. The liniment is suitably applied to a delicate part of the skin. A liniment receiving the base fabric retaining the medicine every piece of fabric in the packaging bag is preferable. The packaging bag is formed by a laminated film comprising polyethylene terephthalate layer/aluminium foil layer/unstretched polypropylene layer. The method for applying the medicine by directly contacting the base fabric retaining the medicine to the part of body is disclosed.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a wet tissue type coating agent, a packaged wet tissue type coating agent, and a method for applying them. More specifically, the present invention provides a wet-tissue-type applied drug which is hygienic without needing to directly touch the affected area with a finger, reduces the resistance to treatment, and can easily apply a drug, and a packaged wet. The present invention relates to a tissue type coating agent and a method for applying the same.

[0002]

2. Description of the Related Art As a form of an external medicine applied to the skin,
Generally, there are an ointment type, a cream type and a liquid type. When applying these types of medicines to the skin, the finger may become dirty, and ointment, creamy and liquid medicines may flow and cannot be applied successfully. In particular, there is a problem that the external medicine for care of the delicate zone (pubic area) of a woman cannot be applied well with the conventional external medicine as described above because the resistance to applying with a finger and the affected part cannot be seen. .

[0003] On the other hand, there is a type in which a disinfectant is impregnated in gauze, absorbent cotton, or the like, and there is a type of clean cotton for wiping a body part. However, since these disinfecting cotton and cleaning cotton are wiped for disinfection and cleaning, it is not necessary to leave the drug in the body part for a long time. The function is completely different from the application medicine to make it.

[0004] Such sterilizing cotton and clean cotton cannot solve the above-mentioned problems in the conventional coating agent, and there has been a wide demand for the development of an easy-to-use coating agent.

[0005]

SUMMARY OF THE INVENTION The object of the present invention is to solve the above-mentioned conventional problems and eliminate the need for directly touching the affected area with a finger. It is an object of the present invention to provide a wet tissue type coating agent that can be applied, an easy-to-use, hygienic packaged wet tissue type coating agent, and an easy application method using these.

[0006]

SUMMARY OF THE INVENTION The present inventor has conducted intensive studies to solve the above-mentioned problems of the prior art, and as a result, has made a wet tissue type application drug in which a drug to be applied is held on a base cloth, and is used for treatment. By bringing the wet tissue into contact with the affected area and applying the drug, it is no longer necessary to directly touch the affected area with a finger, and it is possible to apply the drug to the affected area without discomfort, hygienically, and well, The present invention has been completed.

[0007] That is, the wet tissue type coating composition of the present invention is characterized by comprising a drug and a base cloth for holding the drug in a moisturized state. The base fabric is regenerated cellulose,
It is preferable to be made of at least one material selected from synthetic fibers and natural fibers. Further, the base cloth may include a medicine layer for holding the medicine in a moisturized state, and a back sheet for adhering to one surface of the medicine layer and preventing the medicine from being released.

Further, it is preferable that the base cloth holds the medicine in a liquid state at room temperature. The drug held by the base cloth preferably contains an antipruritic anti-inflammatory agent. In addition, a wet tissue type coating agent comprising the above-described agent and a base cloth holding the agent can be applied to the delicate zone.

The packaged wet tissue type coating composition of the present invention is characterized in that a wet tissue type coating composition comprising a drug and a base cloth for holding the drug in a moist state is stored in a packaging bag. The base fabric in this application is
Regenerated cellulose, preferably composed of at least one selected from synthetic fibers and natural fibers,
This base cloth may be composed of a drug layer that holds the drug in a moisturized state, and a back sheet that adheres to one surface of the drug layer and prevents release of the drug.

[0010] In the above-mentioned packaged wet-tissue type application medicine, it is preferable that the base cloth for holding the medicine in a moisturizing state is stored in a packaging bag for each sheet, and the base cloth is in an unfolded state or once. The folded shape may be used. Further, it is preferable that such a base cloth holds the medicine in a liquid state at room temperature.

[0011] Further, as the drug held by the base cloth, an antipruritic anti-inflammatory agent containing 0.1 to 10% by weight of an antihistamine, 0.1 to 10% by weight of a bactericide and 0 to 30% by weight of a wetting agent. Preferably, the antihistamine contained in the antipruritic anti-inflammatory agent is at least one compound selected from the group consisting of diphenhydramine hydrochloride, isotipendyl hydrochloride, and diphenhydramine lauryl sulfate, and the fungicide is benzalkonium chloride; Benzethonium chloride, cetylpyridinium chloride, povidone iodine, at least one compound selected from the group consisting of chlorhexidine gluconate, the wetting agent is ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-
More preferably, it is at least one polyhydric alcohol selected from the group consisting of butanediol, glycerin and sorbit.

