JPH0446117A - Preparation of plaster with adhesive sheet - Google Patents

Abstract

PURPOSE:To prepare the subject plaster by spreading a drug on a supporter, laminating a peelable liner to the spread drug, cutting the drug in a prescribed shape, putting the laminate comprising the cut drug and the supporter on the second liner and then punching into a specific shape. CONSTITUTION:A drug 22 is spread on a supporter 21 and the first peelable liner is attached to the drug layer 22. The obtained belt-like adhesive 33 is turned inside out and punched with a roll type punching machine 29 to form cutting lines in the supporter 21 and the drug 22. The adhesive agent 24 having a prescribed shape is separated from the surrounding portions 30. The adhesive agent 23 on the first peelable liner is put on the second liner 26 at prescribed intervals (10-20 mm) and laminated to a belt-like adhesive tape 24. Cutting lines are formed in the laminated product with a roll type punching machine 29 and the excessive portions 31 of the adhesive sheet are separated, followed by cutting with a roll type cutting machine 28 to provide the objective products 35. The shapes of the adhesive sheet and the drugs put thereon can be arbitrarily selected.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a patch that is used by being attached to the skin of an affected area, and in particular, the shape of the adhesive sheet and the drug placed on the adhesive sheet. The present invention relates to a method for manufacturing a patch with an adhesive sheet, in which the shape of the adhesive sheet can be arbitrarily selected.

[Prior art] For patches that are applied to the skin of an affected area, an adhesive sheet is further applied over the patch to prevent the patch from slipping or falling off during application. I was using it.

For this reason, some products sell adhesive sheets that match the size and shape of the patch individually, or are sold as an appendix to the patch.

However, it is troublesome to further apply an adhesive sheet after applying the adhesive patch, and there are many failures such as the adhesive sheet slipping off the adhesive. For this reason, there has been a strong desire for a patch with an adhesive sheet that already holds the patch in the center of the adhesive sheet when it is manufactured. A patch with an adhesive sheet that already holds the patch in the center of the adhesive sheet at the time of production has been highly desired, but none of the above-mentioned manufacturing methods for producing a patch with an adhesive sheet are difficult because the drug in the patch is in a gel form. However, it is difficult to handle, and there are problems such as contamination with dust and evaporation of the active ingredient before the release liner is attached.

In addition, it is difficult to accurately attach the adhesive sheet to the adhesive surface, and it is necessary to establish a continuous production process and to create a machine that accurately molds and places the gel-like drug. It was necessary to create a new machine, such as a machine that would allow it to be placed in the same position.

For this reason, the inventors of the present application have provided a poultice with an adhesive tape that eliminates the trouble of attaching an adhesive tape in Japanese Patent Application No. 1-220244, and furthermore, the present inventors have provided a poultice with an adhesive tape that eliminates the trouble of attaching an adhesive tape, and furthermore, the poultice can be continuously manufactured with fewer defective products. We shared the manufacturing method.

[Problems to be Solved by the Invention] The present invention further improves the above-mentioned invention, and allows the shape of the pressure-sensitive adhesive sheet and the shape of the drug placed on the pressure-sensitive adhesive sheet to be arbitrarily selected. Another object of the present invention is to obtain a method for producing a patch with an adhesive sheet that causes less loss of the support.

[Means for Solving the Problems] The method for producing a patch with an adhesive sheet according to the present invention includes the steps of spreading and coating a drug onto a support surface, and bonding a first release liner to the drug surface side; cutting the support-drug laminate into adjacent punched shapes leaving a first release liner; peeling the adjacent laminates from the first release liner; and a step of replacing it with a second release liner at a predetermined interval.

A process of bonding an adhesive sheet to the surface of the second release liner so as to cover the laminate. The adhesive sheet covering the laminate is punched out into another predetermined shape, and the excess adhesive sheet other than the shape is removed from the second release liner. The second release liner is removed from the second release liner; and the second release liner is cut into small pieces.

