JP3460092B2 - Method for producing ointment-based patch - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pressure-sensitive adhesive sheet holding an ointment and an ointment-based patch with a release liner, and more particularly to a method for reducing the amount of the ointment remaining on the release liner. The present invention relates to an applied ointment-based patch. [0002] An ointment intended for topical or systemic percutaneous absorption is a semi-solid external preparation of uniform quality having an appropriate consistency which can be easily applied to the skin. Some ointment-combined drugs are expected to be transiently effective, while other ointments are expected to be effective over a long period of time by continuously administering them to the affected area over time. [0003] For example, there are antiphlogistic analgesics, cardiovascular drugs, hormonal drugs, hypertensive drugs, etc., as well as burns, athlete's foot, acne,
Ointments for bedsores and the like are intended to be administered to an affected area over time and used. On the other hand, there are cataplasms and the like as agents for percutaneous absorption over time, and a support obtained by spreading and applying a plaster containing a drug to a base material such as a shape-retaining agent and an adhesive; There has already been proposed a pressure-sensitive adhesive sheet having a configuration in which a pressure-sensitive adhesive layer protruding along the outer periphery is covered with a release liner, and a patch with a release liner (Japanese Patent Application No. 1-220244). [0005] By the way, in the case of a plaster such as a poultice which has a shape-retaining property and does not leave the plaster on the liner at the time of use, the plaster is spread and applied on the surface of the support and the release liner is stretched. After the combination, the laminate of the support and the plaster is punched out leaving the release liner, and the excess support and the plaster are removed from the release liner, and an adhesive tape is stuck thereon and cut into small pieces. Is obtained. [0006] However, in a patch holding an ointment or the like having no shape-retaining property, the ointment is soft, so that the ointment remains on the release liner during use. In the above-mentioned manufacturing method, there is a problem that the adhesive force of the adhesive tape is significantly impaired by the ointment remaining on the release liner. [0007] The present invention relates to an ointment-based patch in which an adhesive sheet and a release liner are integrated with each other so that the ointment can be easily applied to an affected area and administered over time, and particularly, a release liner when used. It is an object of the present invention to obtain a patch and a method for producing the patch, in which almost no ointment remains. [0008] According to a first aspect of the present invention, there is provided a method for producing an ointment-based patch, comprising :
Apply a screen on one side of the support and peel off on the ointment side
Bonding the other of the release liner or the support,
The ointment is screen coated leaving the release liner
The support is punched out according to the screen coating shape.
Excess support other than the punched shape is placed on the release liner.
And holding the punched ointment
Of the release liner in a state where the support is left on the surface
A process of laminating an adhesive sheet on all surfaces, and the laminated product
And subdividing and cutting. [0010] In the ointment-based patch of the present invention, the support holding the ointment on the upper surface and inside thereof, and the support so that the adhesive periphery protrudes along the outer periphery of the support. An ointment having no shape-retaining property on the support because the pressure-sensitive adhesive sheet has a pressure-sensitive adhesive sheet holding the lower surface of the body on the pressure-sensitive adhesive surface and a release liner covering the upper surface of the support and the pressure-sensitive adhesive surface of the pressure-sensitive adhesive peripheral edge of the pressure-sensitive adhesive sheet Since the agent is retained, the amount of the ointment remaining on the liner when the release liner is removed is reduced. That is, since the support holds the ointment on the upper surface and the inside thereof, the support serves as a core, so that a soft ointment having no shape retention can be given a certain degree of shape retention. . As a result, the amount of the ointment remaining on the liner when peeled is reduced, the waste of the ointment is reduced, and the utilization of the ointment is improved. Also in the present invention, it is possible to obtain an ointment-based patch in which an adhesive sheet and a release liner are integrated with each other, which makes it easy to apply the ointment to the affected part and to administer it over time. Of course, there is no need to provide a separate support such as gauze or other locking means such as a zipper or a bandage, and an advantage of not requiring the operation of applying an ointment to another prepared support. Have The ointment used in the present invention is not particularly limited. If it is intended for transdermal absorption locally or systemically, it can be applied to a support such as gauze.
Almost all ointments that have a usage applied to the affected area can be used. These ointments include, for example, antiphlogistic analgesics, cardiovascular drugs, hormonal drugs, hypertensive drugs and the like. Further, since the ointment for burns, athlete's foot, acne, bedsores, etc. is intended to be used with time, it is particularly effective for applying the present invention. The material of each part of the support, the pressure-sensitive adhesive sheet and the release liner is not particularly limited as long as it meets the object of the present invention. Specifically, the support may be any as long as it can hold the ointment well on the upper surface and inside thereof.
A nonwoven fabric or the like having good osmotic compatibility with the ointment is selected. The form is preferably a mesh or gauze. The size, thickness, density, etc. of the support are appropriately selected according to the amount of the ointment applied. In addition, measures such as installation of a film for preventing the ointment from passing through the support itself and perforation of a ventilation hole for preventing stuffiness may be taken. Further, the pressure-sensitive adhesive sheet is provided with a support holding an ointment all around the support in order to fit the support to the skin. Therefore, preferably, the ointment does not peel off due to close contact with the skin. Any ointment may be used as long as it has a sufficient adhesive strength so as not to protrude from the surroundings.