It is preferable that the packaging bag containing the base cloth holding the above-mentioned medicine is formed of a laminated film having a polyethylene terephthalate layer, an aluminum foil layer and an unstretched polypropylene layer. The wet-tissue type application medicine comprising the medicine and a base cloth holding the medicine can be applied to the delicate zone by opening the packaging bag and taking it out.

According to the method for applying a wet tissue type coating agent of the present invention, a wet tissue type coating agent comprising a drug and a base cloth for holding the drug in a moist state, or the wet tissue type coating agent is stored in a packaging bag. When applying a packaged wet tissue-type application medicine, the medicine held in the base cloth is transferred to a portion to be applied by directly contacting the base cloth holding the medicine in a moisturized state with the body part. I have.

A delicate zone can be used as the above-mentioned scheduled application portion. The base fabric used in this application method may be composed of a drug layer for holding the drug in a moisturized state, and a back sheet for adhering to one surface of the drug layer and preventing release of the drug. Further, it is preferable that the base fabric holds the medicine in a liquid state at room temperature.

The agent used in such an application method is an antipruritic and antiinflammatory agent containing 0.1 to 10% by weight of an antihistamine, 0.1 to 10% by weight of a bactericide and 0 to 30% by weight of a wetting agent. Preferably, further, the antihistamine contained in the antipruritic anti-inflammatory agent is at least one compound selected from the group consisting of diphenhydramine hydrochloride, isotipendyl hydrochloride, diphenhydramine lauryl sulfate, and the disinfectant is benzalkonium chloride, benzethonium chloride, At least one compound selected from the group consisting of cetylpyridinium chloride, popidone iodine, and chlorhexidine gluconate, wherein the wetting agent is ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl -1,3-
More preferably, it is at least one polyhydric alcohol selected from the group consisting of butanediol, glycerin and sorbit.

[0016]

DETAILED DESCRIPTION OF THE INVENTION Next, the wet tissue type coating agent and the packaged wet tissue type coating agent of the present invention and a coating method using these will be described in detail. The wet-tissue type application medicine of the present invention comprises a medicine and a base cloth which holds the medicine in a moisturized state. In addition, the packaged wet tissue type coating composition of the present invention is obtained by storing a wet tissue type coating composition comprising a drug and a base cloth for holding the drug in a moist state in a packaging bag. Application of application medicine The wet tissue application medicine and the packaging wet tissue application medicine of the present invention are medicines for treating an affected part by applying the medicine.

Therefore, the wet-tissue type coating composition and the packaged wet-tissue type coating composition of the present invention are not particularly limited as long as they are applied and treated, and are not particularly limited. It can be applied to any of them. Further, the body part to which the wet tissue type application medicine and the packaged wet tissue type application medicine of the present invention are applied may be an affected part to be treated by applying the medicine, and may be applied to any part of the body, that is, to any part to be applied. can do.

In particular, the above-mentioned application agent is suitable for an affected part which is resistant to direct application with a finger or a part where the affected part is difficult to see and is difficult to apply with a finger, for example, a delicate zone (pubic part) of a woman. Can be used. Further, since it is not necessary to directly touch the affected part with a finger, it can be used as a hygienic therapeutic agent for any part of the body. Drug In the wet tissue type coating agent and the packaged wet tissue type coating agent of the present invention, the agent is held on the base cloth in a moisturized state.

As such a drug, as described above,
Any drug having any medicinal effect may be used as long as it is treated by applying it to the body. For example, it is possible to use a drug that is effective in treating itch, soreness, rash, dermatitis, eczema, heat rash, urticaria, suppuration, insect bite and the like. Examples of such drugs include antipruritic agents.

Specific active ingredients having an effect as an antipruritic agent include antihistamines.
It is preferable that a bactericide, an antimicrobial agent for promoting fine blood flow, an antioxidant, a local anesthetic, etc. are appropriately used as an active ingredient together with the antihistamine. For example, by blending a bactericide together with an antihistamine, it suppresses symptoms such as itching and suppresses the growth of various germs.

Examples of antihistamines include diphenhydramine hydrochloride, dimenhydrinate, homochlorcyclidine hydrochloride, phenatadine hydrochloride, isotipendyl hydrochloride, laphenyl diphenhydramine sulfate, and the like.
Among them, diphenhydramine hydrochloride, isotipendyl hydrochloride, diphenhydramine lauryl sulfate and the like are preferable.
Examples of the disinfectant include benzalkonium chloride, isopropylmethylphenol, povidone-iodine, benzethonium chloride, cetylpyridinium chloride, chlorhexidine gluconate, among which benzalkonium chloride, popidone-iodine, benzethonium chloride, cetylpyridinium chloride, chlorhexidine gluconate, etc. Is preferred.
More preferred are benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate and the like.