[Function] The present invention includes the steps of spreading and coating a drug onto the support surface, bonding a first release liner to the drug surface side, and bonding the drug to the support while leaving the first release liner. cutting the laminate into adjacent punched shapes; and: peeling off the adjacent laminate from the first release liner and replacing it with a second release liner with a predetermined interval between the adjacent laminates. and a step of bonding an adhesive sheet to the surface of the second release liner so as to cover the laminate: punching out the adhesive sheet covering the laminate into another predetermined punched shape, and removing any excess adhesive sheet other than the punched shape. and cutting the second release liner into small pieces; therefore, when punching out the first punched shape, the area required for the adhesive peripheral portion is removed. Since there is no need to make allowances, there is no loss of chemicals or raw materials that would have been required for the adhesive periphery.

Additionally, since the first and second release liners are used in a connected roll, they are easy to position, and each manufacturing step is a series of mechanical flows, reducing costs due to material loss during the process. In comparison, manufacturing efficiency is very high due to reduction in defective products.

[Example] FIG. 1 is a top view showing the structure of a patch with an adhesive sheet obtained according to the present invention, and FIG. 2 is a sectional view of FIG. 1.

In the figure, a drug 22 is applied to the entire surface of a support 21 having a rounded rectangular shape.
There is a patch 23 which is formed by spreading and applying a laminated layer. A rectangular pressure-sensitive adhesive sheet 24 with rounded corners is attached along the outer periphery of the adhesive patch 23 . This adhesive patch includes a rectangular release liner 26 that covers the drug 22 of the adhesive patch 23 and the adhesive surface 34 of the adhesive periphery of the adhesive sheet 24.

Although the external shape of the adhesive patch 23 is a rectangular shape with rounded corners in this embodiment, it can be freely selected from other shapes such as a rectangular shape, an oval shape, a square shape, a diamond shape, a gourd shape, etc.
The shape of the patch 23 may have a uniform width along the outer circumference of the adhesive patch 23 as in this embodiment, or may be of any size as long as it can at least cover a wide range of adhesive patches 23 of various shapes. It may be of any shape. Furthermore, if the release liner 26 also covers at least the drug 22 of the patch 23 and the adhesive surface 34 of the adhesive periphery of the adhesive sheet 24,
It can take any shape.

Preferably, the width of the adhesive periphery of the adhesive sheet extending along the outer periphery of the patch 23 is 5 mm or more, more preferably 5 to 10 mm. That is, if it is less than 5 mm, the adhesive force will decrease due to the expansion and contraction of the affected area, and the rice will not be able to be removed. If it is more than 110 ff, there will be no decrease in adhesive force, but the area of the adhesive sheet will need to be widened. This is because the cost increases.

In addition, the drug 22 of the adhesive sheet-attached patch according to the present invention is as follows:
It contains drugs that have a direct effect on the skin and drugs that have a local or systemic effect through transdermal absorption in a base such as a shape-preserving agent or adhesive.

A specific example of the effective drug contained in this drug 22 is indomethacin as an analgesic and anti-inflammatory agent.

These include ketoprofen, flurbiprofen, ibuprofen, piroxicam, methyl salicylate, glycol salicylate, l-menthol, d-camphor, varynylylaceto nonylate, kabnisin, and various herbal medicines. Coronary vasodilators include nitroglycerin, nifedipine, isosorbite nitrate, and the like. Other drugs include clonidine and kallikrein (antihypertensive drugs).

There are corticosteroids, antibacterial agents, etc.

In addition, examples of shape-retaining/adhesive agents that may be included in the drug 22 as needed include carboxydimethyl cellulose sodium,
Sodium methylcellulose, polyvinyl alcohol,
Thickeners such as sodium alginate, sodium polyacrylate, polyvinylpyrrolidone, gelatin, carphobol, natural rubber type 1 synthetic rubber type, styrene-isoprene-
There are adhesives based on styrene block copolymers, silicone resins, and polyvinyl ethers.

Furthermore, as a humectant to be used as necessary, there are glycerin, propylene glycol, sorbitol, and the like.

Moreover, the support body 21 of the adhesive sheet-attached patch according to the present invention
serves to apply and retain the drug, and the most suitable one is selected depending on the properties of the drug. That is, the material used is one that has good elasticity, breathability, and texture so that it adheres closely to the drug, prevents the drug from leaking, and improves the fit to the skin.