For this reason, it is formed of a material such as a nonwoven fabric or a plastic film, and preferably a material having high air permeability is used. For this reason, it is possible to take a structure having a fine vent or a large vent at the center. The width of the peripheral edge of the adhesive provided so as to protrude along the outer periphery of the support is preferably 5 to 10 mm. That is, 5
mm or less, it is impossible to oppose the decrease in adhesive force due to expansion and contraction of the affected part, and if it is 10 mm or less, there is no decrease in adhesive force, but it is necessary to increase the area of the adhesive sheet,
This is because the cost increases. Specific examples of the pressure-sensitive adhesive for the pressure-sensitive adhesive sheet include polyacrylates, natural / synthetic rubbers, and styrene-isoprene-styrene block polymers, which have side effects such as rash on the skin. Is selected. As the release liner, it is natural that the ointment is well protected and the property of self-confidence is not changed by the ointment. For example, glassine paper, PET, P
There are P, PE, aluminum film, and the like, or a laminate of those selected from them, and those obtained by subjecting them to silicon processing. Further, in the production method of the present invention, a step of applying an ointment to one of the release liner or the support by a screen and bonding the other of the release liner or the support to the ointment surface side; A step of punching the support on which the ointment is screen-coated in accordance with the screen coating shape while leaving a liner, and removing excess support other than the punched shape from the release liner; and The step of bonding the pressure-sensitive adhesive sheet to the entire surface of the release liner in a state where the held support is left on the surface, and the step of subdividing and cutting the bonded product, so that the above-mentioned ointment-based adhesive is attached. The agents are obtained sequentially in a flow process. That is, in the present production method, first, an ointment is screen-coated on a release liner, and a support is laminated on the release liner to cover the ointment. By screen application of the ointment on this release liner, not only can a certain amount of soft ointment be applied, but when removing the excess support, the ointment is not held in the portion to be removed,
The ointment does not remain on the release liner, and even if the pressure-sensitive adhesive sheet is bonded to the release liner, the adhesive force of the pressure-sensitive adhesive tape protruding around the support is not impaired. Next, leaving the release liner, the laminated support is punched out according to the shape of the ointment coated on the screen, and an extra support other than the punched shape is removed from the release liner. The positioning of the punching of the shape of the ointment applied with the screen can be easily adjusted to the position where the screen is applied by a machine, for example, in a flow operation. The ointment having the support bonded thereto slightly spreads due to the bonding of the support and the permeation of the capillary into the support, so that the punching shape should be slightly wider than the screen coating shape and punched out. Is good. Subsequently, an adhesive sheet is attached to the entire surface of the release liner in a state where the support holding the punched ointment from which the excess support has been removed is left on the surface. At this time, since the ointment does not remain on the release liner covered with the adhesive sheet, the adhesive strength of the adhesive sheet does not decrease as described above. Finally, the product with the adhesive sheet adhered is cut into small pieces to obtain a product. As described above, in the present production method, even with a soft ointment, a patch integrated with the adhesive sheet is continuously obtained. FIG. 1 is a partially enlarged sectional view showing the structure of an embodiment of the ointment-based patch of the present invention. As shown in the figure, an ointment (11) is supported on the upper surface and inside (12)
The adhesive sheet (14) adheres the support (12) to the adhesive surface (15) so that the adhesive periphery (13) projects along the outer periphery of the support (12).
Holding on. Furthermore, by the release liner (16),
Ointment (11) of support (12) and adhesive margin (1) of adhesive sheet (14)
It covers the adhesive surface (15) of 3). In the patch of this embodiment, the ointment (11) is held on the support (12) in advance, and the adhesive sheet (14) covers the periphery of the ointment (11). And zipper,
It is not necessary to prepare locking means such as an adhesive bandage, and also, it is not necessary to perform an operation of applying an ointment to the prepared support, it is not only a simple patch, but also the support (12) of the present example. Is to hold the ointment (11) on the top and inside,
Soft ointment with support (12) as core and no shape retention
(11) can be given a certain degree of shape retention. Thereby, the amount of the ointment (11) remaining on the liner (16) when peeled is reduced, and the ointment (11) can be used without waste. FIG. 2 is a process chart showing one embodiment of the manufacturing process of the patch of FIG. In the step shown in FIG. 2A, the ointment (11) is screen-coated on a strip-shaped release liner (16) that continuously flows using a rotary screen (21) that masks a portion other than the predetermined coated surface shape. And this ointment (11)
A continuous strip-shaped support (12) is attached to the surface side. The screen application of the ointment (11) onto the release liner (16) allows the soft ointment (11) to be applied in a predetermined shape and in a predetermined amount, and of course, an extra support for each coating portion. When removing the body (12), the ointment (11) is not held on the liner of the part to be removed, so the ointment
(11) does not remain on the release liner (16), and even if the adhesive sheet (14) is attached to the release liner (16), the adhesive tape (14) overhanging around the support (12) Adhesive strength is not impaired. In the step shown in FIG. B, the bonded body to which the support (12) is bonded is formed by a punching device (22) having a punching shape slightly larger than the coating surface shape of the rotary screen (21) of the screen printing device. ) By release liner (1
6) is punched out according to the shape of the ointment (11) coated on the screen, leaving an extra support (1) other than the punched shape.