Examples of the fine blood flow promoting / antioxidant include tocopherol acetate and tocopherol nicotinate. As local anesthetics, ethyl aminobenzoate, lidocaine, lidocaine hydrochloride, procaine hydrochloride,
Examples include dibucaine hydrochloride and tetracaine hydrochloride.

[0023] In addition to the above-mentioned active ingredients, a wetting agent, a solubilizer, a preservative, a solvent and the like can be further added, if necessary. In particular, it is preferable to mix a wetting agent for protecting the skin and transferring the drug from the base cloth to the portion to be applied, and spreading the drug to the entire portion to be coated. For example, examples of the wetting agent include polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol, glycerin, and sorbitol. .

As such a wetting agent, it is preferable to use a liquid compound such as a polyhydric alcohol having a relatively high boiling point. And the ink is uniformly spread over the entire portion to be coated. Moreover, since these compounds have a high affinity for the skin, they also have the effect of coating the surface of the skin and keeping the drug there for a relatively long time even after the water has evaporated.

As the solubilizer, C 2-8, preferably C 2-8, such as ethanol, propanol and butanol.
About 5 lower alcohols and the like can be mentioned. Preservatives include phenol, parachlorometacresol, parachlorometaxylenol, isopropylmethylphenol, resorcin, resorcin monoacetate,
Phenols such as orthophenylphenol, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, phenoxyethanol, thymol, pologalol, cresol, hinokitiol, hydroxybenzosatiol, benzoic acid and its salts, salicylic acid and its salts, dehydro Acetic acid and its salts, sorbic acid and its salts, acids such as boric acid, hexachlorophene, halogenated bisphenols such as 2,4,4'-trichloro-2-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide , 3-
Amides such as trifluoromethyl-4,4'-dichlorocarbanilide, undecylic acid monoethanolamide, chloroacetamide, benzalkonium chloride, alkylisoquinolinium bromide, benzethonium chloride, cetylpyridinium chloride, decalinium chloride, chloride Examples thereof include quaternary ammonium compounds such as alkyltrimethylammonium, amphoteric surfactants such as lauryldi (aminoethyl) glycine and lauryldiaminoethylglycine, bis (parachlorophenylbiguanide) hexane, and tetramethyllaudisulide. .

Among such preservatives, paraoxygens such as methyl paraoxybenzoate, ethyl paraoxybenzoate, and propyl paraoxybenzoate, which have relatively low irritation, are inexpensive and highly effective, and are stably soluble in water. Preferred are benzoates, sodium benzoate, benzalkonium chloride, cetylpyridinium chloride and the like. Examples of the solvent include aqueous media such as water and water-alcohol (alcohol having 1 to 5 carbon atoms is preferable).

Further, other components other than the above-mentioned components, for example, known components for protecting the skin, applicability to the skin, and maintaining the ointment, cream or liquid of the drug may be added. Examples include lanolin alcohol, isopropyl myristate, triethanolamine, dried sodium sulfite, sodium edetate, and the like.

The coating composition of the present invention preferably contains no oil in order to give a refreshing feeling without stickiness. In the present invention, the drug held in a moist state on the base cloth can be used in any of ointment, cream and liquid types. Above all, wiping of affected area and reduction of dirt on underwear by applied medicine
From the viewpoint of ease of removal and the like, it is preferable that the drug held by the base fabric is in a liquid state at room temperature (25 ° C.). The drug may be highly viscous (eg, gel, emulsion).

In general, it is desirable that the drug held in the liquid state is held in the base cloth as a solution in which the active ingredient or other compounding component is dissolved in a solvent such as an aqueous solvent, depending on the effect of the drug. . For example, when the antipruritic antiphlogistic is retained in the base cloth in a liquid state, an antihistamine such as diphenhydramine hydrochloride and a bactericide such as benzalkonium chloride are used as active ingredients in a solvent such as an aqueous solvent.
And if necessary, other active ingredients such as micro blood flow promoting / antioxidant, local anesthetic, and other ingredients such as wetting agents, dissolving agents, preservatives, and solvents are appropriately blended to form a solution. can do.

In this case, it is preferable to add a solubilizing / wetting agent such as a polyhydric alcohol in order to increase the solubility of the active ingredient such as an antihistamine and a bactericide. Further, a dissolving agent such as ethanol may be blended to increase the solubility of the other blending components such as the above-mentioned active ingredient and preservative. In the present invention, in particular, by using a large amount of a solubilizing / wetting agent such as a polyhydric alcohol, the solubility of the active ingredient and the like can be further increased. Or the use of a lysing agent can be dispensed with.

The content of the antihistamine in the drug solution as described above is usually 0.1 to 10% by weight, preferably 0.5 to 5% by weight, more preferably 0.75 to 4% by weight. The content of the fungicide is usually 0.1
It is 10 to 10% by weight, preferably 0.2 to 3% by weight, more preferably 0.5 to 2% by weight.