Specific examples include flannel, woven stockinette 1
Single or composite materials such as non-woven fabric, aluminum film, and plastic film can be selected. In addition, since the manufacturing method according to the present invention includes a punching process, rounded corners,
You can freely create shapes with slits, etc.

Furthermore, the release liner 26 is also made of glassine paper, PET, etc.
, PP, PE, aluminum film, etc. processed with silicon, or as is, can be selected based on quality maintenance aspects such as drug adhesion and component migration.

The support of the adhesive sheet 24 of the adhesive patch according to the present invention is made of a single or composite material of non-woven fabric (including mesh and stretchable fabric), aluminum film, plastic film, raw rubber, synthetic polymer, etc. , one with an adhesive material such as resin can be selected. This adhesive sheet 24 is provided around the entire circumference in order to make the drug and support body fit better into the skin, and the drug 22 adheres closely to the skin and does not come off, and prevents the drug from protruding from the surrounding area. Various shapes can be selected depending on the affected area.

As described above, a patch with an adhesive sheet can be obtained that does not cause the drug 22 to stick to underwear or the like and does not easily peel off. Specific materials for the adhesive sheet 24 include nonwoven fabric,
Highly breathable materials such as plastic films are used,
It is also possible to have a structure with small ventilation holes or a large ventilation hole in the center.

Specific examples of the adhesive used in the adhesive sheet 24 include polyacrylic acid ester, natural/synthetic rubber, and styrene-isoprene-styrene block polymers, which cause less irritation to the skin. be done.

FIG. 3AXD is a process diagram showing an example of the manufacturing process of a patch with an adhesive sheet.

As shown in FIG. 3a, a drug 22 is spread and coated on a strip-shaped support 21, and a first release liner 25 is laminated on the surface of the drug 22 layer to form a strip-shaped patch 33. As mentioned above, drug 22
Since the first release liner 25 is bonded to the surface of the drug 22 layer immediately after it is spread and coated on the support 21, there is little chance of contamination with dust or the like and evaporation of the active ingredient.

As shown in FIG. 3b, the strip-shaped patch 33 is turned upside down, and the first release liner 25. @Agent 22 and support 21. Cutting lines are cut into the support 21 and the drug 22 from above using a roll-type punching machine 29 having a rounded rectangular cutting die, and the patch 23 and the excess portion 30 on its outer periphery are cut out. so that Furthermore, the excess portion 30 around the patch 23 is removed by the first release liner 25.
Remove from above. The obtained adhesive patch 23 is placed continuously on the strip-shaped first peeling liner 25.

At this time, the punching die of the roll-type punching machine 29 can be freely selected from the rectangular shape with rounded corners in this embodiment, such as rectangular, elliptical, rectangular, diamond-shaped, etc.; Good efficiency in molds.

Further, in addition to the roll type punching machine 29, a punching machine such as a regular plate punching machine can be used.

Next, as shown in FIG. 3C, the traveling direction of the release liner 25a on which the patch is placed is changed, and the patch 23 continuously placed on the release liner 25a is peeled off.

At this time, the release liner 25 after peeling off the patch 23
The angle α formed by b and the release liner 25a on which the patch 23 is placed is lJ> smaller than 90°. l! The first release liner can be used many times, so the first release liner can be used many times, so it is best to use the release liner in two stages. There will be no disadvantage.

The patch 23 peeled off from the release liner 25a is i3
Attach it to the second release liner 26 as shown in Figure c. At this time, a space is provided between adjacent adhesive patches 23 as much as necessary for the adhesive periphery, even if it does not fit between the adhesive patches 23. Preferably, the width of the adhesive periphery is 5 to 10 mm, so the adhesive patch 23
The interval should be 10 to 20+no+. A specific method is to temporarily increase the speed of the second release liner 26 at the cutting line between the patches 23 by combining a pulse motor and a control device to drive the second release liner 26. Yes. It is also possible to attach a stop motor to the drive section of the first liner 25 and adjust the speed at the cutting line in the same way.