2) is wound off from the release liner (16) and removed. The positioning of the punching of the shape of the ointment applied on the screen can be easily adjusted to the screen application position by a machine in, for example, a flow operation. Note that the ointment with the support bonded thereto slightly spreads due to the bonding of the support and the permeation of the capillaries into the support, so that the punching shape is slightly wider than the screen coating shape and punched out. In the step of FIG. C, the excess support (12) is removed, and the support (1) holding the punched ointment (11) is removed.
2), on the entire surface of the release liner (16) left on the surface,
The strip-shaped pressure-sensitive adhesive sheet (14) from which the release paper (23) has been removed is bonded, and the bonded material is cut into small pieces by a cutting device (24). At this time, since the ointment does not remain on the release liner coated on the adhesive sheet, the adhesive strength of the adhesive sheet does not decrease as described above. Finally, the laminated product obtained by laminating the pressure-sensitive adhesive sheet is cut into small pieces to obtain a product. As described above, in the present production method, even with a soft ointment, a patch integrated with the adhesive sheet is continuously obtained. The amount of the ointment remaining on the release liner of the ointment-based patch of this example, in which the ointment obtained as described above was held on a support, was examined. As a comparative example, a patch was prepared in which an ointment layer was provided on an adhesive sheet. Specifically, the amount of the ointment applied to the support and the pressure-sensitive adhesive sheet was 3 g each, and the ointment was applied to 8 × 12 cm ² . The material, size, and weight of the adhesive sheet and the release liner were all the same. The support in this embodiment is a thin mesh (90% rayon, 10% polyester, 0.20 mm thick, Example 1) and a slightly thicker mesh (50% rayon, 50% polyester, thickness: 50%). 0.7
7 mm, Example 2). After the prototypes of Examples 1 and 2 and Comparative Example were left to stand overnight, the release liner was peeled off, and the amount remaining on the liner was measured. The results, as shown in Table 1 below, confirmed that the residual on the liner could be reduced according to the penetration of the ointment into the support. [Table 1] As described above, the ointment-based patch of the present invention is a patch in which an ointment is held in advance on a support and an adhesive sheet covers the periphery thereof. Since it is a patch in which an adhesive sheet is integrated as a drug, it is easy to apply an ointment to an affected part and to administer it over time. Also,
The support holding the ointment is unlikely to peel off from the affected area without the need for another means for supporting an ointment such as gauze or another locking means such as a wrapper. In addition, since the support holds the ointment on the upper surface and the inside, the support serves as a core to give a certain degree of shape retention to a soft ointment having no shape retention. Can be. As a result, the amount of the ointment remaining on the liner at the time of peeling is reduced, the waste of the ointment is reduced, and the utilization rate of the ointment is improved. In the production method of the present invention, the ointment is screen-applied on a release liner, a support is attached to the ointment surface side, and then the ointment screen-applied except for the release liner. Punching according to the shape, removing excess support other than the punched shape from the release liner, and further adhering to the entire surface of the release liner leaving the support holding the punched ointment on the surface. By laminating the sheets and subdividing and cutting the laminated material, an ointment-type patch is obtained continuously. In particular, since the ointment is not retained at the portion to be removed when the excess support is removed by the screen application of the ointment on the release liner, the ointment does not remain on the release liner. Even if the pressure-sensitive adhesive sheet is stuck to the release liner, there is an effect that the pressure-sensitive adhesive force of the pressure-sensitive adhesive tape protruding around the support is not impaired.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a partially enlarged sectional view showing the configuration of an embodiment of an ointment-based patch of the present invention. 2 is a process chart showing one embodiment of a production process of the patch of FIG. 1; FIG. A shows a step of applying an ointment on a release liner by screen application and laminating a support; FIG. The step of punching and removing excess support, and FIG. C is the step of laminating and subdividing the adhesive sheet. [Description of Signs] (11) ointment, (12) support, (13) adhesive margin, (14) adhesive sheet, (15) adhesive surface, (16) release liner, (21) … Rotary clean, (22)… Punching device, (23)… Release paper, (24)… Cutting device,

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-7-97315 (JP, A) JP-A-3-85160 (JP, A) JP-A 52-97987 (JP, U) 48233 (JP, B1) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 9/70

Claims (1)

(57) Claims 1. A step of applying an ointment to a release liner or a support on a screen, and bonding the other of the release liner or the support to the ointment surface side; A step of punching the support on which the ointment is screen-coated in accordance with the screen coating shape while leaving a release liner, and removing excess support other than the punched shape from the release liner; An ointment-based patch, comprising: a step of adhering an adhesive sheet to the entire surface of the release liner in a state where the support holding the surface is left on the surface; and a step of dividing and cutting the bonded material. Manufacturing method.