Other active ingredients such as a micro blood flow promoting / antioxidant and a local anesthetic are usually 0 to 5% by weight, preferably 0.1 to 3% by weight, respectively, in a drug solution.
Within the range. The solubilizing / wetting agent is usually 0 to 30% by weight, preferably 1%, in the drug solution.
-20% by weight, more preferably 2-10% by weight.

As the dissolving agent, usually 0 to 0
30% by weight, preferably in the range of 0 to 5% by weight. Base cloth In the wet tissue type coating composition and packaged wet tissue type coating composition of the present invention, the base fabric used for holding the drug in a moisturized state holds the drug without adversely affecting the action as the drug. Any material and form may be used so that the medicine held on the base cloth can be smoothly applied to the affected part when the base cloth is brought into contact with the affected part.

Since the base cloth in the present invention is to be brought into contact with the affected part, it is preferable to use a base cloth made of a material which is not irritating to the skin and has good touch. For example, viscose rayon, polynosic rayon, cupra, regenerated cellulose such as saponified acetate, polypropylene, polyethylene, synthetic fibers such as polyester, paper, a base fabric made of natural fibers such as absorbent cotton, has good drug retention,
In addition, the skin feels good, and the drug can be applied well to the affected area.

The base fabric made of such a material may be a woven fabric, a nonwoven fabric, a fiber aggregate, or a combination of two or more of these materials. Any form can be used as long as the above is satisfied. Although the shape of the base fabric is not particularly limited, it is usually easy to use a sheet having an appropriate size according to the affected area, and it is easy to manufacture. In addition, the sheet-like one also leads to a compact product.

As the base cloth, several types of products having dimensions corresponding to the size of the affected area may be prepared so that they can be selectively used according to the affected area. Alternatively, the base cloth may be folded and folded once or more. Is also good. In the case of such a folded product, the base cloth can be opened to its original size or opened to an appropriate size according to the size of the affected part. Also,
The base cloth is composed of only a drug layer that holds the active ingredient and other compound components constituting the drug in a moist state, and releases the compound layer such as the active ingredient on one surface of the drug layer and the drug layer. A back sheet for prevention may be provided.

In this case, the hand (finger) is applied to the back sheet, and the medicine is applied by bringing the medicine layer into contact with the affected part, and the adhesion of the medicine to the hand (finger) can be more effectively prevented. . The material of such a back sheet may be appropriately selected according to the material of the drug layer. For example, when the drug layer is a natural fiber such as regenerated cellulose or absorbent cotton, a hot-melt resin such as an acrylate copolymer can be used as the back sheet.

Such a hot-melt resin can be heated and melted, applied to the drug layer, and cooled to form a back sheet on one surface of the drug layer. Further, the medicine layer and the back sheet layer may be brought into close contact with each other by pressure bonding or an adhesive. The thickness of the base fabric is usually 0.1 to 2 mm from the viewpoints of drug retention, applicability, ease of use, and product compactness.
Preferably, it is within the range of 0.2 to 0.5 mm. Retention of Drug In the wet tissue type application and packaged wet tissue type application of the present invention, the above-mentioned antihistamine,
An agent obtained by mixing a predetermined amount of an active ingredient such as a bactericide and other components such as a wetting agent and a preservative, if necessary, is held in a moist state on the base cloth.

The medicine can be held by the base cloth as long as the medicine has a moisturizing property and is held on the base cloth to such an extent that the medicine can be applied well when the base cloth is brought into contact with the affected part. As described above, any of ointment, cream, and liquid can be used as the drug. There are no particular restrictions on the method of retaining the drug on the base fabric, for example, ointment, cream,
Alternatively, a method of forming a layer made of a drug on the surface of the base fabric by applying a liquid drug as it is or by adding a solvent or the like as necessary to give a predetermined moisture retention to the base fabric, and the like can be mentioned. Above all, a method in which the medicine is held in the base cloth by attaching the medicine to the base cloth in a liquid state is desirable.

When the medicine is attached in a liquid state, the medicine can easily spread over the entire base cloth, and the medicine can be uniformly and favorably held on the base cloth. Further, the base cloth, which holds the medicine in a liquid state at room temperature (25 ° C.), touches the affected part more gently, so that it is easy to use and can apply the medicine to the affected part well. Furthermore, since the medicine is in a liquid state, the affected part can be easily wiped, and dirt and the like of the underwear due to the applied medicine can be reduced or the dirt and the like can be easily removed.