Next, as shown in FIG. 3d, a strip-shaped adhesive sheet with the peeling paper 27 removed from the entire surface of the second peeling liner 25 on which the cutout-shaped drug 22 and the adhesive patch 23 of the support 21 are placed. 2
After bonding 4, the die-shaped adhesive sheet 1-24 and the excess adhesive sheet 31 on its outer periphery are cut out using a roll-type punching machine 39 having another rounded rectangular cutting die from above. Insert a cutting line so that it can move apart. Further, the excess portion 31 is removed from the second release liner 26. At this time, the shape of the adhesive sheet 1-24 may have a uniform peripheral width along the outer circumference of the patch 23, and it may have any shape as long as it has a thickness that at least covers the patch 23 widely. It's good too.

As shown in Figure 3e, the patch 23 is cut using a roll cutting machine 28.
Product 35 was obtained by cutting the pieces into small pieces.

As described above, the drug 22 is removed from the surface of the first release liner 25.
The support 21 is punched out into a predetermined shape, and an adhesive sheet 24 is pasted on the punched drug 22 and the front surface of the support 21.
Furthermore, in order to punch it into a predetermined shape, the pasting IQ 23 and the adhesive sheet 24 can be prepared so as to cover the rigidifying liner 25, 26, respectively, so that positioning is easy and continuous production is easy. Furthermore, since the release liner is used in the first and second stages, there is less loss of the drug and support portion.

In addition, in the above-mentioned figures 3a and 3b, the terminal end may continue to the next step or may be wound up on a drum or the like.

Furthermore, the punching machines 29 and 39 and the cutting machine 28 are not limited to those in the embodiments, and for example, a punching machine such as a lithographic punching machine may be used, and a flat blade type cutting machine may be used as the cutting machine. May be used.

As described above, in this manufacturing method, the extra parts around the customer-handled mold that occur during the punching process have to be discarded, which increases costs, but compared to conventional continuous manufacturing, manufacturing errors are more likely to occur. Since the amount is extremely small, this manufacturing method is quite profitable.

[Effects of the Invention] As explained above, the present invention includes the steps of: spreading and coating a drug on the support surface, and bonding a first release liner to the drug surface side; leaving the first release liner behind; cutting the support and drug laminate into adjacent punched shapes; peeling the adjacent laminate from the first release liner;
a step of replacing the adjoining laminates with a second release liner with a predetermined interval between them; a step of pasting an adhesive sheet on the surface of the second release liner so as to cover the laminate; A step of punching out the adhesive sheet into a predetermined different punched shape, removing the excess adhesive sheet other than the punched shape from the second release liner, and cutting the second release liner into small pieces. Therefore, the shape of the pressure-sensitive adhesive sheet can be made into any desired shape, and it can be fitted to the application site. Furthermore, since the release liner is used in two stages, the first and second stages, there is less loss of material.

In addition, since the first and second release liners are used in a connected roll, they are easy to position and manufactured using a mechanical process, which reduces the cost of producing defective products compared to the cost of material loss during the process. This has the effect of greatly improving manufacturing efficiency due to the reduction of

[Brief explanation of drawings]

FIG. 1 is a top view showing the structure of a patch with an adhesive sheet according to the present invention, FIG. 2 is a sectional view of FIG. 1, and FIG.
% e Figure is a process diagram showing an example of the manufacturing process of a patch with an adhesive sheet. Agent: Patent Attorney Tadashi Sato

Claims (1)

[Scope of Claims] A step of spreading and coating a drug on the support surface and laminating a first release liner on the drug surface side; and laminating the support and the drug while leaving the first release liner. cutting the body into adjacent punched shapes; peeling the adjacent laminates from the first release liner and replacing them with a second release liner with a predetermined interval between the adjacent laminates; bonding an adhesive sheet to the surface of the second release liner so as to cover the cut-out shaped laminate of the drug and the support; punching out the adhesive sheet covering the laminate into another predetermined cut-out shape; Remove the excess adhesive sheet other than the cutout shape from the second
A method for producing a patch with an adhesive sheet, comprising: removing the second release liner from above; and cutting the second release liner into small pieces.