As a method for keeping the drug in a liquid state, a base material is sprayed with a drug solution in which necessary components such as the above-mentioned active ingredients are blended, and a base material is impregnated with the drug solution. Alternatively, a method of dropping a drug solution onto a base cloth can be adopted. When holding the drug on the base cloth, after holding the drug on the entire surface of the base cloth by any of the above-described methods, the base cloth holding the drug is packaged as described below, and the packaged wet tissue type coating agent is used. can do.

Further, the medicine is adhered to a part of the base cloth by any of the above methods, immediately stored in a packaging bag as described below and sealed, and the medicine is applied to the entire surface of the base cloth in the packaging bag. By unfolding, the medicine may be completely retained on the base cloth, and may be packaged at the same time to obtain a packaged wet tissue type applied medicine. By carrying out in this manner, the manufacturing time of the packaged wet tissue type coating agent can be reduced.

Further, in the case where the above-mentioned base cloth is folded one or more times, the base cloth may be folded after holding the medicine. However, the base cloth may be folded in advance and the folded base cloth may be folded. The above-described method for holding a medicine may be applied to a cloth. In this case, similar to the above, before the base cloth is wrapped, the medicine holding may be completed,
After the medicine is attached to a part of the base cloth, the medicine may be immediately stored in a packaging bag or the like, and the medicine holding may be completed in the packaging bag.

Further, the drug layer and the back sheet as described above
In the case of a base cloth consisting of
Apply the drug as described above to the surface of the drug layer on the other side
Thereby, a base cloth holding the medicine can be obtained. this
In this case, it is preferable to hold the drug in a liquid state. medicine
When the agent is held in the liquid state,
The retention (impregnation) magnification is usually 1 to 6 times, preferably 2 to 5 times.
It is desirable that the workability is good. Packaging In the present invention, the above drugs are kept in a moisturized state.
Wrapped by storing the base fabric
Obtain an etishish type application.

As the packaged wet-tissue application medicine, a plurality of base cloths holding the medicine in a moisturized state may be stored in a sealed container or a sealed bag.
It is preferable that the base cloth is wrapped for each sheet. 1 base cloth
As a form of packaging each sheet, such as bags, containers, etc.,
Any form may be used as long as it is suitable for drug storage.

Among them, bags are preferable because they are easy to use. In the case of an application medicine in which the base cloth is wrapped one by one, only the required number of the applied medicines can be opened at the time of use, so that the remaining application medicines remain sealed. It has good medicinal properties and is hygienic.
Further, since only the required number can be held in a sanitary manner, it is easy to use and convenient to carry.

The packaging material for accommodating the base cloth holding the above-mentioned medicine can be appropriately selected depending on the medicine to be filled and its form. Normally, it has hygiene and safety that does not adversely affect drugs, and has excellent drug storage properties such as strength, gas barrier properties, light shielding properties, moisture resistance, heat resistance and cold resistance, and strength and heat sealing properties. It is preferable that the material is excellent in terms of processability and product properties such as printability.

As a material having these properties, a laminated resin film obtained by combining a plurality of materials having the above properties can be used. For example, examples of the film having excellent gas barrier properties, light-shielding properties, and moisture-proof properties include a resin film having a vapor-deposited layer of a metal such as aluminum (Al) or a layer made of a metal foil. The base materials of these metallized films and metal foil laminated films include polyolefins such as polyethylene (PE) and polypropylene (PP), and polyethylene terephthalate (PE).
T), polyesters such as polybutylene terephthalate (PBT) and polyethylene naphthalate (PEN), and polyamides such as nylon 6, nylon 66, and nylon 12 can be used.

Examples of the film having mechanical strength, chemical resistance, moisture resistance and heat resistance include polyolefins such as polypropylene. These polyolefins may be unstretched (eg, CPP) or stretched. (Example: OPP) can also be used, and among them, CPP is preferable because it has excellent heat sealability. Examples of the film having printability and heat resistance include biaxially stretched polyethylene terephthalate (PET). In addition, polyethylene terephthalate has scratch resistance in addition to the above properties.

Specifically, a polyethylene terephthalate (PET) layer and an aluminum foil (A
l) A laminated film composed of a layer and an unstretched polypropylene (CPP) layer, a laminated film composed of a polyethylene terephthalate (PET) layer, an aluminum foil (Al) layer and a polyethylene (PE) layer can be suitably used.

Among them, polyethylene terephthalate (PE)
A laminated film composed of a T) layer, an aluminum foil (Al) layer and an unstretched polypropylene (CPP) layer is preferred. Such a laminated film has hygiene and safety, strength,
It has excellent chemical storage properties such as gas barrier properties, light-shielding properties, moisture-proof properties, heat resistance and cold resistance, and is also excellent in terms of strength, heat sealability, printability, processability, product properties, and cost.

As a packaging bag film for accommodating each base fabric, the thickness of the laminated film is usually 20 to
It is 150 μm, preferably 30 to 100 μm, and more preferably 40 to 90 μm. In the laminated film having the polyethylene terephthalate (PET) layer, the aluminum foil (Al) layer, and the unstretched polypropylene (CPP) layer, the thickness of the PET layer, the Al layer, and the CPP layer is 5 to 30 μm, respectively. It is preferably from 5 to 20 μm and from 20 to 80 μm.

The above-mentioned laminated film is produced by a known method according to the material to be used. For example, an extruder extrudes a hot-melt film onto a substrate, laminates it, and cools and solidifies it. Extrusion lamination, hot-melt that applies heat-melted resin onto the substrate, attaches the substrate, and cools it Laminating or hot-melt coating is applied to the base material, hot-melt coating is applied to the base material with an adhesive dissolved in an organic solvent, and then dried. And a wet lamination method in which the substrate is coated in a wet state immediately after coating the substrate and then dried.

In the present invention, a wet-tissue-type coating agent containing a base cloth holding the above-mentioned chemicals in a moisturized state in a bag or the like made of such a laminated film and packing it by sealing is provided. can get. One example is shown in FIG. FIG. 1 is a partially cutaway perspective view schematically showing an example of a packaged wet tissue type coating agent of the present invention.

As shown in FIG. 1, two laminated films as described above are superposed on each other, and three edge portions 11, 12, and 13 are formed.
Is heat-sealed to form a packaging bag having an open edge portion 14. Then, from the open edge 14 of the packaging bag,
After storing the fabric 20 holding the medicine in a moisturized state (the folded fabric is shown in the figure), the edge portion 14 is heat-sealed to obtain the packaged wet-tissue type application medicine 10.

When packing the base cloth, as described above, when the medicine is held in the base cloth in a liquid state, it is necessary to complete the holding of the medicine in the base cloth before packing the base cloth. Alternatively, after the medicine is attached to a part of the base cloth, the medicine may be immediately stored in a packaging bag, sealed, and the medicine holding may be completed in the packaging bag. The edge 11,
Heat sealing of 12, 13 and 14 is usually 190 to
A heat seal bar heated to a temperature of 250 ° C., preferably 185 to 220 ° C. is applied to the above-mentioned edge, and usually 0.1 mm.
It can be carried out by press-compression bonding for up to 5 seconds, preferably for 0.5 to 1 second.

Further, it is preferable that a notch 15 is formed in the edge portion 11 of the packaging bag 10 which is heat-sealed in the longitudinal direction. In FIG. 1, the packaging bag is formed by laminating two laminated films. However, the packaging bag may be formed by folding one laminated film. In this case, 2
Formed into a bag shape by heat sealing the other edge,
By storing and sealing the base cloth holding the medicine from the other open edge, a packaged wet tissue type application medicine is obtained.

When forming a packaging bag with a laminated film, which layer of the laminated film is to be placed inside the packaging bag is appropriately determined according to the layers constituting the laminated film. For example, it is preferable that a layer made of polypropylene or polyethylene having good heat sealability and chemical resistance is placed inside the packaging bag, and a layer made of polyethylene terephthalate having good printability and scratch resistance is placed outside the packaging bag. Coating method In the method for applying a wet tissue type coating agent of the present invention, a wet tissue type coating agent comprising the above-mentioned agent and a base cloth for holding the agent in a moisturized state, or the wet tissue type coating agent is packed in a packaging bag. When applying the wet tissue type coating medicine packaged and stored in the base cloth, the base cloth holding the medicine in a moisturized state is brought into direct contact with the body part, so that the medicine held by the base cloth is applied to the body. Can be applied.

As described above, in the application method of the present invention, the medicine is applied by placing a hand (finger) on one surface of the base cloth and bringing the other surface into contact with the affected part. In such an application method, since the base cloth is brought into direct contact with the body part, there is no need to directly touch the affected part with a finger, and the treatment can be performed hygienically and comfortably. In addition, according to the above-mentioned application method, it is not necessary to directly touch the affected part with a finger, it can be applied hygienically, and it can be applied to the part to be applied without fail, so that it is easy to treat,
An early effect of the treatment is also expected, and the above-described application method can be applied to any part of the body.

Furthermore, in the above-mentioned application method, since it is not necessary to directly touch the affected part with a finger, it is particularly difficult to see the affected part or the affected part that is resistant to direct application with a finger, and it is difficult to apply the affected part with a finger. The drug can be applied well to a part, for example, a delicate zone. Also,
Since the base cloth holding the medicine used in the above-mentioned application method is a wet tissue type, it gently touches the affected part, so that the medicine can be favorably applied to the affected part. In particular,
In the application method using the base cloth holding the medicine in a liquid state, the base cloth holding the medicine touches the affected part more gently, so that the application effect is large.

Further, when a coating method using a base cloth holding a drug in a liquid state is performed, since the applied drug is in a liquid state, the affected area is easily wiped off, and the underwear is stained by the applied drug. And the like are reduced, or dirt and the like are easily removed. In addition, in a coating method using a drug layer that holds a drug in a moisturized state and a backing cloth that is in close contact with one surface of the drug layer and prevents release of the drug, a hand (finger) is placed on the back sheet. Since the medicine is applied by bringing the medicine layer into contact with the affected part, the adhesion of the medicine to the hand (finger) can be more effectively prevented.

[0062]

Hereinafter, the present invention will be described specifically with reference to examples, but the present invention is not limited to these examples.

[0063]

Example 1 A formulation example in the case of using the coating preparation of the present invention as an antipruritic antiinflammatory agent is shown below.

[0064]

[Table 1]

(Manufacture of application drug) Absorbent cotton (standard:
Use this absorbent cotton (130 mm x 99) using Japanese Pharmacopoeia).
mm) Approximately 0.77 g was impregnated with 3.1 ml of the drug solution of the above formulation to obtain one base cloth holding the drug.
The base cloth (absorbent cotton) holding the chemical was folded in the horizontal (99 mm) direction along the crease shown in FIG. 2 and then folded in the vertical (130 mm) direction to obtain a product size of 33 mm.
× 65 mm folded-type wet tissue type application drug of the present invention: antipruritic anti-inflammatory agent (active ingredient: diphenhydramine hydrochloride 1.0% by weight, benzalkonium chloride 0.2)
% By weight, other: wetting agent, etc., base cloth: absorbent cotton 60 g /
m ² , impregnation ratio: 4 times).

As a result of using the obtained coating agent, it was possible to satisfactorily apply it to the body part without directly touching the skin with the finger and hardly visible body part. (Packing) Laminated film: polyethylene terephthalate (PET) layer thickness 16 μm / aluminum foil (Al) layer thickness 9 μm / unstretched polypropylene (CP)
P) Using a layer thickness of 40 μm, this laminated film (61 m
(m × 90 mm) were superposed on each other, and the three edges were heat-sealed to form one packaging bag (61 mm × 90 mm).

Next, the above-mentioned folded base fabric 1
After storing the pieces in the bag from the side where the mouth of the packaging bag is open,
The packaged wet tissue type coating composition of the present invention was sealed by heat sealing and stored in a packaging bag. In the packaging bag made of the laminated film, an unstretched polypropylene (CPP) layer forms the inside of the bag, a polyethylene terephthalate (PET) layer forms the outside of the bag, and an aluminum foil (Al) layer forms the CPP layer and the PET. The bag is formed so as to be in the middle of the layer.

The edge of the laminated film was heated at a temperature of 200 ° C.
Then, heat sealing was performed by pressure bonding for 1 second.
A plurality of packaged wet tissue-type applied medicines stored in a packaging bag for each base cloth obtained in the same manner as above are boxed,
Alternatively, the product can be packed in a bag.

[0069]

EFFECTS OF THE INVENTION In the wet tissue type coating agent, the packaged wet tissue type coating agent and the coating method of the present invention, the medicine can be applied by bringing the base cloth holding the drug in a moisturized state into contact with the affected part. There is no need to directly touch the finger, and it is hygienic and can apply the medicine satisfactorily without leaving any residue.

Therefore, it can be used for any part of the body. The application medicine and the application method of the present invention do not need to directly touch the affected part with a finger, so that the treatment can be performed comfortably without any discomfort. In particular, an affected part having resistance to direct application with a finger, an affected part is difficult to see, a part that is difficult to apply with a finger, a delicate zone, and the like, the application agent and the application method of the present invention can be suitably used. .

The packaged wet tissue type coating composition of the present invention packaged for each base cloth is convenient to carry and easy to use. Furthermore, by wrapping each base cloth,
At the time of use, only the required number can be opened, so that the unused packaged medicine is not adversely affected and its efficacy is maintained for a long time.

[Brief description of the drawings]

FIG. 1 is a partially cutaway perspective view schematically showing an example of a packaged wet tissue type coating agent of the present invention.

FIG. 2 is an explanatory diagram illustrating an example of how to fold a base fabric according to the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 ... Packaging wet tissue type application | coating agent 11 ... Edge 12 ... Edge 13 ... Edge 14 ... Edge 15 ... Notch 20 ... Base cloth holding medicine

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61P 17/04 A61M 35/00 Z (72) Inventor Ichiro Yasaku 5 Kanda Toyama-cho, Chiyoda-ku, Tokyo 1 F-Terminology within Vision Co., Ltd. (reference) 4C076 AA71 AA88 BB31 CC17 EE01 EE31 FF68 4C084 AA02 AA21 MA02 MA63 NA10 ZA891 ZB351 ZC131

Claims (22)

[Claims] 1. A wet-tissue type coating composition comprising a drug and a base cloth for holding the drug in a moisturized state. 2. The wet tissue type coating composition according to claim 1, wherein the base fabric is made of at least one material selected from the group consisting of regenerated cellulose, synthetic fibers and natural fibers. 3. The wet according to claim 1, wherein the base cloth comprises a drug layer for holding the drug in a moisturized state, and a back sheet for tightly adhering to one surface of the drug layer and preventing the release of the drug. Tissue-type application medicine. 4. The wet tissue type application medicine according to claim 1, wherein the base cloth holds the medicine in a liquid state at room temperature. 5. The wet tissue-type applied medicine according to claim 1, wherein the medicine contains an antipruritic agent. 6. The wet tissue type coating composition according to claim 1, wherein the wet tissue type coating composition comprising the chemical and a base cloth holding the chemical is applied to a delicate zone. 7. A packaged wet tissue type coating agent characterized in that a wet tissue type coating agent comprising a drug and a base cloth for holding the drug in a moist state is stored in a packaging bag. 8. The packaged wet tissue type coating composition according to claim 7, wherein the base fabric is made of at least one selected from the group consisting of regenerated cellulose, synthetic fibers and natural fibers. 9. The packaging according to claim 7, wherein the base fabric comprises a drug layer for holding the drug in a moisturized state, and a back sheet for adhering to one surface of the drug layer and preventing the release of the drug. Wet tissue type application. 10. The packaged wet tissue-type applied medicine according to any one of claims 7 to 9, wherein a base cloth for holding the medicine in a moisturized state is housed in a packaging bag one by one. 11. The base fabric according to claim 7, wherein the base fabric is in an unfolded state or in a shape folded at least once.
0. The packaged wet-tissue-type applied medicine according to any one of 0. 12. The packaged wet tissue-type applied medicine according to claim 7, wherein the base cloth holds the medicine in a liquid state at room temperature. 13. The medicine held in the base cloth is 0.1 to 10% by weight of an antihistamine and 0.1 to 10% of a fungicide.
The packaged wet tissue-type applied medicine according to any one of claims 7 to 12, which is an antipruritic antiinflammatory agent containing 0 to 30% by weight of a wetting agent. 14. The antihistamine is at least one compound selected from the group consisting of diphenhydramine hydrochloride, isothipendyl hydrochloride, diphenhydramine lauryl sulfate, and the bactericide is benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, popidone iodine, At least one compound selected from the group consisting of chlorhexidine gluconate, wherein the wetting agent is ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3
The packaged wet-tissue application according to claim 13, which is at least one polyhydric alcohol selected from the group consisting of butanediol, glycerin and sorbit. 15. The packaging bag according to claim 7, wherein the packaging bag is formed of a laminated film having a polyethylene terephthalate layer, an aluminum foil layer, and an unstretched polypropylene layer.
14. The packaged wet tissue-type application medicine according to any of 14. 16. A wet tissue-type applied drug comprising the drug and a base cloth holding the drug is taken out by opening a packaging bag and applied to the delicate zone.
5. The packaged wet tissue-type application medicine according to any one of 5. 17. A method for applying a wet tissue type coating agent comprising a drug and a base cloth for holding the drug in a moisturized state or a packaged wet tissue type coating agent containing the wet tissue type coating agent in a packaging bag. A method for applying a wet-tissue type coating agent, wherein the agent held in the substrate cloth is transferred to a portion to be applied by directly contacting a base cloth holding the agent in a moisturized state with a body part. 18. The method for applying a wet tissue type coating agent according to claim 17, wherein the scheduled application portion is a delicate zone. 19. The wet tissue according to claim 17, wherein the base fabric comprises a drug layer for holding the drug in a moisturized state, and a back sheet for adhering to one surface of the drug layer and preventing the release of the drug. How to apply the mold application drug. 20. The method according to claim 17, wherein the base fabric holds the medicine in a liquid state at room temperature. 21. The medicine held in the base cloth is 0.1 to 10% by weight of an antihistamine and 0.1 to 10% by weight of a fungicide.
21. The method for applying a wet tissue type application according to any one of claims 17 to 20, which is an antipruritic anti-inflammatory agent containing 0 to 30% by weight of a wetting agent. 22. The antihistamine is at least one compound selected from the group consisting of diphenhydramine hydrochloride, isotipendyl hydrochloride, diphenhydramine lauryl sulfate, and the bactericide is benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, popidone iodine, At least one compound selected from the group consisting of chlorhexidine gluconate, wherein the wetting agent is ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3
22. The method for applying a wet-tissue type coating composition according to claim 21, which is at least one kind of polyhydric alcohol selected from the group consisting of butanediol, glycerin and sorbit.